Research Topics
| S M InnisSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Neonatal polyunsaturated fatty acid metabolismS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Lipids 34:139-49. 1999....- trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infantsS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Am J Clin Nutr 70:383-90. 1999..The effects of milk trans, n-6, and n-3 fatty acids in breast-fed infants are unclear, although n-6 and n-3 fatty acids are important in infant growth and development... - Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirementsS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Am J Clin Nutr 71:238S-44S. 2000..Animal studies can provide important information on the mechanisms of both beneficial and adverse effects and the pathways of brain 22:6n-3 uptake... - The role of dietary n-6 and n-3 fatty acids in the developing brainS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, B C, Canada
Dev Neurosci 22:474-80. 2000..These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n-3 fatty acids and to clinical conditions where n-3 fatty acids may have benefit... - Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and lengthS L Elias
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Am J Clin Nutr 73:807-14. 2001..33) and between TFA and AA concentrations in cholesteryl esters (r = -0.23). CONCLUSION: The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation... - Dietary fatty acid composition in pregnancy alters neurite membrane fatty acids and dopamine in newborn rat brainS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada V5Z 4H4
J Nutr 131:118-22. 2001..The functional importance, however, is not known at this time... - Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of ageS M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada
Am J Clin Nutr 64:40-6. 1996.... - Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants?S M Innis
Department of Paediatrics, University of British Columbia, Vancouver, Canada
J Pediatr 139:532-8. 2001..To determine whether docosahexaenoic acid (DHA) is related to visual and neural development in term breast-fed infants... 
Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid compositionA Tijerina-Sáenz
Food, Nutrition and Health, University of British Columbia, Vancouver, BC, Canada
Acta Paediatr 98:1793-8. 2009..The aim of this study was to use the Oxygen Radical Absorbance Capacity assay to assess human milk antioxidant capacity and find correlations with milk components...- Cholesterol synthesis and accretion within various tissues of the fetal and neonatal ratN C Haave
Department of Pathology, University of British Columbia, Vancouver, Canada
Metabolism 50:12-8. 2001..However, the fetal liver may support cholesterol accretion in other tissues through rates of synthesis in excess of accumulation and secretion into plasma. The placenta may derive some cholesterol from the maternal and/or fetal plasma... 
Long chain omega-3 fatty acids: micronutrients in disguiseS M Innis
Department of Paediatrics, Nutrition and Metabolism Research Program, Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4
Prostaglandins Leukot Essent Fatty Acids 88:91-5. 2013....- Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal developmentE M Novak
Nutrition and Metabolism Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Ave, Vancouver, B C, Canada V5Z 4H4
Prostaglandins Leukot Essent Fatty Acids 86:93-8. 2012..These findings suggest low placental transfer of 18:2n-6 may be a specific mechanism to prevent inhibition of fetal Δ6 desaturase and facilitate fetal cellular phospholipid 22:6n-3 accretion... - Essential fatty acid transfer and fetal developmentS M Innis
Department of Paediatrics, Nutrition Research Program, University of British Columbia, B C Research Institute for Maternal and Child Health, Room 179, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
Placenta 26:S70-5. 2005..Consideration needs to be given to whether fetal plasma 22:6n-3 and 20:4n-6 enrichment and the low 18:2n-6 facilitates accretion of 22:6n-3 and 20:4n-6 in developing tissues... - Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3D An
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada, V6T 1Z3
Diabetologia 49:2174-84. 2006..However, at high concentrations, metformin causes proton and lactate accumulation, leading to cell damage that is independent of caspase-3... - Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsiaA W Shand
Department of Maternal Fetal Medicine, BC Women s Hospital, Vancouver, BC, Canada
BJOG 117:1593-8. 2010..To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes...