Stephen M T Hoke

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, N6A5C1, Canada
    BMC Biochem 8:16. 2007
  2. ncbi Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, N6A 5C1, Canada
    BMC Genet 9:46. 2008
  3. ncbi A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    J Mol Biol 384:743-55. 2008
  4. ncbi Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1
    Stephen M T Hoke
    Department of Biochemistry, University of Western Ontario, London, Canada
    Curr Genet 56:447-65. 2010
  5. ncbi The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain
    A Irina Mutiu
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Mol Genet Genomics 277:491-506. 2007
  6. ncbi Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1
    A Irina Mutiu
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A5C1, Canada
    Genetics 177:151-66. 2007

Collaborators

Detail Information

Publications6

  1. ncbi C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, N6A5C1, Canada
    BMC Biochem 8:16. 2007
    ..Two forms of Spt7 have been identified, the second of which is truncated at its C-terminus and found in the SAGA-like (SLIK) complex...
  2. ncbi Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, N6A 5C1, Canada
    BMC Genet 9:46. 2008
    ..To identify genetic interactions for TRA1 and provide insight into its function we have performed a systematic genetic array analysis (SGA) on tra1SRR3413, an allele that is defective in transcriptional regulation...
  3. ncbi A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids
    Stephen M T Hoke
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    J Mol Biol 384:743-55. 2008
    ..We also show that the central region of Ada2 interacts with phospholipids. Since phosphatidylserine binding paralleled Ada2 function, we suggest that lipid binding may play a role in the function or regulation of the SAGA complex...
  4. ncbi Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1
    Stephen M T Hoke
    Department of Biochemistry, University of Western Ontario, London, Canada
    Curr Genet 56:447-65. 2010
    ..These findings demonstrate the regulatory potential of mechanisms targeting the FATC domains of PIKK proteins...
  5. ncbi The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain
    A Irina Mutiu
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Mol Genet Genomics 277:491-506. 2007
    ..Finally, by comparing gene expression changes in the htb1 ( K123R ) strain with those in a strain deleted for rad6, we conclude that lysine 123 affects transcription primarily because of it being a site of ubiquitylation...
  6. ncbi Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1
    A Irina Mutiu
    Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A5C1, Canada
    Genetics 177:151-66. 2007
    ..While the tra1 alleles have some phenotypic similarities with deletions of SAGA and NuA4 components, their distinct nature may arise from the simultaneous alteration of SAGA and NuA4 functions...