K Hynynen

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Progress and problems in the application of focused ultrasound for blood-brain barrier disruption
    Natalia Vykhodtseva
    Department of Radiology, Focused Ultrasound Laboratory, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Room 515, 75 Francis Street, Boston, MA 02115, USA
    Ultrasonics 48:279-96. 2008
  2. ncbi request reprint Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison
    Natalia Vykhodtseva
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 32:1923-9. 2006
  3. pmc Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease
    Jessica F Jordão
    Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
    PLoS ONE 5:e10549. 2010
  4. ncbi request reprint Drug delivery across the blood-brain barrier using focused ultrasound
    Alison Burgess
    Sunnybrook Research Institute, Physical Sciences, 2075 Bayview Avenue, S665, Toronto, ON M4N 3M5, Canada 1 416 480 5765
    Expert Opin Drug Deliv 11:711-21. 2014
  5. ncbi request reprint MRIgHIFU: a tool for image-guided therapeutics
    Kullervo Hynynen
    Imaging Research, Sunnybrook Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    J Magn Reson Imaging 34:482-93. 2011
  6. pmc Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
    Shahrzad Jalali
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Neurol 10:114. 2010
  7. pmc Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays
    Kullervo Hynynen
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    IEEE Trans Ultrason Ferroelectr Freq Control 56:557-64. 2009
  8. ncbi request reprint Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada
    Expert Opin Drug Deliv 4:27-35. 2007
  9. ncbi request reprint Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
  10. ncbi request reprint Clinical applications of focused ultrasound-the brain
    K Hynynen
    Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Canada
    Int J Hyperthermia 23:193-202. 2007

Research Grants

  1. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2010
  2. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2004
  3. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2005
  4. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2005
  5. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2006
  6. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2006
  7. Local harmonic motion imaging for thermal surgery
    Kullervo Hynynen; Fiscal Year: 2006
  8. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2007
  9. Opening of the Blood Brain Barrier for Molecular Imaging
    Kullervo Hynynen; Fiscal Year: 2007
  10. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2006

Detail Information

Publications99

  1. pmc Progress and problems in the application of focused ultrasound for blood-brain barrier disruption
    Natalia Vykhodtseva
    Department of Radiology, Focused Ultrasound Laboratory, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Room 515, 75 Francis Street, Boston, MA 02115, USA
    Ultrasonics 48:279-96. 2008
    ..Recent advances in the development of noninvasive, targeted drug delivery by MRI-guided ultrasound-induced BBB disruption are also summarized...
  2. ncbi request reprint Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison
    Natalia Vykhodtseva
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 32:1923-9. 2006
    ..1 +/- 3.4 necrotic cells per field. In conclusion, FUS combined with Optison could produce lesions that are dominated by apoptosis, presumably induced primarily via ischemia after cavitation-produced damage to the brain vasculature...
  3. pmc Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease
    Jessica F Jordão
    Brain Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
    PLoS ONE 5:e10549. 2010
    ..In conclusion, this is the first report to demonstrate that MRIgFUS delivery of anti-Abeta antibodies provides the combined advantages of using a low dose of antibody and rapidly reducing plaque pathology...
  4. ncbi request reprint Drug delivery across the blood-brain barrier using focused ultrasound
    Alison Burgess
    Sunnybrook Research Institute, Physical Sciences, 2075 Bayview Avenue, S665, Toronto, ON M4N 3M5, Canada 1 416 480 5765
    Expert Opin Drug Deliv 11:711-21. 2014
    ..Focused ultrasound (FUS) has been developed as a noninvasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain...
  5. ncbi request reprint MRIgHIFU: a tool for image-guided therapeutics
    Kullervo Hynynen
    Imaging Research, Sunnybrook Health Sciences Centre, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    J Magn Reson Imaging 34:482-93. 2011
    ..This review examines the rapid development of MRI-guided HIFU (MRIgHIFU) methods over the past few years and discuss their future potential...
  6. pmc Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats
    Shahrzad Jalali
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    BMC Neurol 10:114. 2010
    ..Therefore, the aim of this study was to investigate the activation of cell survival signaling molecules in response to ultrasound-mediated BBB opening;..
  7. pmc Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays
    Kullervo Hynynen
    Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    IEEE Trans Ultrason Ferroelectr Freq Control 56:557-64. 2009
    ..Acoustic intensity (averaged over the cylinder diameter) over 10 W / cm(2) (a therapeutically relevant intensity) was measured from these elements...
  8. ncbi request reprint Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada
    Expert Opin Drug Deliv 4:27-35. 2007
    ..However, effective clinical devices and methods need to be developed further and the clinical feasibility demonstrated...
  9. ncbi request reprint Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Neurosurg 105:445-54. 2006
    ....
  10. ncbi request reprint Clinical applications of focused ultrasound-the brain
    K Hynynen
    Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Canada
    Int J Hyperthermia 23:193-202. 2007
    ..This paper provides a historic and contemporary overview of the use of focused ultrasound for treating brain disorders...
  11. doi request reprint Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, and Sunnybrook Health Sciences Centre, Imaging Research, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Int J Hyperthermia 26:12-5. 2010
    ..The impact of the research presented in the paper on the development of the current image-guided noninvasive surgery and treatments will also be discussed...
  12. pmc Ultrasound for drug and gene delivery to the brain
    Kullervo Hynynen
    Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada
    Adv Drug Deliv Rev 60:1209-17. 2008
    ..Most notably, the delivery of the chemotherapy agents (liposomal Doxorubicin and Herceptin) has been shown in a rat model...
  13. doi request reprint MRI-guided focused ultrasound treatments
    Kullervo Hynynen
    Sunnybrook Health Sciences Centre, Imaging Research, Department of Medical Biophysics, University of Toronto, 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5
    Ultrasonics 50:221-9. 2010
    ..This paper will review the current technical and clinical status of MRI-guided focused ultrasound therapy and discuss future research and development opportunities...
  14. ncbi request reprint Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging
    R V Mulkern
    Department of Radiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Med Phys 24:1899-906. 1997
    ..011 ppm over the course of the experiments, leading to an estimated temperature accuracy of +/- 1.6 degrees C in vivo...
  15. pmc Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study
    N Hosseinkhah
    Department of Medical Biophysics, University of Toronto, Sunnybrook Research Institute, 2075 Bayview Avenue, Room C713, Toronto, Ontario M4N 3M5, Canada
    J Acoust Soc Am 134:1875-85. 2013
    ..44-6 MPa while invaginated. This finding confirmed that vascular damage could occur during vascular invaginations. Predicted thresholds in which these stresses are higher during vessel invagination were calculated from simulations...
  16. ncbi request reprint Temperature monitoring in fat with MRI
    K Hynynen
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Magn Reson Med 43:901-4. 2000
    ..This can be very important for breast tumor surgery, fat ablation, and for treating deep seated tumors through superficial fat layers. Magn Reson Med 43:901-904, 2000...
  17. ncbi request reprint Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning
    K Mahoney
    Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 46:1785-98. 2001
    ..0 to 1.7 times the experimental results, again varying with mode. Thus, a significant improvement in the treatment planning can be obtained by using actual measured ultrasound field distributions in combination with backward projection...
  18. ncbi request reprint Non-invasive opening of BBB by focused ultrasound
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acta Neurochir Suppl 86:555-8. 2003
    ..v.. After the sacrifice of the animals blue spots were found in the brain in the sonicated locations. This method may have potential for targeted delivery of macromolecules in the brain...
  19. ncbi request reprint Demonstration of potential noninvasive ultrasound brain therapy through an intact skull
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 24:275-83. 1998
    ..559 MHz. In summary, the results showed that transcranial delivery of therapeutic ultrasound into the brain may be feasible...
  20. ncbi request reprint MRI monitoring of the thermal ablation of tissue: effects of long exposure times
    N McDannold
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson Imaging 13:421-7. 2001
    ..The thermal dose model predicted the extent of tissue damage well for subsequent one minute sonications. These results will have implications for MRI guidance of thermal therapies with long exposure times...
  21. pmc A three-dimensional model of an ultrasound contrast agent gas bubble and its mechanical effects on microvessels
    N Hosseinkhah
    University of Toronto, 2075 Bayview Avenue, Rm C713, Toronto, Ontario M4N 3M5, Canada
    Phys Med Biol 57:785-808. 2012
    ..The circumferential stress was largest when the bubble wall was closer to the vessel wall. An oscillating off-centre bubble forms a mushroom shape with the most damping on the points closest to the vessel wall...
  22. pmc Longitudinal and shear mode ultrasound propagation in human skull bone
    P J White
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 32:1085-96. 2006
    ..This study was performed within the frequency range of 0.2 to 0.9 MHz...
  23. ncbi request reprint Cylindrical ultrasonic transducers for cardiac catheter ablation
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Biomed Eng 44:144-51. 1997
    ..4 +/- 2.5 mm. In conclusion, the results show that cylindrical ultrasound transducers can be used for cardiac tissue ablation and that they may be able to produce deeper tissue necrosis than other methods currently in use...
  24. ncbi request reprint MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 219:176-85. 2001
    ..To test the feasibility of noninvasive magnetic resonance (MR) imaging-guided focused ultrasound surgery (FUS) of benign fibroadenomas in the breast...
  25. ncbi request reprint Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 220:640-6. 2001
    ..To determine if focused ultrasound beams can be used to locally open the blood-brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) imaging can be used to monitor this procedure...
  26. ncbi request reprint The feasibility of using focused ultrasound for transmyocardial revascularization
    N B Smith
    Brigham and Women s Hospital, Harvard Medical School, Department of Radiology, Boston, MA 02115, USA
    Ultrasound Med Biol 24:1045-54. 1998
    ..The results demonstrated that ultrasound could be used to create small channels through myocardium. The most important potential for ultrasound is its ability to generate these channels completely noninvasively...
  27. ncbi request reprint Temperature monitoring with line scan echo planar spectroscopic imaging
    N McDannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02155, USA
    Med Phys 28:346-55. 2001
    ..A new magnetic resonance imaging method, line scan echo planar spectroscopic imaging (LSEPSI), is shown capable of providing rapid, internally referenced temperature monitoring from water and fat chemical shifts...
  28. ncbi request reprint A focused ultrasound method for simultaneous diagnostic and therapeutic applications--a simulation study
    E Konofagou
    Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Phys Med Biol 46:2967-84. 2001
    ..This study showed that relatively higher frequencies constitute the optimal range in the use of USAE for coagulation monitoring. A preliminary experimental verification in vitro is also provided...
  29. ncbi request reprint Apoptosis in ultrasound-produced threshold lesions in the rabbit brain
    N Vykhodtseva
    Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 27:111-7. 2001
    ..By 48 h after the sonications, the number of apoptotic cells had increased up to 17 +/- 9%. The impact of this finding for therapy needs to be explored further...
  30. ncbi request reprint MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Int J Hyperthermia 20:725-37. 2004
    ..Overall, this emerging modality holds significant potential for non-invasive tumour treatment of both benign and malignant tumours...
  31. ncbi request reprint The role of internal reflection in transskull phase distortion
    G T Clement
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasonics 39:109-13. 2001
    ..Additionally, a comparison of the measurements with simulated data supports the contention that for reasonably small incident angles, reflection within the skull causes minimal phase shift...
  32. ncbi request reprint Superresolution ultrasound imaging using back-projected reconstruction
    G T Clement
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Acoust Soc Am 118:3953-60. 2005
    ..The method is demonstrated using 0.34- and 0.60-mm wires with a focused 1.05-MHz ultrasound signal and then a human hair (approximately 0.03 mm) with a 4.7-MHz signal...
  33. ncbi request reprint Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery
    K Kuroda
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Magn Reson Imaging 8:175-81. 1998
    ..01 [P, significance level]) was obtained. Temperature distributions during a 20-second sonication were visualized every 3.3 seconds with a 2.3-mm3 spatial resolution and 4 degrees C temperature uncertainty...
  34. ncbi request reprint Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease
    N B Smith
    Brigham and Women s Hospital, Harvard Medical School, Department of Radiology, Boston, MA 02115, USA
    Int J Hyperthermia 17:271-82. 2001
    ..These results demonstrated the feasibility of a temperature feedback for controlling the heating from an intracavitary transrectal array based on temperature information from MR images...
  35. ncbi request reprint Thermal effects of focused ultrasound energy on bone tissue
    N B Smith
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 27:1427-33. 2001
    ..The results suggest that, when focused US energy is directed at or near bone-muscle interfaces, precautions should be taken to avoid thermal damage to the bone that can compromise its strength for extended periods...
  36. pmc Local frequency dependence in transcranial ultrasound transmission
    P J White
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Phys Med Biol 51:2293-305. 2006
    ..This finding demonstrates a potential applicability of a multiple-frequency approach in transcranial ultrasound transmission...
  37. ncbi request reprint Noninvasive arterial occlusion using MRI-guided focused ultrasound
    K Hynynen
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 22:1071-7. 1996
    ..This study showed that appropriately focused ultrasound can be used to close arteries noninvasively. This finding has significant clinical potential...
  38. ncbi request reprint Forced linear oscillations of microbubbles in blood capillaries
    E Sassaroli
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Acoust Soc Am 115:3235-43. 2004
    ..The motivation of this study lies in the possibility of using gas microbubbles as an aid to therapeutic focused ultrasound treatments...
  39. ncbi request reprint Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery
    P E Huber
    Department of Radiology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
    Gene Ther 10:1600-7. 2003
    ..3 MPa peak pressure. The entire procedure was feasible and safe for the animals, and the results suggest that HIFU has the potential to assist in the noninvasive spatial regulation of gene transfer into the vascular system...
  40. ncbi request reprint Enhanced ultrasound transmission through the human skull using shear mode conversion
    G T Clement
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02145, USA
    J Acoust Soc Am 115:1356-64. 2004
    ..Med. Biol. 47(8), 1219-1236 (2002)] to be simplified and extended to a larger region in the brain...
  41. doi request reprint Computational aspects in high intensity ultrasonic surgery planning
    A Pulkkinen
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada
    Comput Med Imaging Graph 34:69-78. 2010
    ..However, the current simulation methods are accurate only with relatively large F-numbers and better models need to be developed for sharply focused transducers...
  42. ncbi request reprint Preliminary results using ultrasound transmission for image-guided thermal therapy
    R L King
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Ultrasound Med Biol 29:293-9. 2003
    ..An R(2) of 0.919 resulted when lesion size detected from the camera was compared to the actual lesion size. Preliminary results may indicate that the camera has an application for monitoring thermal surgery...
  43. ncbi request reprint Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience
    Nathan Mcdannold
    Harvard Medical School, Brigham and Women s Hospital, Department of Radiology, Boston, Massachusetts 02115, USA
    Med Phys 33:4307-13. 2006
    ..This simple method to evaluate the performance appeared to be sensitive to small changes in system performance, which was adequately stable over a four-year time period...
  44. pmc Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption
    Manabu Kinoshita
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:11719-23. 2006
    ..Histological changes attributable to this procedure were minimal. This method may represent a powerful technique for the delivery of macromolecular agents such as antibodies to treat patients with diseases of the central nervous system...
  45. ncbi request reprint Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits
    Nathan J McDannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Ave, LMRC 521, Boston, MA 02115, USA
    Radiology 241:95-106. 2006
    ....
  46. ncbi request reprint Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study
    Xiangtao Yin
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1138-49. 2006
    ..As a first step toward feasibility, controllable tissue coagulation in cardiac tissue without damage to the esophagus was demonstrated numerically...
  47. ncbi request reprint Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography
    Janne Heikkilä
    Department of Applied Physics, University of Kuopio, 70211 Kuopio, Finland
    Phys Med Biol 51:4587-601. 2006
    ..Therefore, measurements of absolute stiffness parameters may not be accurately achieved because this method is so dependent on the whole target structure, whereas the monitoring of changes during some process may be feasible...
  48. ncbi request reprint Modular design for in vivo optical imaging and ultrasound treatment in the murine brain
    Scott B Raymond
    IEEE Trans Ultrason Ferroelectr Freq Control 54:431-4. 2007
    ..Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption...
  49. pmc Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 33:584-90. 2007
    ..However, under the experimental conditions used in this study, Optison produced a larger effect for the same acoustic pressure amplitude...
  50. pmc Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 34:1093-104. 2008
    ..These promising features can be exploited in the future development of this method that could enable the delivery of drugs, antibodies or genes to targeted locations in the brain...
  51. pmc Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 34:930-7. 2008
    ..This data suggests that over the range of parameters tested, BBB disruption is not affected by PRF or ultrasound contrast agent dose. However, both the BBB disruption magnitude and its threshold depend on the burst length...
  52. pmc Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 34:834-40. 2008
    ..It also suggests that lower frequency sonication produces less red blood cell extravasation per unit area...
  53. pmc Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging
    Laura Curiel
    Imaging Research Department at Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
    IEEE Trans Med Imaging 26:1740-6. 2007
    ..This demonstration of technical feasibility and the development of a prototype system open up the potential to investigate the promising clinical applications of this combined technology...
  54. ncbi request reprint Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study
    Samuel Pichardo
    Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Ave Rm C713 Toronto, ON M4N 3M5, Canada
    Phys Med Biol 52:7313-32. 2007
    ..In conclusion, shear waves provide a useful method for trans-cranial focusing in regions close to the skull surface...
  55. pmc A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique
    Sai Chun Tang
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1772-83. 2007
    ..As a conclusion, this study demonstrated that the proposed pulser-receiver system with the shear mode technique is promising for transskull fluid detecting, such as mucus in a sinus...
  56. ncbi request reprint Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study
    Samuel Pichardo
    Imaging Research Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room C713, Toronto, Ontario, Canada
    Phys Med Biol 52:4923-42. 2007
    ....
  57. pmc Cavitation threshold of microbubbles in gel tunnels by focused ultrasound
    Elisabetta Sassaroli
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 33:1651-60. 2007
    ..The evaluation of inertial cavitation in gel tunnels rather than tubes provides a novel opportunity to investigate microbubble collapse in a situation that simulates in vivo blood vessels better than tubes with solid walls do...
  58. ncbi request reprint Chemotherapy delivery issues in central nervous system malignancy: a reality check
    Leslie L Muldoon
    Department of Neurology, Oregon Health and Science University, Portland, and the Veterans Administration Medical Center, OR 97239 3098, USA
    J Clin Oncol 25:2295-305. 2007
    ..This review assesses the current state of knowledge regarding preclinical and clinical pharmacology for brain tumor chemotherapy and evaluates relevant brain tumor pharmacology studies before October 2006...
  59. ncbi request reprint A novel phase assignment protocol and driving system for a high-density focused ultrasound array
    R Erich Caulfield
    Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:793-801. 2007
    ..Results indicate that the use of this technique would make it possible to drive more than 10,000 elements with 33 input lines. The implementation of this method could have a large impact on ultrasound therapy and diagnostic devices...
  60. ncbi request reprint Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 32:1399-409. 2006
    ....
  61. ncbi request reprint Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo
    Scott B Raymond
    Harvard Biophysics Program, Harvard University, Boston, Massachusetts, USA
    J Cereb Blood Flow Metab 27:393-403. 2007
    ..These data corroborated previous studies suggesting increased endothelial transcytosis and breached tight junctions and demonstrated vasoconstriction, which might alter BBB permeability by modifying cerebral blood flow...
  62. ncbi request reprint Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery
    Christopher W Connor
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 51:1693-706. 2004
    ....
  63. ncbi request reprint Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
    Nickolai Sheikov
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 30:979-89. 2004
    ..free passage through the injured endothelium (with the higher power sonications). These findings could be considered in further development of the strategy for drug delivery to brain parenchyma...
  64. ncbi request reprint 500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Magn Reson Med 52:100-7. 2004
    ..As a conclusion, this study demonstrates that it is possible to create ultrasound-induced lesions in vivo through a human skull under MRI guidance with this large-scale phased array...
  65. ncbi request reprint Simulation study for thermal dose optimization in ultrasound surgery of the breast
    Matti Malinen
    Department of Applied Physics, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Med Phys 31:1296-307. 2004
    ..5 to 2.4 cm, depending on the position of tumor. The maximum temperature limitations of 45 degrees C in healthy region and 80 degrees C in tumor region can be maintained in all simulations...
  66. ncbi request reprint MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:913-23. 2004
    ..The temperature information was better than the applied acoustic power or energy for predicting the damage than the ultrasound parameters. MRI was sensitive in detecting threshold-level damage...
  67. ncbi request reprint Optical monitoring of ultrasound-induced bioeffects in glass catfish
    Subha Maruvada
    Department of Radiology, Division of MRI, Brigham and Women s Hospital, Boston, MA 02139, USA
    Ultrasound Med Biol 30:67-74. 2004
    ..1 MPa, respectively, for the three pulse durations. The thresholds for damage were the lowest for the 0.747-MHz sonications: they were 2.6 MPa for damage to the rods, 3.7 MPa for gas bubble formation and 2.4 MPa for hemorrhaging...
  68. ncbi request reprint Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, 221 Longwood Ave, LMRC 007C, Boston, MA 02115, USA
    Radiology 230:743-52. 2004
    ....
  69. ncbi request reprint Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields
    Tomi Huttunen
    Department of Applied Physics, University of Kuopio, Finland
    IEEE Trans Ultrason Ferroelectr Freq Control 50:1486-500. 2003
    ..The presence of membrane hydrophone in the CW field generated notable standing waves. Furthermore, the standing waves caused a periodic distortion to the signal of the membrane hydrophone...
  70. ncbi request reprint Localized harmonic motion imaging: theory, simulations and experiments
    Elisa E Konofagou
    Department of Radiology MRI research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 29:1405-13. 2003
    ..Due to the highly localized and harmonic nature of the estimated response, this technique may be proven to be highly suitable for simple and accurate estimation of the elastic modulus variation in tissues due to disease...
  71. ncbi request reprint Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro
    Tonia Giesecke
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 29:1359-65. 2003
    ..The results indicate that the physical properties of these droplets are such that they may be useful for localized US therapies...
  72. ncbi request reprint The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison)
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Ultrasound Med Biol 29:473-81. 2003
    ..However, one should be aware that brain damage can be induced if the exposure level is increased...
  73. ncbi request reprint A unified model for the speed of sound in cranial bone based on genetic algorithm optimization
    Christopher W Connor
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 47:3925-44. 2002
    ..Furthermore, using a skull that was not part of the optimization process, this model is also tested against a published homogeneous speed-of-sound model and shown to return an improved prediction of transcranial ultrasound propagation...
  74. ncbi request reprint Correlation of ultrasound phase with physical skull properties
    G T Clement
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ultrasound Med Biol 28:617-24. 2002
    ..In addition, the measurements provide coefficients for phase dependence on skull thickness and density that can be used in clinical treatments...
  75. ncbi request reprint Micro-receiver guided transcranial beam steering
    Greg T Clement
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:447-53. 2002
    ..A focus intense enough to coagulate the tissue is achieved at a predetermined location 10 mm from the receiver, the maximum distance that this large element array can electronically steer the focus...
  76. ncbi request reprint The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain
    Nathan Mcdannold
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 29:356-65. 2002
    ..Even with this underestimation of the power, this method will be useful because it will allow an estimate of the proper power to use during FUS surgery without exact knowledge of the tissue parameters...
  77. ncbi request reprint Effects of parameter errors in the simulation of transcranial focused ultrasound
    Timothy E Vaughan
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 47:37-45. 2002
    ..The results of our simulations indicate that each of these errors may change the predicted pressure gain by up to a few percent, but the predicted optimal frequency is not significantly affected...
  78. ncbi request reprint Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications
    Kullervo Hynynen
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 24:12-20. 2005
    ..The electron microscopy findings demonstrated HRP passage through vessel walls via both transendothelial and paraendothelial routes. These results demonstrate that completely noninvasive focal disruption of the BBB is possible...
  79. ncbi request reprint A numerical study of transcranial focused ultrasound beam propagation at low frequency
    Xiangtao Yin
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 50:1821-36. 2005
    ....
  80. ncbi request reprint Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound
    Manabu Kinoshita
    Department of Radiology, Brigham and Womens Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Biochem Biophys Res Commun 340:1085-90. 2006
    ..Using MRI, we were able to monitor the extent of BBB disruption. This novel technology should be useful in delivering macromolecular therapeutic or diagnostic agents to the CNS for the treatment of various CNS disorders...
  81. ncbi request reprint MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    Ultrasound Med Biol 31:1527-37. 2005
    ..These findings indicate that this method is safe for targeted drug delivery, at least when compared with the currently available invasive methods...
  82. ncbi request reprint Transcranial ultrasound focus reconstruction with phase and amplitude correction
    Jason White
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1518-22. 2005
    ..These results indicate that amplitude correction according to the transmission properties of various segments of the skull have a clear effect on ultrasound energy throughput into a target site within the brain parenchyma...
  83. ncbi request reprint Acoustic transmission losses and field alterations due to human scalp hair
    Scott B Raymond
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1415-9. 2005
    ..27-2.8 MHz. The negligible losses observed below 0.5 MHz suggest that, at such frequencies, hair removal is unnecessary for low-power imaging or therapeutic applications...
  84. ncbi request reprint A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound
    Manabu Kinoshita
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Biochem Biophys Res Commun 335:393-9. 2005
    ..Although further optimization is necessary, our novel method for siRNA transduction represents a powerful tool for using siRNA in vivo and possibly in the clinical setting...
  85. ncbi request reprint A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy
    Gregory T Clement
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Ultrasound Med 24:1117-25. 2005
    ....
  86. ncbi request reprint Scanning path optimization for ultrasound surgery
    Matti Malinen
    Department of Applied Physics, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland Matti
    Phys Med Biol 50:3473-90. 2005
    ..The robustness of the optimized scanning path is studied by varying the perfusion and absorption in the tumour region...
  87. ncbi request reprint Focal beam distortion and treatment planning in abdominal focused ultrasound surgery
    Hao Li Liu
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Med Phys 32:1270-80. 2005
    ..This study may offer important implications and information for treatment planning toward optimizing focused ultrasound surgery in uterine fibroid or other abdominal tumor treatments...
  88. ncbi request reprint A full-wave Helmholtz model for continuous-wave ultrasound transmission
    Tomi Huttunen
    Department of Applied Physics, University of Kuopio, Finland
    IEEE Trans Ultrason Ferroelectr Freq Control 52:397-409. 2005
    ....
  89. ncbi request reprint Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols
    Fiona M Fennessy
    Department of Radiology, Harvard Medical School Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Radiology 243:885-93. 2007
    ..To prospectively assess patient response (after 12 months) to magnetic resonance (MR) imaging-guided focused ultrasound surgery in treatment of uterine leiomyomas by using two treatment protocols...
  90. ncbi request reprint Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes
    Milla Kopakkala-Tani
    Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
    Biorheology 43:271-82. 2006
    ..Heat treatment alone did not increase proteoglycan synthesis. In conclusion, our study confirms that pulsed ultrasound stimulation can induce proteoglycan synthesis in chondrocytes...
  91. ncbi request reprint Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound
    Manabu Kinoshita
    Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Pharm Res 22:716-20. 2005
    ..To investigate the possibility of intracellular delivery of Bak BH3 peptide using sonoporation effect by microbubble-enhanced ultrasound...
  92. ncbi request reprint A new ultrasound method for determining the acoustic phase shifts caused by the skull bone
    Jussi Aarnio
    Department of Applied Physics, University of Kuopio, Kuopio, Finland
    Ultrasound Med Biol 31:771-80. 2005
    ..The procedure could eventually be applied toward phasing multielement arrays. Such an application could have implications in both therapeutic and diagnostic brain procedures...
  93. ncbi request reprint MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study
    Clare M C Tempany
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 226:897-905. 2003
    ..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences...
  94. ncbi request reprint Feasibility of internally referenced brain temperature imaging with a metabolite signal
    Kagayaki Kuroda
    Department of Image Based Medicine, Institute of Biomedical Research and Innovation, Kobe, Japan
    Magn Reson Med Sci 2:17-22. 2003
    ..5 cm3 and 4.5 min. A higher signal-to-noise ratio and optimization of the water and outer-volume suppression capabilities will be required to further enhance the temperature-mapping capabilities...
  95. ncbi request reprint Image-guided neurosurgery at Brigham and Women's Hospital
    Simon P DiMaio
    Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    IEEE Eng Med Biol Mag 25:67-73. 2006
  96. ncbi request reprint Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study
    Janne Heikkilä
    Department of Applied Physics, University of Kuopio, 70211 Kuopio, Finland
    Ultrason Imaging 28:97-113. 2006
    ....
  97. ncbi request reprint MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs
    Nathan Mcdannold
    Department of Radiology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 51:1061-5. 2004
    ..3 W/cm(2) at an acoustic power of 10 W. The ability to monitor the temperature rise next to the skull with MRI-based thermometry, as shown here, will allow for safety monitoring during clinical trials of transcranial focused ultrasound...
  98. ncbi request reprint Forward planar projection through layered media
    Gregory T Clement
    Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 50:1689-98. 2003
    ..Hydrophone measurements indicate correlation between measured and simulated fields for angles below the longitudinal critical angles of the layered materials...
  99. ncbi request reprint Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound
    Lisa H Treat
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 121:901-7. 2007
    ..Our technique using MRI-guided focused ultrasound to achieve therapeutic levels of DOX in the brain offers a large step forward in the use of chemotherapy to treat patients with CNS malignancies...

Research Grants30

  1. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2010
    ..During this research we plan to develop such a system and perform all of the experiments needed prior to starting clinical trials. This research may have a major impact on patient care. ..
  2. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2004
    ..This could result in significant cost savings and lead to a cure of thousands of patients. ..
  3. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2005
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  4. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2005
    ..This could result in significant cost savings and lead to a cure of thousands of patients. ..
  5. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2006
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  6. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2006
    ..This could result in significant cost savings and lead to a cure of thousands of patients. ..
  7. Local harmonic motion imaging for thermal surgery
    Kullervo Hynynen; Fiscal Year: 2006
    ..Therefore the potential clinical impact of the proposed research is significant. ..
  8. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2007
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  9. Opening of the Blood Brain Barrier for Molecular Imaging
    Kullervo Hynynen; Fiscal Year: 2007
    ..A successful implementation of this method will make many new molecular imaging approaches possible in brain. The development of even one such imaging method for routine clinical use would have a major impact on patient care. ..
  10. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2006
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  11. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2009
    ..Our vision is that successful trans- skull sonications could have a major impact on the treatment of many brain disorders. Therefore this research may have a major impact on patient care. ..
  12. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2009
    ..During this research we plan to develop such a system and perform all of the experiments needed prior to starting clinical trials. This research may have a major impact on patient care. ..
  13. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2004
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  14. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 1999
    ..The noninvasive focused ultrasound coagulation of liver tumors has a large clinical potential in reducing complication rates and costs associated with open surgery. ..
  15. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 1999
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  16. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2000
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  17. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 2000
    ..The noninvasive focused ultrasound coagulation of liver tumors has a large clinical potential in reducing complication rates and costs associated with open surgery. ..
  18. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2001
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  19. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 2001
    ..The noninvasive focused ultrasound coagulation of liver tumors has a large clinical potential in reducing complication rates and costs associated with open surgery. ..
  20. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2002
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  21. HIGH TEMPERATURE ULTRASOUND THERAPY GUIDED BY MRI
    Kullervo Hynynen; Fiscal Year: 2002
    ..The noninvasive focused ultrasound coagulation of liver tumors has a large clinical potential in reducing complication rates and costs associated with open surgery. ..
  22. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2003
    ..A successful implementation of even one of the possible ultrasound therapies in the brain to routine cIinical practice would have a maior impact on patient care. ..
  23. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2010
    ..Our vision is that successful trans- skull sonications could have a major impact on the treatment of many brain disorders. Therefore this research may have a major impact on patient care. ..