Bruce J Holub

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. ncbi request reprint Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease
    Diana J Philbrick
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Kidney Int 63:1230-9. 2003
  2. pmc Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care
    Bruce J Holub
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ont
    CMAJ 166:608-15. 2002
  3. doi request reprint Oral docosapentaenoic acid (22:5n-3) is differentially incorporated into phospholipid pools and differentially metabolized to eicosapentaenoic acid in tissues from young rats
    Bruce J Holub
    Department of Human Biology and Nutritional Sciences, Animal Science and Nutrition Building, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Lipids 46:399-407. 2011
  4. pmc Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios
    Bruce J Holub
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Nutr J 8:58. 2009
  5. doi request reprint Docosahexaenoic acid (DHA) and cardiovascular disease risk factors
    Bruce J Holub
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
    Prostaglandins Leukot Essent Fatty Acids 81:199-204. 2009
  6. ncbi request reprint Omega-3 fatty acids from fish oils and cardiovascular disease
    Darren J Holub
    Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biochem 263:217-25. 2004
  7. ncbi request reprint Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
    Ken D Stark
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Clin Nutr 79:765-73. 2004
  8. doi request reprint N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria
    Andrew Ramadeen
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Heart Rhythm 9:1115-1122.e4. 2012
  9. doi request reprint Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men
    Heather E C Hanwell
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Nutr 139:1128-34. 2009
  10. ncbi request reprint The postprandial effects of dietary antioxidants in humans
    Colin D Kay
    Department of Human Biology and Nutritional Sciences, University of Guelph, ANNU Building, Room 342, Guelph, Ontario N1G 2W1, Canada
    Curr Atheroscler Rep 5:452-8. 2003

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney disease
    Diana J Philbrick
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Kidney Int 63:1230-9. 2003
    ..The effects of feeding a saponin-enriched alcohol extract (SEAE) from SPI, an isoflavone- and saponin-enriched soy supplement (Novasoy 400), or a 99.5% pure soyasaponin Bb powder on cyst growth are reported here...
  2. pmc Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care
    Bruce J Holub
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ont
    CMAJ 166:608-15. 2002
  3. doi request reprint Oral docosapentaenoic acid (22:5n-3) is differentially incorporated into phospholipid pools and differentially metabolized to eicosapentaenoic acid in tissues from young rats
    Bruce J Holub
    Department of Human Biology and Nutritional Sciences, Animal Science and Nutrition Building, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Lipids 46:399-407. 2011
    ..74 in kidney phosphatidylethanolamine. The serum lipid-lowering potential of dietary DPA and its impact in the kidney with the derived EPA warrants investigation...
  4. pmc Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratios
    Bruce J Holub
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Nutr J 8:58. 2009
    ....
  5. doi request reprint Docosahexaenoic acid (DHA) and cardiovascular disease risk factors
    Bruce J Holub
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
    Prostaglandins Leukot Essent Fatty Acids 81:199-204. 2009
    ....
  6. ncbi request reprint Omega-3 fatty acids from fish oils and cardiovascular disease
    Darren J Holub
    Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biochem 263:217-25. 2004
    ..Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease...
  7. ncbi request reprint Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
    Ken D Stark
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Clin Nutr 79:765-73. 2004
    ..Hormone replacement therapy (HRT) influences circulating lipid concentrations and fatty acid metabolism. DHA supplementation has not been studied in postmenopausal women...
  8. doi request reprint N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria
    Andrew Ramadeen
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Heart Rhythm 9:1115-1122.e4. 2012
    ..Prophylactic supplementation with omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The effect of PUFAs given after cardiac injury has occurred is unknown...
  9. doi request reprint Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic men
    Heather E C Hanwell
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Nutr 139:1128-34. 2009
    ..Neither the study meal nor the FO or ISO induced significant changes in oxidative stress biomarkers. The current study adds to a limited literature on the acute effects of FO and ISO interventions on postprandial biomarkers of CVD risk...
  10. ncbi request reprint The postprandial effects of dietary antioxidants in humans
    Colin D Kay
    Department of Human Biology and Nutritional Sciences, University of Guelph, ANNU Building, Room 342, Guelph, Ontario N1G 2W1, Canada
    Curr Atheroscler Rep 5:452-8. 2003
    ..Because many nonfasting reactions represent major risk for disease, postprandial risk analysis must form a larger part of the diagnostic strategy for disease prevention in the future...
  11. ncbi request reprint Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil
    Ken D Stark
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Nutrition 18:627-30. 2002
    ....
  12. ncbi request reprint Directly quantitated dietary (n-3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendations
    Jennifer Denomme
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Nutr 135:206-11. 2005
    ..Nutritional education of pregnant women to ensure adequate intakes of (n-3) PUFA for optimal health of mother and child and the inclusion of DHA in prenatal vitamins may be pertinent...
  13. ncbi request reprint Effects of supplementation with fish oil-derived n-3 fatty acids and gamma-linolenic acid on circulating plasma lipids and fatty acid profiles in women
    Maggie Laidlaw
    Department of Human Biology and Nutritional Sciences, University of Guelph, Canada
    Am J Clin Nutr 77:37-42. 2003
    ..The effects of supplement mixtures of these fatty acids on plasma lipids and the fatty acid compositions of serum phospholipids have received little attention...
  14. ncbi request reprint Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women
    Julie A Conquer
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Lipids 37:947-51. 2002
    ..Women supplemented with fish oil had increased levels of n-3 NEFA IEPA, DHA, and docosapentaenoic acid (DPA)] prior to exercise. Exercise did not, however, increase the absolute levels of n-3 NEFA in the blood...
  15. doi request reprint Direct diet quantification indicates low intakes of (n-3) fatty acids in children 4 to 8 years old
    Sarah M M Madden
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Nutr 139:528-32. 2009
    ..These results demonstrate a moderate shortfall in ALA intake in Canadian children and a nutrient gap for the LC (n-3) PUFA, including DHA, when comparing intakes for this population to suggested and recommended intakes...
  16. doi request reprint n-3 Polyunsaturated fatty acids alter expression of fibrotic and hypertrophic genes in a dog model of atrial cardiomyopathy
    Andrew Ramadeen
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Heart Rhythm 7:520-8. 2010
    ..We previously showed that omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The mechanisms underlying this effect are unknown...
  17. ncbi request reprint Anthocyanins exist in the circulation primarily as metabolites in adult men
    Colin D Kay
    Department of Human Biology and Nutritional Sciences, University of Guelph, ON, Canada
    J Nutr 135:2582-8. 2005
    ..The above results indicate that cyanidin 3-glycosides are rapidly absorbed and metabolized extensively following a moderate-to-high oral dose in humans...
  18. ncbi request reprint The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects
    Colin D Kay
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Br J Nutr 88:389-98. 2002
    ..It has been suggested that increasing the antioxidant status of serum may result in the reduced risk of many chronic degenerative diseases...
  19. ncbi request reprint Fatty acid composition of serum phospholipid of premenopausal women and postmenopausal women receiving and not receiving hormone replacement therapy
    Ken D Stark
    Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    Menopause 10:448-55. 2003
    ..To compare the fatty acid composition of serum phospholipid of premenopausal women with that of postmenopausal women receiving and not receiving hormone replacement therapy (HRT)...
  20. ncbi request reprint Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects
    G Mazza
    Food Research Program, Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Summerland, British Columbia, Canada
    J Agric Food Chem 50:7731-7. 2002
    ....
  21. pmc Treating hypertriglyceridemia
    Bruce J Holub
    CMAJ 177:604; author reply 604-5. 2007
  22. ncbi request reprint Clinical trial to evaluate omega-3 fatty acids and alternate day prednisone in patients with IgA nephropathy: report from the Southwest Pediatric Nephrology Study Group
    Ronald J Hogg
    St Joseph s Hospital and Medical Center, 222 W Thomas Road, Suite 410, Phoenix, AZ, USA
    Clin J Am Soc Nephrol 1:467-74. 2006
    ..However, the relatively short follow-up period, inequality of baseline UP/C ratios, and small numbers of patients precludes definitive conclusions...
  23. ncbi request reprint Omega-3 fatty acids and risk of cognitive impairment and dementia
    Danielle Laurin
    Laval University Geriatric Research Unit, Quebec, QC, Canada
    J Alzheimers Dis 5:315-22. 2003
    ..03) concentrations were found in dementia cases. These findings do not support the hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia...
  24. ncbi request reprint Gestational age and birth weight in relation to n-3 fatty acids among Inuit (Canada)
    Michel Lucas
    Public Health Research Unit, Laval University Medical Research Centre, Centre Hospitalier Universitaire de Quebec, Quebec G1V 5B3, Canada
    Lipids 39:617-26. 2004
    ..In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA...