Research Topics
Genomes and GenesSpecies | Håvard JenssenSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricinHåvard Jenssen
Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
Antiviral Res 79:192-8. 2008..In contrast, the cellular localization of iron-saturated (holo)-Lf appeared to differ from that of apo-Lf, indicating that holo- and apo-Lf may exhibit different antiviral mechanisms...
Anti herpes simplex virus activity of lactoferrin/lactoferricin -- an example of antiviral activity of antimicrobial protein/peptideH Jenssen
Centre for Microbial Diseases and Immunity Research, University of British Colombia, Room 232, 2259 Lower Mall Research Station, Vancouver, BC, V6T 1Z4, Canada
Cell Mol Life Sci 62:3002-13. 2005..Mode of action studies and knowledge about the anti-HSV activity of lactoferricin have also been successfully employed in the design of new, more specific HSV blockers...- Prediction of activity, synthesis and biological testing of anti-HSV active peptidesHåvard Jenssen
Department of Medical Microbiology, University Hospital of North Norway, Tromsø, N 9038, Norway
Chem Biol Drug Des 68:58-66. 2006..This may reflect differences in mode of action of peptides depending on the amino acid content... - Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugsArtem Cherkasov
Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, British Columbia V6T 1Z3, Canada
ACS Chem Biol 4:65-74. 2009.... - Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptorsHåvard Jenssen
Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
J Pept Sci 11:97-103. 2005..In this study it is shown that theoretically derived amino acid descriptors can be used to model the anti-viral activity of peptides, as well as other peptide properties, even more accurately... - QSAR modeling and computer-aided design of antimicrobial peptidesHåvard Jenssen
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
J Pept Sci 14:110-4. 2008.... - Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surfaceJeanette H Andersen
Department of Medical Microbiology, University Hospital of North Norway, Tromsø, Norway
J Med Virol 74:262-71. 2004..Both LF and Lfcin were dependent on the presence of heparan sulphate at the cell surface to exert their antiviral activity... - Structural studies of a peptide with immune modulating and direct antimicrobial activityMichal Wieczorek
Chemistry Department, University of British Columbia, Vancouver, BC, Canada
Chem Biol 17:970-80. 2010..The structural data are discussed in light of the ability of 1018 to potently induce chemokine responses, suppress the LPS-induced TNF-α response, and directly kill both Gram-positive and Gram-negative bacteria... - Optimization of antibacterial peptides by genetic algorithms and cheminformaticsChristopher D Fjell
Faculty of Medicine, Division of Infectious Diseases, Department of Medicine, University of British Columbia, 2733 Heather Street, Vancouver, BC, Canada
Chem Biol Drug Des 77:48-56. 2011..While GA significantly improves the possibility of identifying candidate peptides, we encountered important pitfalls to this method that should be considered when using GA... - A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virusHåvard Jenssen
Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
Antiviral Res 64:119-26. 2004..The two most potent antiviral peptides exhibited synergy with acyclovir against HSV... - Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfateHåvard Jenssen
Department of Medical Microbiology, University Hospital of North Norway, 9038, Tromsø, Norway
Antiviral Res 61:101-9. 2004..Structural parameters such as hydrophobicity, molecular size, spatial distribution of charged and lipophilic amino acids, and the cyclic structure of Lfcin also seem to be important factors to govern antiviral activity against HSV... 
Peptide antimicrobial agentsHåvard Jenssen
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Lower Mall Research Station, 232 2259 Lower Mall, Vancouver, British Columbia V6T 1Z4, Canada
Clin Microbiol Rev 19:491-511. 2006..Knowledge regarding the relationship between peptide structure and function as well as their mechanism of action is being applied in the design of antimicrobial peptide variants as potential novel therapeutic agents...- Importance of residue 13 and the C-terminus for the structure and activity of the antimicrobial peptide aurein 2.2John T J Cheng
Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
Biophys J 99:2926-35. 2010..aureus are discussed. The results suggest that the presence of the 13th residue in aurein 2.2 is important for structure and activity, but the exact nature of residue 13 is less important as long as it is a hydrophobic residue... - Screening and characterization of surface-tethered cationic peptides for antimicrobial activityKai Hilpert
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada
Chem Biol 16:58-69. 2009..Structure-activity modeling of the structural features determining the activity of tethered peptides indicated that the extent and positioning of positive charges and hydrophobic residues were influential in determining activity... - Identification of novel antibacterial peptides by chemoinformatics and machine learningChristopher D Fjell
Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Med Chem 52:2006-15. 2009.... - The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRSLucía Fernández
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
Antimicrob Agents Chemother 56:6212-22. 2012..These findings provide greater insight into the complex regulation of LPS modification in Pseudomonas aeruginosa, which involves the participation of at least 4 two-component systems... - Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infectionsMehdi Kazemzadeh-Narbat
Department of Materials Engineering, University of British Columbia, 309 6350 Stores Road, Vancouver, BC, V6T 1Z4, Canada
Biomaterials 31:9519-26. 2010..A device coated with CaP-Tet213 could be a potential solution for the prevention of the peri-implant infection in orthopaedics... - Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genomeChristopher D Fjell
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Proteins 73:420-30. 2008..Since we could find no technical reasons these would be missed and no references to bovine alpha-defensins in the literature, this suggests that cattle lack this important family of host defense peptides... - Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survivalMiriam A Lynn
Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Department of Medical Genetics, Vancouver, Canada
PLoS Negl Trop Dis 5:e1141. 2011.... - Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitmentAnastasia Nijnik
Department of Microbiology and Immunology, Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
J Immunol 184:2539-50. 2010.... - Antimicrobial properties of lactoferrinHåvard Jenssen
Centre for Microbial Diseases and Immunity Research, 232 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
Biochimie 91:19-29. 2009..In this review, we focus on the antimicrobial activities of lactoferrin with particular emphasis on antibacterial and antiviral activities, although its antifungal and -parasitic activity are also discussed... - Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureusOrjan Samuelsen
Department of Medical Microbiology, University Hospital of North Norway, P O Box 56, N 9038 Tromsø, Norway
FEBS Lett 579:3421-6. 2005..In conclusion, this study shows that S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides... - Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosaHåvard Jenssen
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Chem Biol Drug Des 70:134-42. 2007..7 +/- 1.6 peptides. The model has also been proven significantly more accurate than a simpler model (Bac2a- #1), where the inductive and conventional quantitative structure-activity relationship descriptors were excluded... - Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovirJeanette Hammer Andersen
Department of Medical Microbiology, University Hospital of North Norway, N 9038, Tromsø, Norway
Antiviral Res 58:209-15. 2003..The 50% effective concentration (EC(50)) for ACV and LF or Lfcin, when combined with ACV, could be reduced by two- to sevenfold compared to the EC(50) when the drugs were used alone... - A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunityJason Kindrachuk
Centre for Microbial Diseases and Immunity Research, University of British Columbia, BC, Canada
Vaccine 27:4662-71. 2009..This study demonstrates the potential application of the HH2-CpG complex as a vaccine adjuvant... - Novel anti-infectives: is host defence the answer?Pamela Hamill
Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall, Vancouver, British Columbia, Canada, V6T 1Z3
Curr Opin Biotechnol 19:628-36. 2008..A broad variety of therapies are already available or increasingly under development, to stimulate protective innate immunity without overtly stimulating harmful inflammation or even suppressing such damaging pro-inflammatory responses... - Serum stability of peptidesHåvard Jenssen
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada
Methods Mol Biol 494:177-86. 2008..However, issues have been raised regarding the stability of peptide therapeutics for systemic use. The focus of this chapter is assays for measuring peptide stability in the presence of serum, both in vitro and in vivo...