Jack H Jhamandas
Affiliation: University of Alberta
Fu W, Shi D, Westaway D, Jhamandas J. Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. J Biol Chem. 2015;290:12504-13 pubmed publisher
..These studies shed light on the unique bioenergetic mechanisms within astrocytes that may contribute to the development of AD pathology. ..
Kimura R, MacTavish D, Yang J, Westaway D, Jhamandas J. Pramlintide Antagonizes Beta Amyloid (AÎ²)- and Human Amylin-Induced Depression of Hippocampal Long-Term Potentiation. Mol Neurobiol. 2017;54:748-754 pubmed publisher
..Amylin receptor antagonists may thus serve as potentially useful therapeutic agents in treatment of AD. ..
Jhamandas J, Harris K, MacTavish D, Jassar B. Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: implications for its role in Alzheimer's disease. J Neurophysiol. 2002;87:696-704 pubmed
..This action might serve to delay the progression of AD pathology linked to a reduction in central cholinergic tone...
Jhamandas J, MacTavish D. Central administration of neuropeptide FF (NPFF) causes increased neuronal activation and up-regulation of NPFF gene expression in the rat brainstem. J Comp Neurol. 2002;447:300-7 pubmed
..c.v. at the higher dose. The up-regulation of NPFF may play a homeostatic role in response to specific cardiovascular challenges, such as hypotension. ..
Jhamandas J, Harris K, Cho C, Fu W, MacTavish D. Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J Neurophysiol. 2003;89:2923-30 pubmed
..Furthermore, the two peptides may share a common mechanism of action. The ability of an amylin antagonist to block the responses evoked by hAmylin and A beta may provide a novel therapeutic approach for Alzheimer's disease. ..
Jhamandas J, Simonin F, Bourguignon J, Harris K. Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1872-80 pubmed
Jhamandas J, MacTavish D. ?-Amyloid protein (A?) and human amylin regulation of apoptotic genes occurs through the amylin receptor. Apoptosis. 2012;17:37-47 pubmed publisher
..These data allow us to identify key elements in the A?-induced apoptosis that are blocked by antagonism of the amylin receptor and further support the potential for amylin receptor blockade as a potential therapeutic avenue in AD. ..
Patel A, Vasanthan V, Fu W, Fahlman R, MacTavish D, Jhamandas J. Histamine induces the production of matrix metalloproteinase-9 in human astrocytic cultures via H1-receptor subtype. Brain Struct Funct. 2016;221:1845-60 pubmed publisher
..Furthermore, MMP-9 appears to cleave soAÎ² into less toxic monomeric species. Given the key role of histamine in MMP-9 release, this neurotransmitter may serve as a potential therapeutic target for AD. ..
Fu W, Patel A, Kimura R, Soudy R, Jhamandas J. Amylin Receptor: A Potential Therapeutic Target for Alzheimer's Disease. Trends Mol Med. 2017;23:709-720 pubmed publisher
..Here, by discussing available evidence, we posit that the amylin receptor could be considered a potential therapeutic target for AD, and present the rationale for using amylin receptor antagonists to treat this debilitating condition. ..