W G Honer

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint A randomized, double-blind, placebo-controlled study of the safety and tolerability of high-dose quetiapine in patients with persistent symptoms of schizophrenia or schizoaffective disorder
    William G Honer
    BC Mental Health and Addictions Research Institute, Vancouver, Canada
    J Clin Psychiatry 73:13-20. 2012
  2. ncbi request reprint Clozapine alone versus clozapine and risperidone with refractory schizophrenia
    William G Honer
    Centre for Complex Disorders and the Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
    N Engl J Med 354:472-82. 2006
  3. pmc A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacy
    William G Honer
    BC Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 34:433-42. 2009
  4. ncbi request reprint The potential impact of genetic counseling for mental illness
    J C Austin
    Centre for Complex Disorders, and Department of Psychiatry, University of British Columbia, 203 828 West 10th Avenue, Vancouver, British Columbia V5Z 1L8, Canada
    Clin Genet 67:134-42. 2005
  5. ncbi request reprint Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophrenia
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    CNS Drugs 21:699-714. 2007
  6. doi request reprint White matter tract abnormalities in first-episode psychosis
    D Y Lee
    Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada
    Schizophr Res 141:29-34. 2012
  7. ncbi request reprint An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone
    D J Lang
    Molecular Psychiatry and Therapeutics Laboratory, Department of Psychiatry, Dalhousie University, Queen Elizabeth-II Health Sciences Centre, Halifax, Nova Scotia, Canada
    Am J Psychiatry 158:625-31. 2001
  8. ncbi request reprint Neuropsychological correlates of the PANSS Cognitive Factor
    T S Ehmann
    Department of Psychiatry, St Paul s Hospital, Vancouver, Canada
    Psychopathology 37:253-8. 2004
  9. ncbi request reprint Low birthweight in schizophrenia: prematurity or poor fetal growth?
    G N Smith
    Department of Psychiatry, University of British Columbia, Vancouver Hospital Research Pavilion, 828 West 10th Avenue, BC V5Z 1L8, Vancouver, BC, V5Z 1L8, Canada
    Schizophr Res 47:177-84. 2001
  10. pmc Clinical features of schizophrenia in a woman with hyperandrogenism
    L C Kopala
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Psychiatry Neurosci 22:56-60. 1997

Detail Information

Publications79

  1. doi request reprint A randomized, double-blind, placebo-controlled study of the safety and tolerability of high-dose quetiapine in patients with persistent symptoms of schizophrenia or schizoaffective disorder
    William G Honer
    BC Mental Health and Addictions Research Institute, Vancouver, Canada
    J Clin Psychiatry 73:13-20. 2012
    ..Quetiapine is often prescribed at higher than approved doses. We investigated the safety, tolerability, and efficacy of quetiapine > 800 mg/d...
  2. ncbi request reprint Clozapine alone versus clozapine and risperidone with refractory schizophrenia
    William G Honer
    Centre for Complex Disorders and the Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
    N Engl J Med 354:472-82. 2006
    ..The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known...
  3. pmc A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacy
    William G Honer
    BC Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 34:433-42. 2009
    ..Better linkage between the components of translational research may improve the appropriate use of medications such as clozapine in psychiatric practice...
  4. ncbi request reprint The potential impact of genetic counseling for mental illness
    J C Austin
    Centre for Complex Disorders, and Department of Psychiatry, University of British Columbia, 203 828 West 10th Avenue, Vancouver, British Columbia V5Z 1L8, Canada
    Clin Genet 67:134-42. 2005
    ..The review allows a preliminary formulation of a series of suggestions for genetic counseling in mental illness...
  5. ncbi request reprint Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophrenia
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    CNS Drugs 21:699-714. 2007
    ..Trials need to be designed to investigate widely used approaches such as antipsychotic polypharmacy, where actual practice diverges from evidence-based guidelines...
  6. doi request reprint White matter tract abnormalities in first-episode psychosis
    D Y Lee
    Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada
    Schizophr Res 141:29-34. 2012
    ..05), nor did TBSS reveal any other differences in FA values between groups in other regions. Relationships between tract volumes and symptom severity were not observed in this study...
  7. ncbi request reprint An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone
    D J Lang
    Molecular Psychiatry and Therapeutics Laboratory, Department of Psychiatry, Dalhousie University, Queen Elizabeth-II Health Sciences Centre, Halifax, Nova Scotia, Canada
    Am J Psychiatry 158:625-31. 2001
    ..Movement disorders were observed in both first-episode and chronically treated patients, suggesting effects of both illness and medications...
  8. ncbi request reprint Neuropsychological correlates of the PANSS Cognitive Factor
    T S Ehmann
    Department of Psychiatry, St Paul s Hospital, Vancouver, Canada
    Psychopathology 37:253-8. 2004
    ..The present study sought to further explore the factor by examining the relationships between 4 versions of the cognitive factor and a set of neuropsychological tests...
  9. ncbi request reprint Low birthweight in schizophrenia: prematurity or poor fetal growth?
    G N Smith
    Department of Psychiatry, University of British Columbia, Vancouver Hospital Research Pavilion, 828 West 10th Avenue, BC V5Z 1L8, Vancouver, BC, V5Z 1L8, Canada
    Schizophr Res 47:177-84. 2001
    ..These results suggest that poor fetal growth and prematurity are associated with distinct patterns of childhood maladjustment in individuals who develop schizophrenia...
  10. pmc Clinical features of schizophrenia in a woman with hyperandrogenism
    L C Kopala
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Psychiatry Neurosci 22:56-60. 1997
    ..Additionally, acute estrogen depletion following cessation of oral contraceptives may have precipitated psychosis, while recommencement of oral contraceptives could have contributed to subsequent improvement in symptoms...
  11. ncbi request reprint Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia
    W G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Neuroscience 78:99-110. 1997
    ....
  12. ncbi request reprint Violence in treatment resistant psychotic inpatients
    T S Ehmann
    Department of Psychiatry, St Vincent's Hospital, Vancouver, British Columbia, Canada
    J Nerv Ment Dis 189:716-21. 2001
    ..Standardized definitions of violence are urged in order to accurately study its prevalence and correlates. Models combining both historical/demographic and clinical data may enhance prediction of violence...
  13. pmc Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment
    Ric M Procyshyn
    Department of Research, Riverview Hospital, Port Coquitlam, BC, Canada
    J Psychiatry Neurosci 32:331-8. 2007
    ..The primary objective of this study was to determine whether an increase in serum lipids is associated with improvement in schizophrenia symptoms during steady state treatment with clozapine...
  14. ncbi request reprint Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Psychopharmacol 19:277-85. 2005
    ..In this group, family history and poor premorbid functioning appear to be associated with increased risk for movement disorders...
  15. doi request reprint Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatients
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
    J Clin Psychiatry 71:566-73. 2010
    ....
  16. doi request reprint Childhood maltreatment and corpus callosum volume in recently diagnosed patients with bipolar I disorder: data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    J Bücker
    Department of Psychiatry, University of British Columbia, Vancouver, Canada Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, INCT TM, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Psychiatr Res 48:65-72. 2014
    ..It might mean there may be two sources of CC volume reduction in these patients: the reduction due to trauma, and the further reduction due to the illness...
  17. pmc Cognitive reserve, presynaptic proteins and dementia in the elderly
    W G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Transl Psychiatry 2:e114. 2012
    ..001). In conclusion, greater amounts of specific presynaptic proteins and distinct protein-protein interactions may be structural or functional components of cognitive reserve that reduce the risk of dementia with aging...
  18. ncbi request reprint Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortex
    Alasdair M Barr
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
    Alcohol Clin Exp Res 29:1915-20. 2005
    ....
  19. pmc The need for speed: an update on methamphetamine addiction
    Alasdair M Barr
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Psychiatry Neurosci 31:301-13. 2006
    ..It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies...
  20. ncbi request reprint Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia
    Donna J Lang
    VGH Research Pavilion, Centre for Complex Disorders, West 10th Ave, Room 211 828, Vancouver, British Columbia, Canada V5Z 1L8
    Am J Psychiatry 161:1829-36. 2004
    ..A follow-up study of patients with schizophrenia was conducted to examine change in striatal volumes and extrapyramidal symptoms after a change in medication...
  21. ncbi request reprint The genomic era and perceptions of psychotic disorders: genetic risk estimation, associations with reproductive decisions and views about predictive testing
    Jehannine C Austin
    Department of Psychiatry, Centre for Complex Disorders, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet B Neuropsychiatr Genet 141:926-8. 2006
    ..Facilitating accurate risk perception through genetic counseling could significantly impact reproductive decisions, and the appropriate use of genetic tests in the future...
  22. ncbi request reprint The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia
    Daniel J Muller
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ont M5T 1R8, Canada
    Neurosci Lett 379:81-9. 2005
    ..Weight changes do not seem to be associated with polymorphism of the SNAP-25 gene, however, replication in independent samples is warranted...
  23. ncbi request reprint Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway
    Alasdair M Barr
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, 828 West 10th Avenue, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 9:457-63. 2006
    ..These results indicate that presynaptic proteins represent a potential molecular substrate for the effects of antipsychotic drugs on hippocampal synaptic connectivity...
  24. ncbi request reprint The genomic era and serious mental illness: a potential application for psychiatric genetic counseling
    Jehannine C Austin
    Department of Psychiatry, University of British Columbia, 203 828 West 10th Ave, Vancouver, British Columbia, Canada V5Z 1L8
    Psychiatr Serv 58:254-61. 2007
    ..The authors endorse a multidisciplinary approach in which a psychiatrist and genetic counselor collaborate to provide comprehensive psychiatric genetic counseling...
  25. ncbi request reprint A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
    William J Panenka
    Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada, V5Z 1L8
    Schizophr Res 94:288-92. 2007
    ..This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine...
  26. ncbi request reprint Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses...
  27. doi request reprint Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatment
    Alasdair M Barr
    Faculty of Medicine, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 100:252-60. 2008
    ..While a number of theories have been proposed to account for such high rates of smoking, little is known about the subjective motivation for why schizophrenia patients smoke in comparison with those without the disease...
  28. ncbi request reprint Treatment of a first episode of psychotic illness with quetiapine: an analysis of 2 year outcomes
    Lili C Kopala
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 81:29-39. 2006
    ..The first episode of a psychotic disorder provides a unique opportunity to initiate optimal treatment but when a new medication becomes available, little data exist to guide the appropriate use in this population...
  29. doi request reprint Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins
    Alasdair M Barr
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Eur J Neurosci 27:2568-74. 2008
    ..However, it is unlikely that these behavioral differences may be accounted for by altered regional levels of presynaptic proteins...
  30. pmc A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia
    Vilte E Barakauskas
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 35:1226-38. 2010
    ..SNARE proteins and their interactions may be a novel target for the development of therapeutics...
  31. doi request reprint Predictors of starting to smoke cigarettes in patients with first episode psychosis
    Geoffrey N Smith
    University of British Columbia, Vancouver, Canada
    Schizophr Res 108:258-64. 2009
    ..However, genetic, obstetric and early life conditions are risks for starting to smoke in the general population but their role in psychotic patients is unclear...
  32. doi request reprint Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia
    Clare L Beasley
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 109:159-66. 2009
    ..Observed changes in lactate and alanine levels indicate metabolic abnormalities within the ALIC in schizophrenia...
  33. ncbi request reprint Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex
    W G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Brain Res 609:9-20. 1993
    ..The SP antibodies may be useful probes for studies of human synaptic proteins, and for studies of pathological conditions which disrupt these molecules...
  34. ncbi request reprint The incidence of schizophrenia in European immigrants to Canada
    G N Smith
    Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada V5Z 1L8
    Schizophr Res 87:205-11. 2006
    ..A second objective was to determine whether changing social stresses are associated with changes to the incidence of schizophrenia...
  35. ncbi request reprint Left nostril olfactory identification impairment in a subgroup of male patients with schizophrenia
    K P Good
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Schizophr Res 33:35-43. 1998
    ....
  36. ncbi request reprint Olfactory function in monozygotic twins discordant for schizophrenia
    L C Kopala
    Department of Psychiatry, Dalhousie University, Halifax, N S, Canada
    Am J Psychiatry 155:134-6. 1998
    ..The authors studied the potential role of genetic factors in olfactory dysfunction by assessing monozygotic twins discordant for schizophrenia and matched comparison subjects...
  37. ncbi request reprint Reduced anterior internal capsule and thalamic volumes in first-episode psychosis
    D J Lang
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 87:89-99. 2006
    ..In this study, we investigated the relationship between the anterior limb of the internal capsule, posterior limb of the internal capsule, and thalamus in first-episode psychosis (FEP)...
  38. doi request reprint Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels
    Vilte E Barakauskas
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:669-73. 2010
    ..Our findings suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications...
  39. ncbi request reprint Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine
    Babak Khorram
    Centre for Complex Disorders, VGH Research Pavilion, Rm 203 828 West 10th Ave, Vancouver, BC, Canada V5Z 1L8
    Am J Psychiatry 163:2005-7. 2006
    ..The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications...
  40. ncbi request reprint Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness
    William G Honer
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Cereb Cortex 12:349-56. 2002
    ..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders...
  41. ncbi request reprint Donepezil for memory dysfunction in schizophrenia
    Andrew K Howard
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Psychopharmacol 16:267-70. 2002
    ..A case is reported of a 54-year-old female patient with schizophrenia and cognitive impairment. Her memory dysfunction improved following the addition of donepezil to quetiapine. The possible implications for future studies are reviewed...
  42. ncbi request reprint Developmental abnormalities of the hippocampus in first-episode schizophrenia
    Geoffrey N Smith
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Psychiatry 53:555-61. 2003
    ..The primary purpose of this study was to determine if hippocampal fissures are evident in schizophrenia. A second goal was to assess the association between HF size and premorbid and clinical features of the illness...
  43. ncbi request reprint Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminals
    William G Honer
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, BC, Canada V5Z 1L8
    Neurobiol Aging 24:1047-62. 2003
    ..Detailed studies of presynaptic pathology in transgenic mouse models related to Alzheimer's disease may provide important insights concerning these observations...
  44. ncbi request reprint Outcome measurement in pharmacological trials: validity of the Routine Assessment of Patient Progress (RAPP)
    T S Ehmann
    Department of Psychiatry, St Vincent s Hospital, Vancouver, BC, Canada
    J Psychopharmacol 17:425-9. 2003
    ..In patients rated as unchanged, RAPP scores displayed significantly less change than did the PANSS scores. These findings support the validity of the RAPP as an outcome measure in treatment trials...
  45. doi request reprint Depression during pregnancy: the potential impact of increased risk for fetal aneuploidy on maternal mood
    C Hippman
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Clin Genet 75:30-6. 2009
    ..4% of women, respectively, scored above 12. Mean EPDS score was significantly higher in the MG group than in the control group (p < 0.0001). These results suggest a place for depression screening in prenatal genetic counseling...
  46. ncbi request reprint Presynaptic proteins and schizophrenia
    William G Honer
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Canada
    Int Rev Neurobiol 59:175-99. 2004
  47. ncbi request reprint The impact of monetary reward on memory in schizophrenia spectrum disorder
    Allen E Thornton
    Department of Psychology, Simon Fraser University, British Columbia, Canada
    Neuropsychology 21:631-45. 2007
    ..The influence was relatively small and dependent on the specific neurocognitive operation examined, the mental health status of the participants, and for patients, their particular symptoms and pharmacological treatments...
  48. ncbi request reprint Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia
    Alasdair M Barr
    Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
    Eur J Neurosci 20:303-7. 2004
    ....
  49. ncbi request reprint Smaller corpus callosum subregions containing motor fibers in schizophrenia
    Vina M Goghari
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Schizophr Res 73:59-68. 2005
    ..Structural differences in the corpus callosum may be a substrate for interhemispheric functional dysconnectivity in schizophrenia...
  50. doi request reprint Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968 to 2007
    M J Hunter
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 152:147-52. 2010
    ..There is a need to identify barriers to psychiatric genetic counseling and develop strategies to improve access...
  51. ncbi request reprint A meta-analysis of profile and time-course of symptom change in acute schizophrenia treated with atypical antipsychotics
    Megan Sherwood
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 9:357-66. 2006
    ..A curvilinear profile of schizophrenia symptom reduction has possible implications with respect to trial design and clinical decision-making...
  52. doi request reprint Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats
    A M Barr
    Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada British Columbia Mental Health and Addictions Research Institute, 938 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada Electronic address
    Neuroscience 255:147-57. 2013
    ..These findings indicate that exercise may have beneficial effects on the hippocampus when antipsychotic medication can contribute to changes in volume. ..
  53. ncbi request reprint Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia
    G Zai
    Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
    Genes Brain Behav 4:2-9. 2005
    ..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene...
  54. doi request reprint Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder
    I J Torres
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Psychol Med 41:971-82. 2011
    ..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder...
  55. pmc Assessing the machinery of mind: synapses in neuropsychiatric disorders
    W G Honer
    Department of Psychiatry, University of British Columbia, Vancouver
    J Psychiatry Neurosci 24:116-21. 1999
    ..Molecular and cellular abnormalities in neural connectivity may underlie functional abnormalities observed in vivo using positron emission tomography or functional magnetic resonance imaging...
  56. ncbi request reprint Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease
    Jeremy M Van Raamsdonk
    Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
    Exp Neurol 196:266-72. 2005
    ..Overall, this work demonstrates the feasibility of experimental therapeutics in the YAC128 mouse model and suggests that experiments in these mice may be predictive for future human clinical trials...
  57. ncbi request reprint The genetic and environmental basis of the relationship between schizotypy and personality: a twin study
    Kerry L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Nerv Ment Dis 193:153-9. 2005
    ..Environmental factors appear to be unique to each measure. On the basis of these findings, it is suggested that the environment mediates change in personality function to psychosis as proposed by Meehl's original concept of schizotaxia...
  58. ncbi request reprint DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling
    Gary M Wilson
    Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Suite 100, 570 West 7th Avenue, Vancouver, BC, Canada V5Z 4S6
    Hum Mol Genet 15:743-9. 2006
    ..Further scrutiny of these regions may reveal insights into the etiology and genetic risk factors for these complex psychiatric disorders...
  59. ncbi request reprint Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylation
    Rujun Kang
    Department of Psychiatry, Centre for Complex Disorders, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 279:50524-36. 2004
    ..We conclude that palmitoylation is involved in trafficking of specific elements involved in transmitter release and that distinct mechanisms regulate addition and removal of palmitate on select neuronal proteins...
  60. ncbi request reprint Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness
    K Sawada
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada V5Z 1L8
    Mol Psychiatry 7:484-92. 2002
    ..Alterations of complexins may contribute to the molecular substrate for abnormalities of neural connectivity in severe mental disorders...
  61. ncbi request reprint Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteins
    S W Flynn
    Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Mol Psychiatry 8:811-20. 2003
    ..05; myelin-associated glycoprotein by 27%, P=0.14). Impaired myelination in schizophrenia could contribute to abnormalities of neural connectivity and persistent functional impairment in the illness...
  62. doi request reprint Impaired efficiency of functional networks underlying episodic memory-for-context in schizophrenia
    Liang Wang
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1, Canada
    J Neurosci 30:13171-9. 2010
    ..These findings suggest that loss of gray matter volume may contribute to local inefficiencies in the architecture of the network underlying memory-for-context in schizophrenia...
  63. ncbi request reprint Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory function
    Kimberley P Good
    Department of Psychiatry, Dalhousie University, Suite 4019 5909, Jubilee Road, Halifax, NS B3H 2E2, Canada
    Schizophr Res 56:211-23. 2002
    ..The data are consistent with reports linking the right temporal lobe integrity to adequate olfactory processing...
  64. doi request reprint Medication errors in psychiatry: a comprehensive review
    Ric M Procyshyn
    British Columbia Mental Health and Addictions Services Research Institute, Vancouver, British Columbia, Canada
    CNS Drugs 24:595-609. 2010
    ..Medication errors in psychiatry have been studied almost exclusively in the inpatient setting and thus little is known about the incidence and significance in outpatient and community settings...
  65. doi request reprint Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episode
    Ivan J Torres
    Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
    J Clin Psychiatry 71:1234-42. 2010
    ..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode...
  66. ncbi request reprint Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia
    Thomas Schneider-Axmann
    Department of Psychiatry and Psychotherapy, University of Saarland, D 66421 Homburg Saar, Germany
    J Psychiatr Res 40:646-55. 2006
    ..The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic changes as schizophrenic patients and how state of genetic loading contribute to these abnormalities...
  67. ncbi request reprint Hippocampal complexin proteins and cognitive dysfunction in schizophrenia
    Ken Sawada
    Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
    Arch Gen Psychiatry 62:263-72. 2005
    ..A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II...
  68. ncbi request reprint Microsmia in postmenopausal women with genetic vulnerability to psychosis
    Kimberley P Good
    Schizophr Res 61:327-8. 2003
  69. ncbi request reprint Disturbed frontal gyrification within families affected with schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
    J Psychiatr Res 41:805-13. 2007
    ....
  70. ncbi request reprint Association between schizophrenia and the syntaxin 1A gene
    Albert H C Wong
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 56:24-9. 2004
    ..Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia...
  71. ncbi request reprint The temporal lobe in schizophrenia from uni- and multiply affected families
    Peter Falkai
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 325:25-8. 2002
    ..Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia...
  72. ncbi request reprint Relations between brain pathology and temporal lobe epilepsy
    Xia Zhang
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
    J Neurosci 22:6052-61. 2002
    ....
  73. ncbi request reprint Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia
    Kai Vogeley
    Research Center Juelich, Institute of Medicine, 52425 Juelich, Germany
    Schizophr Res 62:133-40. 2003
    ..The described automated image analysis method providing cytoarchitectonic profiles can be applied as a fast and observer-independent scanning tool to detect cytoarchitectonic abnormalities in multiple brain regions...
  74. ncbi request reprint Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI study
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003
    ..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn...
  75. doi request reprint A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Psychiatr Genet 18:143-6. 2008
    ..003). No CNP-MAG gene-gene interaction conferred increased risk for schizophrenia. Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population...
  76. ncbi request reprint Changes in hippocampal SNAP-25 expression following afferent lesions
    Maria J Ramirez
    Department of Pharmacology, School of Medicine University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain
    Brain Res 997:133-5. 2004
    ..It is concluded that changes in SNAP-25 may represent early markers of synaptic loss following afferent lesions to the hippocampus...
  77. ncbi request reprint Reduction of the internal capsule in families affected with schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
    Biol Psychiatry 63:65-71. 2008
    ..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed...
  78. ncbi request reprint Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal view
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
    Psychiatry Res 132:261-71. 2004
    ..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...
  79. doi request reprint Automated gray level index measurements reveal only minor cytoarchitectonic changes of Brodmann area 9 in schizophrenia
    Ralf Tepest
    Department of Psychiatry and Psychotherapy, University of Cologne, Köln Cologne, Germany
    Psychiatry Res 163:183-92. 2008
    ..Since increases in GLI were found only in selected layers (V and VI) of BA9, these findings do not support a generalized neuropil reduction across all cortical layers...