Research Topics
| Bruce J HolubSummaryAffiliation: University of Guelph Country: Canada Publications
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Detail Information
Publications
Evidence that soyasaponin Bb retards disease progression in a murine model of polycystic kidney diseaseDiana J Philbrick
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Kidney Int 63:1230-9. 2003..CONCLUSION: Soyasaponin Bb can impede kidney enlargement and cyst growth in the pcy mouse model of PKD. Further studies are needed to determine its most effective dose and mechanism of action...
Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular careBruce J Holub
Department of Human Biology and Nutritional Sciences, University of Guelph, Ont
CMAJ 166:608-15. 2002
Oral docosapentaenoic acid (22:5n-3) is differentially incorporated into phospholipid pools and differentially metabolized to eicosapentaenoic acid in tissues from young ratsBruce J Holub
Department of Human Biology and Nutritional Sciences, Animal Science and Nutrition Building, University of Guelph, Guelph, ON, N1G 2W1, Canada
Lipids 46:399-407. 2011..74 in kidney phosphatidylethanolamine. The serum lipid-lowering potential of dietary DPA and its impact in the kidney with the derived EPA warrants investigation...- Correlation of omega-3 levels in serum phospholipid from 2053 human blood samples with key fatty acid ratiosBruce J Holub
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Nutr J 8:58. 2009.... - Docosahexaenoic acid (DHA) and cardiovascular disease risk factorsBruce J Holub
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
Prostaglandins Leukot Essent Fatty Acids 81:199-204. 2009.... - Omega-3 fatty acids from fish oils and cardiovascular diseaseDarren J Holub
Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Mol Cell Biochem 263:217-25. 2004..Current dietary intakes of EPA/DHA in North America and elsewhere are well below those recommended by the American Heart Association for the management of patients with coronary heart disease... - Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapyKen D Stark
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Am J Clin Nutr 79:765-73. 2004..DHA supplementation can also favorably influence selected cardiovascular disease risk factors in postmenopausal women... - N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atriaAndrew Ramadeen
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
Heart Rhythm 9:1115-1122.e4. 2012..Prophylactic supplementation with omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The effect of PUFAs given after cardiac injury has occurred is unknown... - Acute fish oil and soy isoflavone supplementation increase postprandial serum (n-3) polyunsaturated fatty acids and isoflavones but do not affect triacylglycerols or biomarkers of oxidative stress in overweight and obese hypertriglyceridemic menHeather E C Hanwell
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Nutr 139:1128-34. 2009..Neither the study meal nor the FO or ISO induced significant changes in oxidative stress biomarkers. The current study adds to a limited literature on the acute effects of FO and ISO interventions on postprandial biomarkers of CVD risk... - The postprandial effects of dietary antioxidants in humansColin D Kay
Department of Human Biology and Nutritional Sciences, University of Guelph, ANNU Building, Room 342, Guelph, Ontario N1G 2W1, Canada
Curr Atheroscler Rep 5:452-8. 2003..Because many nonfasting reactions represent major risk for disease, postprandial risk analysis must form a larger part of the diagnostic strategy for disease prevention in the future... - Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oilKen D Stark
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Nutrition 18:627-30. 2002..The present findings also support the hypothesis of genetically decreased Delta5-desaturase potential in the Greenland Inuit compared with Canadian postmenopausal women... - Directly quantitated dietary (n-3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendationsJennifer Denomme
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
J Nutr 135:206-11. 2005..Nutritional education of pregnant women to ensure adequate intakes of (n-3) PUFA for optimal health of mother and child and the inclusion of DHA in prenatal vitamins may be pertinent... - Effects of supplementation with fish oil-derived n-3 fatty acids and gamma-linolenic acid on circulating plasma lipids and fatty acid profiles in womenMaggie Laidlaw
Department of Human Biology and Nutritional Sciences, University of Guelph, Canada
Am J Clin Nutr 77:37-42. 2003..On the basis of calculated PROCAM values, the 4:2 group was estimated to have a 43% reduction in the 10-y risk of myocardial infarction... - Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal womenJulie A Conquer
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
Lipids 37:947-51. 2002..Women supplemented with fish oil had increased levels of n-3 NEFA IEPA, DHA, and docosapentaenoic acid (DPA)] prior to exercise. Exercise did not, however, increase the absolute levels of n-3 NEFA in the blood... - Direct diet quantification indicates low intakes of (n-3) fatty acids in children 4 to 8 years oldSarah M M Madden
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Nutr 139:528-32. 2009..These results demonstrate a moderate shortfall in ALA intake in Canadian children and a nutrient gap for the LC (n-3) PUFA, including DHA, when comparing intakes for this population to suggested and recommended intakes... - n-3 Polyunsaturated fatty acids alter expression of fibrotic and hypertrophic genes in a dog model of atrial cardiomyopathyAndrew Ramadeen
Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Heart Rhythm 7:520-8. 2010..We previously showed that omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The mechanisms underlying this effect are unknown... - Anthocyanins exist in the circulation primarily as metabolites in adult menColin D Kay
Department of Human Biology and Nutritional Sciences, University of Guelph, ON, Canada
J Nutr 135:2582-8. 2005..The above results indicate that cyanidin 3-glycosides are rapidly absorbed and metabolized extensively following a moderate-to-high oral dose in humans... - The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjectsColin D Kay
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Br J Nutr 88:389-98. 2002..It has been suggested that increasing the antioxidant status of serum may result in the reduced risk of many chronic degenerative diseases... - Fatty acid composition of serum phospholipid of premenopausal women and postmenopausal women receiving and not receiving hormone replacement therapyKen D Stark
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
Menopause 10:448-55. 2003..To compare the fatty acid composition of serum phospholipid of premenopausal women with that of postmenopausal women receiving and not receiving hormone replacement therapy (HRT)... - Absorption of anthocyanins from blueberries and serum antioxidant status in human subjectsG Mazza
Food Research Program, Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Summerland, British Columbia, Canada
J Agric Food Chem 50:7731-7. 2002.... - Treating hypertriglyceridemiaBruce J Holub
CMAJ 177:604; author reply 604-5. 2007 - Clinical trial to evaluate omega-3 fatty acids and alternate day prednisone in patients with IgA nephropathy: report from the Southwest Pediatric Nephrology Study GroupRonald J Hogg
St Joseph s Hospital and Medical Center, 222 W Thomas Road, Suite 410, Phoenix, AZ, USA
Clin J Am Soc Nephrol 1:467-74. 2006..However, the relatively short follow-up period, inequality of baseline UP/C ratios, and small numbers of patients precludes definitive conclusions... - Omega-3 fatty acids and risk of cognitive impairment and dementiaDanielle Laurin
Laval University Geriatric Research Unit, Quebec, QC, Canada
J Alzheimers Dis 5:315-22. 2003..03) concentrations were found in dementia cases. These findings do not support the hypothesis that omega-3 polyunsaturated fatty acids play a protective role in cognitive function and dementia... - Gestational age and birth weight in relation to n-3 fatty acids among Inuit (Canada)Michel Lucas
Public Health Research Unit, Laval University Medical Research Centre, , , Canada
Lipids 39:617-26. 2004..In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA...