Jeffrey A Johnson

..We evaluated the prevalence of engagement in lifestyle behaviors for management of the disease, as well as the impact of healthcare professional support on these behaviors...

..Our objective is to comprehensively evaluate a collaborative care model for comorbid depression and type 2 diabetes within a Canadian primary care setting...

..This paper reviews factors related to cancer incidence in the diabetic population; the second paper relates to studies of cancer mortality...

..The primary aim of this study was to compare the efficacy of three physical activity (PA) behavioural intervention strategies in a sample of adults with type 2 diabetes...

..To elicit societal and patient utilities associated with diabetic symptomatic non-severe hypoglycaemia for three health states: 1) rare (quarterly), 2) intermittent (monthly), 3) and frequent (weekly) hypoglycaemia episodes...

..Rosiglitazone remained available for use as more definitive safety trials were ongoing. This issue was reported in the lay media...

..Our objective was to compare health care utilization and per capita expenditures according to Registered Indian and diabetes status in the province of Saskatchewan...

..To compare the performance of the RAND-12 and SF-12 physical and mental health summary scores, in a sample of people with type 2 diabetes, in distinguishing groups of differing disease severity...

..Most quality improvement efforts for type 2 diabetes have neglected cardiovascular risk factors and are limited by a lack of information about generalizability across settings or persistence of effect over time...

..This study examined metformin use in relation to risk of cardiovascular-related hospitalization and mortality...

..We were interested to determine if data from major randomised controlled trials would support a hypothesis that improving glycaemic control may reduce the risk of cancer outcomes...

..To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D)...

..We assessed whether provision of free testing strips would improve glycaemic control in non-insulin-treated Type 2 diabetic patients...

..The aim of this study was to examine the relationship between use of metformin and sulfonylurea and mortality in new users of these agents...

..To compare changes in diagnosed diabetes prevalence and incidence among Status Aboriginal men and women living in urban and rural areas of Alberta...

..To compare recent trends of diabetes prevalence, incidence and mortality between men and women living in urban and rural Alberta, Canada...

..Those individuals with type 2 diabetes who used insulin had higher testing supply costs than those on oral antidiabetic medication alone (359 vs 131 dollars; p < 0.001)...

..The objective of the study was to examine the risks of site-specific cancer in people with incident type 2 diabetes during different time windows following diabetes onset...

..To analyze trends in health care costs in the decade after identification of diabetes, contrasting type 1 and 2 diabetes...

..It is uncertain whether this increased risk is related to a deleterious effect of sulfonylurea and insulin or a protective effect of metformin or due to some unmeasured effect related to both choice of therapy and cancer risk...

..Overall HUI3 scores were significantly predictive of all three categories of health-care resource use. CONCLUSION: Observed differences between groups contribute further evidence of the construct validity of the HUI3 in type 2 diabetes...

..The purpose of this analysis was to use generic measures of HRQL to describe HRQL deficits associated with varying degrees of severity of type 2 diabetes...

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..Results of this substudy suggest that pharmacists should target this patient group for interventions in cholesterol risk management...

..We assessed the HRQL burden in patients with these comorbid conditions, postulating that they would have even greater HRQL deficits...

..CONCLUSIONS: Metformin, alone or in combination, in subjects with heart failure and type 2 diabetes was associated with lower morbidity and mortality compared with sulfonylurea monotherapy...

..Overall, 36% of the variance in the Health Utilities Index Mark 3 was explained. CONCLUSION: Social and environmental factors are important, but comorbidities have the largest impact on HRQL among people with type 2 diabetes...

..Recent reports suggest that the health status of individuals residing in rural areas (as much as one third of the Canadian population) may be inferior to those who live in urban areas...

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..However, we found significant underuse of aspirin therapy among our study population. Aspirin should be included and better promoted as a factor in high-quality, evidence-based DM management...

..The objective of the study is to evaluate the implementation of an evidence-based self- management program for patients with T2DM within a newly established primary care network (PCN) environment...

..Since most patients were still not at the target LDL level, this finding suggests that continuing intervention is necessary to help patients reach this target...

..The results of this study contribute evidence of construct validity of the HUI2, HUI3 and RAND-12 in type 2 diabetes...

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..HRQL in people with type 2 diabetes was positively associated with exercise adherence, which was related to a positive PPR. Adherence to diet was also related to a positive PPR, but diet adherence had no association with HRQL...

..Although thiazolidinediones precipitate fluid retention in clinical trials, current guidelines advocate their use for patients with diabetes who are felt to be at low risk for heart failure (HF)...

..To determine if the risk of developing heart failure (HF) is associated with the use of sulfonylurea or metformin in patients with diabetes...

..We estimated the prevalence and specific patterns of multimorbidity across different adult age groups. Furthermore, we examined the associations of multimorbidity with socio-demographic factors...

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..We examined the apparent association between oral antidiabetic therapy and mortality by simulating the effects of restrictive drug coverage policies...

..Therefore, we attempted to conduct a pilot study to evaluate the feasibility of undertaking a large randomized controlled trial with clinical endpoints...

..Recent reports suggest that the health status of individuals residing in rural areas (as much as one third of the Canadian population) may be inferior to those who live in urban areas...

..These are patient subgroups that should be targeted as opportunities to improve hypertension management at the population level...

..Despite the availability of proved effective therapies, treatment gaps were present for this cohort of patients...

..We aimed to evaluate the changes in cardiovascular-related health care utilization (drug therapies, hospitalizations) and mortality for the diabetic population during a 9-year period in Saskatchewan, Canada...

..INTERPRETATION: Using a large, population-based administrative cohort, we found little evidence that type 2 diabetes increases the risk of depression once comorbid diseases and the burden of diabetes complications were accounted for...

..5%, p = 0.006). INTERPRETATION: Patients without insurance for self-monitoring test strips had poorer glycemic control...

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..This study was done to evaluate the quality of the evidence (based on consideration of its internal validity, clinical relevance, and applicability) underlying therapy recommendations in evidence-based clinical practice guidelines...

..Programs to improve the quality of cardiovascular risk reduction in these high-risk patients are needed...

..The objective of this study was to evaluate the differential risk of diabetes among people with depression taking antidepressant therapy...

..To review the literature on the association between antidiabetic agents and morbidity and mortality in people with heart failure and diabetes...

..030), hospitalization days (812 versus 341, P = .003), and cost of care (2,531 Canadian dollars less per patient) in favor of the PSP. CONCLUSION: Simple interventions can improve ACE inhibitor use and patient outcomes...

..26-0.30, relative to controls. CONCLUSIONS: The illness burden experienced by individuals with diabetes is not only associated with diabetes itself, but largely with comorbid medical conditions...

..The same relation was not observed with metformin. This implies that the manner in which blood glucose concentration is lowered may be as important as achieving recommended glucose targets...

..The objectives of this study were to examine: (1) determinants of QoL in adults with T1D; and, (2) differences in QoL determinants between T1D and T2D groups...

..To assess the cross-sectional construct validity of the Health Utilities Index Mark 3 (HUI3) in Alzheimer disease (AD), arthritis (AR), and cataracts (CA)...

..The present study explores the ability of the EQ-5D HRQL measure to differentiate among those with a clinical diagnosis of MDE and/or anxiety disorders...

..We compared the incidence and prevalence of diabetes, and its impact on mortality, among status Aboriginal adults and adults in the general population between 1995 and 2007...

..43, 95% CI 1.17-1.75). CONCLUSION: Compared with sulfonylurea therapy, metformin therapy appears to be associated with a delay in the onset of secondary failure...

..Future strategies must address a number of dimensions beyond simple education...

..CONCLUSIONS: A diabetes outreach service has the potential to improve the quality of diabetes care for rural patients. Future studies need to involve longer timelines and larger sample sizes...

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..To track and compare trends in diabetes rates from 1995 to 2007 for Status Aboriginal and general population youth...

..To evaluate the effect of adding pharmacists to primary care teams on the management of hypertension and other cardiovascular risk factors in patients with type 2 diabetes...

..We recently published an economic evaluation assessing the use of drug-eluting stents in patients undergoing percutaneous coronary intervention (PCI)...

..Despite the high risk for future fractures and the availability of effective treatments, fewer than 10% to 20% of patients who sustain a fragility fracture are tested or treated for osteoporosis...

..To evaluate the prevalence of cardiovascular risk factors (CV-RF) and disease (CV-D) in people with schizophrenia...

..To evaluate the relation between adherence to drug therapy, including placebo, and mortality...

..44-0.90]; P = 0.012). CONCLUSIONS: The use of ACE inhibitors was associated with a significant reduction in all-cause and cardiovascular-related mortality in a broad spectrum of patients with type 2 diabetes and no cardiovascular disease...

..We compared the relative responsiveness of generic and heart failure specific HRQL instruments, as measured both by common psychometric indices and by external clinical criteria...

..Little is known regarding health-related quality of life and its relation with physical activity level in the general population. Our primary objective was to systematically review data examining this relationship...

..0-12.0 g/dL) and high hemoglobin target levels (>12.0 g/dL) and performed a meta-analysis of all available 36-item short-form (SF-36) RCT data...

..We determined the incidence of stroke in people newly treated for type 2 diabetes...

..We hypothesized that the inclusion of HRQL in routine clinical care would improve patient-clinician communication, affect clinical management, and improve patients' HRQL...

..A secondary objective was to evaluate demographic and health behavioural characteristics of the participants of the study to assess the degree of respondent bias...

..This study examines the longitudinal validity of the modified Edmonton symptom assessment system (ESAS) to determine the impact of change in symptom burden on the change in HRQL of haemodialysis (HD) patients...

..Conclusion. The BMU survey demonstrated reasonable reliability and validity characteristics in this first clinical experience. Despite high adherence, patients still reported barriers that may hinder optimal drug use...

..This study aimed to determine the effect of a program of community pharmacist intervention on the process of cholesterol risk management in patients at high risk for cardiovascular events...

..The absence of a significant association between overall medication nonadherence and health outcomes may reflect study limitations and/or the need to differentiate among types of nonadherent behaviours...

..An economic analysis of the trial now demonstrates that the intervention tested "dominates" usual care: over a lifetime horizon, it reduces fracture, increases quality-adjusted life years, and saves the healthcare system money...

..We explored the relationship between glucose-lowering agents and cancer mortality rates in type 2 diabetes patients, hypothesising a decreased risk of cancer mortality with metformin use and a dose-risk gradient for insulin therapy...

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..Violations of assumptions of the OLS regression model indicate the need for further investigation into the modelling technique used in deriving a single index score...

..The incremental cost to provide the program appeared minimal from both government and pharmacy manager perspectives. It is hoped that these results could support negotiations for reimbursement of clinical pharmacy services with payors...

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..70, P<0.01. Symptom burden is high and adversely affects HRQL in dialysis patients. The modified ESAS is a reliable, valid, simple, and useful method for regular symptom assessment in this patient population...

..The SF-12 appeared to be more sensitive to differences associated with less severe morbidity...

..Our objective was to examine longer-term outcomes, reproducibility, and cost-effectiveness of this intervention...

..To determine the efficacy of a program of intervention by pharmacists on lipid risk management in patients at high risk for cardiovascular events...

..Both self-reported and proxy assessments were evaluated for replicability...

..To evaluate the relationship between self-reported health status and satisfaction with pharmacy services...

..Whether increasing dialysis adequacy in large patients not achieving KDOQI targets improves HRQL is unknown...

..Dialysis adequacy was significantly associated with HRQOL in hemodialysis patients. Controlled studies that examine the effect of increasing Kt/V on HRQOL are needed...

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..Second, it provides needed data to demonstrate the value of enhanced pharmacy practice. Thorough understanding of pharmacists' opinions is necessary to optimize the design of future studies...

..However, recently developed questionnaires do not specifically quantify severity of the symptom...