Research Topics
Species | Jonathan IrishSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinomaPatricia P Reis
Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
Mol Cancer 9:238. 2010..We also examined PDCD4 regulation by microRNA 21 (miR-21) in OSCC...- microRNA evaluation of unknown primary lesions in the head and neckEmma V Barker
Department of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute and University Health Network, Toronto, Ontario M5G 2M9, Canada
Mol Cancer 8:127. 2009..This may be clinically relevant to predict the primary site of origin of metastatic disease, when the primary site remains obscure... - Low prevalence of human papillomavirus in oral cavity carcinomasJerry Machado
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Head Neck Oncol 2:6. 2010..Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported... - SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinomaJoerg Schwock
Department of Laboratory Medicine and Pathobiology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
BMC Clin Pathol 10:1. 2010..We hypothesized that SNAI1 reactivation occurs in oral squamous cell carcinoma (OSCC) where it might also be associated with focal adhesion kinase (FAK) expression and p63 loss... 
Quality of life in patients with maxillectomy prosthesesJonathan Irish
Department of Otolaryngology Surgical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Head Neck 31:813-21. 2009..This cross-sectional study sought to determine patient quality of life and function after prosthetic rehabilitation for maxillary and palate defects following cancer resection...- Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapyShao Hui Huang
Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 82:276-83. 2012..To report atypical clinical behavior observed in human papillomavirus (HPV)-related oropharyngeal carcinoma (OPC) treated with radiotherapy... - A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrencePatricia P Reis
Div, of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
BMC Cancer 11:437. 2011..Therefore, molecular analysis of histologically normal resection margins and the corresponding OSCC may aid in identifying a gene signature predictive of recurrence... - Morbidity and functional outcomes following gastro-omental free flap reconstruction of circumferential pharyngeal defectsRajan S Patel
Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Head Neck 31:655-63. 2009..This study reviews our experience with this flap... 
Primary and salvage (hypo)pharyngectomy: Analysis and outcomeJonathan R Clark
Department of Head and Neck Surgical Oncology, Princess Margaret Hospital, Wharton Head and Neck Centre, 610 University Avenue, Toronto, ON M5G 2M9
Head Neck 28:671-7. 2006..Patients with nodal metastases, ECS, and poorly differentiated tumors are likely to succumb to their disease and should be selected for adjuvant therapy when possible...- Molecular classification of oral cancer by cDNA microarrays identifies overexpressed genes correlated with nodal metastasisGiles C Warner
Department of Cellular and Molecular Biology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
Int J Cancer 110:857-68. 2004..Application of this methodology represents an advance in the classification of oral cavity tumors and may ultimately aid in the development of more tailored therapies for oral carcinoma... - Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionationBrian O'Sullivan
Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
Radiother Oncol 103:49-56. 2012..To report outcome of HPV-related [HPV(+)] oropharyngeal cancer (OPC) managed predominantly by altered-fractionation radiotherapy-alone (RT-alone)... - Circumferential pharyngeal reconstruction: history, critical analysis of techniques, and current therapeutic recommendationsRajan S Patel
Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
Head Neck 32:109-20. 2010..Each technique is critically appraised with particular reference to postoperative morbidity and functional rehabilitation. Treatment recommendations are made based on the available evidence... - Second free flaps in head and neck reconstructionGary Ross
Division of Plastic and Reconstructive Surgery, University Health Network, 200 Elizabeth Street, 8N 865, Toronto, ON M5G 2C4, Canada
J Plast Reconstr Aesthet Surg 65:1165-8. 2012..The objective of this study was to assess outcomes following a second free flap in head and neck reconstruction... - Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinomaPatricia Pintor dos Reis
Division of Applied Molecular Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Cancer 113:3169-80. 2008..Their goal was to examine CLDN1 expression in a large series of primary OSCCs and to further investigate whether CLDN1 overexpression plays a role in invasion in OSCC... - Predictors of morbidity following free flap reconstruction for cancer of the head and neckJonathan R Clark
Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, Toronto, Ontario, Canada
Head Neck 29:1090-101. 2007..The aim was to determine if there was an association between perioperative variables and postoperative outcome... - Mucosal melanomas of the head and neck: experience of the Princess Margaret HospitalGideon Bachar
Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
Head Neck 30:1325-31. 2008..The aim of this study was to identify the prognostic variables in mucosal melanoma of the head and neck... - Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse modelAntti A Makitie
Department of Cellular and Molecular Biology, Ontario Cancer Institute and Princess Margaret Hospital, The University Health Network, Toronto, Ontario, Canada
Lab Invest 85:947-61. 2005..Our data suggest that Ptn and Cd24a may be genetic markers associated with salivary gland tumorigenesis and/or progression... - mRNA transcript quantification in archival samples using multiplexed, color-coded probesPatricia P Reis
Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
BMC Biotechnol 11:46. 2011..We assessed the ability of this technology for mRNA expression quantification in archived formalin-fixed, paraffin-embedded (FFPE) oral carcinoma samples... - Identification of a microRNA signature associated with progression of leukoplakia to oral carcinomaNilva K Cervigne
Division of Applied Molecular Oncology, Toronto General Hospital, Ontario Cancer Institute, The University Health Network, Toronto, ON, Canada
Hum Mol Genet 18:4818-29. 2009..Our study provides the first evidence of an miR signature potentially useful for identifying leukoplakias at risk of malignant transformation... - TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynxStephen F Hall
Department of Otolaryngology, Queen s University, Kingston, Ontario, Canada
Head Neck 31:1-8. 2009.... - Towards further understanding of prognostic factors for head and neck cancer patients: the example of hypopharyngeal cancerStephen F Hall
Department of Otolaryngology, The Cancer Care and Epidemiology Division of Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
Laryngoscope 119:696-702. 2009..The objectives of this study were to demonstrate that prognostic factors and their impact can vary depending on study design and to examine the relationships between select prognostic factors... - Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancerShao Hui Huang
Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
Oral Oncol 49:79-85. 2013..To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC)... - Response rates for mailout survey-driven studies in patients waiting for thyroid surgeryAntoine Eskander
Department of Otolaryngology Head and Neck Surgery, University Health Network, Princess Margaret Hospital, University of Toronto
J Otolaryngol Head Neck Surg 40:462-7. 2011..The objective of this article is to summarize response rates in patients waiting for thyroid surgery and to document the methodology of mailout survey questionnaires... - Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?Stephen F Hall
Department of Otolaryngology, Cancer Care and Epidemiology Division, Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
Cancer 115:5711-22. 2009..There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group... - Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 casesGideon Bachar
Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
Head Neck 30:1012-9. 2008..Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm... - Impact of positive frozen section microscopic tumor cut-through revised to negative on oral carcinoma control and survival ratesRajan S Patel
Department of Otolaryngology Head and Neck Surgery, Sunnybrook Health Sciences Centre Odette Cancer Centre and University of Toronto, Toronto, Ontario, Canada
Head Neck 32:1444-51. 2010.... - Truths and myths about radiotherapy for verrucous carcinoma of larynxShao Hui Huang
Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
Int J Radiat Oncol Biol Phys 73:1110-5. 2009..To address these concerns, we report our experience... - Cutaneous metastatic squamous cell carcinoma to the parotid gland: analysis and outcomeNathalie Audet
Princess Margaret Hospital, Wharton Head and Neck Centre 3-951, 610 University Avenue, Toronto, Ontario M4S 1C6, Canada
Head Neck 26:727-32. 2004..The presence of a lesion in excess of 6 cm or with facial nerve involvement is associated with a poor prognosis... - Morbidity after flap reconstruction of hypopharyngeal defectsJonathan R Clark
Department of Otolaryngology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Laryngoscope 116:173-81. 2006..Swallowing function is acceptable; however, less than half of the patients undergoing pharyngectomy had tracheoesophageal puncture voice restoration... - Adult soft tissue sarcomas of the head and neckJean-Pierre Jeannon
Department of Otolaryngology/Surgical Oncology, Wharton Head and Neck Centre, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
Asian J Surg 25:5-12. 2002 - Response rates for mailout survey-driven studies in patients with head and neck cancerDavid P Goldstein
Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
Head Neck 32:1585-91. 2010..The objective of this paper is to summarize response rates in patients with head and neck cancer, and to provide recommendations surrounding methodology used to design and implement mailout survey questionnaires... - A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervixJennifer J Knox
Departments of Medical Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 5 218, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
Eur J Cancer 41:523-30. 2005..We conclude that the administration of lovastatin at 7.5 mg/kg/day for 21 consecutive days on a 28-day schedule is well tolerated in patients with good renal function and warrants further clinical evaluation... - Preoperative radiotherapy for adult head and neck soft tissue sarcoma: assessment of wound complication rates and cancer outcome in a prospective seriesPatrick Gullane
Department of Radiation Oncology, The Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
World J Surg 27:875-83. 2003..This is especially important when tumor may be adjacent to critical head and neck structures which may be protected from the high-dose RT area... - The natural history of patients with squamous cell carcinoma of the hypopharynxStephen F Hall
Department of Otolaryngology, The Division of Cancer Care and Epidemiology, Queen s University, Kingston, Ontario, Canada
Laryngoscope 118:1362-71. 2008.... - Current applications of microarrays in head and neck cancer researchGiles C Warner
Department of Cellular and Molecular Biology, Ontario Cancer Institute and Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
Laryngoscope 114:241-8. 2004..Although still relatively new, this powerful methodology has immense potential to aid in understanding of the genetic changes that are important in head and neck cancer... - Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastomaIlan Weinreb
Department of Pathology, University Health Network, Toronto, Ontario, Canada
Hum Pathol 40:1330-5. 2009..None of these markers definitively correlated with patient outcome. Neurotrophin receptors do not appear to have a prognostic role; however, Trk's may play an oncogenic role in olfactory neuroblastoma... - Correlation of Epstein-Barr virus DNA in cell-free plasma, functional imaging and clinical course in locally advanced nasopharyngeal cancer: a pilot studyAntti A Makitie
Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 610 University Ave, Suite 5 210, Toronto, M5G 2M9, Canada
Head Neck 26:815-22. 2004.... - Usefulness of cone-beam computed tomography in determining the position of ossicular prostheses: a cadaveric modelEric Monteiro
Department of Otolaryngology Head and Neck Surgery, University of Toronto, Ontario, Canada
Otol Neurotol 32:1358-63. 2011..Cone-beam computed tomography (CT) is proving useful in various operative settings. We hypothesize that it has great potential as an intraoperative assessment tool for ossicular prosthesis positioning... - Accuracy and reproducibility of automatic versus manual registration using a cone-beam CT image guidance systemDustin Dalgorf
Department of Otolaryngology Head and Neck Surgery, University of Toronto, 2 344 Roselawn Avenue, Toronto, Ontario
J Otolaryngol Head Neck Surg 40:75-80. 2011..Intraoperative imaging reveals morphologic changes and resolves anatomic uncertainties during surgery. The automatic registration (AR) approach provides registered intraoperative images for real-time tracking within seconds of acquisition... - Noncontiguous bilateral esthesioneuroblastoma: a case reportAnnesse Lee
Division of Otolaryngology Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada
Skull Base 17:405-7. 2007..This case illustrates that esthesioneuroblastoma must remain as part of the differential diagnosis for a multifocal, noncontiguous intranasal and paranasal sinus mass... - Wait times in the diagnosis and treatment of head and neck cancer: comparison between wait times in 1995 and 2005--a prospective studyDavid Goldstein
Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
J Otolaryngol 36:336-43. 2007.... - Intraoperative use of cone-beam computed tomography in a cadaveric ossified cochlea modelEmma Barker
Departments of Otolaryngology Head and Neck Surgery and Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
Otolaryngol Head Neck Surg 140:697-702. 2009..To describe a cadaveric temporal bone model of labyrinthitis ossificans and investigate the utility of intraoperative cone-beam computed tomography (CBCT) in the facilitating cochlear implantation... - Bisphosphonates and avascular necrosis of the mandible: case report and review of the literatureDylan J Murray
Division of Plastic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
J Plast Reconstr Aesthet Surg 61:94-8. 2008..Avascular necrosis of the mandible or maxilla is being recognized with increasing frequency in patients who are being treated with bisphosphonates for metastatic cancers... - Molecular cytogenetic analysis of head and neck squamous cell carcinoma: By comparative genomic hybridization, spectral karyotyping, and expression array analysisJeremy A Squire
Department of Laboratory Medicine and Pathobiology, The University of Toronto and The University Health Network, Toronto, Ontario, Canada
Head Neck 24:874-87. 2002..Such combinatorial studies may help to identify recurrent patterns of altered gene expression in the context of specific chromosomal changes...