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Genomes and Genes | W G HonerSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
A randomized, double-blind, placebo-controlled study of the safety and tolerability of high-dose quetiapine in patients with persistent symptoms of schizophrenia or schizoaffective disorderWilliam G Honer
BC Mental Health and Addictions Research Institute, Vancouver, Canada
J Clin Psychiatry 73:13-20. 2012..Quetiapine is often prescribed at higher than approved doses. We investigated the safety, tolerability, and efficacy of quetiapine > 800 mg/d...
Clozapine alone versus clozapine and risperidone with refractory schizophreniaWilliam G Honer
Centre for Complex Disorders and the Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
N Engl J Med 354:472-82. 2006..The treatment of schizophrenia with multiple antipsychotic drugs is common, but the benefits and risks are not known...
A translational research approach to poor treatment response in patients with schizophrenia: clozapine-antipsychotic polypharmacyWilliam G Honer
BC Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC, Canada
J Psychiatry Neurosci 34:433-42. 2009..Better linkage between the components of translational research may improve the appropriate use of medications such as clozapine in psychiatric practice...- Conceptual and methodological issues in the design of clinical trials of antipsychotics for the treatment of schizophreniaWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
CNS Drugs 21:699-714. 2007..Trials need to be designed to investigate widely used approaches such as antipsychotic polypharmacy, where actual practice diverges from evidence-based guidelines... - The potential impact of genetic counseling for mental illnessJ C Austin
Centre for Complex Disorders, and Department of Psychiatry, University of British Columbia, 203 828 West 10th Avenue, Vancouver, British Columbia V5Z 1L8, Canada
Clin Genet 67:134-42. 2005..The review allows a preliminary formulation of a series of suggestions for genetic counseling in mental illness... - An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidoneD J Lang
Molecular Psychiatry and Therapeutics Laboratory, Department of Psychiatry, Dalhousie University, Queen Elizabeth-II Health Sciences Centre, Halifax, Nova Scotia, Canada
Am J Psychiatry 158:625-31. 2001..Movement disorders were observed in both first-episode and chronically treated patients, suggesting effects of both illness and medications... - Neuropsychological correlates of the PANSS Cognitive FactorT S Ehmann
Department of Psychiatry, St. Paul's Hospital, Vancouver, Canada
Psychopathology 37:253-8. 2004..CONCLUSIONS: The PANSS cognitive factor may reflect verbal ability and memory, but is not sufficiently comprehensive to be considered as a replacement for direct assessment of cognitive functioning... - Low birthweight in schizophrenia: prematurity or poor fetal growth?G N Smith
Department of Psychiatry, University of British Columbia, Vancouver Hospital Research Pavilion, 828 West 10th Avenue, BC V5Z 1L8, Vancouver, BC, V5Z 1L8, Canada
Schizophr Res 47:177-84. 2001..These results suggest that poor fetal growth and prematurity are associated with distinct patterns of childhood maladjustment in individuals who develop schizophrenia... - Clinical features of schizophrenia in a woman with hyperandrogenismL C Kopala
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
J Psychiatry Neurosci 22:56-60. 1997..Additionally, acute estrogen depletion following cessation of oral contraceptives may have precipitated psychosis, while recommencement of oral contraceptives could have contributed to subsequent improvement in symptoms... - White matter tract abnormalities in first-episode psychosisD Y Lee
Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada
Schizophr Res 141:29-34. 2012..05), nor did TBSS reveal any other differences in FA values between groups in other regions. Relationships between tract volumes and symptom severity were not observed in this study... - Violence in treatment resistant psychotic inpatientsT S Ehmann
Department of Psychiatry, St Vincent's Hospital, Vancouver, British Columbia, Canada
J Nerv Ment Dis 189:716-21. 2001..Standardized definitions of violence are urged in order to accurately study its prevalence and correlates. Models combining both historical/demographic and clinical data may enhance prediction of violence... - Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatmentRic M Procyshyn
Department of Research, Riverview Hospital, Port Coquitlam, BC, Canada
J Psychiatry Neurosci 32:331-8. 2007..The primary objective of this study was to determine whether an increase in serum lipids is associated with improvement in schizophrenia symptoms during steady state treatment with clozapine... - Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illnessWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Psychopharmacol 19:277-85. 2005..In this group, family history and poor premorbid functioning appear to be associated with increased risk for movement disorders... - Persistent antipsychotic polypharmacy and excessive dosing in the community psychiatric treatment setting: a review of medication profiles in 435 Canadian outpatientsRic M Procyshyn
British Columbia Mental Health and Addictions Research Institute, A3 113, 938 W 28th Ave, Vancouver, British Columbia, Canada, V5Z 4H4
J Clin Psychiatry 71:566-73. 2010.... - Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophreniaDonna J Lang
VGH Research Pavilion, Centre for Complex Disorders, West 10th Ave, Room 211 828, Vancouver, British Columbia, Canada V5Z 1L8
Am J Psychiatry 161:1829-36. 2004..A follow-up study of patients with schizophrenia was conducted to examine change in striatal volumes and extrapyramidal symptoms after a change in medication... - Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortexAlasdair M Barr
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, Vancouver, Canada
Alcohol Clin Exp Res 29:1915-20. 2005.... - The genomic era and perceptions of psychotic disorders: genetic risk estimation, associations with reproductive decisions and views about predictive testingJehannine C Austin
Department of Psychiatry, Centre for Complex Disorders, University of British Columbia, Vancouver, British Columbia, Canada
Am J Med Genet B Neuropsychiatr Genet 141:926-8. 2006..Facilitating accurate risk perception through genetic counseling could significantly impact reproductive decisions, and the appropriate use of genetic tests in the future... - The genomic era and serious mental illness: a potential application for psychiatric genetic counselingJehannine C Austin
Department of Psychiatry, University of British Columbia, 203 828 West 10th Ave, Vancouver, British Columbia, Canada V5Z 1L8
Psychiatr Serv 58:254-61. 2007..The authors endorse a multidisciplinary approach in which a psychiatrist and genetic counselor collaborate to provide comprehensive psychiatric genetic counseling... - A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophreniaWilliam J Panenka
Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada, V5Z 1L8
Schizophr Res 94:288-92. 2007..This longitudinal study measured changes in symptoms and hippocampal volume in patients switched from typical antipsychotics to olanzapine... - The need for speed: an update on methamphetamine addictionAlasdair M Barr
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
J Psychiatry Neurosci 31:301-13. 2006..It is hoped that increased knowledge of MA abuse will provide the basis for future treatment strategies... - The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophreniaDaniel J Muller
Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ont M5T 1R8, Canada
Neurosci Lett 379:81-9. 2005..Weight changes do not seem to be associated with polymorphism of the SNAP-25 gene, however, replication in independent samples is warranted... - Self-reported motivation to smoke in schizophrenia is related to antipsychotic drug treatmentAlasdair M Barr
Faculty of Medicine, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 100:252-60. 2008..While a number of theories have been proposed to account for such high rates of smoking, little is known about the subjective motivation for why schizophrenia patients smoke in comparison with those without the disease... - Treatment of a first episode of psychotic illness with quetiapine: an analysis of 2 year outcomesLili C Kopala
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 81:29-39. 2006..The first episode of a psychotic disorder provides a unique opportunity to initiate optimal treatment but when a new medication becomes available, little data exist to guide the appropriate use in this population... - A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophreniaVilte E Barakauskas
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 35:1226-38. 2010..SNARE proteins and their interactions may be a novel target for the development of therapeutics... - Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathwayAlasdair M Barr
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, 828 West 10th Avenue, Vancouver, BC, Canada
Int J Neuropsychopharmacol 9:457-63. 2006..These results indicate that presynaptic proteins represent a potential molecular substrate for the effects of antipsychotic drugs on hippocampal synaptic connectivity... - Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophreniaClare L Beasley
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 109:159-66. 2009..Observed changes in lactate and alanine levels indicate metabolic abnormalities within the ALIC in schizophrenia... - Predictors of starting to smoke cigarettes in patients with first episode psychosisGeoffrey N Smith
University of British Columbia, Vancouver, Canada
Schizophr Res 108:258-64. 2009..However, genetic, obstetric and early life conditions are risks for starting to smoke in the general population but their role in psychotic patients is unclear... - Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteinsAlasdair M Barr
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
Eur J Neurosci 27:2568-74. 2008..However, it is unlikely that these behavioral differences may be accounted for by altered regional levels of presynaptic proteins... - Reductions in cholesterol and synaptic markers in association cortex in mood disordersClare L Beasley
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
Bipolar Disord 7:449-55. 2005..The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses... - Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophreniaW G Honer
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Neuroscience 78:99-110. 1997.... - Left nostril olfactory identification impairment in a subgroup of male patients with schizophreniaK P Good
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
Schizophr Res 33:35-43. 1998.... - The incidence of schizophrenia in European immigrants to CanadaG N Smith
Department of Psychiatry, University of British Columbia, 828 West 10th Ave, Vancouver, BC, Canada V5Z 1L8
Schizophr Res 87:205-11. 2006..A second objective was to determine whether changing social stresses are associated with changes to the incidence of schizophrenia... - Olfactory function in monozygotic twins discordant for schizophreniaL C Kopala
Department of Psychiatry, Dalhousie University, Halifax, N S, Canada
Am J Psychiatry 155:134-6. 1998..The authors studied the potential role of genetic factors in olfactory dysfunction by assessing monozygotic twins discordant for schizophrenia and matched comparison subjects... - Reduced anterior internal capsule and thalamic volumes in first-episode psychosisD J Lang
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 87:89-99. 2006..In this study, we investigated the relationship between the anterior limb of the internal capsule, posterior limb of the internal capsule, and thalamus in first-episode psychosis (FEP)... - Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapineBabak Khorram
Centre for Complex Disorders, VGH Research Pavilion, Rm. 203-828 West 10th Ave, Vancouver, BC, Canada V5Z 1L8
Am J Psychiatry 163:2005-7. 2006..CONCLUSIONS: Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers... - Pathology of presynaptic proteins in Alzheimer's disease: more than simple loss of terminalsWilliam G Honer
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver General Hospital Research Pavilion, BC, Canada V5Z 1L8
Neurobiol Aging 24:1047-62. 2003..Detailed studies of presynaptic pathology in transgenic mouse models related to Alzheimer's disease may provide important insights concerning these observations... - Developmental abnormalities of the hippocampus in first-episode schizophreniaGeoffrey N Smith
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
Biol Psychiatry 53:555-61. 2003..The association between HF size and anxiety-depression symptoms suggests that hippocampal abnormalities underlying HF dilatation may be a predisposing factor for increased stress sensitivity... - Donepezil for memory dysfunction in schizophreniaAndrew K Howard
Department of Psychiatry, University of British Columbia, Vancouver, Canada
J Psychopharmacol 16:267-70. 2002..A case is reported of a 54-year-old female patient with schizophrenia and cognitive impairment. Her memory dysfunction improved following the addition of donepezil to quetiapine. The possible implications for future studies are reviewed... - Effects of sub-chronic clozapine and haloperidol administration on brain lipid levelsVilte E Barakauskas
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Prog Neuropsychopharmacol Biol Psychiatry 34:669-73. 2010..Our findings suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications... - Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illnessWilliam G Honer
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Cereb Cortex 12:349-56. 2002..These abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders... - Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortexW G Honer
Department of Psychiatry, University of British Columbia, Vancouver, Canada
Brain Res 609:9-20. 1993..The SP antibodies may be useful probes for studies of human synaptic proteins, and for studies of pathological conditions which disrupt these molecules... - Outcome measurement in pharmacological trials: validity of the Routine Assessment of Patient Progress (RAPP)T S Ehmann
Department of Psychiatry, St Vincent s Hospital, Vancouver, BC, Canada
J Psychopharmacol 17:425-9. 2003..In patients rated as unchanged, RAPP scores displayed significantly less change than did the PANSS scores. These findings support the validity of the RAPP as an outcome measure in treatment trials... - Depression during pregnancy: the potential impact of increased risk for fetal aneuploidy on maternal moodC Hippman
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Clin Genet 75:30-6. 2009..4% of women, respectively, scored above 12. Mean EPDS score was significantly higher in the MG group than in the control group (p < 0.0001). These results suggest a place for depression screening in prenatal genetic counseling... - Smaller corpus callosum subregions containing motor fibers in schizophreniaVina M Goghari
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Schizophr Res 73:59-68. 2005..Structural differences in the corpus callosum may be a substrate for interhemispheric functional dysconnectivity in schizophrenia... - Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968 to 2007M J Hunter
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Am J Med Genet A 152:147-52. 2010..There is a need to identify barriers to psychiatric genetic counseling and develop strategies to improve access... - The impact of monetary reward on memory in schizophrenia spectrum disorderAllen E Thornton
Department of Psychology, Simon Fraser University, British Columbia, Canada
Neuropsychology 21:631-45. 2007..The influence was relatively small and dependent on the specific neurocognitive operation examined, the mental health status of the participants, and for patients, their particular symptoms and pharmacological treatments... - Presynaptic proteins and schizophreniaWilliam G Honer
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Canada
Int Rev Neurobiol 59:175-99. 2004 - Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophreniaAlasdair M Barr
Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
Eur J Neurosci 20:303-7. 2004.... - A meta-analysis of profile and time-course of symptom change in acute schizophrenia treated with atypical antipsychoticsMegan Sherwood
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Int J Neuropsychopharmacol 9:357-66. 2006..A curvilinear profile of schizophrenia symptom reduction has possible implications with respect to trial design and clinical decision-making... - Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophreniaG Zai
Neurogenetics Section, Centre for Addiction and Mental Health Clarke Site, Department of Psychiatry, University of Toronto, Canada
Genes Brain Behav 4:2-9. 2005..233, P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were also not significant. Although our data are negative, the intriguing hypothesis for MOG in SCZ may warrant further investigation of this gene... - Assessing the machinery of mind: synapses in neuropsychiatric disordersW G Honer
Department of Psychiatry, University of British Columbia, Vancouver
J Psychiatry Neurosci 24:116-21. 1999..Molecular and cellular abnormalities in neural connectivity may underlie functional abnormalities observed in vivo using positron emission tomography or functional magnetic resonance imaging... - Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorderI J Torres
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Psychol Med 41:971-82. 2011..The purpose of this study was to evaluate the impact of cognitive functioning on longitudinal 6-month functional and clinical outcome in recently diagnosed clinically stable patients with bipolar disorder... - Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylationRujun Kang
Department of Psychiatry, Centre for Complex Disorders, University of British Columbia, Vancouver, British Columbia, Canada
J Biol Chem 279:50524-36. 2004..We conclude that palmitoylation is involved in trafficking of specific elements involved in transmitter release and that distinct mechanisms regulate addition and removal of palmitate on select neuronal proteins... - Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington diseaseJeremy M Van Raamsdonk
Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, British Columbia Research Institute for Children's and Women's Health, University of British Columbia, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
Exp Neurol 196:266-72. 2005..Overall, this work demonstrates the feasibility of experimental therapeutics in the YAC128 mouse model and suggests that experiments in these mice may be predictive for future human clinical trials... - DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signalingGary M Wilson
Canada s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Suite 100, 570 West 7th Avenue, Vancouver, BC, Canada V5Z 4S6
Hum Mol Genet 15:743-9. 2006..Further scrutiny of these regions may reveal insights into the etiology and genetic risk factors for these complex psychiatric disorders... - The genetic and environmental basis of the relationship between schizotypy and personality: a twin studyKerry L Jang
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
J Nerv Ment Dis 193:153-9. 2005..Environmental factors appear to be unique to each measure. On the basis of these findings, it is suggested that the environment mediates change in personality function to psychosis as proposed by Meehl's original concept of schizotaxia... - Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illnessK Sawada
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada V5Z 1L8
Mol Psychiatry 7:484-92. 2002..Alterations of complexins may contribute to the molecular substrate for abnormalities of neural connectivity in severe mental disorders... - Abnormalities of myelination in schizophrenia detected in vivo with MRI, and post-mortem with analysis of oligodendrocyte proteinsS W Flynn
Centre for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Mol Psychiatry 8:811-20. 2003..05; myelin-associated glycoprotein by 27%, P=0.14). Impaired myelination in schizophrenia could contribute to abnormalities of neural connectivity and persistent functional impairment in the illness... - Impaired efficiency of functional networks underlying episodic memory-for-context in schizophreniaLiang Wang
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 2A1, Canada
J Neurosci 30:13171-9. 2010..These findings suggest that loss of gray matter volume may contribute to local inefficiencies in the architecture of the network underlying memory-for-context in schizophrenia... - Neurocognitive functioning in patients with bipolar I disorder recently recovered from a first manic episodeIvan J Torres
Research Department, Riverview Hospital, British Columbia Mental Health and Addictions Services, Coquitlam, British Columbia, Canada
J Clin Psychiatry 71:1234-42. 2010..The purpose of this study was to determine whether neuropsychological impairments are present in clinically stable patients with bipolar disorder shortly after resolution of their first manic episode... - Medication errors in psychiatry: a comprehensive reviewRic M Procyshyn
British Columbia Mental Health and Addictions Services Research Institute, Vancouver, British Columbia, Canada
CNS Drugs 24:595-609. 2010..Medication errors in psychiatry have been studied almost exclusively in the inpatient setting and thus little is known about the incidence and significance in outpatient and community settings... - Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory functionKimberley P Good
Department of Psychiatry, Dalhousie University, Suite 4019 5909, Jubilee Road, Halifax, NS B3H 2E2, Canada
Schizophr Res 56:211-23. 2002..The data are consistent with reports linking the right temporal lobe integrity to adequate olfactory processing... - Hippocampal complexin proteins and cognitive dysfunction in schizophreniaKen Sawada
Department of Neuropsychiatry, Kochi Medical School, Kochi, Japan
Arch Gen Psychiatry 62:263-72. 2005..CONCLUSIONS: The pathology of hippocampal complexin proteins might play an important role in schizophrenia, especially concerning cognitive disturbances... - Disturbed frontal gyrification within families affected with schizophreniaPeter Falkai
Department of Psychiatry and Psychotherapy, University of Gottingen, Von Siebold Str 5, 37075 Gottingen, Germany
J Psychiatr Res 41:805-13. 2007.... - Association between schizophrenia and the syntaxin 1A geneAlbert H C Wong
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Biol Psychiatry 56:24-9. 2004..Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia... - Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophreniaThomas Schneider-Axmann
Department of Psychiatry and Psychotherapy, University of Saarland, D-66421 Homburg/Saar, Germany
J Psychiatr Res 40:646-55. 2006..However, this correlation is independent of the factor diagnosis and is therefore not specific for schizophrenia... - Microsmia in postmenopausal women with genetic vulnerability to psychosisKimberley P Good
Schizophr Res 61:327-8. 2003 - Reduction of the internal capsule in families affected with schizophreniaThomas Wobrock
Department of Psychiatry and Psychotherapy, University of the Saarland, Germany
Biol Psychiatry 63:65-71. 2008..To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed... - A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophreniaAristotle N Voineskos
Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Psychiatr Genet 18:143-6. 2008..003). No CNP-MAG gene-gene interaction conferred increased risk for schizophrenia. Our finding provides support for potential association of the CNP gene but not the MAG gene in schizophrenia in a Caucasian population... - Automated gray level index measurements reveal only minor cytoarchitectonic changes of Brodmann area 9 in schizophreniaRalf Tepest
Department of Psychiatry and Psychotherapy, University of Cologne, Köln Cologne, Germany
Psychiatry Res 163:183-92. 2008..Since increases in GLI were found only in selected layers (V and VI) of BA9, these findings do not support a generalized neuropil reduction across all cortical layers... - Influence of genetic loading, obstetric complications and premorbid adjustment on brain morphology in schizophrenia: a MRI studyPeter Falkai
Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
Eur Arch Psychiatry Clin Neurosci 253:92-9. 2003..Genetic loading seems to have an impact on frontal regions as the interhemispheric fissure and on the temporal horn... - Changes in hippocampal SNAP-25 expression following afferent lesionsMaria J Ramirez
Department of Pharmacology, School of Medicine University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain
Brain Res 997:133-5. 2004..It is concluded that changes in SNAP-25 may represent early markers of synaptic loss following afferent lesions to the hippocampus... - The temporal lobe in schizophrenia from uni- and multiply affected familiesPeter Falkai
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
Neurosci Lett 325:25-8. 2002..Comparing subjects from uni- and multiply affected families may be a useful strategy to reduce variability for future studies of environmental interactions with genetic risk for schizophrenia... - Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophreniaKai Vogeley
Research Center Juelich, Institute of Medicine, 52425 Juelich, Germany
Schizophr Res 62:133-40. 2003..The described automated image analysis method providing cytoarchitectonic profiles can be applied as a fast and observer-independent scanning tool to detect cytoarchitectonic abnormalities in multiple brain regions... - Relations between brain pathology and temporal lobe epilepsyXia Zhang
Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E4
J Neurosci 22:6052-61. 2002.... - Shape changes in prefrontal, but not parieto-occipital regions: brains of schizophrenic patients come closer to a circle in coronal and sagittal viewPeter Falkai
Department of Psychiatry and Psychotherapy, University of the Saarland, D 66421 Homburg Saar, Germany
Psychiatry Res 132:261-71. 2004..As the frontal lobe takes shape late in brain development, underlying genetic mechanisms may be dysregulated in schizophrenic patients and subjects at risk to develop the disorder...