Jonathan Irish

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
    Patricia P Reis
    Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Mol Cancer 9:238. 2010
  2. pmc microRNA evaluation of unknown primary lesions in the head and neck
    Emma V Barker
    Department of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute and University Health Network, Toronto, Ontario M5G 2M9, Canada
    Mol Cancer 8:127. 2009
  3. pmc Low prevalence of human papillomavirus in oral cavity carcinomas
    Jerry Machado
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Head Neck Oncol 2:6. 2010
  4. pmc SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma
    Joerg Schwock
    Department of Laboratory Medicine and Pathobiology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    BMC Clin Pathol 10:1. 2010
  5. doi request reprint Quality of life in patients with maxillectomy prostheses
    Jonathan Irish
    Department of Otolaryngology Surgical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Head Neck 31:813-21. 2009
  6. doi request reprint Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Oral Oncol 49:79-85. 2013
  7. doi request reprint Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:276-83. 2012
  8. doi request reprint Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    Brian O'Sullivan
    Room 5 624, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 31:543-50. 2013
  9. pmc A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence
    Patricia P Reis
    Div, of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    BMC Cancer 11:437. 2011
  10. ncbi request reprint Molecular classification of oral cancer by cDNA microarrays identifies overexpressed genes correlated with nodal metastasis
    Giles C Warner
    Department of Cellular and Molecular Biology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Int J Cancer 110:857-68. 2004

Collaborators

Detail Information

Publications50

  1. pmc Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
    Patricia P Reis
    Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Mol Cancer 9:238. 2010
    ..We also examined PDCD4 regulation by microRNA 21 (miR-21) in OSCC...
  2. pmc microRNA evaluation of unknown primary lesions in the head and neck
    Emma V Barker
    Department of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute and University Health Network, Toronto, Ontario M5G 2M9, Canada
    Mol Cancer 8:127. 2009
    ..This may be clinically relevant to predict the primary site of origin of metastatic disease, when the primary site remains obscure...
  3. pmc Low prevalence of human papillomavirus in oral cavity carcinomas
    Jerry Machado
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Head Neck Oncol 2:6. 2010
    ..Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported...
  4. pmc SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma
    Joerg Schwock
    Department of Laboratory Medicine and Pathobiology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    BMC Clin Pathol 10:1. 2010
    ..We hypothesized that SNAI1 reactivation occurs in oral squamous cell carcinoma (OSCC) where it might also be associated with focal adhesion kinase (FAK) expression and p63 loss...
  5. doi request reprint Quality of life in patients with maxillectomy prostheses
    Jonathan Irish
    Department of Otolaryngology Surgical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Head Neck 31:813-21. 2009
    ..This cross-sectional study sought to determine patient quality of life and function after prosthetic rehabilitation for maxillary and palate defects following cancer resection...
  6. doi request reprint Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Oral Oncol 49:79-85. 2013
    ..To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC)...
  7. doi request reprint Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:276-83. 2012
    ..To report atypical clinical behavior observed in human papillomavirus (HPV)-related oropharyngeal carcinoma (OPC) treated with radiotherapy...
  8. doi request reprint Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    Brian O'Sullivan
    Room 5 624, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 31:543-50. 2013
    ..02). CONCLUSION HPV-positive T1-3N0-2c patients have a low DM risk, but N2c patients from this group have a reduced DC when treated with RT alone and seem less suited for deintensification strategies that omit chemotherapy...
  9. pmc A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence
    Patricia P Reis
    Div, of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    BMC Cancer 11:437. 2011
    ..Therefore, molecular analysis of histologically normal resection margins and the corresponding OSCC may aid in identifying a gene signature predictive of recurrence...
  10. ncbi request reprint Molecular classification of oral cancer by cDNA microarrays identifies overexpressed genes correlated with nodal metastasis
    Giles C Warner
    Department of Cellular and Molecular Biology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Int J Cancer 110:857-68. 2004
    ..Application of this methodology represents an advance in the classification of oral cavity tumors and may ultimately aid in the development of more tailored therapies for oral carcinoma...
  11. doi request reprint Morbidity and functional outcomes following gastro-omental free flap reconstruction of circumferential pharyngeal defects
    Rajan S Patel
    Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Head Neck 31:655-63. 2009
    ..This study reviews our experience with this flap...
  12. ncbi request reprint Primary and salvage (hypo)pharyngectomy: Analysis and outcome
    Jonathan R Clark
    Department of Head and Neck Surgical Oncology, Princess Margaret Hospital, Wharton Head and Neck Centre, 610 University Avenue, Toronto, ON M5G 2M9
    Head Neck 28:671-7. 2006
    ....
  13. doi request reprint Waiting for thyroid surgery: a study of psychological morbidity and determinants of health associated with long wait times for thyroid surgery
    Antoine Eskander
    Department of Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
    Laryngoscope 123:541-7. 2013
    ..Uncertainty during this wait can have negative psychologically impact. This study aims to determine the degree of psychological morbidity in patients waiting for thyroid surgery...
  14. doi request reprint Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 103:49-56. 2012
    ..To report outcome of HPV-related [HPV(+)] oropharyngeal cancer (OPC) managed predominantly by altered-fractionation radiotherapy-alone (RT-alone)...
  15. doi request reprint Circumferential pharyngeal reconstruction: history, critical analysis of techniques, and current therapeutic recommendations
    Rajan S Patel
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Head Neck 32:109-20. 2010
    ..Each technique is critically appraised with particular reference to postoperative morbidity and functional rehabilitation. Treatment recommendations are made based on the available evidence...
  16. doi request reprint Second free flaps in head and neck reconstruction
    Gary Ross
    Division of Plastic and Reconstructive Surgery, University Health Network, 200 Elizabeth Street, 8N 865, Toronto, ON M5G 2C4, Canada
    J Plast Reconstr Aesthet Surg 65:1165-8. 2012
    ..The objective of this study was to assess outcomes following a second free flap in head and neck reconstruction...
  17. ncbi request reprint Predictors of morbidity following free flap reconstruction for cancer of the head and neck
    Jonathan R Clark
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, Toronto, Ontario, Canada
    Head Neck 29:1090-101. 2007
    ..The aim was to determine if there was an association between perioperative variables and postoperative outcome...
  18. doi request reprint Claudin 1 overexpression increases invasion and is associated with aggressive histological features in oral squamous cell carcinoma
    Patricia Pintor dos Reis
    Division of Applied Molecular Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Cancer 113:3169-80. 2008
    ..Their goal was to examine CLDN1 expression in a large series of primary OSCCs and to further investigate whether CLDN1 overexpression plays a role in invasion in OSCC...
  19. doi request reprint Mucosal melanomas of the head and neck: experience of the Princess Margaret Hospital
    Gideon Bachar
    Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
    Head Neck 30:1325-31. 2008
    ..The aim of this study was to identify the prognostic variables in mucosal melanoma of the head and neck...
  20. ncbi request reprint Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model
    Antti A Makitie
    Department of Cellular and Molecular Biology, Ontario Cancer Institute and Princess Margaret Hospital, The University Health Network, Toronto, Ontario, Canada
    Lab Invest 85:947-61. 2005
    ..Our data suggest that Ptn and Cd24a may be genetic markers associated with salivary gland tumorigenesis and/or progression...
  21. pmc mRNA transcript quantification in archival samples using multiplexed, color-coded probes
    Patricia P Reis
    Division of Applied Molecular Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    BMC Biotechnol 11:46. 2011
    ..We assessed the ability of this technology for mRNA expression quantification in archived formalin-fixed, paraffin-embedded (FFPE) oral carcinoma samples...
  22. doi request reprint Towards further understanding of prognostic factors for head and neck cancer patients: the example of hypopharyngeal cancer
    Stephen F Hall
    Department of Otolaryngology, The Cancer Care and Epidemiology Division of Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Laryngoscope 119:696-702. 2009
    ..The objectives of this study were to demonstrate that prognostic factors and their impact can vary depending on study design and to examine the relationships between select prognostic factors...
  23. doi request reprint TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx
    Stephen F Hall
    Department of Otolaryngology, Queen s University, Kingston, Ontario, Canada
    Head Neck 31:1-8. 2009
    ....
  24. doi request reprint Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma
    Nilva K Cervigne
    Division of Applied Molecular Oncology, Toronto General Hospital, Ontario Cancer Institute, The University Health Network, Toronto, ON, Canada
    Hum Mol Genet 18:4818-29. 2009
    ..Our study provides the first evidence of an miR signature potentially useful for identifying leukoplakias at risk of malignant transformation...
  25. ncbi request reprint Response rates for mailout survey-driven studies in patients waiting for thyroid surgery
    Antoine Eskander
    Department of Otolaryngology Head and Neck Surgery, University Health Network, Princess Margaret Hospital, University of Toronto
    J Otolaryngol Head Neck Surg 40:462-7. 2011
    ..The objective of this article is to summarize response rates in patients waiting for thyroid surgery and to document the methodology of mailout survey questionnaires...
  26. doi request reprint Impact of positive frozen section microscopic tumor cut-through revised to negative on oral carcinoma control and survival rates
    Rajan S Patel
    Department of Otolaryngology Head and Neck Surgery, Sunnybrook Health Sciences Centre Odette Cancer Centre and University of Toronto, Toronto, Ontario, Canada
    Head Neck 32:1444-51. 2010
    ....
  27. doi request reprint Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?
    Stephen F Hall
    Department of Otolaryngology, Cancer Care and Epidemiology Division, Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer 115:5711-22. 2009
    ..There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group...
  28. doi request reprint Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases
    Gideon Bachar
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
    Head Neck 30:1012-9. 2008
    ..Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm...
  29. doi request reprint The burden of stress in head and neck cancer
    Gerald M Devins
    Ontario Cancer Institute, Toronto, Canada
    Psychooncology 22:668-76. 2013
    ..e., cancer-induced interference with lifestyles, activities, and interests), and distress. We also investigated whether reported exposure rates differ between self-administered and interviewer-administered measures...
  30. doi request reprint Truths and myths about radiotherapy for verrucous carcinoma of larynx
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:1110-5. 2009
    ..To address these concerns, we report our experience...
  31. ncbi request reprint Cutaneous metastatic squamous cell carcinoma to the parotid gland: analysis and outcome
    Nathalie Audet
    Princess Margaret Hospital, Wharton Head and Neck Centre 3 951, 610 University Avenue, Toronto, Ontario M4S 1C6, Canada
    Head Neck 26:727-32. 2004
    ..Our aim was to review the presentation, treatment, and outcome of patients with metastatic cutaneous squamous cell carcinoma involving the parotid gland at a tertiary referral center...
  32. doi request reprint Negative cancer stereotypes and disease-specific self-concept in head and neck cancer
    Janice C Wong
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Psychooncology 22:1055-63. 2013
    ....
  33. ncbi request reprint Morbidity after flap reconstruction of hypopharyngeal defects
    Jonathan R Clark
    Department of Otolaryngology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Laryngoscope 116:173-81. 2006
    ..In addition, we detail a reconstructive algorithm for management of partial and total laryngopharyngectomy defects...
  34. doi request reprint Response rates for mailout survey-driven studies in patients with head and neck cancer
    David P Goldstein
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Head Neck 32:1585-91. 2010
    ..The objective of this paper is to summarize response rates in patients with head and neck cancer, and to provide recommendations surrounding methodology used to design and implement mailout survey questionnaires...
  35. ncbi request reprint Adult soft tissue sarcomas of the head and neck
    Jean Pierre Jeannon
    Department of Otolaryngology Surgical Oncology, Wharton Head and Neck Centre, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Asian J Surg 25:5-12. 2002
  36. doi request reprint Social environment, secondary smoking exposure, and smoking cessation among head and neck cancer patients
    Aidin Kashigar
    Otolaryngology Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
    Cancer 119:2701-9. 2013
    ..The purpose of this report was to evaluate sociodemographic predictors of smoking cessation in HNC patients to support the development of a smoking cessation program...
  37. ncbi request reprint A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix
    Jennifer J Knox
    Departments of Medical Oncology, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 5 218, 610 University Avenue, Toronto, Ont, Canada M5G 2M9
    Eur J Cancer 41:523-30. 2005
    ..We conclude that the administration of lovastatin at 7.5 mg/kg/day for 21 consecutive days on a 28-day schedule is well tolerated in patients with good renal function and warrants further clinical evaluation...
  38. doi request reprint Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma
    Ilan Weinreb
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    Hum Pathol 40:1330-5. 2009
    ..None of these markers definitively correlated with patient outcome. Neurotrophin receptors do not appear to have a prognostic role; however, Trk's may play an oncogenic role in olfactory neuroblastoma...
  39. ncbi request reprint Preoperative radiotherapy for adult head and neck soft tissue sarcoma: assessment of wound complication rates and cancer outcome in a prospective series
    Brian O'Sullivan
    Department of Radiation Oncology, The Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    World J Surg 27:875-83. 2003
    ..This is especially important when tumor may be adjacent to critical head and neck structures which may be protected from the high-dose RT area...
  40. ncbi request reprint Current applications of microarrays in head and neck cancer research
    Giles C Warner
    Department of Cellular and Molecular Biology, Ontario Cancer Institute and Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Laryngoscope 114:241-8. 2004
    ..The objective was to introduce microarray technology and its applications in cancer research to the head and neck clinician...
  41. doi request reprint The natural history of patients with squamous cell carcinoma of the hypopharynx
    Stephen F Hall
    Department of Otolaryngology, The Division of Cancer Care and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Laryngoscope 118:1362-71. 2008
    ....
  42. ncbi request reprint Correlation of Epstein-Barr virus DNA in cell-free plasma, functional imaging and clinical course in locally advanced nasopharyngeal cancer: a pilot study
    Antti A Makitie
    Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, 610 University Ave, Suite 5 210, Toronto, M5G 2M9, Canada
    Head Neck 26:815-22. 2004
    ....
  43. doi request reprint The psychosocial impact of stigma in people with head and neck or lung cancer
    Sophie Lebel
    University of Ottawa, Ottawa, Ontario, Canada
    Psychooncology 22:140-52. 2013
    ..We investigated cancer site, self-blame, disfigurement, and sex as determinants, benefit finding as a moderator, and illness intrusiveness as a mediator of the relation between stigma and its psychosocial impact...
  44. pmc Noncontiguous bilateral esthesioneuroblastoma: a case report
    Annesse Lee
    Division of Otolaryngology Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada
    Skull Base 17:405-7. 2007
    ..This case illustrates that esthesioneuroblastoma must remain as part of the differential diagnosis for a multifocal, noncontiguous intranasal and paranasal sinus mass...
  45. ncbi request reprint Accuracy and reproducibility of automatic versus manual registration using a cone-beam CT image guidance system
    Dustin Dalgorf
    Department of Otolaryngology Head and Neck Surgery, University of Toronto, 2 344 Roselawn Avenue, Toronto, Ontario
    J Otolaryngol Head Neck Surg 40:75-80. 2011
    ..Intraoperative imaging reveals morphologic changes and resolves anatomic uncertainties during surgery. The automatic registration (AR) approach provides registered intraoperative images for real-time tracking within seconds of acquisition...
  46. ncbi request reprint Wait times in the diagnosis and treatment of head and neck cancer: comparison between wait times in 1995 and 2005--a prospective study
    David Goldstein
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    J Otolaryngol 36:336-43. 2007
    ....
  47. doi request reprint Usefulness of cone-beam computed tomography in determining the position of ossicular prostheses: a cadaveric model
    Eric Monteiro
    Department of Otolaryngology Head and Neck Surgery, University of Toronto, Ontario, Canada
    Otol Neurotol 32:1358-63. 2011
    ..Cone-beam computed tomography (CT) is proving useful in various operative settings. We hypothesize that it has great potential as an intraoperative assessment tool for ossicular prosthesis positioning...
  48. pmc Intraoperative use of cone-beam computed tomography in a cadaveric ossified cochlea model
    Emma Barker
    Departments of Otolaryngology Head and Neck Surgery and Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Otolaryngol Head Neck Surg 140:697-702. 2009
    ..To describe a cadaveric temporal bone model of labyrinthitis ossificans and investigate the utility of intraoperative cone-beam computed tomography (CBCT) in the facilitating cochlear implantation...
  49. ncbi request reprint Bisphosphonates and avascular necrosis of the mandible: case report and review of the literature
    Dylan J Murray
    Division of Plastic Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Plast Reconstr Aesthet Surg 61:94-8. 2008
    ..Avascular necrosis of the mandible or maxilla is being recognized with increasing frequency in patients who are being treated with bisphosphonates for metastatic cancers...
  50. ncbi request reprint Molecular cytogenetic analysis of head and neck squamous cell carcinoma: By comparative genomic hybridization, spectral karyotyping, and expression array analysis
    Jeremy A Squire
    Department of Laboratory Medicine and Pathobiology, The University of Toronto and The University Health Network, Toronto, Ontario, Canada
    Head Neck 24:874-87. 2002
    ..Such combinatorial studies may help to identify recurrent patterns of altered gene expression in the context of specific chromosomal changes...