Graham P Holloway

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. doi request reprint Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle
    E A F Herbst
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON N1G 2W1, Canada
    J Physiol 592:1341-52. 2014
  2. doi request reprint Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, NIG, 2W1
    Diabetologia 57:832-40. 2014
  3. pmc Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol
    Brennan K Smith
    G P Holloway Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, Canada, N1G 2W1
    J Physiol 591:6089-101. 2013
  4. doi request reprint Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance
    G P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, ANNU Building 70, Guelph, ON, Canada
    Diabetologia 54:1457-67. 2011
  5. pmc In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 589:169-80. 2011
  6. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
  7. pmc Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Diabetes 59:819-28. 2010
  8. doi request reprint FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle
    Graham P Holloway
    1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R960-7. 2009
  9. doi request reprint Mitochondrial function and dysfunction in exercise and insulin resistance
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:440-6. 2009
  10. ncbi request reprint Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G2W1
    Am J Physiol Endocrinol Metab 292:E1782-9. 2007

Collaborators

Detail Information

Publications33

  1. doi request reprint Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle
    E A F Herbst
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON N1G 2W1, Canada
    J Physiol 592:1341-52. 2014
    ..The current data strongly emphasize a role for omega-3s in reorganizing the composition of mitochondrial membranes while promoting improvements in ADP sensitivity. ..
  2. doi request reprint Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada, NIG, 2W1
    Diabetologia 57:832-40. 2014
    ..Therefore, we aimed to identify specific intramuscular fatty acids and subcellular lipid localisations associated with improved insulin sensitivity following chronic muscle contraction...
  3. pmc Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol
    Brennan K Smith
    G P Holloway Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, Canada, N1G 2W1
    J Physiol 591:6089-101. 2013
    ....
  4. doi request reprint Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance
    G P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, ANNU Building 70, Guelph, ON, Canada
    Diabetologia 54:1457-67. 2011
    ..We also examined whether FATP1 is altered in insulin-resistant obese Zucker rats...
  5. pmc In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 589:169-80. 2011
    ..Rather, increased sarcolemmal LCFA transport proteins and rates of LCFA transport result in a greater number of lipid droplets within cardiac muscle...
  6. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
    ..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
  7. pmc Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Diabetes 59:819-28. 2010
    ....
  8. doi request reprint FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle
    Graham P Holloway
    1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R960-7. 2009
    ..Nevertheless, the KO animals reveal that FAT/CD36 contributes to the regulation of mitochondrial fatty acid oxidation, which is especially important for meeting the increased metabolic demands during muscle contraction...
  9. doi request reprint Mitochondrial function and dysfunction in exercise and insulin resistance
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:440-6. 2009
    ..This work suggests that the accumulation of skeletal muscle lipids, regardless of changes in mitochondria, is attributable to an increased rate of LCFA transport that exceeds the capacity for oxidation...
  10. ncbi request reprint Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G2W1
    Am J Physiol Endocrinol Metab 292:E1782-9. 2007
    ..In addition, it appears that mitochondrial FAT/CD36 may be involved in regulating fatty acid oxidation in human skeletal muscle...
  11. doi request reprint PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 294:E1060-9. 2008
    ..Also, it does not appear that alterations in the proteins associated with mitochondrial network formation and degradation can account for the observed decrease in mitochondrial content...
  12. pmc Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada, N1G 2W1
    J Physiol 582:393-405. 2007
    ....
  13. doi request reprint Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    Arend Bonen
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1202-12. 2009
    ..Upregulation of fatty acid transport increased red muscle, but not cardiac, triacylglycerol accumulation. White muscle lipid metabolism dysregulation was not observed...
  14. doi request reprint In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 296:E738-47. 2009
    ..The additional fatty acid taken up is channeled primarily to esterification, suggesting that upregulation in fatty acid transport as opposed to altered fatty acid oxidation is the major determinant of intramuscular lipid accumulation...
  15. pmc The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
    Brendon J Gurd
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Physiol 587:1817-28. 2009
    ..Taken altogether these experiments are not consistent with the notion that SIRT1 protein plays an obligatory regulatory role in the process of PGC-1alpha-mediated mitochondrial biogenesis in mammalian muscle...
  16. pmc Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle
    Swati S Jain
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    FEBS Lett 586:2428-35. 2012
    ..Hence, Munc18c provides stimulus-specific regulation of GLUT4 trafficking, but not FA transporter trafficking...
  17. pmc In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation
    Jay T McFarlan
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 287:23502-16. 2012
    ..Thus, sarcolemmal CD36 has a key role in muscle fuel selection, exercise performance, and training-induced muscle FAO adaptation, challenging long held views of mechanisms involved in acute and adaptive regulation of muscle FAO...
  18. doi request reprint Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Clin Nutr 89:455S-62S. 2009
    ..These findings imply that obese individuals would benefit from interventions that increase the skeletal muscle mitochondrial content and the potential for oxidizing FAs...
  19. doi request reprint Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 299:E180-8. 2010
    ..These results suggest that increases in skeletal muscle fatty acid oxidation following training are related in part to changes in fatty acid transport protein content and localization...
  20. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
    ..These data suggest that exercise causes translocation of PGC-1╬▒ preferentially to SS mitochondria in an AMPK-dependent manner...
  21. pmc Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 586:1755-66. 2008
    ..Moreover, these studies identify for the first time a mechanism by which rosiglitazone stimulates fatty acid oxidation in skeletal muscle, namely the chronic, subcellular relocation of FAT/CD36 to mitochondria...
  22. pmc Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Biochem J 448:13-20. 2012
    ....
  23. pmc Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle
    Christopher G R Perry
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    J Physiol 590:5475-86. 2012
    ..This enhanced regulation of miCK-dependent phosphate shuttling may improve energy homeostasis through more efficient coupling of oxidative phosphorylation to perturbations in cellular energy charge during subsequent bouts of contraction...
  24. ncbi request reprint Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signals
    James G Nickerson
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 32:865-73. 2007
    ..Finally, studies in FAT/CD36 null mice indicate that this transporter has a key role in regulating fatty acid metabolism in muscle...
  25. pmc Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics
    James S V Lally
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 8:e55660. 2013
    ..Altogether, and contrary to evidence from lower order cell lines, our results indicate that over-expressing MFN-2 in healthy muscle does not influence mitochondrial bioenergetics in mature mammalian skeletal muscle...
  26. doi request reprint A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 35:699-706. 2010
    ..Overall, this study demonstrates that a decrease in the n-6/n-3 ratio can enhance glucose tolerance in healthy animals, independent of changes in mitochondrial content...
  27. ncbi request reprint A dual mechanism of action for skeletal muscle FAT/CD36 during exercise
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Exerc Sport Sci Rev 40:211-7. 2012
    ..Specifically, fatty acid translocase/CD36 seems to have a novel dual mechanism of action with regard to fatty acid oxidation during exercise, influencing transport of lipids across the sarcolemmal membrane and into the mitochondria...
  28. doi request reprint Unsaturation of mitochondrial membrane lipids is related to palmitate oxidation in subsarcolemmal and intermyofibrillar mitochondria
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    J Membr Biol 245:165-76. 2012
    ..g., percent mole fraction of other predominant membrane phospholipids, chain length, and ratio of phosphatidylcholine to phosphatidylethanolamine) were not significantly correlated...
  29. doi request reprint FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation
    Brennan K Smith
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    Biochem J 437:125-34. 2011
    ..We further support this model by providing evidence that FAT/CD36 is not located in mitochondrial contact sites, and therefore does not directly interact with carnitine palmitoyltransferase-I as original proposed...
  30. pmc Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle
    Yuko Yoshida
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 582:1317-35. 2007
    ..e. an intracellular lactate shuttle) does not occur within the matrix in either IMF or SS mitochondria obtained from red or white rat skeletal muscle, because of the very limited quantity of LDH within mitochondria...
  31. doi request reprint Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats
    Marie Soleil Beaudoin
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 305:R542-51. 2013
    ..Collectively, these data demonstrate that RSV can induce adipose tissue mitochondrial biogenesis in parallel with increases in GNG and adiponectin secretion...
  32. doi request reprint Exercise training increases the expression and nuclear localization of mRNA destabilizing proteins in skeletal muscle
    Sarthak Matravadia
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 305:R822-31. 2013
    ....
  33. ncbi request reprint Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
    Carley R Benton
    Departments of Kinesiology and Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Biol Chem 283:4228-40. 2008
    ....