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Genomes and Genes | Graham P HollowaySummaryAffiliation: University of Guelph Country: Canada Publications
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Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exerciseGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
J Physiol 571:201-10. 2006..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistanceG P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, ANNU Building 70, Guelph, ON, Canada
Diabetologia 54:1457-67. 2011..We also examined whether FATP1 is altered in insulin-resistant obese Zucker rats...- In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidationGraham P Holloway
Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
J Physiol 589:169-80. 2011..Rather, increased sarcolemmal LCFA transport proteins and rates of LCFA transport result in a greater number of lipid droplets within cardiac muscle... - Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF ratsGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Diabetes 59:819-28. 2010.... - FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscleGraham P Holloway
1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Am J Physiol Regul Integr Comp Physiol 297:R960-7. 2009..Nevertheless, the KO animals reveal that FAT/CD36 contributes to the regulation of mitochondrial fatty acid oxidation, which is especially important for meeting the increased metabolic demands during muscle contraction... - Mitochondrial function and dysfunction in exercise and insulin resistanceGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Appl Physiol Nutr Metab 34:440-6. 2009..This work suggests that the accumulation of skeletal muscle lipids, regardless of changes in mitochondria, is attributable to an increased rate of LCFA transport that exceeds the capacity for oxidation... - PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta proteinGraham P Holloway
Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Am J Physiol Endocrinol Metab 294:E1060-9. 2008..Also, it does not appear that alterations in the proteins associated with mitochondrial network formation and degradation can account for the observed decrease in mitochondrial content... - Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscleGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada, N1G 2W1
J Physiol 582:393-405. 2007.... 
Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese womenGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G2W1
Am J Physiol Endocrinol Metab 292:E1782-9. 2007..In addition, it appears that mitochondrial FAT/CD36 may be involved in regulating fatty acid oxidation in human skeletal muscle...- Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty ratsArend Bonen
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Am J Physiol Regul Integr Comp Physiol 297:R1202-12. 2009..Upregulation of fatty acid transport increased red muscle, but not cardiac, triacylglycerol accumulation. White muscle lipid metabolism dysregulation was not observed... - In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidationGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Am J Physiol Endocrinol Metab 296:E738-47. 2009..The additional fatty acid taken up is channeled primarily to esterification, suggesting that upregulation in fatty acid transport as opposed to altered fatty acid oxidation is the major determinant of intramuscular lipid accumulation... - The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesisBrendon J Gurd
Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
J Physiol 587:1817-28. 2009..Taken altogether these experiments are not consistent with the notion that SIRT1 protein plays an obligatory regulatory role in the process of PGC-1alpha-mediated mitochondrial biogenesis in mammalian muscle... - Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscleSwati S Jain
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
FEBS Lett 586:2428-35. 2012..Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking... - In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidationJay T McFarlan
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
J Biol Chem 287:23502-16. 2012..Thus, sarcolemmal CD36 has a key role in muscle fuel selection, exercise performance, and training-induced muscle FAO adaptation, challenging long held views of mechanisms involved in acute and adaptive regulation of muscle FAO... - Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individualsGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Am J Clin Nutr 89:455S-62S. 2009..These findings imply that obese individuals would benefit from interventions that increase the skeletal muscle mitochondrial content and the potential for oxidizing FAs... - Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscleJason L Talanian
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 299:E180-8. 2010..These results suggest that increases in skeletal muscle fatty acid oxidation following training are related in part to changes in fatty acid transport protein content and localization... - Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondriaCarley R Benton
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
J Physiol 586:1755-66. 2008..Moreover, these studies identify for the first time a mechanism by which rosiglitazone stimulates fatty acid oxidation in skeletal muscle, namely the chronic, subcellular relocation of FAT/CD36 to mitochondria... - Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscleChristopher G R Perry
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
J Physiol 590:5475-86. 2012..This enhanced regulation of miCK-dependent phosphate shuttling may improve energy homeostasis through more efficient coupling of oxidative phosphorylation to perturbations in cellular energy charge during subsequent bouts of contraction... - A dual mechanism of action for skeletal muscle FAT/CD36 during exerciseBrennan K Smith
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
Exerc Sport Sci Rev 40:211-7. 2012..Specifically, fatty acid translocase/CD36 seems to have a novel dual mechanism of action with regard to fatty acid oxidation during exercise, influencing transport of lipids across the sarcolemmal membrane and into the mitochondria... - AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscleBrennan K Smith
Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
J Physiol 591:1551-61. 2013..These data suggest that exercise causes translocation of PGC-1α preferentially to SS mitochondria in an AMPK-dependent manner... - Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation ratesBrennan K Smith
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
Biochem J 448:13-20. 2012.... - Unsaturation of mitochondrial membrane lipids is related to palmitate oxidation in subsarcolemmal and intermyofibrillar mitochondriaGraham P Holloway
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
J Membr Biol 245:165-76. 2012..g., percent mole fraction of other predominant membrane phospholipids, chain length, and ratio of phosphatidylcholine to phosphatidylethanolamine) were not significantly correlated... - A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose toleranceBrennan K Smith
Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada
Appl Physiol Nutr Metab 35:699-706. 2010..Overall, this study demonstrates that a decrease in the n-6/n-3 ratio can enhance glucose tolerance in healthy animals, independent of changes in mitochondrial content... - Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signalsJames G Nickerson
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
Appl Physiol Nutr Metab 32:865-73. 2007..Finally, studies in FAT/CD36 null mice indicate that this transporter has a key role in regulating fatty acid metabolism in muscle... - FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidationBrennan K Smith
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
Biochem J 437:125-34. 2011..We further support this model by providing evidence that FAT/CD36 is not located in mitochondrial contact sites, and therefore does not directly interact with carnitine palmitoyltransferase-I as original proposed... - Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscleYuko Yoshida
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
J Physiol 582:1317-35. 2007..e. an intracellular lactate shuttle) does not occur within the matrix in either IMF or SS mitochondria obtained from red or white rat skeletal muscle, because of the very limited quantity of LDH within mitochondria... - Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergeticsJames S V Lally
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 8:e55660. 2013..Altogether, and contrary to evidence from lower order cell lines, our results indicate that over-expressing MFN-2 in healthy muscle does not influence mitochondrial bioenergetics in mature mammalian skeletal muscle... - Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondriaCarley R Benton
Departments of Kinesiology and Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
J Biol Chem 283:4228-40. 2008....