S M Innis

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Dietary triacylglycerol structure and its role in infant nutrition
    Sheila M Innis
    Child and Family Research Institute, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Adv Nutr 2:275-83. 2011
  2. ncbi request reprint Trans fatty intakes during pregnancy, infancy and early childhood
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Atheroscler Suppl 7:17-20. 2006
  3. ncbi request reprint Increased levels of mercury associated with high fish intakes among children from Vancouver, Canada
    Sheila M Innis
    Nutrition Research Program, Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 148:759-63. 2006
  4. ncbi request reprint n-6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadian preschool children
    Sheila M Innis
    Nutrition Research Program, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Am J Clin Nutr 80:768-73. 2004
  5. ncbi request reprint Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 77:473-8. 2003
  6. ncbi request reprint Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    J Pediatr 143:351-6. 2003
  7. ncbi request reprint Dietary (n-3) fatty acids and brain development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Nutr 137:855-9. 2007
  8. doi request reprint Omega-3 Fatty acids and neural development to 2 years of age: do we know enough for dietary recommendations?
    Sheila M Innis
    Child and Family Research Institute and Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr Gastroenterol Nutr 48:S16-24. 2009
  9. doi request reprint Dietary omega 3 fatty acids and the developing brain
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, B C, Canada
    Brain Res 1237:35-43. 2008
  10. doi request reprint Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis
    Sheila M Innis
    Nutrition and Metabolism Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 93:564-8. 2011

Collaborators

Detail Information

Publications76

  1. pmc Dietary triacylglycerol structure and its role in infant nutrition
    Sheila M Innis
    Child and Family Research Institute, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Adv Nutr 2:275-83. 2011
    ....
  2. ncbi request reprint Trans fatty intakes during pregnancy, infancy and early childhood
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    Atheroscler Suppl 7:17-20. 2006
    ..This support the need to reduce industrially produced trans fatty acids (IP-TFA) and improve dietary fat quality, particularly by increasing intake of n-3 fatty acids...
  3. ncbi request reprint Increased levels of mercury associated with high fish intakes among children from Vancouver, Canada
    Sheila M Innis
    Nutrition Research Program, Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 148:759-63. 2006
    ..To assess exposure to mercury (Hg) among children in population subgroups whose traditional dietary practices include fish...
  4. ncbi request reprint n-6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadian preschool children
    Sheila M Innis
    Nutrition Research Program, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Am J Clin Nutr 80:768-73. 2004
    ..The n-3 fatty acid status of preschool children has not been described, and data are lacking on whether low 22:6n-3 is accompanied by high 22:5n-6 in humans...
  5. ncbi request reprint Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 77:473-8. 2003
    ..Little is known about n-3 fatty acid intakes in pregnant women, although human milk concentrations of DHA have decreased in recent years...
  6. ncbi request reprint Increased plasma homocysteine and S-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
    J Pediatr 143:351-6. 2003
    ..Methyl groups from methionine via SAM are used for sequential methylation of PE to form phosphatidylcholine (PC) with the generation of S-adenosylhomocysteine (SAH) and homocysteine...
  7. ncbi request reprint Dietary (n-3) fatty acids and brain development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Nutr 137:855-9. 2007
    ....
  8. doi request reprint Omega-3 Fatty acids and neural development to 2 years of age: do we know enough for dietary recommendations?
    Sheila M Innis
    Child and Family Research Institute and Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr Gastroenterol Nutr 48:S16-24. 2009
    ....
  9. doi request reprint Dietary omega 3 fatty acids and the developing brain
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, B C, Canada
    Brain Res 1237:35-43. 2008
    ..Consideration of omega-3 fatty acid to include brain development, optimizing omega-3 and omega-6 fatty acids in gestation and lactation, and in fatty acid nutrition support for intravenous and formula-fed neonates is important...
  10. doi request reprint Plasma choline depletion is associated with decreased peripheral blood leukocyte acetylcholine in children with cystic fibrosis
    Sheila M Innis
    Nutrition and Metabolism Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 93:564-8. 2011
    ..Plasma free choline concentrations are low in children with cystic fibrosis (CF), but the implications for acetylcholine are unknown...
  11. ncbi request reprint Dietary lipids in early development: relevance to obesity, immune and inflammatory disorders
    Sheila M Innis
    Department of Paediatrics, Nutrition Research Program, Child and Family Research Institute, Faculty of Medicine, Vancouver, British Columbia, Canada
    Curr Opin Endocrinol Diabetes Obes 14:359-64. 2007
    ..This review focuses on the possible contribution of fatty acids to the link between obesity and inflammation in young children...
  12. ncbi request reprint Polyunsaturated fatty acids in human milk: an essential role in infant development
    Sheila M Innis
    Department of Paediatrics, BC Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, Canada V5Z, 4H4
    Adv Exp Med Biol 554:27-43. 2004
    ....
  13. ncbi request reprint Dietary fatty acid composition in pregnancy alters neurite membrane fatty acids and dopamine in newborn rat brain
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada V5Z 4H4
    J Nutr 131:118-22. 2001
    ..The functional importance, however, is not known at this time...
  14. doi request reprint Metabolic programming of long-term outcomes due to fatty acid nutrition in early life
    Sheila M Innis
    Departments of Paediatrics and Pathology, Nutrition and Metabolism, Child and Family Research Institute of British Columbia, 950 West 28th Avenue, Vancouver, BC, Canada
    Matern Child Nutr 7:112-23. 2011
    ..Further work is needed to understand the needs for different ω-6 and ω-3 fatty acids during fetal and infant life, and their roles with respect to development of energy homeostasis and metabolism...
  15. ncbi request reprint The role of dietary n-6 and n-3 fatty acids in the developing brain
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, B C, Canada
    Dev Neurosci 22:474-80. 2000
    ..These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n-3 fatty acids and to clinical conditions where n-3 fatty acids may have benefit...
  16. ncbi request reprint Fatty acids and early human development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada
    Early Hum Dev 83:761-6. 2007
    ..The implications of recent changes in the dietary fatty acids on maternal to infant fatty acid transfer, including the composition of human milk has been insufficiently studied...
  17. ncbi request reprint Human milk: maternal dietary lipids and infant development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Proc Nutr Soc 66:397-404. 2007
    ....
  18. ncbi request reprint Essential n-3 fatty acids in pregnant women and early visual acuity maturation in term infants
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada V56Z 4H4
    Am J Clin Nutr 87:548-57. 2008
    ..Docosahexaenoic acid (DHA) is important to neural development. Whether DHA intakes are low enough in some pregnant women to impair infant development is uncertain...
  19. ncbi request reprint Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 71:238S-44S. 2000
    ..Animal studies can provide important information on the mechanisms of both beneficial and adverse effects and the pathways of brain 22:6n-3 uptake...
  20. doi request reprint Dietary arachidonic acid to EPA and DHA balance is increased among Canadian pregnant women with low fish intake
    Russell W Friesen
    Child and Family Research Institute, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    J Nutr 139:2344-50. 2009
    ..Median fish and DHA intakes below the recommended 1-2 servings/wk fish for pregnant women suggest major changes in the availability, cost, or acceptance of fish are needed...
  21. ncbi request reprint Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length
    S L Elias
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 73:807-14. 2001
    ..33) and between TFA and AA concentrations in cholesteryl esters (r = -0.23). CONCLUSION: The results suggest possible important effects of TFAs and of AA on fetal growth and length of gestation...
  22. ncbi request reprint Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men
    Y Angela Liou
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, Canada V52 4H40
    J Nutr 137:945-52. 2007
    ..In conclusion, high LA intakes decrease plasma phospholipid EPA and increase the ARA:EPA ratio, but do not favor higher ARA...
  23. ncbi request reprint trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 70:383-90. 1999
    ..The effects of milk trans, n-6, and n-3 fatty acids in breast-fed infants are unclear, although n-6 and n-3 fatty acids are important in infant growth and development...
  24. doi request reprint Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development
    E M Novak
    Nutrition and Metabolism Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Ave, Vancouver, B C, Canada V5Z 4H4
    Prostaglandins Leukot Essent Fatty Acids 86:93-8. 2012
    ..These findings suggest low placental transfer of 18:2n-6 may be a specific mechanism to prevent inhibition of fetal Δ6 desaturase and facilitate fetal cellular phospholipid 22:6n-3 accretion...
  25. ncbi request reprint Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 64:40-6. 1996
    ....
  26. ncbi request reprint Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants?
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    J Pediatr 139:532-8. 2001
    ..To determine whether docosahexaenoic acid (DHA) is related to visual and neural development in term breast-fed infants...
  27. doi request reprint Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women
    Russell W Friesen
    Nutrition and Metabolism Program, Child and Family Research Institute, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 91:23-31. 2010
    ..As in the brain, red blood cell (RBC) ethanolamine phosphoglycerides (EPGs) are high in plasmalogen, ARA, and DHA...
  28. ncbi request reprint Behavioral responses are altered in piglets with decreased frontal cortex docosahexaenoic acid
    Kai Fong Ng
    Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4
    J Nutr 133:3222-7. 2003
    ..Our work establishes the neonatal piglet as a model with which to study the behavioral effects of diet-induced changes in brain 22:6(n-3), and provides functional evidence that brain 22:6(n-3) is important in central dopamine metabolism...
  29. ncbi request reprint Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat
    Russell Friesen
    Nutrition Research Program, Research Institute for Child and Family Health, 950 W 28th Ave, Vancouver, British Columbia, Canada V5Z 4H4
    Am J Physiol Gastrointest Liver Physiol 290:G505-10. 2006
    ..Maternal dietary fat can influence tissue composition by manipulation of amniotic fluid that is swallowed by the fetus or by transport across the placenta...
  30. ncbi request reprint Essential fatty acid transfer and fetal development
    S M Innis
    Department of Paediatrics, Nutrition Research Program, University of British Columbia, B C Research Institute for Maternal and Child Health, Room 179, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Placenta 26:S70-5. 2005
    ..Consideration needs to be given to whether fetal plasma 22:6n-3 and 20:4n-6 enrichment and the low 18:2n-6 facilitates accretion of 22:6n-3 and 20:4n-6 in developing tissues...
  31. ncbi request reprint Dietary polyunsaturated fatty acids in gestation alter fetal cortical phospholipids, fatty acids and phosphatidylserine synthesis
    Odilia Tam
    Nutrition Research Program and Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Dev Neurosci 28:222-9. 2006
    ....
  32. ncbi request reprint Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine
    Alice H Chen
    Department of Paediatrics and the Nutrition Research Program, University of British Columbia, Vancouver, Canada
    Am J Clin Nutr 81:686-91. 2005
    ..The intestinal absorption of phosphatidylcholine in CF is unknown...
  33. ncbi request reprint Bakery foods are the major dietary source of trans-fatty acids among pregnant women with diets providing 30 percent energy from fat
    Sandra L Elias
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    J Am Diet Assoc 102:46-51. 2002
    ..To estimate intake and identify major dietary sources of trans-fatty acids consumed by healthy, pregnant women...
  34. doi request reprint Long chain omega-3 fatty acids: micronutrients in disguise
    S M Innis
    Department of Paediatrics, Nutrition and Metabolism Research Program, Child and Family Research Institute, Vancouver, BC, Canada V5Z 4H4
    Prostaglandins Leukot Essent Fatty Acids 88:91-5. 2013
    ....
  35. pmc Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid composition
    A Tijerina-Sáenz
    Food, Nutrition and Health, University of British Columbia, Vancouver, BC, Canada
    Acta Paediatr 98:1793-8. 2009
    ..The aim of this study was to use the Oxygen Radical Absorbance Capacity assay to assess human milk antioxidant capacity and find correlations with milk components...
  36. ncbi request reprint Are plasma homocysteine and methionine elevated when binging and purging behavior complicates anorexia nervosa? Evidence against the transdiagnostic theory of eating disorders
    S M Innis
    The Nutrition Research Program, Child and Family Research Institute, Deaprtment of Paediatrics, University of British Columbia, Vancouver, BC V6T 2A1, Canada
    Eat Weight Disord 14:e184-9. 2009
    ..To determine whether plasma total homocysteine (tHcy) and plasma methionine levels are different in anorexia nervosa restricting type (AN-R) compared to anorexia nervosa binge eating/purging type (AN-BP)...
  37. ncbi request reprint Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    J Pediatr 140:547-54. 2002
    ..To determine if docosahexaenoic acid (DHA) and arachidonic acid (ARA) supplementation influences growth or visual acuity of formula-fed premature infants...
  38. ncbi request reprint Dietary lipids in early development and intestinal inflammatory disease
    Sheila M Innis
    Department of Paediatrics, Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Nutr Rev 65:S188-93. 2007
    ..High dietary n-6 PUFA intake may be an important environmental modifier that contributes to inflammatory bowel diseases...
  39. doi request reprint Identification of novel protein targets regulated by maternal dietary fatty acid composition in neonatal rat liver
    Elizabeth M Novak
    Department of Pediatrics, Nutrition Research Program, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, B C, Canada V5Z 4H4
    J Proteomics 73:41-9. 2009
    ..We demonstrate that early fatty acid nutrition impacts hepatic metabolic pathways relevant to gluconeogenesis, redox balance and nitric oxide signaling...
  40. ncbi request reprint Choline-related supplements improve abnormal plasma methionine-homocysteine metabolites and glutathione status in children with cystic fibrosis
    Sheila M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada
    Am J Clin Nutr 85:702-8. 2007
    ....
  41. ncbi request reprint Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids
    Sheila M Innis
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 143:S1-8. 2003
    ....
  42. doi request reprint Effects of d-3-hydroxybutyrate treatment on hypoglycemic coma in rat pups
    Peter W Schutz
    Department of Pediatrics, British Columbia Children s Hospital and University of British Columbia, Vancouver, BC, Canada
    Exp Neurol 227:180-7. 2011
    ..3OHB treatment delays the onset of clinical and burst-suppression coma during hypoglycemia, but the prolonged duration of hypoglycemia is associated with increased mortality after resuscitation and cellular white matter injury...
  43. ncbi request reprint Cholesterol synthesis and accretion within various tissues of the fetal and neonatal rat
    N C Haave
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Metabolism 50:12-8. 2001
    ..However, the fetal liver may support cholesterol accretion in other tissues through rates of synthesis in excess of accumulation and secretion into plasma. The placenta may derive some cholesterol from the maternal and/or fetal plasma...
  44. ncbi request reprint Neonatal polyunsaturated fatty acid metabolism
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, Canada
    Lipids 34:139-49. 1999
    ....
  45. ncbi request reprint Trans fatty acids in human milk in Canada declined with the introduction of trans fat food labeling
    Russell Friesen
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Nutr 136:2558-61. 2006
    ..Our studies show trans fatty acids have decreased in human milk in Canada, which suggests a concomitant decrease in trans fatty acid intake among lactating women and breast-fed infants...
  46. doi request reprint High dietary omega-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth
    Elizabeth M Novak
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, B C, Canada
    Brain Res 1237:136-45. 2008
    ..Our results suggest the need to consider whether current high dietary omega-6 fatty acid intakes compromise brain DHA accretion and contribute to poor neurodevelopment...
  47. ncbi request reprint Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
    Angela M Devlin
    Nutrition Research Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V6H 3N1, Canada
    J Biol Chem 282:37082-90. 2007
    ..05), and lower Delta6-desaturase activity (p<0.001) in liver from mice with HHcy. These findings suggest that methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of HHcy...
  48. ncbi request reprint Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet
    Kevan Jacobson
    Division of Gastroenterology, Department of Pediatrics and Nutrition Research Program, British Columbia Institute for Children s and Women s Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 289:G13-20. 2005
    ..We demonstrate that maternal dietary fat influences the composition of intestinal lipids and responsiveness to experimental colitis in nursing offspring...
  49. doi request reprint Dietary long chain n-3 fatty acids are more closely associated with protein than energy intakes from fat
    E M Novak
    Nutrition and Metabolism Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Ave, Vancouver, B C, Canada V5Z 4H4
    Prostaglandins Leukot Essent Fatty Acids 86:107-12. 2012
    ..Recommendations regarding EPA and DHA intake should focus on protein sources, rather than diet fat, and consider their potential roles in amino acid and protein metabolism...
  50. doi request reprint Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia
    A W Shand
    Department of Maternal Fetal Medicine, BC Women s Hospital, Vancouver, BC, Canada
    BJOG 117:1593-8. 2010
    ..To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes...
  51. ncbi request reprint Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3
    D An
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada, V6T 1Z3
    Diabetologia 49:2174-84. 2006
    ..Metformin has been shown to increase fatty acid oxidation, an effect mediated by AMP activated protein kinase (AMPK). We hypothesised that metformin could prevent both caspase-3 activation and apoptosis when induced by palmitic acid...
  52. ncbi request reprint Incidence of iron-deficiency anaemia and depleted iron stores among nine-month-old infants in Vancouver, Canada
    S M Innis
    Department of Paediatrics, University of British Columbia
    Can J Public Health 88:80-4. 1997
    ..This study shows iron-deficiency anaemia is a problem among a significant number of nine-month-old infants in Canada, and is not explained by failure to introduce iron-fortified infant cereals...
  53. ncbi request reprint Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid
    Sheila M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada, V5Z 4H4
    J Lipid Res 43:1529-36. 2002
    ..These studies suggest conversion of 22:5n-3 limits 22:6n-3 synthesis, and show astrocytes release fatty acids in CE...
  54. doi request reprint Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia
    Angela M Devlin
    Department of Pathology and Laboratory Medicine, Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver V5Z 4H4, Canada
    J Nutr 140:231-7. 2010
    ..These findings show altered methylation and expression of Soat2/ACAT2 in liver from mice with HHcy and suggest a role for changes in liver CE in the pathology of HHcy...
  55. doi request reprint Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men
    Y Angela Liou
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, B C, V5Z 4H4, Canada
    Prostaglandins Leukot Essent Fatty Acids 80:201-6. 2009
    ..8% energy, and they suggest current LA intakes saturate Delta-6 desaturation and adversely affect n-3 fatty acid metabolism. Factors other than n-6 fatty acid intake are important modifiers of plasma ARA...
  56. ncbi request reprint Dietary polyunsaturated fat that is low in (n-3) and high in (n-6) fatty acids alters the SNARE protein complex and nitrosylation in rat hippocampus
    Julie L Pongrac
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Nutr 137:1852-6. 2007
    ..These studies suggest that altered SNARE complex binding or disassembly could be important in explaining the diverse cellular events associated with altered tissue DHA...
  57. doi request reprint Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis
    Ying Fai Ngai
    Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Endocrinology 151:5226-36. 2010
    ..In addition to its known role in lipid transport, these results demonstrate the importance of the Ldlr in energy homeostasis and suggest a direct physiological link between altered lipid transport and energy balance...
  58. ncbi request reprint Cardiac proinflammatory pathways are altered with different dietary n-6 linoleic to n-3 alpha-linolenic acid ratios in normal, fat-fed pigs
    Sanjoy Ghosh
    Nutrition Research Program, Child and Family Research Institute, Department of Pedicatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 293:H2919-27. 2007
    ..The increased nitrosative stress in the unstressed heart with high dietary LA suggests that biomarkers of nitrosative stress may offer a useful early marker of the effects of dietary fat on oxidative tissue stress...
  59. ncbi request reprint Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary omega-6 polyunsaturated fatty acids
    Sanjoy Ghosh
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Free Radic Biol Med 41:1413-24. 2006
    ..Our study, for the first time, demonstrates that consumption of a high fat diet rich in omega-6 PUFA for only 4 weeks instigates mitochondrial nitrosative damage and causes cardiac dysfunction at high afterloads...
  60. ncbi request reprint Acute intralipid infusion reduces cardiac luminal lipoprotein lipase but recruits additional enzyme from cardiomyocytes
    Dake Qi
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    Cardiovasc Res 72:124-33. 2006
    ..Lipoprotein lipase (LPL) metabolizes the triglyceride (TG) core of lipoproteins. We evaluated whether circulating lipids can regulate LPL by influencing the transfer of enzyme from the myocyte to the endothelial lumen...
  61. ncbi request reprint Predictors and outcomes of household food insecurity among inner city families with preschool children in Vancouver
    Margaret A Broughton
    Health Care and Epidemiology, University of British Columbia, Vancouver
    Can J Public Health 97:214-6. 2006
    ....
  62. doi request reprint Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations
    Timothy J Green
    Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada
    Br J Nutr 103:1629-34. 2010
    ..If elevated plasma AdoHcy is detrimental, this may explain why B-vitamins have generally failed to reduce vascular events in clinical trials...
  63. ncbi request reprint Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death
    Sanjoy Ghosh
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Department of Pediatrics, The University of British Columbia, Vancouver, Canada
    Nutrition 20:916-23. 2004
    ..We used 20% (w/w) sunflower oil (SO; a diet rich in omega-6 polyunsaturated fatty acids) as an isocaloric control...
  64. ncbi request reprint Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain
    Pauline Coti Bertrand
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Nutr 136:1570-5. 2006
    ..These studies demonstrate that (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain, which could be explained by delay or inhibition of normal development...
  65. ncbi request reprint Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA
    Sanjoy Ghosh
    Div of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Univ of British Columbia, 2146 East Mall, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Heart Circ Physiol 287:H2518-27. 2004
    ..Thus, although promoted as being beneficial, excess n-6 PUFA, with its predisposition to induce obesity, insulin resistance, and ultimately diabetes, could accelerate myocardial abnormalities in diabetic patients...
  66. doi request reprint Cystic fibrosis and nutrition: linking phospholipids and essential fatty acids with thiol metabolism
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, and Cystic Fibrosis Clinic, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada V5Z H4H
    Annu Rev Nutr 28:55-72. 2008
    ..However, further research is needed before such strategies can be included in clinical care of individuals with CF...
  67. ncbi request reprint Evidence of choline depletion and reduced betaine and dimethylglycine with increased homocysteine in plasma of children with cystic fibrosis
    Sheila M Innis
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Nutr 136:2226-31. 2006
    ..These studies suggest that choline depletion may contribute to increased homocysteine in children with CF. Choline depletion and altered thiol metabolism may contribute to the clinical complications associated with CF...
  68. doi request reprint Impact of maternal dietary n-3 and n-6 fatty acids on milk medium-chain fatty acids and the implications for neonatal liver metabolism
    Elizabeth M Novak
    Nutrition and Metabolism Program, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Endocrinol Metab 301:E807-17. 2011
    ....
  69. ncbi request reprint High dietary sodium intake among young children in Vancouver, British Columbia
    Kelly A Mulder
    Department of Paediatrics, Nutrition and Metabolism Program, University of British Columbia, Vancouver, BC, Canada
    J Am Coll Nutr 30:73-8. 2011
    ..To determine the intake distribution and food sources of sodium among young children...
  70. ncbi request reprint Food frequency questionnaire for assessing infant iron nutrition
    Patricia L Williams
    Department of Pediatrics, University of British Columbia, Vancouver, BC
    Can J Diet Pract Res 66:176-82. 2005
    ....
  71. ncbi request reprint AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes
    Girish Kewalramani
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    J Mol Cell Cardiol 42:333-42. 2007
    ....
  72. doi request reprint Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
    Vilte E Barakauskas
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:669-73. 2010
    ..Our findings suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications...
  73. ncbi request reprint Altered cardiac fatty acid composition and utilization following dexamethasone-induced insulin resistance
    Dake Qi
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 291:E420-7. 2006
    ..Whether these acute effects of Dex on FA oxidation, TG storage, and arachidonic acid accumulation can be translated into increased cardiovascular risk following chronic therapy has yet to be determined...
  74. pmc Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene
    David M Selva
    Department of Obstetrics and Gynecology, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Clin Invest 117:3979-87. 2007
    ..This provides a biological explanation for why SHBG is a sensitive biomarker of the metabolic syndrome and the metabolic disturbances associated with increased fructose consumption...
  75. ncbi request reprint Controversial nutrients that potentially affect preterm neurodevelopment: essential fatty acids and iron
    Michael K Georgieff
    University of Minnesota School of Medicine, Minneapolis 55455, USA
    Pediatr Res 57:99R-103R. 2005
  76. ncbi request reprint Auditory brainstem evoked response in juvenile rats fed rat milk formulas with high docosahexaenoic acid
    Nancy Auestad
    625 Cleveland Avenue, Ross Products Division, Abbott Laboratories, Columbus, OH 43215, USA
    Nutr Neurosci 6:335-41. 2003
    ..In the present study, ABR was assessed in juvenile rats fed high-DHA diets only postnatally...