T Jin

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells
    Jane Sun
    Division of Cell and Molecular Biology, University Health Network, Canada
    Cell Signal 20:219-29. 2008
  2. doi request reprint Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells
    Fenghua Yi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7
    Endocrinology 149:2341-51. 2008
  3. doi request reprint Why diabetes patients are more prone to the development of colon cancer?
    Tianru Jin
    Department of Medicine, University of Toronto, Canada
    Med Hypotheses 71:241-4. 2008
  4. doi request reprint Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines
    Diana Islam
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College St, Toronto, Ontario M5G 1L7
    Am J Physiol Endocrinol Metab 296:E174-81. 2009
  5. pmc The role of the Wnt signaling pathway in incretin hormone production and function
    Yu Ting A Chiang
    Department of Physiology, University of Toronto Toronto, ON, Canada
    Front Physiol 3:273. 2012
  6. pmc Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Canada
    PLoS ONE 7:e28784. 2012
  7. pmc Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter
    Lijun Wang
    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat Sen University, Guangzhou, People s Republic of China
    Lipids Health Dis 12:34. 2013
  8. pmc The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Diabetes 62:789-800. 2013
  9. doi request reprint P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice
    Yuting Alex Chiang
    Departments of Physiology, University of Toronto, Ontario, Canada M5S 1A8
    Endocrinology 154:77-88. 2013
  10. pmc The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis
    Wilfred Ip
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 303:E1166-76. 2012

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells
    Jane Sun
    Division of Cell and Molecular Biology, University Health Network, Canada
    Cell Signal 20:219-29. 2008
    ..Our observations support the existence of crosstalk between insulin and Wnt signaling pathways, and suggest that the crosstalk involves a PKB-independent mechanism...
  2. doi request reprint Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells
    Fenghua Yi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7
    Endocrinology 149:2341-51. 2008
    ....
  3. doi request reprint Why diabetes patients are more prone to the development of colon cancer?
    Tianru Jin
    Department of Medicine, University of Toronto, Canada
    Med Hypotheses 71:241-4. 2008
    ..A pathological consequence of this compensation will be the stimulated expression of proto-oncogenes, including c-Myc...
  4. doi request reprint Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell lines
    Diana Islam
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College St, Toronto, Ontario M5G 1L7
    Am J Physiol Endocrinol Metab 296:E174-81. 2009
    ..secretion of glucagon and GLP-1 in response to cAMP elevation...
  5. pmc The role of the Wnt signaling pathway in incretin hormone production and function
    Yu Ting A Chiang
    Department of Physiology, University of Toronto Toronto, ON, Canada
    Front Physiol 3:273. 2012
    ..In this review, we have introduced the incretin hormones and the Wnt signaling pathway, summarized recent findings in the field, and provided our perspectives...
  6. pmc Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Canada
    PLoS ONE 7:e28784. 2012
    ..This is in contrast with the known repressive effect of curcumin on Wnt signaling in other cell lineages...
  7. pmc Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter
    Lijun Wang
    Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat Sen University, Guangzhou, People s Republic of China
    Lipids Health Dis 12:34. 2013
    ..Here we hypothesized that betaine supplement and subsequent DNA methylation modifications alter the expression of genes that are involved in hepatic lipid metabolism and hence alleviate hepatic triglyceride accumulation...
  8. pmc The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Diabetes 62:789-800. 2013
    ....
  9. doi request reprint P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice
    Yuting Alex Chiang
    Departments of Physiology, University of Toronto, Ontario, Canada M5S 1A8
    Endocrinology 154:77-88. 2013
    ..We suggest that Pak1 mediates the cross talk between insulin and Wnt signaling pathways on gut and brain gcg expression, and its ablation impairs glucose homeostasis...
  10. pmc The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis
    Wilfred Ip
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 303:E1166-76. 2012
    ..These observations suggest that Wnt signaling and TCF7L2 are negative regulators of hepatic gluconeogenesis, and TCF7L2 is among the downstream effectors of insulin in hepatocytes...
  11. pmc The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective
    Wilfred Ip
    Institute of Medical Science, University of Toronto, Toronto, Canada
    Cell Biosci 2:28. 2012
    ..We then expanded our view into the crosstalk among Wnt, insulin and FOXO signaling cascades, which further illustrates the complexity of the Wnt signaling pathway in metabolic homeostasis. Finally, we have presented our perspectives...
  12. pmc Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2
    Peixiang Wang
    Div of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 10 354 Toronto Medical Discovery Tower, The MaRS Building, 101 College St, Toronto, Ontario M5G 1L7, Canada
    BMC Cell Biol 11:56. 2010
    ..Oct-1 binds to Cdx-2 promoter and represses its expression. cAMP elevation leads to increased nuclear exclusion of Oct-1, associated with reduced recruitment of nuclear co-repressors to the Cdx-2 promoter and increased Cdx-2 expression...
  13. ncbi request reprint The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
    Tianru Jin
    Department of Medicine, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Mol Endocrinol 22:2383-92. 2008
    ....
  14. ncbi request reprint Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin
    Tianru Jin
    Department of Medicine, University of Toronto, Canada
    Cell Signal 20:1697-704. 2008
    ..These observations provide new insight to understand how Wnt, insulin/growth factors, and FOXOs are involved in versatile physiological events and the development and progression of various human diseases...
  15. ncbi request reprint The WNT signalling pathway and diabetes mellitus
    T Jin
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetologia 51:1771-80. 2008
    ..These observations shed new light on the pathogenesis of type 2 diabetes as an age-dependent disease...
  16. doi request reprint Mechanisms underlying proglucagon gene expression
    Tianru Jin
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Endocrinol 198:17-28. 2008
    ..This review summarizes our current understanding on the mechanisms underlying gcg transcription and presented my interpretations on how the interactions between different signaling networks regulate gcg expression...
  17. ncbi request reprint Characterization of a novel silencer element in the human aromatase gene PII promoter
    T Jin
    Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Ontario, Canada
    Breast Cancer Res Treat 62:151-9. 2000
    ....
  18. ncbi request reprint Examination of POU homeobox gene expression in human breast cancer cells
    T Jin
    Oncology Research Laboratories, Toronto Hospital, University of Toronto, Ontario, Canada
    Int J Cancer 81:104-12. 1999
    ..As OCT3 expression was detected only in the breast cancerous cells, this embryonic transcription factor could play an important role in mammary gland carcinogenesis...
  19. ncbi request reprint Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2
    T Jin
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada
    J Biol Chem 276:14752-8. 2001
    ....
  20. ncbi request reprint PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP
    Liang Chen
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario
    FEBS J 272:2746-59. 2005
    ..Taken together, our observations suggest that Cdx-2 expression is regulated by the second messenger cAMP, cell-type specifically, via the Epac pathway...
  21. doi request reprint The role of insulin signaling in the development of β-cell dysfunction and diabetes
    Qinghua Wang
    Division of Endocrinology and Metabolism, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Islets 1:95-101. 2009
    ..It is hypothesized that a strategy to improve intra-islet insulin action via enhancing β-cell responsiveness could be a considerable benefit in the prevention and treatment of T2DM...
  22. pmc The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells
    Peixiang Wang
    Department of Medicine, University of Toronto, 67 College Street, Toronto, ON, Canada M5G 2M1
    Biochem J 375:199-205. 2003
    ..These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression...
  23. ncbi request reprint Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cells
    Tao Liu
    Department of Medicine and Institute of Medical Science, University of Toronto, Rm 410, 67 College Street, Toronto, Ont, Canada M5G 2M1
    Mol Cell Endocrinol 249:140-9. 2006
    ..We suggest that this study reveals a novel function for Pbx1 in pancreatic islet physiology: regulating proglucagon expression by serving as a co-factor for Cdx-2...
  24. doi request reprint Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes
    A Maharaj
    Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    Diabetologia 55:1458-68. 2012
    ..We aimed to study the effects of a 'decoy receptor' for circulating glucagon on modulating beta cell function and glucose homeostasis in mice by over-producing the glucagon receptor (GCGR) in skeletal muscles...
  25. doi request reprint Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice
    D Song
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    Diabetologia 54:1181-9. 2011
    ..Here we examined the relative contributions of acute CNS and extra-CNS CB1R modulation on insulin sensitivity using pharmacological gain- and loss-of-function of CB1R in mice...
  26. doi request reprint Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells
    Jane Sun
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada Division of Cell and Molecular Biology, University Health Network, Canada
    Biochim Biophys Acta 1800:344-51. 2010
    ..Insulin was shown to stimulate Wnt target gene expression, utilizing the effector of the Wnt signaling pathway. Whether insulin affects expression of components of Wnt pathway has not been extensively examined...
  27. pmc POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP
    Peixiang Wang
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 284:26456-65. 2009
    ..Our study therefore identifies a novel mechanism by which cAMP regulates hormone-gene expression and suggests that ubiquitously expressed Oct-1 may play a role in metabolic homeostasis by functioning as a sensor for cAMP...
  28. ncbi request reprint Role of Cdx-2 in insulin and proglucagon gene expression: a study using the RIN-1056A cell line with an inducible gene expression system
    Yi Zhao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
    J Endocrinol 186:179-92. 2005
    ..We suggest that Cdx-2 may mediate the second messenger cAMP in regulating insulin gene transcription...
  29. ncbi request reprint Redundant and synergistic effect of Cdx-2 and Brn-4 on regulating proglucagon gene expression
    Peixiang Wang
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Ontario, Canada
    Endocrinology 147:1950-8. 2006
    ..Our observations suggest that Cdx-2 and Brn-4, two HD proteins that belong to two different families, exert a synergistic and redundant effect on proglucagon gene expression...
  30. ncbi request reprint Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells
    Shamim Lotfi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 67 College Street, Toronto, Ontario, Canada M5G 2M1
    Endocrinology 147:3727-36. 2006
    ..We therefore suggest that cAMP at least partially regulates proglucagon gene expression via the Epac-Ras/Rap-Raf-MEK-ERK signaling pathway...
  31. ncbi request reprint TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta
    Fenghua Yi
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2M1, Canada
    J Biol Chem 280:1457-64. 2005
    ..We have therefore identified a unique mechanism that regulates glu expression in gut endocrine cells only. Tissue-specific expression of TCF factors thus may play a role in the diversity of the Wnt pathway...
  32. ncbi request reprint P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine
    J Sun
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Oncogene 28:3132-44. 2009
    ..Our observations suggest that PAK-1 serves as an important linker between insulin and Wnt signaling pathways...
  33. doi request reprint Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway
    L Li
    Keenan Research Centre, LiKaShing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
    Biochem Cell Biol 89:515-21. 2011
    ..The LPA/Rho/ROCK pathway inhibits expression of PPARγ and adipogenesis in part through a delayed activation of the canonical Wnt-signaling pathway based on increased Wnt10b expression and β-catenin induction...
  34. ncbi request reprint Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells
    Zuyao Ni
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Ontario M5G 2M1, Canada
    J Biol Chem 278:1380-7. 2003
    ..These observations indicate that the proglucagon gene is among the targets of the Wnt signaling pathway...
  35. doi request reprint Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas
    Joshua Columbus
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    J Endocrinol 207:77-86. 2010
    ..We suggest that hyperinsulinemia represses Tcf gene expression in the pancreas. Whether and how this reduction alters the function of pancreatic β cells during hyperinsulinemia deserves further investigation...
  36. ncbi request reprint Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells
    Weijuan Shao
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Canada Banting and Best Diabetes Centre, Faculty of Medicine, University of Toronto, Canada Dept of Medicine, University of Toronto, Canada
    Cell Signal 22:1240-6. 2010
    ..We suggest that proteasome-dependent TxNIP degradation is a novel mechanism by which Ex-4-cAMP signaling protects pancreatic beta cells...
  37. ncbi request reprint The Blimp-1 gene regulatory region directs EGFP expression in multiple hematopoietic lineages and testis in mice
    Dingyan Wang
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 620 University Avenue, Room 8 205, Toronto, ON, Canada, M5G 2C1
    Transgenic Res 17:193-203. 2008
    ..Our studies collectively suggest that Blimp-1 may play a general role in the development of hematopoietic lineages and a stage-specific role in spermatogenesis...
  38. doi request reprint Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1
    Adam S Sirek
    Department of Physiology, University of Toronto, Toronto, Canada
    Endocrinology 150:3483-92. 2009
    ..Our observations therefore identify Oct-1 as a transcriptional repressor of ChREBP and suggest that insulin stimulates ChREBP expression via attenuating the repressive effect of Oct-1...
  39. ncbi request reprint The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell
    Gareth E Lim
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 150:5249-61. 2009
    ..Taken together, these data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1, and GLP-1 secretion in response to insulin...
  40. doi request reprint New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1)
    Zhiwen Yu
    Banting and Best Diabetes Centre, University of Toronto, Canada
    Cell Signal 22:1-8. 2010
    ..Together, these novel findings bring us a new insight into the role of cAMP in the production and function of the incretin hormone GLP-1...
  41. ncbi request reprint Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells
    Philip R Debruyne
    Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 130:1191-206. 2006
    ..The present studies examine the expression of GC-C in normal tissues and tumors from esophagus and stomach and mechanisms regulating its expression by acid and bile acids...