Martin Holcik

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Conditionally lethal genes in the N pilus region of plasmid pCU1
    M Holcik
    Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
    Plasmid 42:53-9. 1999
  2. ncbi request reprint Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis
    Martin Holcik
    Apoptosis Research Center, Children s Hospital of Eastern Ontario Research Institute and Department of Pediatrics, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, USA
    Expert Opin Ther Targets 8:241-53. 2004
  3. ncbi request reprint Targeting translation for treatment of cancer--a novel role for IRES?
    Martin Holcik
    Apoptosis Research Center, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1 Canada
    Curr Cancer Drug Targets 4:299-311. 2004
  4. ncbi request reprint Translational upregulation of the X-linked inhibitor of apoptosis
    Martin Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Department of Pediatrics, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1 Canada
    Ann N Y Acad Sci 1010:249-58. 2003
  5. ncbi request reprint Translational control in stress and apoptosis
    Martin Holcik
    Apoptosis Research Center, Room R3116, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Nat Rev Mol Cell Biol 6:318-27. 2005
  6. pmc The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2
    Martin Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Mol Cell Biol 23:280-8. 2003
  7. ncbi request reprint The IAP proteins
    Martin Holcik
    Department of Pediatrics, University of Ottawa, Children s Hospital of Eastern Ontario Research Institute, Room R310, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
    Trends Genet 18:537. 2002
  8. ncbi request reprint XIAP, the guardian angel
    M Holcik
    Children s Hospital of Eastern Ontario Research Institute, and AEgera Oncology Inc, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    Nat Rev Mol Cell Biol 2:550-6. 2001
  9. ncbi request reprint Internal ribosome initiation of translation and the control of cell death
    M Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, ON, K1H 8L1, Ottawa, Canada
    Trends Genet 16:469-73. 2000
  10. pmc The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress
    Stephen M Lewis
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1 Canada
    Nucleic Acids Res 36:168-78. 2008

Collaborators

  • Tatyana Pestova
  • Jaime D Blais
  • Amelia B Bellamy-Royds
  • Bernard J Jasmin
  • Peng Liu
  • Bruce C McKay
  • Heather P Harding
  • M Rodriguez
  • Marc R Fabian
  • Christina L Addison
  • N Sonenberg
  • Xuhua Xia
  • Sylvia Balabanian
  • Kishore Wary
  • Xuejun Liu
  • D Ron
  • John Bell
  • Stephen M Lewis
  • Faraz Farooq
  • Jeremiah Hadwen
  • Urszula Liwak
  • Stephen D Baird
  • Alex MacKenzie
  • Tyson E Graber
  • Duncan MacKenzie
  • Nicoleta Hosszu Ungureanu
  • Pedro Miura
  • Lindsay E Jordan
  • Fahad Shamim
  • Brian D Melanson
  • Mame Daro Faye
  • Nehal Thakor
  • Robert G Korneluk
  • James Uniacke
  • Alura Riley
  • Meghan Andrews
  • Stefanie Galban
  • Anne Cammas
  • Stephan Vagner
  • Sophie Bonnal
  • Marcel Turcotte
  • Sonia Cerquozzi
  • Damiano Conte
  • Yoko Yamagiwa
  • Dinesh Warnakulasuriyarachchi
  • Tara A Nevins
  • Kevin Mongeon
  • Christian Brochu
  • Jeffrey D Hamill
  • Francisco Abadía-Molina
  • Poonam Singh
  • Kristen A Marcellus
  • Federico Roncaroli
  • Miguel A Cabrita
  • Elysia Pan
  • Ian A Lorimer
  • Jennifer E L Hanson
  • Sean O'Reilly
  • Sally Davidson Von-Holt
  • Reetesh Bose
  • Danielle Durie
  • Tong T Zhao
  • Olivier E Pardo
  • Chet E Holterman
  • Mathieu D Jacob
  • Arnim Pause
  • Rajat Roy
  • Stephen Lee
  • Aleksandra Franovic
  • Gabriel Lachance
  • Michael Seckl
  • Josianne Payette
  • Francisco Abadía Molina
  • Matthew Osmond
  • Luke Witherspoon
  • Youngjun Dang
  • Kotb Abdelmohsen
  • Yuki Kuwano
  • Jennifer L Martindale
  • Myriam Gorospe
  • Xiaoling Yang
  • Jun O Liu
  • Rudolf Pullmann
  • Ashish Lal
  • Hyeon Ho Kim
  • Anne Veyrier
  • Frédéric Pileur
  • Nicolas Leveque
  • Kathryn E Wright
  • Eric LaCasse

Detail Information

Publications37

  1. ncbi request reprint Conditionally lethal genes in the N pilus region of plasmid pCU1
    M Holcik
    Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, K1S 5B6, Canada
    Plasmid 42:53-9. 1999
    ..kilC expression in E. coli leads to cell death accompanied by an increase in average cell length without affecting septum formation...
  2. ncbi request reprint Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis
    Martin Holcik
    Apoptosis Research Center, Children s Hospital of Eastern Ontario Research Institute and Department of Pediatrics, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, USA
    Expert Opin Ther Targets 8:241-53. 2004
    ..Indeed, available data suggest that the therapeutic downregulation of IAPs by antisense targeting or their adenovirally-mediated overexpression, can in fact be used to successfully modulate cell death...
  3. ncbi request reprint Targeting translation for treatment of cancer--a novel role for IRES?
    Martin Holcik
    Apoptosis Research Center, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON K1H 8L1 Canada
    Curr Cancer Drug Targets 4:299-311. 2004
    ....
  4. ncbi request reprint Translational upregulation of the X-linked inhibitor of apoptosis
    Martin Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Department of Pediatrics, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, K1H 8L1 Canada
    Ann N Y Acad Sci 1010:249-58. 2003
    ..The IRES regulation of XIAP translation points to an important mechanism in the control and regulation of apoptosis...
  5. ncbi request reprint Translational control in stress and apoptosis
    Martin Holcik
    Apoptosis Research Center, Room R3116, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada
    Nat Rev Mol Cell Biol 6:318-27. 2005
    ....
  6. pmc The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2
    Martin Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Mol Cell Biol 23:280-8. 2003
    ..Given the central role of XIAP in the regulation of apoptosis these results are important for our understanding of the control of apoptosis...
  7. ncbi request reprint The IAP proteins
    Martin Holcik
    Department of Pediatrics, University of Ottawa, Children s Hospital of Eastern Ontario Research Institute, Room R310, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
    Trends Genet 18:537. 2002
  8. ncbi request reprint XIAP, the guardian angel
    M Holcik
    Children s Hospital of Eastern Ontario Research Institute, and AEgera Oncology Inc, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    Nat Rev Mol Cell Biol 2:550-6. 2001
    ..One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation...
  9. ncbi request reprint Internal ribosome initiation of translation and the control of cell death
    M Holcik
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, ON, K1H 8L1, Ottawa, Canada
    Trends Genet 16:469-73. 2000
    ..Thus, IRES-mediated translational control might have evolved to regulate cellular responses in acute but transient stress conditions that would otherwise lead to cell death...
  10. pmc The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress
    Stephen M Lewis
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1 Canada
    Nucleic Acids Res 36:168-78. 2008
    ..Thus, DAP5/p97 is a translational activator that selectively modulates translation of specific mRNAs during conditions of cellular stress in both a caspase-dependent and caspase-independent manner...
  11. pmc Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon
    Mame Daro Faye
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, and University of Ottawa, Ottawa, Ontario, Canada
    Mol Cell Biol 33:307-18. 2013
    ..This study uncovers a novel role for NF45 in regulating ploidy and highlights the importance of IRES-mediated translation in cellular homeostasis...
  12. pmc Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation
    Stephen M Lewis
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8L1, Canada
    Mol Biol Cell 18:1302-11. 2007
    ..Our findings demonstrate that cytoplasmic hnRNP A1 is a negative regulator of XIAP IRES-dependent translation, indicating a novel function for the cytoplasmic form of this protein...
  13. pmc A search for structurally similar cellular internal ribosome entry sites
    Stephen D Baird
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, ON, Canada
    Nucleic Acids Res 35:4664-77. 2007
    ..We therefore propose that cellular IRES are not defined by overall structure, as viral IRES, but are instead dependent upon short motifs and trans-acting factors for their function...
  14. pmc Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2
    Urszula Liwak
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
    Mol Cell Biol 32:1818-29. 2012
    ....
  15. ncbi request reprint The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers
    Pedro Miura
    Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:32997-3005. 2005
    ..These findings provide a novel target for up-regulating levels of utrophin A in Duchenne muscular dystrophy muscle fibers via pharmacological interventions...
  16. pmc IRES-mediated translation of utrophin A is enhanced by glucocorticoid treatment in skeletal muscle cells
    Pedro Miura
    Department of Cellular and Molecular Medicine, Centre for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 3:e2309. 2008
    ..Targeting the utrophin A IRES may thus offer an important and novel therapeutic avenue for developing drugs appropriate for DMD patients...
  17. doi request reprint p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR
    Faraz Farooq
    University of Ottawa, Ottawa K1H 8M5, Canada
    Hum Mol Genet 18:4035-45. 2009
    ....
  18. ncbi request reprint Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element
    Dinesh Warnakulasuriyarachchi
    Apoptosis Research Center, Children s Hospital of Eastern Ontario, Department of Pediatrics, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada
    J Biol Chem 279:17148-57. 2004
    ..These data suggest an existence of a novel mechanism that regulates apoptotic response in ER stress...
  19. pmc Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system
    Martin Holcik
    Apoptosis Research Center, Children s Hospital of Eastern Ontario, Ottawa, Canada
    RNA 11:1605-9. 2005
    ..In this paper, we demonstrate that the splicing within the XIAP 5' UTR specifically occurs only in the context of mRNA produced from the Rluc/Fluc but not the pbetagal/CAT bicistronic reporter plasmid...
  20. ncbi request reprint Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death
    Nicoleta Hosszu Ungureanu
    Apoptosis Research Center, Children s Hospital of Eastern Ontario, Ottawa, Ontario K1H 8L1
    J Biol Chem 281:15155-63. 2006
    ..These data suggest that progression of UV-induced apoptosis requires IRES-mediated translation of Apaf-1 to ensure continuous levels of Apaf-1 despite an overall suppression of protein synthesis...
  21. doi request reprint VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models
    Jeremiah Hadwen
    University of Ottawa, Ottawa K1H 8M5, Canada
    Orphanet J Rare Dis 9:4. 2014
    ..One of the treatment strategies for SMA is to induce the expression of the protein from the homologous SMN2 gene, a rescuing paralog for SMA...
  22. pmc Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway
    Faraz Farooq
    University of Ottawa, Ottawa, Canada
    J Clin Invest 121:3042-50. 2011
    ..Our results confirm earlier work suggesting STAT5 pathway activators as potential therapeutic compounds for the treatment of SMA and identify PRL as one such promising agent...
  23. pmc Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival
    Damiano Conte
    Apoptosis Research Center, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Rm R3114, Ottawa, Ontario K1H 8L1, Canada
    Mol Cell Biol 26:699-708. 2006
    ..Hence, cIAP2 is critical in the maintenance of a normal innate immune inflammatory response...
  24. doi request reprint Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation
    Faraz Farooq
    University of Ottawa, Ottawa, Canada K1H 8M5
    Hum Mol Genet 22:3415-24. 2013
    ..Critically, celecoxib treatment increased SMN levels, improved motor function and enhanced survival in a severe SMA mouse model. Our results identify low dose celecoxib as a potential new member of the SMA therapeutic armamentarium. ..
  25. ncbi request reprint Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1
    Tara A Nevins
    Solange Gauthier Karsh Molecular Genetics Laboratory, Children s Hospital of Eastern Ontario, Canada
    J Biol Chem 278:3572-9. 2003
    ..Our results suggest that the regulation of IRES translation during stress contributes to the fine-tuning of cell fate...
  26. pmc Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
    Jaime D Blais
    Ottawa Health Research Institute, Ottawa, ON K1H 1C4, Canada
    Mol Cell Biol 26:9517-32. 2006
    ....
  27. ncbi request reprint Cap-independent regulation of gene expression in apoptosis
    Tyson E Graber
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, Room 3116, 401 Smyth Road, Ottawa, Ontario, Canada K1H 8L1
    Mol Biosyst 3:825-34. 2007
    ..In addition, recent advances towards our understanding of the physiological role and mechanism of IRES-mediated translation in the context of cell stress-induced apoptosis and human disease will be examined...
  28. pmc Searching for IRES
    Stephen D Baird
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1H 8M5, Canada
    RNA 12:1755-85. 2006
    ....
  29. pmc Translation mechanism and regulation: old players, new concepts. Meeting on translational control and non-coding RNA
    Martin Holcik
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada
    EMBO Rep 8:639-43. 2007
  30. pmc Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress
    Alura Riley
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario, Ottawa, Canada
    Nucleic Acids Res 38:4665-74. 2010
    ....
  31. pmc Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma multiforme through de-repression of Bcl-xL translation
    Urszula Liwak
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
    Oncotarget 4:1365-72. 2013
    ..Our results identify Bcl-xL as a novel marker of GBM chemoresistance and advocate for the combined use of Bcl-xL antagonists and existing chemotherapeutics as a treatment option for this aggressive tumor. ..
  32. pmc A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression
    Brian D Melanson
    Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada, K1H 8L6
    Nucleic Acids Res 41:5692-703. 2013
    ..These results provide clear evidence that nuclear and cytoplasmic processing of the DDB2 mRNA is inextricably linked...
  33. doi request reprint An oxygen-regulated switch in the protein synthesis machinery
    James Uniacke
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Nature 486:126-9. 2012
    ..These findings demonstrate that cells have evolved a program by which oxygen tension switches the basic translation initiation machinery...
  34. pmc Strong eukaryotic IRESs have weak secondary structure
    Xuhua Xia
    Department of Biology and Center for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Canada
    PLoS ONE 4:e4136. 2009
    ..The objective of this work was to investigate the hypothesis that eukaryotic Internal Ribosome Entry Sites (IRES) lack secondary structure and to examine the generality of the hypothesis...
  35. pmc Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs
    Anne Cammas
    Institut National de la Sante et de la Recherche Medicale U563, Toulouse, F 31000, France
    Mol Biol Cell 18:5048-59. 2007
    ..Our data highlight a new way to regulate protein synthesis in eukaryotes through the subcellular relocalization of a nuclear mRNA-binding protein...
  36. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...
  37. ncbi request reprint Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival
    Yoko Yamagiwa
    Scott and White Clinic, College of Medicine, Texas A and M University System Health Science Center, 2401 South 31st Street, Temple, TX 76502, USA
    Cancer Res 64:1293-8. 2004
    ....