J E Jan

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders
    J E Jan
    Visually Impaired Program, BC s Children s Hospital, Vancouver, Canada
    J Pineal Res 29:34-9. 2000
  2. ncbi request reprint Evidence supporting the use of melatonin in short gestation infants
    James E Jan
    Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, BC, Canada, and Child Health, Chelsea and Westminster Campus, Imperial College, London, UK
    J Pineal Res 42:22-7. 2007
  3. doi request reprint Sleep hygiene for children with neurodevelopmental disabilities
    James E Jan
    Child and Family Research Institute, University of British Columbia and BC Children s Hospital, 4500 Oak St, Vancouver, British Columbia, Canada V6H 3N1
    Pediatrics 122:1343-50. 2008
  4. doi request reprint Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities
    James E Jan
    Pediatric Neurology, University of British Columbia, Vancouver, BC, Canada
    Eur J Paediatr Neurol 16:403-12. 2012
  5. ncbi request reprint Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?
    James E Jan
    BC s Children s Hospital, Vancouver, Canada
    Dev Med Child Neurol 46:776-82. 2004
  6. doi request reprint The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders
    James E Jan
    Melatonin Research Group, BC Children s Hospital, Vancouver, Canada
    J Pineal Res 46:1-7. 2009
  7. doi request reprint Long-term sleep disturbances in children: a cause of neuronal loss
    James E Jan
    Pediatric Neurology and Developmental Pediatrics, University of British Columbia, BC, Canada
    Eur J Paediatr Neurol 14:380-90. 2010
  8. doi request reprint Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesis
    James E Jan
    Diagnostic Neurophysiology, BC Children s Hospital, Vancouver, BC, Canada
    J Pineal Res 50:233-40. 2011
  9. ncbi request reprint Melatonin replacement therapy in a child with a pineal tumor
    J E Jan
    Division of Developmental Paediatrics, University of British Columbia, Vancouver
    J Child Neurol 16:139-40. 2001
  10. doi request reprint Cerebral modulation of circadian sleep-wake rhythms
    James E Jan
    Diagnostic Neurophysiology, British Columbia Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada
    J Clin Neurophysiol 28:165-9. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders
    J E Jan
    Visually Impaired Program, BC s Children s Hospital, Vancouver, Canada
    J Pineal Res 29:34-9. 2000
    ..7 mg (2-12 mg). The studies showed that the FR melatonin was most effective when there was only delayed sleep onset, but CR formulations were more useful for sleep maintenance. Children appeared to require higher doses than adults...
  2. ncbi request reprint Evidence supporting the use of melatonin in short gestation infants
    James E Jan
    Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, BC, Canada, and Child Health, Chelsea and Westminster Campus, Imperial College, London, UK
    J Pineal Res 42:22-7. 2007
    ..We believe that this treatment might result in a wide range of health benefits, improved quality of life and reduced healthcare costs...
  3. doi request reprint Sleep hygiene for children with neurodevelopmental disabilities
    James E Jan
    Child and Family Research Institute, University of British Columbia and BC Children s Hospital, 4500 Oak St, Vancouver, British Columbia, Canada V6H 3N1
    Pediatrics 122:1343-50. 2008
    ....
  4. doi request reprint Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities
    James E Jan
    Pediatric Neurology, University of British Columbia, Vancouver, BC, Canada
    Eur J Paediatr Neurol 16:403-12. 2012
    ..In the future, the existing definitions for the different forms of CRSD should be modified by experts in pediatric sleep medicine in order to include children with neurodevelopmental disabilities...
  5. ncbi request reprint Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?
    James E Jan
    BC s Children s Hospital, Vancouver, Canada
    Dev Med Child Neurol 46:776-82. 2004
  6. doi request reprint The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders
    James E Jan
    Melatonin Research Group, BC Children s Hospital, Vancouver, Canada
    J Pineal Res 46:1-7. 2009
    ..Together, the thalamic and chronobiological control of sleep leads to a new and improved understanding of the pathophysiology of circadian rhythm sleep disorders and also of the principles of sleep hygiene interventions...
  7. doi request reprint Long-term sleep disturbances in children: a cause of neuronal loss
    James E Jan
    Pediatric Neurology and Developmental Pediatrics, University of British Columbia, BC, Canada
    Eur J Paediatr Neurol 14:380-90. 2010
    ..Further research is urgently needed because these findings have major implications for the treatment of sleep disorders...
  8. doi request reprint Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesis
    James E Jan
    Diagnostic Neurophysiology, BC Children s Hospital, Vancouver, BC, Canada
    J Pineal Res 50:233-40. 2011
    ..Thus, the hypnotic action of melatonin and the mechanisms involving the circadian rhythms are separate neurological functions. This is contrary to the presently accepted view...
  9. ncbi request reprint Melatonin replacement therapy in a child with a pineal tumor
    J E Jan
    Division of Developmental Paediatrics, University of British Columbia, Vancouver
    J Child Neurol 16:139-40. 2001
    ..Sleep difficulties should be considered in the management of pineal lesions. Melatonin replacement therapy is beneficial for those patients who have deficient melatonin synthesis...
  10. doi request reprint Cerebral modulation of circadian sleep-wake rhythms
    James E Jan
    Diagnostic Neurophysiology, British Columbia Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada
    J Clin Neurophysiol 28:165-9. 2011
    ....
  11. ncbi request reprint Long-term outcome of children with cortical visual impairment
    Carey A Matsuba
    BC s Children s Hospital, Vancouver, BC, Canada
    Dev Med Child Neurol 48:508-12. 2006
    ..Additional disabilities were common, but those children with better visual acuity outcomes faired better. Given the frequency of comorbid conditions, appropriate diagnostic assessment services are needed...
  12. ncbi request reprint Light, dark, and melatonin: emerging evidence for the importance of melatonin in ocular physiology
    R Brennan
    Department of Ophthalmology, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
    Eye (Lond) 21:901-8. 2007
    ..In this review, we discuss the physiological roles of melatonin in the eye, as well as the potential therapeutic avenues currently under study...
  13. ncbi request reprint Eye-poking
    J E Jan
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Dev Med Child Neurol 36:321-5. 1994
    ..The treatment is exceedingly difficult. Further studies are needed to develop specific management techniques to prevent eye-poking, which adds to the physical and emotional burden on the caregivers...
  14. ncbi request reprint Visual impairment due to a dyskinetic eye movement disorder in children with dyskinetic cerebral palsy
    J E Jan
    Division of Developmental Pediatrics, Visually Impaired Program, British Columbia's Children's Hospital, Vancouver, Canada
    Dev Med Child Neurol 43:108-12. 2001
    ..They are often misdiagnosed as blind, due to cortical visual impairment. Early recognition of dyskinetic eye moment disorder and appropriate developmental and educational management are important...
  15. ncbi request reprint Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders
    Roxanne Carr
    Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, BC, Canada
    J Pineal Res 43:351-9. 2007
    ..Hypnotics for children with CRSD should be considered a second line of treatment for those who fail to respond to sleep hygiene and/or melatonin...
  16. ncbi request reprint A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities
    Michael B Wasdell
    Melatonin Research Group, Department of Psychiatry, BC Children s Hospital, Vancouver, Canada
    J Pineal Res 44:57-64. 2008
    ..Children with neurodevelopmental disabilities, who had treatment resistant chronic delayed sleep phase syndrome and impaired sleep maintenance, showed improvement in melatonin therapy...
  17. ncbi request reprint Conscious visual abilities in a patient with early bilateral occipital damage
    Deborah Giaschi
    Department of Ophthalmology, University of British Columbia UBC, Vancouver, Canada
    Dev Med Child Neurol 45:772-81. 2003
    ..This case demonstrates remarkable plasticity in the human visual system and may have implications for understanding the functional organization of the motion pathways...
  18. ncbi request reprint Optic nerve hypoplasia with intracranial arachnoid cyst
    Christopher Lyons
    Department of Ophthalmology, British Columbia Children s Hospital, Bancouver, British Columbia, Canada
    J AAPOS 8:61-6. 2004
    ..The frequent association between optic nerve hypoplasia (ONH) and other central nervous system abnormalities has been widely reported in the literature. Occasional reference has been made to arachnoid cyst as one of the associated findings...
  19. ncbi request reprint 'Visual impairment in children with brain damage'
    Carey A Matsuba
    Dev Med Child Neurol 46:720. 2004
  20. ncbi request reprint Re: Mann--melatonin for ulcerative colitis?
    James E Jan
    Am J Gastroenterol 98:1446. 2003
  21. doi request reprint Melatonin--an orphan drug
    James E Jan
    Dev Med Child Neurol 50:558. 2008
  22. ncbi request reprint Visual development in preterm infants
    Ashima Madan
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Dev Med Child Neurol 47:276-80. 2005