Karin H Humphries

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..The aim of this study was to examine sex differences in outcome after transcatheter aortic valve replacement (TAVR) with real-world data from 2 large centers in Canada...

..Here, we describe the process of translating our data merging solution to ICD-10, and then validating its performance...

..This paper presents a list of high-priority methodological areas for researchers using health administrative data...

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..This study sought to evaluate gender differences and trends in 30-day mortality after coronary artery bypass surgery (CABG)...

..The role of statins in patients with existing AF is poorly understood. We examined the effect of statins on recurrence of AF in patients after successful cardioversion...

..AF significantly increases the risk of stroke, and anticoagulation has been shown to reduce this risk. However, Canadian data on the prevalence of AF and the use of warfarin in these patients are lacking...

..The sex specificity of this finding is unclear. We therefore undertook an evaluation of sex differences in rehospitalization for acute coronary syndrome (ACS) or chest pain in patients with "angiographically normal" coronaries...

..The aim of this study was to evaluate the impact of mitral regurgitation (MR) on outcomes after transcatheter aortic valve replacement (TAVR) and the impact of TAVR on MR...

..Alberta and British Columbia have comprehensive cardiac databases that provide detailed demographic, clinical and procedural data, including coronary anatomy, on all patients undergoing cardiac catheterization...

..After its initial diagnosis, atrial fibrillation (AF) may progress from paroxysmal to chronic AF (CAF). The rate of progression and risk factors for progression are not clearly defined...

..We also evaluated warfarin use over time and compared left atrial dimensions in patients with atrial flutter with those with atrial fibrillation...

..CONCLUSION: Patients with CKD undergoing PCI in the stenting era show improved outcomes. Additional studies are needed to determine optimal revascularization strategies in patients with CKD...

..Higher levels of risk factors for CVD in South Asians are predominantly because of the unique phenotype of South Asians having greater VAT than Europeans even at the same BMI...

..Implications of CAD and preprocedural revascularization in the setting of transcatheter aortic valve implantation (TAVI) are not known...

..The pharmacologic management of atrial fibrillation (AF), the most common sustained cardiac arrhythmia, has been traditionally dichotomized into control of ventricular rate or re-establishment and maintenance of sinus rhythm...

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..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...

..To compare the prediction of percentage body fat using BMI and visceral adipose tissue (VAT) using waist circumference (WC) in individuals of Chinese, European, and South Asian origin...

..The PCI rate is rising compared with the CABG rate, likely reflecting changes in patient selection and improved PCI technology, as well as a limited ability of the system to provide surgical procedures...

..To construct a calculator to assess the risk of 30-day mortality following PCI...

..The objective of this study is to use propensity scoring to compare early clinical outcomes after transapical aortic valve implantation and conventional aortic valve replacement...

..Transcatheter aortic valve replacement (AVR) is a promising approach to aortic valve disease. The implications of this new therapy are not entirely known. We describe the potential for the development of new atrioventricular (AV) block...

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..The patient population identified by this tool may represent a population best suited to a noninvasive diagnostic strategy...

..The purpose of this study was to assess whether the early discontinuation of eptifibatide infusion in nonemergent percutaneous coronary intervention (PCI) is associated with a higher frequency of periprocedural ischemic myonecrosis...

..The purpose of this study was to determine the independent association of time since immigration with sub-clinical atherosclerosis in immigrants of Chinese, European and South Asian origin...

..73 m(2). These findings provide considerable refinement in our understanding of eGFR as a powerful prognostic marker in patients with CVD undergoing cardiac catheterization...

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..We hypothesized that VAT is an independent risk factor for atherosclerosis...

..Using percutaneous coronary intervention (PCI) balloon inflation as a model of myocardial ischaemia, we explored sex differences in reported symptoms of ischaemia...

..We sought to examine the utility of this lipoprotein as a predictor of CVD outcomes in the HFH population at our lipid clinic...

..The objective of this study was to perform an economic evaluation of RFA versus antiarrhythmic drug therapy (AAD) as first-line treatment of symptomatic paroxysmal AF...

..We compared the risk of cardiovascular disease among Canadian Aboriginal and European populations using the current thresholds for body mass index and waist circumference...

..The objective of this study was to evaluate, in a blinded, randomized, placebo-controlled fashion, whether intravenous NAC reduced CIN in the setting of cardiac catheterization in patients with preexisting renal insufficiency...

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..CONCLUSIONS: We used propensity score methods to reduce selection bias in a population-based cohort of patients undergoing MV repair/replacement. Repair was associated with better survival, but a trend to increased re-operation...

..However, bleeding complications are common. We report our experience of VA-ECMO without systemic anticoagulation...

..The purpose of the study is to compare the relationship between visceral adipose tissue (VAT) and total body fat in men and women of Aboriginal, Chinese, and South Asian origin with a similar group of men and women of European origin...

..In this article we review the current evidence of the risks and benefits of HRT...

..Variation in rates of valve surgery exists across provinces. These results provide a starting point from which to track future trends in use and outcomes for these major procedures...

..Patients with renal insufficiency are less likely to be prescribed efficacious therapies, but have better outcomes if they receive these medications...

..Patients with no or paroxysmal recurrence had no change in LA dimension over a 4-year period. These findings have implications in tailoring modes of therapy in patients with AF...

..However, the interaction between sex-and gender-related factors and CVD outcomes in women remains largely unknown...

..Provincial governments independently establish reimbursement plans. We sought to describe variations in publicly funded provincial drug plans across Canada and to examine the impact of this variation on patients' annual expenditures...