Karin H Humphries

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Limitations to antiarrhythmic drug use in patients with atrial fibrillation
    Karin H Humphries
    Department of Medicine, University of British Columbia and Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC
    CMAJ 171:741-5. 2004
  2. doi request reprint Sex differences in mortality after transcatheter aortic valve replacement for severe aortic stenosis
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 60:882-6. 2012
  3. pmc An administrative data merging solution for dealing with missing data in a clinical registry: adaptation from ICD-9 to ICD-10
    Danielle A Southern
    Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
    BMC Med Res Methodol 8:1. 2008
  4. pmc Identifying priorities in methodological research using ICD-9-CM and ICD-10 administrative data: report from an international consortium
    Carolyn De Coster
    Department of Community Health Sciences, University of Calgary, Calgary, Canada
    BMC Health Serv Res 6:77. 2006
  5. doi request reprint Angina with "normal" coronary arteries: sex differences in outcomes
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    Am Heart J 155:375-81. 2008
  6. ncbi request reprint Statin use and recurrence of atrial fibrillation after successful cardioversion
    Karin H Humphries
    Centre for Health Evaluation and Outcomes Sciences, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am Heart J 154:908-13. 2007
  7. ncbi request reprint Significant improvement in short-term mortality in women undergoing coronary artery bypass surgery (1991 to 2004)
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 49:1552-8. 2007
  8. ncbi request reprint Population rates of hospitalization for atrial fibrillation/flutter in Canada
    Karin H Humphries
    University of British Columbia, Vancouver, Canada
    Can J Cardiol 20:869-76. 2004
  9. ncbi request reprint Cross-provincial use of cardiac services: the importance of data-sharing for clinical registries and outcomes research
    Karin H Humphries
    St Paul s Hospital, Vancouver, Canada
    Can J Cardiol 21:267-72. 2005
  10. doi request reprint Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation
    Stefan Toggweiler
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 59:2068-74. 2012

Detail Information

Publications52

  1. pmc Limitations to antiarrhythmic drug use in patients with atrial fibrillation
    Karin H Humphries
    Department of Medicine, University of British Columbia and Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC
    CMAJ 171:741-5. 2004
    ....
  2. doi request reprint Sex differences in mortality after transcatheter aortic valve replacement for severe aortic stenosis
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 60:882-6. 2012
    ..The aim of this study was to examine sex differences in outcome after transcatheter aortic valve replacement (TAVR) with real-world data from 2 large centers in Canada...
  3. pmc An administrative data merging solution for dealing with missing data in a clinical registry: adaptation from ICD-9 to ICD-10
    Danielle A Southern
    Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada
    BMC Med Res Methodol 8:1. 2008
    ..Here, we describe the process of translating our data merging solution to ICD-10, and then validating its performance...
  4. pmc Identifying priorities in methodological research using ICD-9-CM and ICD-10 administrative data: report from an international consortium
    Carolyn De Coster
    Department of Community Health Sciences, University of Calgary, Calgary, Canada
    BMC Health Serv Res 6:77. 2006
    ..This paper presents a list of high-priority methodological areas for researchers using health administrative data...
  5. doi request reprint Angina with "normal" coronary arteries: sex differences in outcomes
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    Am Heart J 155:375-81. 2008
    ..The sex specificity of this finding is unclear. We therefore undertook an evaluation of sex differences in rehospitalization for acute coronary syndrome (ACS) or chest pain in patients with "angiographically normal" coronaries...
  6. ncbi request reprint Statin use and recurrence of atrial fibrillation after successful cardioversion
    Karin H Humphries
    Centre for Health Evaluation and Outcomes Sciences, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am Heart J 154:908-13. 2007
    ..The role of statins in patients with existing AF is poorly understood. We examined the effect of statins on recurrence of AF in patients after successful cardioversion...
  7. ncbi request reprint Significant improvement in short-term mortality in women undergoing coronary artery bypass surgery (1991 to 2004)
    Karin H Humphries
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 49:1552-8. 2007
    ..This study sought to evaluate gender differences and trends in 30-day mortality after coronary artery bypass surgery (CABG)...
  8. ncbi request reprint Population rates of hospitalization for atrial fibrillation/flutter in Canada
    Karin H Humphries
    University of British Columbia, Vancouver, Canada
    Can J Cardiol 20:869-76. 2004
    ..AF significantly increases the risk of stroke, and anticoagulation has been shown to reduce this risk. However, Canadian data on the prevalence of AF and the use of warfarin in these patients are lacking...
  9. ncbi request reprint Cross-provincial use of cardiac services: the importance of data-sharing for clinical registries and outcomes research
    Karin H Humphries
    St Paul s Hospital, Vancouver, Canada
    Can J Cardiol 21:267-72. 2005
    ....
  10. doi request reprint Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation
    Stefan Toggweiler
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 59:2068-74. 2012
    ..The aim of this study was to evaluate the impact of mitral regurgitation (MR) on outcomes after transcatheter aortic valve replacement (TAVR) and the impact of TAVR on MR...
  11. ncbi request reprint Revascularization use and survival outcomes after cardiac catheterization in British Columbia and Alberta
    Christopher R Thompson
    Division of Cardiology, Department of Medicine, St Paul s Hospital, and the University of British Columbia, Room 2350 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Can J Cardiol 20:1417-23. 2004
    ..Alberta and British Columbia have comprehensive cardiac databases that provide detailed demographic, clinical and procedural data, including coronary anatomy, on all patients undergoing cardiac catheterization...
  12. ncbi request reprint Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: results from the Canadian Registry of Atrial Fibrillation
    Charles R Kerr
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Am Heart J 149:489-96. 2005
    ..After its initial diagnosis, atrial fibrillation (AF) may progress from paroxysmal to chronic AF (CAF). The rate of progression and risk factors for progression are not clearly defined...
  13. doi request reprint 5-year outcome after transcatheter aortic valve implantation
    Stefan Toggweiler
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 61:413-9. 2013
    ..The purpose of this study was to investigate the 5-year outcome following transcatheter aortic valve implantation (TAVI)...
  14. ncbi request reprint Prognostic differences between atrial fibrillation and atrial flutter
    Paul Lelorier
    Division of Cardiology, University of Western Ontario, London, Ontario, Canada
    Am J Cardiol 93:647-9. 2004
    ..We also evaluated warfarin use over time and compared left atrial dimensions in patients with atrial flutter with those with atrial fibrillation...
  15. ncbi request reprint Outcomes after percutaneous coronary interventions in patients with CKD: improved outcome in the stenting era
    Caroline Stigant
    Department of Health Care and Epidemiology, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Am J Kidney Dis 45:1002-9. 2005
    ..The benefit of stents in high-risk patients normally excluded from clinical trials has not been well studied. Outcomes after PCIs in patients with chronic kidney disease (CKD) before and after widespread use of stents were compared...
  16. doi request reprint Elevation in cardiovascular disease risk in South Asians is mediated by differences in visceral adipose tissue
    Scott A Lear
    Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
    Obesity (Silver Spring) 20:1293-300. 2012
    ..Higher levels of risk factors for CVD in South Asians are predominantly because of the unique phenotype of South Asians having greater VAT than Europeans even at the same BMI...
  17. doi request reprint Impact of coronary artery disease on outcomes after transcatheter aortic valve implantation
    Jean Bernard Masson
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Catheter Cardiovasc Interv 76:165-73. 2010
    ..Implications of CAD and preprocedural revascularization in the setting of transcatheter aortic valve implantation (TAVI) are not known...
  18. doi request reprint Antiarrhythmic use from 1991 to 2007: insights from the Canadian Registry of Atrial Fibrillation (CARAF I and II)
    Jason G Andrade
    St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Heart Rhythm 7:1171-7. 2010
    ..The pharmacologic management of atrial fibrillation (AF), the most common sustained cardiac arrhythmia, has been traditionally dichotomized into control of ventricular rate or re-establishment and maintenance of sinus rhythm...
  19. ncbi request reprint N-acetylcysteine reduces urinary albumin excretion following contrast administration: evidence of biological effect
    Adeera Levin
    Division of Nephrology, Room 6010, Providence Health Care Saint Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver V6Z 1Y6, BC, Canada
    Nephrol Dial Transplant 22:2520-4. 2007
    ....
  20. doi request reprint Prophylactic intravenous magnesium sulphate in addition to oral {beta}-blockade does not prevent atrial arrhythmias after coronary artery or valvular heart surgery: a randomized, controlled trial
    Richard C Cook
    University of British Columbia, Vancouver, Canada
    Circulation 120:S163-9. 2009
    ....
  21. ncbi request reprint Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT)
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
    Am J Clin Nutr 86:353-9. 2007
    ..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...
  22. ncbi request reprint The use of BMI and waist circumference as surrogates of body fat differs by ethnicity
    Scott A Lear
    Simon Fraser University, School of Kinesiology, 515 West Hastings Street, Vancouver, BC, Canada V6B 5K3
    Obesity (Silver Spring) 15:2817-24. 2007
    ..To compare the prediction of percentage body fat using BMI and visceral adipose tissue (VAT) using waist circumference (WC) in individuals of Chinese, European, and South Asian origin...
  23. doi request reprint Percutaneous coronary intervention and 30-day mortality: the British Columbia PCI risk score
    Jaap N Hamburger
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    Catheter Cardiovasc Interv 74:377-85. 2009
    ..To construct a calculator to assess the risk of 30-day mortality following PCI...
  24. ncbi request reprint Population rates of invasive cardiac procedures in British Columbia, 1995 to 2001
    Gordon E Pate
    Interventional Cardiology Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Can J Cardiol 20:712-6. 2004
    ..This study examined the rates of coronary angiography (CA), percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) in British Columbia (BC) between 1995 and 2001...
  25. doi request reprint Early clinical outcomes after transapical aortic valve implantation: a propensity-matched comparison with conventional aortic valve replacement
    Jennifer Higgins
    Division of Cardiovascular Surgery, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 142:e47-52. 2011
    ..The objective of this study is to use propensity scoring to compare early clinical outcomes after transapical aortic valve implantation and conventional aortic valve replacement...
  26. doi request reprint Atrioventricular block after transcatheter balloon expandable aortic valve implantation
    Ajay Sinhal
    Heart Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    JACC Cardiovasc Interv 1:305-9. 2008
    ..Transcatheter aortic valve replacement (AVR) is a promising approach to aortic valve disease. The implications of this new therapy are not entirely known. We describe the potential for the development of new atrioventricular (AV) block...
  27. pmc True versus reported waiting times for valvular aortic stenosis surgery
    Brad I Munt
    Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver
    Can J Cardiol 22:497-502. 2006
    ....
  28. doi request reprint Immigration presents a potential increased risk for atherosclerosis
    Scott A Lear
    Simon Fraser University, British Columbia, Canada
    Atherosclerosis 205:584-9. 2009
    ..The purpose of this study was to determine the independent association of time since immigration with sub-clinical atherosclerosis in immigrants of Chinese, European and South Asian origin...
  29. doi request reprint A proposed clinical model for efficient utilization of invasive coronary angiography
    Carolyn M Taylor
    University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 106:457-62. 2010
    ..The patient population identified by this tool may represent a population best suited to a noninvasive diagnostic strategy...
  30. doi request reprint Abbreviated infusion of eptifibatide after successful coronary intervention The BRIEF-PCI (Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention) randomized trial
    Anthony Y Fung
    Vancouver General Hospital, British Columbia, Canada
    J Am Coll Cardiol 53:837-45. 2009
    ..The purpose of this study was to assess whether the early discontinuation of eptifibatide infusion in nonemergent percutaneous coronary intervention (PCI) is associated with a higher frequency of periprocedural ischemic myonecrosis...
  31. ncbi request reprint Refined characterization of the association between kidney function and mortality in patients undergoing cardiac catheterization
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Eur Heart J 27:1191-7. 2006
    ....
  32. ncbi request reprint N-acetylcysteine for prevention of radiographic contrast material-induced nephropathy: is the intravenous route best?
    Stephen J Shalansky
    Pharmacy Department, St Paul s Hospital, and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Pharmacotherapy 25:1095-103. 2005
    ....
  33. doi request reprint Prophylactic magnesium does not prevent atrial fibrillation after cardiac surgery: a meta-analysis
    Richard C Cook
    Division of Cardiovascular Surgery, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Thorac Surg 95:533-41. 2013
    ....
  34. ncbi request reprint Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT)
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
    Stroke 38:2422-9. 2007
    ..We hypothesized that VAT is an independent risk factor for atherosclerosis...
  35. doi request reprint Do younger women fare worse? Sex differences in acute myocardial infarction hospitalization and early mortality rates over ten years
    Mona Izadnegahdar
    1 School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
    J Womens Health (Larchmt) 23:10-7. 2014
    ..These findings highlight the need to intensify strategies to reduce the incidence of AMI and improve outcomes after AMI in younger women. ..
  36. doi request reprint Gender differences in symptoms of myocardial ischaemia
    Martha H Mackay
    School of Nursing, University of British Columbia, St Paul s Hospital, B342, 1081 Burrard St, Vancouver, British Columbia, Canada V6Z 1Y6
    Eur Heart J 32:3107-14. 2011
    ..Using percutaneous coronary intervention (PCI) balloon inflation as a model of myocardial ischaemia, we explored sex differences in reported symptoms of ischaemia...
  37. ncbi request reprint Lipoprotein(a) is an independent risk factor for cardiovascular disease in heterozygous familial hypercholesterolemia
    Daniel T Holmes
    St Paul s Hospital Lipid Clinic and the University of British Columbia Department of Pathology and Laboratory Medicine, Vancouver, Canada
    Clin Chem 51:2067-73. 2005
    ..We sought to examine the utility of this lipoprotein as a predictor of CVD outcomes in the HFH population at our lipid clinic...
  38. doi request reprint Cost comparison of ablation versus antiarrhythmic drugs as first-line therapy for atrial fibrillation: an economic evaluation of the RAAFT pilot study
    Yaariv Khaykin
    Division of Cardiology, Southlake Regional Health Center, Newmarket, Ontario, Canada
    J Cardiovasc Electrophysiol 20:7-12. 2009
    ..The objective of this study was to perform an economic evaluation of RFA versus antiarrhythmic drug therapy (AAD) as first-line treatment of symptomatic paroxysmal AF...
  39. pmc Appropriateness of current thresholds for obesity-related measures among Aboriginal people
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Burnaby, BC
    CMAJ 177:1499-505. 2007
    ..We compared the risk of cardiovascular disease among Canadian Aboriginal and European populations using the current thresholds for body mass index and waist circumference...
  40. doi request reprint Sex differences in clinical outcomes in patients with stable angina and no obstructive coronary artery disease
    Tara L Sedlak
    Vancouver General Hospital, Vancouver, British Columbia, Canada
    Am Heart J 166:38-44. 2013
    ..We comparatively evaluated clinical outcomes in men and women presenting with stable angina with no coronary artery disease (CAD), nonobstructive CAD, and obstructive CAD on coronary angiography...
  41. ncbi request reprint New-onset sustained ventricular tachycardia and fibrillation early after cardiac operations
    John A Yeung-Lai-Wah
    Division of Cardiology and Cardiovascular Surgery, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Thorac Surg 77:2083-8. 2004
    ..The purpose of this study was to evaluate the incidence of new-onset sustained postoperative ventricular tachycardia-ventricular fibrillation and to identify risk factors for the dysrhythmia...
  42. ncbi request reprint A randomized controlled trial of intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy after cardiac catheterization: lack of effect
    John G Webb
    Division of Cardiology, Pharmacy Department, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am Heart J 148:422-9. 2004
    ..The objective of this study was to evaluate, in a blinded, randomized, placebo-controlled fashion, whether intravenous NAC reduced CIN in the setting of cardiac catheterization in patients with preexisting renal insufficiency...
  43. ncbi request reprint Outcome of mitral valve repair or replacement: a comparison by propensity score analysis
    Robert R Moss
    Division of Cardiology, St Paul s Hospital, Vancouver, BC, Canada
    Circulation 108:II90-7. 2003
    ..There are no randomized trials comparing outcomes after mitral valve (MV) repair and replacement. Propensity scoring is a powerful tool that has the potential to reduce selection bias in nonrandomized studies...
  44. doi request reprint Low prevalence of type 2 diabetes mellitus among patients with high levels of high-density lipoprotein cholesterol
    Andrew J Juren
    Healthy Heart Program Prevention Clinic, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Clin Lipidol 7:194-8. 2013
    ..Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases...
  45. ncbi request reprint Thromboembolic events in patients on extracorporeal membrane oxygenation without anticoagulation
    Yoan Lamarche
    From the St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, BC Canada
    Ann Surg 5:424-9. 2010
    ..However, bleeding complications are common. We report our experience of VA-ECMO without systemic anticoagulation...
  46. ncbi request reprint Study design of the Multicultural Community Health Assessment Trial (M-CHAT): a comparison of body fat distribution in four distinct populations
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Vancouver, British Columbia
    Ethn Dis 16:96-100. 2006
    ..The purpose of the study is to compare the relationship between visceral adipose tissue (VAT) and total body fat in men and women of Aboriginal, Chinese, and South Asian origin with a similar group of men and women of European origin...
  47. pmc Risks and benefits of hormone replacement therapy: the evidence speaks
    Karin H Humphries
    Division of Cardiology, Department of Medicine, St Paul s Hospital, University of British Columbia and Centre for Health Evaluation and Outcome Sciences, Vancouver, BC
    CMAJ 168:1001-10. 2003
    ..In this article we review the current evidence of the risks and benefits of HRT...
  48. ncbi request reprint The association of left atrial size and occurrence of atrial fibrillation: a prospective cohort study from the Canadian Registry of Atrial Fibrillation
    Ratika Parkash
    University of Ottawa, Ottawa, Ontario, Canada
    Am Heart J 148:649-54. 2004
    ..We evaluated the effect of LA dimension on the occurrence of AF using 2- and 4-year echocardiographic data in a large cohort of patients with new onset AF...
  49. ncbi request reprint The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease
    Justin Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada T6G 2R7
    J Am Coll Cardiol 44:1587-92. 2004
    ..This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction...
  50. ncbi request reprint Use of valve surgery in Canada
    Ansar Hassan
    Division of Cardiac Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Cardiol 20:149-54. 2004
    ..The objective of the present study was to use administrative data to evaluate use of valve surgery over time and across Canada...
  51. pmc A comprehensive view of sex-specific issues related to cardiovascular disease
    Louise Pilote
    Division of Internal Medicine, The McGill University Health Centre Research Institute, McGill University, Montreal, Que
    CMAJ 176:S1-44. 2007
    ..However, the interaction between sex-and gender-related factors and CVD outcomes in women remains largely unknown...
  52. pmc Comparison of provincial prescription drug plans and the impact on patients' annual drug expenditures
    Virginie Demers
    Division of General Internal Medicine, McGill University Health Centre, Montreal, Que
    CMAJ 178:405-9. 2008
    ..Provincial governments independently establish reimbursement plans. We sought to describe variations in publicly funded provincial drug plans across Canada and to examine the impact of this variation on patients' annual expenditures...