Research Topics
| S A JamalSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
The effects of organic nitrates on osteoporosis: a systematic reviewS A Jamal
Women s College Research Institute, 790 Bay Street, 7th Floor, Toronto, Ontario, M5G 1N8, Canada
Osteoporos Int 24:763-70. 2013..Headaches were the most common adverse event among women taking nitrates. No studies have reported on fracture efficacy. Further research is needed before recommending organic nitrates for the treatment of postmenopausal osteoporosis...
Secondary and tertiary hyperparathyroidismSophie A Jamal
University of Toronto, Women s College Research Institute, Toronto, Ontario, Canada Electronic address
J Clin Densitom 16:64-8. 2013..The etiology and treatment of secondary hyperparathyroidism is relatively straightforward whereas data on the management of tertiary hyperparathyroidism is limited to a few small trials with short follow-up...
Bone mineral density by DXA and HR pQCT can discriminate fracture status in men and women with stages 3 to 5 chronic kidney diseaseS A Jamal
Women s College Research Institute, 790 Bay Street, Suite 725, Toronto, ON, M5G 1N8, Canada
Osteoporos Int 23:2805-13. 2012..Both tests were able to discriminate fracture status. Further, the addition of HR pQCT measurements to DXA measurements did not improve fracture discrimination...
Bone and kidney disease: diagnostic and therapeutic implicationsSophie A Jamal
University of Toronto, Women s College Hospital, Ontario, Canada
Curr Rheumatol Rep 14:217-23. 2012..Bone biopsy may be required, and most treatments, if used, would be off label. Overall, the diagnosis and treatment of bone disease in patients with CKD require further research...
Fracture risk assessment in patients with chronic kidney diseaseS A Jamal
Department of Medicine, University of Toronto, Toronto, ON, Canada
Osteoporos Int 23:1191-8. 2012..Further prospective studies to identify noninvasive measures of bone strength that can be used for fracture risk assessment are needed...
Nitric oxide donors for the treatment of osteoporosisSophie A Jamal
Multidisciplinary Osteoporosis Research Program, Women s College Hospital, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada
Curr Osteoporos Rep 10:86-92. 2012....
Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective studySarah L West
Multidisciplinary Osteoporosis Program, Women s College Hospital, and Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada
BMC Nephrol 11:17. 2010..Our study aims to identify prognostic factors for bone loss and fractures in patients with stages 3 to 5 CKD...
Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis StudyS A Jamal
Medicine, University of Toronto, Toronto, ON, Canada
Osteoporos Int 20:737-44. 2009..Subjects reporting nitrate use had increased BMD compared with non-users, confirming that nitrates have positive BMD effects in women and men...
Kidney function and rate of bone loss at the hip and spine: the Canadian Multicentre Osteoporosis StudySophie A Jamal
University of Toronto, Toronto, Canada
Am J Kidney Dis 55:291-9. 2010..The relationship between kidney function and bone loss is unclear...
Bone mass measurements in men and women with chronic kidney diseaseSophie A Jamal
Women s College Hospital, University of Toronto, Toronto, Ontario, Canada
Curr Opin Nephrol Hypertens 19:343-8. 2010..Bone mass measurements are commonly used to assess fracture risk in the general population, but the utility of these measurements in patients with CKD is unclear...
Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trialSophie A Jamal
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
JAMA 305:800-7. 2011..Nitroglycerin stimulates bone formation and inhibits bone resorption, is inexpensive, and is widely available. Its effects on bone density, bone structure, and bone strength are unknown...
Effects of denosumab on fracture and bone mineral density by level of kidney functionSophie A Jamal
Department of Medicine, University of Toronto, Ontario, Canada
J Bone Miner Res 26:1829-35. 2011..It is concluded that DMAb is effective at reducing fracture risk and is not associated with an increase in adverse events among patients with impaired kidney function...
Bone density and heel ultrasound testing do not identify patients with dialysis-dependent renal failure who have had fracturesSophie A Jamal
Division of Endocrinology, Multidisciplinary Osteoporosis Program, Women s College Ambulatory Care Centre, Toronto, Ontario, Canada
Am J Kidney Dis 39:843-9. 2002..Prospective studies to determine the optimal method of identifying patients with dialysis-dependent renal failure at high risk for fracture are needed...
Low bone mineral density and fractures in long-term hemodialysis patients: a meta-analysisSophie A Jamal
St Michael s Hospital, Toronto, Ontario, Canada
Am J Kidney Dis 49:674-81. 2007..The association between bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) and fracture in patients with stage 5 chronic kidney disease (CKD) is unclear...
Impaired muscle strength is associated with fractures in hemodialysis patientsS A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
Osteoporos Int 17:1390-7. 2006..Fractures are extremely common among hemodialysis (HD) patients...
Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trialSophie A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Ontario M5C 2T2, Canada
J Bone Miner Res 19:1512-7. 2004..After 3 months, women randomized to ISMO had a greater decrease in bone resorption and a greater increase in bone formation compared with placebo. NO donors may prevent postmenopausal bone loss...
Alendronate treatment in women with normal to severely impaired renal function: an analysis of the fracture intervention trialSophie A Jamal
Division of Endocrinology, St Michael s Hospital and the University of Toronto, Toronto, Ont, Canada
J Bone Miner Res 22:503-8. 2007..There was no increase in adverse events among women with impaired renal function treated with alendronate. Alendronate is safe and effective among this group of women with reduced renal function...
Cortical pQCT measures are associated with fractures in dialysis patientsSophie A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, Toronto, Canada
J Bone Miner Res 21:543-8. 2006..To determine if pQCT could identify HD patients with fractures, we conducted a cross-sectional study in 52 men and women on HD. We found that cortical, but not trabecular, pQCT measures were associated with fractures...
Clinical utility of laboratory testing in women with osteoporosisSophie A Jamal
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, University of Toronto, 61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
Osteoporos Int 16:534-40. 2005..4 (95% CI: 1.3-1.6). Our data suggests that when assessing healthy women with osteoporosis ordering a routine panel of laboratory tests is not useful but measuring TSH may be informative...
Hyperhomocysteinaemia and aortic calcification are associated with fractures in patients on haemodialysisS A Jamal
Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Canada
QJM 98:575-9. 2005..Fractures and atherosclerosis are common in patients with renal failure; this may be due to hyperhomocysteinemia...
Risk factors for low bone mass in healthy 40-60 year old women: a systematic review of the literatureE J Waugh
Osteoporosis Research Program, Women s College Hospital, Toronto, ON, Canada
Osteoporos Int 20:1-21. 2009..The use of body weight to identify high risk women may reduce unnecessary BMD testing in this age group...
A clinical prediction rule to identify premenopausal women with low bone massG A Hawker
Division of Rheumatology, Women s College Ambulatory Care Centre, The University of Toronto, Ontario, Canada
Osteoporos Int 13:400-6. 2002..This suggests that a simple risk factor assessment can identify most young women with low peak bone mass. Early intervention in this group of women may reduce the risk for osteoporosis in later life...
Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic reviewV Elliot-Gibson
Mobility Program, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Osteoporos Int 15:767-78. 2004..Barriers included the cost of therapies, time and cost of resources for diagnosis, concerns about medications, and the lack of clarity regarding the responsibility to undertake this care...
The effects of exercise and physical activity participation on bone mass and geometry in postmenopausal women: a systematic review of pQCT studiesC J Hamilton
Women s College Hospital, Toronto, ON, Canada
Osteoporos Int 21:11-23. 2010....
Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopaedic environmentEarl R Bogoch
St Michael s Hospital, University of Toronto, 55 Queen Street East, Suite 800, Toronto, ON M5C 1R6, Canada
J Bone Joint Surg Am 88:25-34. 2006....
The presence of both an energy deficiency and estrogen deficiency exacerbate alterations of bone metabolism in exercising womenMary Jane De Souza
Women s Exercise and Bone Health Laboratory, Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada
Bone 43:140-8. 2008..Bone loss in amenorrheic athletes has been attributed to energy deficiency-related suppression of bone formation, but not increased resorption despite hypoestrogenism...
Effects of calcium on cardiovascular events in patients with kidney disease and in a healthy populationSarah L West
Multidisciplinary Osteoporosis Program, Women s College Hospital, Toronto, Ontario, Canada
Clin J Am Soc Nephrol 5:S41-7. 2010..The etiology of vascular calcification and the specific role calcium supplementation may play in accelerating calcification have not been fully elucidated...
Associations between leisure physical activity participation and cortical bone mass and geometry at the radius and tibia in a Canadian cohort of postmenopausal womenCeleste J Hamilton
University of Toronto, Toronto ON, Canada
Bone 46:774-9. 2010....
The effects of calcium-based versus non-calcium-based phosphate binders on mortality among patients with chronic kidney disease: a meta-analysisSophie A Jamal
University of Toronto, Division of Endocrinology and Metabolism, Women s College Hospital, Toronto, Canada
Nephrol Dial Transplant 24:3168-74. 2009..The effects of calcium compared with non-calcium-based phosphate binders on mortality, cardiovascular events and vascular calcification in patients with chronic kidney disease (CKD) are unknown...
Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literatureJ D Vescovi
Women s Exercise and Bone Health Laboratory, Graduate Department of Exercise Science, University of Toronto, Toronto, ON, Canada M5S 2W6
Osteoporos Int 19:465-78. 2008....
The risk of hip fractures in older individuals with diabetes: a population-based studyLorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Diabetes Care 30:835-41. 2007..However, they may still be at increased risk for hip fractures. Using population-based Ontario health care data, we compared the risk of hip fractures among men and women with and without diabetes...
Renal function and risk of hip and vertebral fractures in older womenKristine E Ensrud
Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
Arch Intern Med 167:133-9. 2007..An increased rate of hip fractures has been reported in patients with end-stage renal disease, but the effect of less severe renal dysfunction on fracture risk is uncertain...
The effect of raloxifene treatment in postmenopausal women with CKDAreef Ishani
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, and Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55417, USA
J Am Soc Nephrol 19:1430-8. 2008..In conclusion, raloxifene increases BMD at both the hip and the spine and reduces the risk for vertebral fractures among individuals with CKD. The effect ofraloxifene on hip BMD is greater among those with mild to moderate CKD...
Low bone mineral density and fracture burden in postmenopausal womenAnn Cranney
Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa, Ont
CMAJ 177:575-80. 2007..5 or less), and to contrast fracture patterns among women 50 to 64 years of age with those among women 65 years of age and older...
Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trialsDouglas C Bauer
Department of Medicine, University of California, San Francisco 94105, USA
Arch Intern Med 164:146-52. 2004....
