James Hogg

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
  2. pmc Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
    Hisashi Suzuki
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Room 166, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 9:25. 2008
  3. pmc State of the art. Bronchiolitis in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia iCAPTURE Centre, St Pauls Hospital, Vancouver, BC, Canada V6Z 1Y6
    Proc Am Thorac Soc 3:489-93. 2006
  4. doi request reprint The pathology of chronic obstructive pulmonary disease
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia and iCapture Center, St Paul s Hospital, Vancouver, BC, Canada
    Annu Rev Pathol 4:435-59. 2009
  5. ncbi request reprint The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
  6. ncbi request reprint Lung structure and function in COPD
    J C Hogg
    University of British Columbia, McDonald Research Laboratories, St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Tuberc Lung Dis 12:467-79. 2008
  7. ncbi request reprint Role of latent viral infections in chronic obstructive pulmonary disease and asthma
    J C Hogg
    University of British Columbia McDonald Research Laboratory iCAPTURE Centre, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:S71-5. 2001
  8. pmc Canadian contributions to pulmonary anatomy and pathology
    James C Hogg
    University of British Columbia, Vancouver, Canada
    Can Respir J 14:393-7. 2007
  9. ncbi request reprint Pulmonary and systemic response to atmospheric pollution
    James C Hogg
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, The University of British Columbia, Vancouver, British Columbia, Canada
    Respirology 14:336-46. 2009
  10. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007

Research Grants

Collaborators

Detail Information

Publications63

  1. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
    ....
  2. pmc Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
    Hisashi Suzuki
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Room 166, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 9:25. 2008
    ..Here we report the behavior of BM-derived lineage negative progenitor cells (Lin- PCs) during pneumococcal pneumonia using quantum dots (QDs), nanocrystal fluorescent probes as a cell-tracking technique...
  3. pmc State of the art. Bronchiolitis in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia iCAPTURE Centre, St Pauls Hospital, Vancouver, BC, Canada V6Z 1Y6
    Proc Am Thorac Soc 3:489-93. 2006
  4. doi request reprint The pathology of chronic obstructive pulmonary disease
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia and iCapture Center, St Paul s Hospital, Vancouver, BC, Canada
    Annu Rev Pathol 4:435-59. 2009
    ..The mechanism(s) that allow small airways to thicken in such close proximity to lung tissue undergoing emphysematous destruction remains a puzzle that needs to be solved...
  5. ncbi request reprint The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  6. ncbi request reprint Lung structure and function in COPD
    J C Hogg
    University of British Columbia, McDonald Research Laboratories, St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Tuberc Lung Dis 12:467-79. 2008
    ....
  7. ncbi request reprint Role of latent viral infections in chronic obstructive pulmonary disease and asthma
    J C Hogg
    University of British Columbia McDonald Research Laboratory iCAPTURE Centre, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:S71-5. 2001
    ..These studies suggest that latent adenoviral infections may have a role in the pathogenesis of obstructive airway disease by amplifying the response to cigarette smoke and inducing steroid resistance...
  8. pmc Canadian contributions to pulmonary anatomy and pathology
    James C Hogg
    University of British Columbia, Vancouver, Canada
    Can Respir J 14:393-7. 2007
  9. ncbi request reprint Pulmonary and systemic response to atmospheric pollution
    James C Hogg
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, The University of British Columbia, Vancouver, British Columbia, Canada
    Respirology 14:336-46. 2009
    ....
  10. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  11. pmc Micro-computed tomography measurements of peripheral lung pathology in chronic obstructive pulmonary disease
    James C Hogg
    Emeritus Lab Medicine, iCAPTURE Center, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Proc Am Thorac Soc 6:546-9. 2009
    ..Conclusions: The centrilobular emphysematous phenotype of COPD is associated with narrowing and obliteration of the terminal bronchioles that begins prior to the onset of emphysematous destruction...
  12. pmc Chronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema
    J C Hogg
    The University of British Columbia McDonald Research Laboratory, St Paul s Hospital, Vancouver, Canada
    Thorax 57:830-4. 2002
    ..The pathology and pathogenesis of emphysema are reviewed, with particular reference to the proteinase-antiproteinase hypothesis...
  13. pmc What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease?
    James C Hogg
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 6:668-72. 2009
    ....
  14. ncbi request reprint Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    James C Hogg
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Lancet 364:709-21. 2004
    ....
  15. ncbi request reprint Particulate air pollution induces progression of atherosclerosis
    Tatsushi Suwa
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 39:935-42. 2002
    ..We sought to determine the effect of exposure to air pollution particulate matter <10 microm (PM(10)) on the progression of atherosclerosis in rabbits...
  16. ncbi request reprint Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
    Bernard Meshi
    UBC McDonald Research Laboratories, The iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 26:52-7. 2002
    ..In this study, the increase in CD4 was associated with cigarette smoke and the increase in CD8 cells with latent Ad infection...
  17. ncbi request reprint Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 27:34-41. 2002
    ..01). These results suggest that the interaction between AMs and HBECs during PM(10) exposure contributes to the production of mediators that induce a systemic inflammatory response...
  18. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
    ..The airflow limitation that defines severity of chronic obstructive pulmonary disease (COPD) is caused by a combination of small airway obstruction and emphysematous lung destruction...
  19. ncbi request reprint Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
    ..The aim of the present study was to determine the nature and mechanism of calcium responses induced by PM(10) in HBECs and its relationship to cytokine synthesis...
  20. ncbi request reprint Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease
    Stephan F van Eeden
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Proc Am Thorac Soc 2:61-7. 2005
    ..We speculate that this mechanism may contribute to the cardiovascular morbidity and mortality associated with COPD...
  21. ncbi request reprint Evaluation of small sample cDNA amplification for microdissected airway expression profiling in COPD
    John V Gosselink
    St Paul s Hospital, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, Vancouver, British Columbia
    COPD 4:91-105. 2007
    ..We conclude that SMART amplification provides cDNA sufficient for studying large numbers of genes even in laser-captured small airways and this cDNA maintains the relative expression found in corresponding unamplified RNAs...
  22. ncbi request reprint Adenovirus infections and lung disease
    Shizu Hayashi
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC V6Z 1Y6, Canada
    Curr Opin Pharmacol 7:237-43. 2007
    ..These results support its additional role in the airway remodeling process reported in COPD...
  23. ncbi request reprint Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation
    Stephan F van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Toxicol Environ Health A 65:1597-613. 2002
    ..We postulate that this systemic response to particulate air pollution augments lung inflammation and changes the phenotype of atherosclerotic plaques to make them more vulnerable to rupture...
  24. ncbi request reprint Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits
    Yukinobu Goto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L79-85. 2004
    ..45, P <0.05). We conclude that atherosclerosis increases the release of monocytes from the BM, and PM(10) exposure accelerates this process in relation to the amount of particles phagocytosed by alveolar macrophages...
  25. ncbi request reprint Characterization of airway plugging in fatal asthma
    Laura M Kuyper
    University of British Columbia McDonald Research Laboratories, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Med 115:6-11. 2003
    ..In this study, we examined the hypothesis that obstruction of the airway lumen by an exudate containing mucus and cells is a key feature of fatal asthma attacks...
  26. doi request reprint Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter
    Kiyoshi Morimoto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 296:L361-71. 2009
    ..E1A regulation of the LPS response may play a role in acute exacerbations as a consequence of bacterial infections in COPD...
  27. ncbi request reprint Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Center, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L290-7. 2003
    ..We suggest that this amplified inflammatory response may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease associated with exposure to particulate matter air pollution...
  28. ncbi request reprint Particulate matter air pollution stimulates monocyte release from the bone marrow
    Yukinobu Goto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Am J Respir Crit Care Med 170:891-7. 2004
    ..9 hours (p < 0.05), but supernatants of AM incubated with CC did not. We conclude that exposure to atmospheric PM(10) stimulates the production of mediators by AM, and these cytokines accelerate the monocyte release from the BM...
  29. ncbi request reprint Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells
    Yuji Higashimoto
    University of British Columbia, McDonald Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 166:200-7. 2002
    ..We conclude that adenoviral E1A transfection transforms primary HBE cells and upregulates their production of mediators that are clinically relevant to the pathogenesis of chronic obstructive pulmonary disease...
  30. ncbi request reprint Ambient air particulates stimulate alveolar macrophages of smokers to promote differentiation of myeloid precursor cells
    Tatsushi Suwa
    McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Exp Lung Res 28:1-18. 2002
    ....
  31. ncbi request reprint Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004
    ..We conclude that AM-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells and that their relative importance may depend on the type of epithelial cell target...
  32. ncbi request reprint Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD
    Emiko Ogawa
    McDonald Research Laboratories iCAPTURE Centre, Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 286:L189-97. 2004
    ..We conclude that latent infection of epithelial cells by adenovirus E1A could contribute to airway remodeling in COPD by the viral E1A gene, inducing TGF-beta 1 and CTGF expression and shifting cells to a more mesenchymal phenotype...
  33. doi request reprint Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells
    Noriho Sakamoto
    University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Toxicol 28:17-23. 2009
    ..It is concluded that statins can modulate the PM(10)-induced inflammatory response in the lung by reducing mediator production by AMs...
  34. ncbi request reprint The effects of radiation dose and CT manufacturer on measurements of lung densitometry
    Ren Yuan
    Department of Radiology, Vancouver General Hospital, 855 West Twelfth Ave, Room 3350 JPN, Vancouver, BC, Canada
    Chest 132:617-23. 2007
    ..To evaluate the effect of radiation dose and scanner manufacturer on quantitative CT scan measurements of lung morphology in smokers...
  35. doi request reprint The disruption of the epithelial mesenchymal trophic unit in COPD
    Ali R Behzad
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Depts of Medicine and Pathology, University of British Columbia, Canada
    COPD 6:421-31. 2009
    ..Development of COPD is associated with significant disruption of the EMTU due to a reduction of contacts between fibroblasts and the epithelium...
  36. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
    ..Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function...
  37. ncbi request reprint Monocyte recruitment into the lungs in pneumococcal pneumonia
    Yukinobu Goto
    McDonald Research Laboratories and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 30:620-6. 2004
    ..9 +/- 0.5% versus 1.1 +/- 0.1%, P < 0.05). We conclude that immature monocytes released from the marrow by pneumonia sequester rapidly in lung microvessels but their migration in pneumonic airspaces is delayed...
  38. pmc Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits
    Erin M Tranfield
    St Paul s Hospital, University of British Columbia, Vancouver
    Can J Cardiol 26:e258-69. 2010
    ..Epidemiological studies have established that cardiovascular events account for the greatest number of air pollution-related deaths. However, the underlying structural changes are still unknown...
  39. ncbi request reprint Flow cytometric method for enumeration and characterization of newly released polymorphonuclear leukocytes from the bone marrow using 5'-bromo-2'-deoxyuridine
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Cell Physiol 289:C757-65. 2005
    ..We conclude that a flow cytometric approach for identifying BrdU-labeled leukocytes provides an objective and accurate method for studying leukocyte kinetics and behavior...
  40. ncbi request reprint Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation
    Katsuhiko Yamada
    UBC McDonald Research Laboratory The iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
    J Allergy Clin Immunol 109:35-42. 2002
    ..We recently reported that allergic lung inflammation in guinea pigs became steroid resistant in the presence of latent adenoviral infection...
  41. ncbi request reprint A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridine
    Yukinobu Goto
    McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada V6Z1Y6
    Am J Physiol Cell Physiol 285:C253-9. 2003
    ..05). We conclude that this nonradioisotope method provides a novel way to monitor monocyte kinetics and confirmed previous reports that a focal pneumonia shortens monocyte marrow transit and increases their release into the circulation...
  42. ncbi request reprint A lung tissue bank for gene expression studies in chronic obstructive pulmonary disease
    Lily Ding
    Department of Pathology, University of British Columbia iCAPTURE Centre McDonald Research Laboratories, Vancouver, British Columbia, Canada
    COPD 1:191-204. 2004
    ..Storage time had no detectable effect on RNA quality. We conclude that both frozen and paraffin-embedded tissues as well as laser-captured cells are suitable for gene expression studies but frozen tissue offered greater sensitivity...
  43. ncbi request reprint Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques
    Kazuhiro Yatera
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Saint Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 294:H944-53. 2008
    ....
  44. ncbi request reprint CCL23/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrow
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Exp Hematol 33:1101-8. 2005
    ..This study concerns in vivo inhibitory effect of CCL23 on production of polymorphonuclear leukocytes (PMNs) and monocytes in the bone marrow and their release into the circulation...
  45. ncbi request reprint The effect of interleukin-6 on L-selectin levels on polymorphonuclear leukocytes
    Tatsushi Suwa
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
    Am J Physiol Heart Circ Physiol 283:H879-84. 2002
    ..We postulate that this prolonged downregulation of L-selectin on circulating PMN could influence their recruitment into inflammatory sites...
  46. ncbi request reprint Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization
    Alison Morris
    M S, Division of Pulmonary and Critical Care Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 170:408-13. 2004
    ..001) and was independent of smoking history. We conclude that there is a strong association between Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pathogenic link with COPD progression...
  47. pmc Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
    Wen Ning
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 101:14895-900. 2004
    ..Our study represents the first comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers and reveals previously unreported candidate genes that may serve as potential molecular targets in COPD...
  48. ncbi request reprint The prediction of small airway dimensions using computed tomography
    Yasutaka Nakano
    Department of Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Respir Crit Care Med 171:142-6. 2005
    ..01). We conclude that CT measurements of airways with a Pi of 0.75 cm or more could be used to estimate the dimensions of the small conducting airways, which are the site of airway obstruction in chronic obstructive pulmonary disease...
  49. pmc Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:533-4. 2006
  50. ncbi request reprint Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 352:1967-76. 2005
    ..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
  51. ncbi request reprint The association between small airway obstruction and emphysema phenotypes in COPD
    Won Dong Kim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Chest 131:1372-8. 2007
    ..This study compares the severity of small airway obstruction in both forms of emphysema and determines its relationship with FEV(1)...
  52. pmc Transpleural ventilation of explanted human lungs
    Cliff K Choong
    Hospital of the University of Pennsylvania, 3400 Spruce St, 6 Silverstein, Philadelphia, Pennsylvania 19104, USA
    Thorax 62:623-30. 2007
    ..The hypothesis that ventilation of emphysematous lungs would be enhanced by communication with the parenchyma through holes in the pleural surface was tested...
  53. pmc In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography
    Tariq S K Tanoli
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Appl Physiol 102:477-84. 2007
    ..The observed sensitivity of our method to emphysema progression suggests that this technique has potential for the diagnosis of emphysema and tracking of disease progression or improvement via a pharmaceutical intervention...
  54. pmc The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research
    Jeffrey L Curtis
    Pulmonary and Critical Care Medicine Section, Department of Veterans Affairs Medical Center, 2215 Fuller Road, Ann Arbor, MI 48105 2303, USA
    Proc Am Thorac Soc 4:512-21. 2007
    ....
  55. ncbi request reprint The effect of smoking cessation and steroid treatment on emphysema in guinea pigs
    Julie Milot
    Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, 2725 Chemin Ste Foy, Quebec, Canada G1V 4G5
    Respir Med 101:2327-35. 2007
    ..Latent adenoviral infection (Ad5) increases emphysema development and the inflammatory response to cigarette smoke and, in allergic lung inflammation, suppresses anti-inflammatory effects of steroids...
  56. ncbi request reprint Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD
    Wen Ning
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Montefiore NW 628, 3459 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:466. 2006
  57. ncbi request reprint Use of CT morphometry to detect changes in lung weight and gas volume
    Andrew Perez
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Chest 128:2471-7. 2005
    ..CT estimates of lung density have been used to estimate the extent and severity of emphysema. The present study was designed to test the hypothesis that quantitative CT can track the changes that occur in diffuse lung disease...
  58. ncbi request reprint Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia
    Gary W Hunninghake
    Department of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    Chest 124:1215-23. 2003
    ..To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP)...
  59. ncbi request reprint Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs
    Christopher J Danek
    Asthmatx, Stanford University El Camino Hospital, Mountain View, CA 94043, USA
    J Appl Physiol 97:1946-53. 2004
    ..54, P < 0.001). We conclude that the temperature-controlled application of radio frequency energy to the airways can reduce airway responsiveness to MCh for at least 3 yr in dogs by reducing airway smooth muscle contractility...
  60. pmc Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema
    Jason C Woods
    Department of Physics, Washington University, St Louis, Missouri 63130 4899, USA
    Magn Reson Med 56:1293-300. 2006
    ..This effect may be due to the smaller histologic sampling size compared to the MRI voxel sizes...
  61. ncbi request reprint The contribution of airway structure to early childhood asthma
    Karen O McKay
    Department of Respiratory Medicine, School of Paediatrics and Child Health, The Children s Hospital at Westmead, University of Sydney, NSW
    Med J Aust 177:S45-7. 2002
    ..as measurement of exhaled gases, provide us with accurate information about inflammation and the pathology of early childhood asthma? What are the real ethical and practical limitations to studying the pathology of early childhood asthma?..
  62. ncbi request reprint Inhaled carbon and lung function in children
    David V Bates
    N Engl J Med 355:1496; author reply 1497. 2006
  63. ncbi request reprint A canine model for production of severe unilateral panacinar emphysema
    Kimiaki Chino
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Exp Lung Res 30:319-32. 2004
    ..The model will be of value in developing imaging techniques capable of safely evaluating the effect of treatment on panacinar emphysema in alpha1-antitrypsin-deficient patients...

Research Grants8

  1. PATHOLOGIC ASSESSMENT OF LUNG VOLUME REDUCTION SURGERY
    James Hogg; Fiscal Year: 2002
    ..The results of this study will provide definite criteria useful in selecting the patients that will receive the greatest benefit from lung volume reduction surgery. ..
  2. ADENOVIRAL INFECTION IN THE PATHOGENESIS OF EMPHYSEMA
    James Hogg; Fiscal Year: 2003
    ..The information gathered from these studies will provide new insights into the pathogenesis of emphysema and help explain why some smokers develop emphysema and others do not. ..