Research Topics
Genomes and Genes | T JinSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cellsJane Sun
Division of Cell and Molecular Biology, University Health Network, Canada
Cell Signal 20:219-29. 2008..Our observations support the existence of crosstalk between insulin and Wnt signaling pathways, and suggest that the crosstalk involves a PKB-independent mechanism...
Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cellsFenghua Yi
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7
Endocrinology 149:2341-51. 2008....- Why diabetes patients are more prone to the development of colon cancer?Tianru Jin
Department of Medicine, University of Toronto, Canada
Med Hypotheses 71:241-4. 2008..A pathological consequence of this compensation will be the stimulated expression of proto-oncogenes, including c-Myc... - Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic alpha- and intestinal L-cell linesDiana Islam
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College St, Toronto, Ontario M5G 1L7
Am J Physiol Endocrinol Metab 296:E174-81. 2009..secretion of glucagon and GLP-1 in response to cAMP elevation... 
The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasisWeijuan Shao
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Diabetes 62:789-800. 2013....- P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 miceYuting Alex Chiang
Departments of Physiology, University of Toronto, Ontario, Canada M5S 1A8
Endocrinology 154:77-88. 2013..We suggest that Pak1 mediates the cross talk between insulin and Wnt signaling pathways on gut and brain gcg expression, and its ablation impairs glucose homeostasis... - The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesisWilfred Ip
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Am J Physiol Endocrinol Metab 303:E1166-76. 2012..These observations suggest that Wnt signaling and TCF7L2 are negative regulators of hepatic gluconeogenesis, and TCF7L2 is among the downstream effectors of insulin in hepatocytes... - The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspectiveWilfred Ip
Institute of Medical Science, University of Toronto, Toronto, Canada
Cell Biosci 2:28. 2012..We then expanded our view into the crosstalk among Wnt, insulin and FOXO signaling cascades, which further illustrates the complexity of the Wnt signaling pathway in metabolic homeostasis. Finally, we have presented our perspectives... - Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2Peixiang Wang
Div of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 10 354 Toronto Medical Discovery Tower, The MaRS Building, 101 College St, Toronto, Ontario M5G 1L7, Canada
BMC Cell Biol 11:56. 2010..Oct-1 binds to Cdx-2 promoter and represses its expression. cAMP elevation leads to increased nuclear exclusion of Oct-1, associated with reduced recruitment of nuclear co-repressors to the Cdx-2 promoter and increased Cdx-2 expression... - Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-cateninTianru Jin
Department of Medicine, University of Toronto, Canada
Cell Signal 20:1697-704. 2008..These observations provide new insight to understand how Wnt, insulin/growth factors, and FOXOs are involved in versatile physiological events and the development and progression of various human diseases... - Mechanisms underlying proglucagon gene expressionTianru Jin
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Endocrinol 198:17-28. 2008..This review summarizes our current understanding on the mechanisms underlying gcg transcription and presented my interpretations on how the interactions between different signaling networks regulate gcg expression... - The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitusTianru Jin
Department of Medicine, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Mol Endocrinol 22:2383-92. 2008.... - The WNT signalling pathway and diabetes mellitusT Jin
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Diabetologia 51:1771-80. 2008..These observations shed new light on the pathogenesis of type 2 diabetes as an age-dependent disease... - Examination of POU homeobox gene expression in human breast cancer cellsT Jin
Oncology Research Laboratories, Toronto Hospital, University of Toronto, Ontario, Canada
Int J Cancer 81:104-12. 1999..As OCT3 expression was detected only in the breast cancerous cells, this embryonic transcription factor could play an important role in mammary gland carcinogenesis... - Characterization of a novel silencer element in the human aromatase gene PII promoterT Jin
Division of Cell and Molecular Biology, Toronto General Research Institute, University of Toronto, Ontario, Canada
Breast Cancer Res Treat 62:151-9. 2000.... - Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2T Jin
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada
J Biol Chem 276:14752-8. 2001.... - The role of insulin signaling in the development of β-cell dysfunction and diabetesQinghua Wang
Division of Endocrinology and Metabolism, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Islets 1:95-101. 2009..It is hypothesized that a strategy to improve intra-islet insulin action via enhancing β-cell responsiveness could be a considerable benefit in the prevention and treatment of T2DM... - PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMPLiang Chen
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario
FEBS J 272:2746-59. 2005..Taken together, our observations suggest that Cdx-2 expression is regulated by the second messenger cAMP, cell-type specifically, via the Epac pathway... - The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cellsPeixiang Wang
Department of Medicine, University of Toronto, 67 College Street, Toronto, ON, Canada M5G 2M1
Biochem J 375:199-205. 2003..These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression... - Pbx1 is a co-factor for Cdx-2 in regulating proglucagon gene expression in pancreatic A cellsTao Liu
Department of Medicine and Institute of Medical Science, University of Toronto, Rm. 410, 67 College Street, Toronto, Ont, Canada M5G 2M1
Mol Cell Endocrinol 249:140-9. 2006..We suggest that this study reveals a novel function for Pbx1 in pancreatic islet physiology: regulating proglucagon expression by serving as a co-factor for Cdx-2... - Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetesA Maharaj
Division of Endocrinology and Metabolism, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
Diabetologia 55:1458-68. 2012..We aimed to study the effects of a 'decoy receptor' for circulating glucagon on modulating beta cell function and glucose homeostasis in mice by over-producing the glucagon receptor (GCGR) in skeletal muscles... - Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in miceD Song
Department of Medicine, University of Toronto, Toronto, ON, Canada
Diabetologia 54:1181-9. 2011..Here we examined the relative contributions of acute CNS and extra-CNS CB1R modulation on insulin sensitivity using pharmacological gain- and loss-of-function of CB1R in mice... - TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3betaFenghua Yi
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, M5G 2M1, Canada
J Biol Chem 280:1457-64. 2005..We have therefore identified a unique mechanism that regulates glu expression in gut endocrine cells only. Tissue-specific expression of TCF factors thus may play a role in the diversity of the Wnt pathway... - Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cellsShamim Lotfi
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 67 College Street, Toronto, Ontario, Canada M5G 2M1
Endocrinology 147:3727-36. 2006..We therefore suggest that cAMP at least partially regulates proglucagon gene expression via the Epac-Ras/Rap-Raf-MEK-ERK signaling pathway... - Role of Cdx-2 in insulin and proglucagon gene expression: a study using the RIN-1056A cell line with an inducible gene expression systemYi Zhao
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
J Endocrinol 186:179-92. 2005..We suggest that Cdx-2 may mediate the second messenger cAMP in regulating insulin gene transcription... - POU homeodomain protein Oct-1 functions as a sensor for cyclic AMPPeixiang Wang
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada
J Biol Chem 284:26456-65. 2009..Our study therefore identifies a novel mechanism by which cAMP regulates hormone-gene expression and suggests that ubiquitously expressed Oct-1 may play a role in metabolic homeostasis by functioning as a sensor for cAMP... - Redundant and synergistic effect of Cdx-2 and Brn-4 on regulating proglucagon gene expressionPeixiang Wang
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Ontario, Canada
Endocrinology 147:1950-8. 2006..Our observations suggest that Cdx-2 and Brn-4, two HD proteins that belong to two different families, exert a synergistic and redundant effect on proglucagon gene expression... - Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cellsJane Sun
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada Division of Cell and Molecular Biology, University Health Network, Canada
Biochim Biophys Acta 1800:344-51. 2010..Insulin was shown to stimulate Wnt target gene expression, utilizing the effector of the Wnt signaling pathway. Whether insulin affects expression of components of Wnt pathway has not been extensively examined... - P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestineJ Sun
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Oncogene 28:3132-44. 2009..Our observations suggest that PAK-1 serves as an important linker between insulin and Wnt signaling pathways... - Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathwayL Li
Keenan Research Centre, LiKaShing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Biochem Cell Biol 89:515-21. 2011..The LPA/Rho/ROCK pathway inhibits expression of PPARγ and adipogenesis in part through a delayed activation of the canonical Wnt-signaling pathway based on increased Wnt10b expression and β-catenin induction... - Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cellsWeijuan Shao
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Canada Banting and Best Diabetes Centre, Faculty of Medicine, University of Toronto, Canada Dept of Medicine, University of Toronto, Canada
Cell Signal 22:1240-6. 2010..We suggest that proteasome-dependent TxNIP degradation is a novel mechanism by which Ex-4-cAMP signaling protects pancreatic beta cells... - Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreasJoshua Columbus
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
J Endocrinol 207:77-86. 2010..We suggest that hyperinsulinemia represses Tcf gene expression in the pancreas. Whether and how this reduction alters the function of pancreatic β cells during hyperinsulinemia deserves further investigation... - Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cellsZuyao Ni
Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Ontario M5G 2M1, Canada
J Biol Chem 278:1380-7. 2003..These observations indicate that the proglucagon gene is among the targets of the Wnt signaling pathway... - The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cellGareth E Lim
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Endocrinology 150:5249-61. 2009..Taken together, these data identify a novel signaling pathway in the endocrine L cell, whereby Cdc42 regulates actin remodeling, activation of the cannonical 1/2-ERK1/2 pathway and PAK1, and GLP-1 secretion in response to insulin... - New insights into the role of cAMP in the production and function of the incretin hormone glucagon-like peptide-1 (GLP-1)Zhiwen Yu
Banting and Best Diabetes Centre, University of Toronto, Canada
Cell Signal 22:1-8. 2010..Together, these novel findings bring us a new insight into the role of cAMP in the production and function of the incretin hormone GLP-1... - Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1Adam S Sirek
Department of Physiology, University of Toronto, Toronto, Canada
Endocrinology 150:3483-92. 2009..Our observations therefore identify Oct-1 as a transcriptional repressor of ChREBP and suggest that insulin stimulates ChREBP expression via attenuating the repressive effect of Oct-1... - The Blimp-1 gene regulatory region directs EGFP expression in multiple hematopoietic lineages and testis in miceDingyan Wang
Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 620 University Avenue, Room 8 205, Toronto, ON, Canada, M5G 2C1
Transgenic Res 17:193-203. 2008..Our studies collectively suggest that Blimp-1 may play a general role in the development of hematopoietic lineages and a stage-specific role in spermatogenesis... - Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cellsPhilip R Debruyne
Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 130:1191-206. 2006..The present studies examine the expression of GC-C in normal tissues and tumors from esophagus and stomach and mechanisms regulating its expression by acid and bile acids...