Sara J Israels

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. doi What we have learned from inherited platelet disorders
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Blood Cancer 60:S2-7. 2013
  2. doi Platelet disorders in children: A diagnostic approach
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Blood Cancer 56:975-83. 2011
  3. doi Inherited disorders of platelet function and challenges to diagnosis of mucocutaneous bleeding
    S J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
    Haemophilia 16:152-9. 2010
  4. doi Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets
    Sara J Israels
    Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
    Thromb Res 125:152-8. 2010
  5. doi Diagnostic evaluation of platelet function disorders in neonates and children: an update
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Semin Thromb Hemost 35:181-8. 2009
  6. ncbi Platelet tetraspanin complexes and their association with lipid rafts
    Sara J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
    Thromb Haemost 98:1081-7. 2007
  7. ncbi Antiplatelet therapy in children
    Sara J Israels
    Department of Pediatrics and Child Health, and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0V9
    Thromb Res 118:75-83. 2006
  8. ncbi CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen
    Sara J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Ave, Winnipeg, Manitoba, R3E 0V9, Canada
    Thromb Haemost 93:311-8. 2005
  9. ncbi Neonatal platelet function
    Sara J Israels
    Department of Pediatrics and Child Health University of Manitoba, Winnipeg, Manitoba, Canada
    Semin Thromb Hemost 29:363-72. 2003
  10. ncbi CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets
    S J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:134-41. 2001

Collaborators

Detail Information

Publications26

  1. doi What we have learned from inherited platelet disorders
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Blood Cancer 60:S2-7. 2013
    ..More recently, genome wide association studies have identified new genes contributing to the variation in normal platelet function...
  2. doi Platelet disorders in children: A diagnostic approach
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Blood Cancer 56:975-83. 2011
    ..Based on results of initial investigations, the algorithm recommends specialized testing for specific diagnoses, including flow cytometry, immunofluorescence microscopy, electron microscopy, and mutational analysis...
  3. doi Inherited disorders of platelet function and challenges to diagnosis of mucocutaneous bleeding
    S J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
    Haemophilia 16:152-9. 2010
    ..Present diagnostic testing for platelet function disorders and von Willebrand's Disease often fails to identify the cause of bleeding in individuals with inherited MCB...
  4. doi Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets
    Sara J Israels
    Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
    Thromb Res 125:152-8. 2010
    ..These results demonstrate that palmitoylation is required for platelet tetraspanin-tetraspanin and tetraspanin-integrin interaction and for complete platelet spreading on a fibrinogen substrate...
  5. doi Diagnostic evaluation of platelet function disorders in neonates and children: an update
    Sara J Israels
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Semin Thromb Hemost 35:181-8. 2009
    ..The majority of these studies, comparing normal children with adults, found only minor differences in platelet responses measured by these assays...
  6. ncbi Platelet tetraspanin complexes and their association with lipid rafts
    Sara J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Mannitoba, Canada
    Thromb Haemost 98:1081-7. 2007
    ..It is probable that TEMs and lipid rafts associate under certain conditions, resulting in the close proximity of distinct sets of signaling molecules, facilitating signal transduction...
  7. ncbi Antiplatelet therapy in children
    Sara J Israels
    Department of Pediatrics and Child Health, and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0V9
    Thromb Res 118:75-83. 2006
    ..Additional studies will be required to evaluate the relative benefits of aspirin and anticoagulants in these settings. A role for newer antiplatelet drugs in the management of pediatric arterial thrombosis is as yet unexplored...
  8. ncbi CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen
    Sara J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Ave, Winnipeg, Manitoba, R3E 0V9, Canada
    Thromb Haemost 93:311-8. 2005
    ..The linkage of CD63 with PI 4-kinase may result in the recruitment of this signaling enzyme to specific membrane locations in the platelet where it influences phosphoinositide-dependent signaling and platelet spreading...
  9. ncbi Neonatal platelet function
    Sara J Israels
    Department of Pediatrics and Child Health University of Manitoba, Winnipeg, Manitoba, Canada
    Semin Thromb Hemost 29:363-72. 2003
    ..In the immediate newborn period, this enhanced platelet adhesion may compensate for the decreased intrinsic platelet activation in healthy neonates, but may leave sick neonates at increased risk of bleeding...
  10. ncbi CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets
    S J Israels
    Department of Pediatrics and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 85:134-41. 2001
    ....
  11. pmc Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    Meghan B Azad
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Autophagy 4:195-204. 2008
    ..Taken together, these results suggest that prolonged hypoxia induces autophagic cell death in apoptosis-competent cells, through a mechanism involving BNIP3...
  12. ncbi Platelet dense granule membranes contain both granulophysin and P-selectin (GMP-140)
    S J Israels
    Department of Paediatrics, University of Manitoba, Winnipeg, Canada
    Blood 80:143-52. 1992
    ..The results demonstrate that granulophysin is localized to the dense granules of platelets and is redistributed to the plasma membrane after platelet activation...
  13. ncbi Beyond hemostasis: the role of platelets in inflammation, malignancy and infection
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cardiovasc Hematol Disord Drug Targets 8:99-117. 2008
    ..The primary focus of this review is the "non-haemostatic" functions of platelets in physiological and pathological states...
  14. ncbi Platelets and anti-platelet therapy
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    J Pharmacol Sci 93:381-96. 2003
    ..Recent advances in understanding of platelet physiology have suggested several novel, if yet untested, targets for anti-platelet therapy. These include the thrombin receptor, the serotonin handling system, and the leptin receptor...
  15. ncbi Effects of the mitogen-activated protein (MAP) kinase kinase inhibitor 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (PD98059) on human platelet activation
    A McNicol
    Department of Oral Biology and Pharmacology, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 55:1759-67. 1998
    ..Furthermore, the inhibitory effects of PD98059 on collagen- and arachidonic acid-induced responses suggest that PD98059 may inhibit the conversion of arachidonic acid to thromboxane, in addition to its reported effects on MEK1...
  16. ncbi Incorporation of map kinases into the platelet cytoskeleton
    A McNicol
    Department of Oral Biology, University of Manitoba, R3E 0W2, Winnipeg, Manitoba, Canada
    Thromb Res 103:25-34. 2001
    ..These data suggest either that MAP kinases play a role in cytoskeletal rearrangement or that the cytoskeleton act as a frame to align MAP kinases with substrates in a highly integrated signal transduction pathway...
  17. ncbi Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    Yongqiang Chen
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9, Canada
    J Cell Sci 120:4155-66. 2007
    ..These results indicate that targeting mETC complex I and II selectively induces autophagic cell death through a ROS-mediated mechanism...
  18. doi Mechanisms of oral bacteria-induced platelet activation
    Archibald McNicol
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 88:510-24. 2010
    ..The current review describes the heterogeneous mechanisms of platelet activation employed by individual bacterial species. The pathological and clinical implications of platelet activation by orally derived bacteria are discussed...
  19. ncbi The empty sack syndrome: a platelet storage pool deficiency associated with empty dense granules
    A McNicol
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Br J Haematol 86:574-82. 1994
    ..This observation represents a novel form of storage pool disease which we have termed the empty sack syndrome...
  20. ncbi The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes
    S J Israels
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 75:623-9. 1996
    ..These data indicate that LAMP-2 is present in the membranes of platelet dense granules in addition to lysosomal granules, and has a similar distribution to CD63...
  21. ncbi Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation
    S J Israels
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Br J Haematol 75:118-21. 1990
    ..Evidence of storage pool deficiency should be considered in all patients with an isolated unexplained prolongation of the bleeding time. The methods used in this study are readily applicable to most clinical laboratories...
  22. ncbi BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
    Shilpa Kothari
    Manitoba Institute of Cell Biology, 675 McDermot Ave, Winnipeg, Canada
    Oncogene 22:4734-44. 2003
    ..Taken together, BNIP3 plays a role in hypoxia-induced cell death in human epithelial cells that could be circumvented by growth factor signaling...
  23. ncbi Inherited platelet-storage pool deficiency associated with a high incidence of acute myeloid leukaemia
    J M Gerrard
    Department of Paediatrics, University of Manitoba, Winnipeg, Canada
    Br J Haematol 79:246-55. 1991
    ..This congenital storage pool deficiency is associated with a high incidence of acute myeloid leukaemia in this family...
  24. ncbi Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency
    A Shalev
    Department of Pediatrics, University of Manitoba, Winnipeg, Canada
    Blood 80:1231-7. 1992
    ..Thus, granulophysin quantitation facilitates characterization of delta-SPD patients and may provide clues to the nature of defective granules in delta-SPD subtypes...
  25. ncbi Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer
    S J Israels
    Department of of Pediatrics and Community Health Sciences and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Pediatr 138:116-9. 2001
    ..These 2 factors may also enhance primary hemostasis in vivo and compensate for the impaired platelet function of the newborn...
  26. ncbi A role for von Willebrand factor in Streptococcus sanguis-induced platelet activation
    Archibald McNicol
    Thromb Haemost 98:1382-4. 2007