Brad G Hoffman

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver
    Brad G Hoffman
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 20:1037-51. 2010
  2. pmc Probabilistic inference for nucleosome positioning with MNase-based or sonicated short-read data
    Xuekui Zhang
    Statistics Department, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e32095. 2012
  3. pmc Expression of Groucho/TLE proteins during pancreas development
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    BMC Dev Biol 8:81. 2008
  4. pmc A seriation approach for visualization-driven discovery of co-expression patterns in Serial Analysis of Gene Expression (SAGE) data
    Olena Morozova
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
    PLoS ONE 3:e3205. 2008
  5. pmc The transcription factor Myt3 acts as a pro-survival factor in β-cells
    Bryan R Tennant
    Child and Family Research Institute, British Columbia Children s Hospital and Sunny Hill Health Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e51501. 2012
  6. pmc Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation
    Peter T W Kim
    Department of Surgery, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e14146. 2010
  7. pmc Identification of transcripts with enriched expression in the developing and adult pancreas
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, Vancouver, BC V5Z 1L3, Canada
    Genome Biol 9:R99. 2008
  8. doi request reprint Genome-wide identification of DNA-protein interactions using chromatin immunoprecipitation coupled with flow cell sequencing
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, Canada
    J Endocrinol 201:1-13. 2009
  9. ncbi request reprint SAGE reveals expression of Wnt signalling pathway members during mouse prostate development
    Tian Jiao Zhang
    Department of Cancer Endocrinology, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
    Gene Expr Patterns 6:310-24. 2006

Collaborators

Detail Information

Publications9

  1. pmc Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver
    Brad G Hoffman
    Department of Cancer Endocrinology, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 20:1037-51. 2010
    ..Finally, we apply these approaches to generate novel insights into how FOXA2, PDX1, and HNF4A cooperate to drive islet- and liver-specific gene expression...
  2. pmc Probabilistic inference for nucleosome positioning with MNase-based or sonicated short-read data
    Xuekui Zhang
    Statistics Department, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e32095. 2012
    ....
  3. pmc Expression of Groucho/TLE proteins during pancreas development
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    BMC Dev Biol 8:81. 2008
    ..Moreover, little is known about the ability of Gro/TLE proteins to interact with transcription factors in the pancreas...
  4. pmc A seriation approach for visualization-driven discovery of co-expression patterns in Serial Analysis of Gene Expression (SAGE) data
    Olena Morozova
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada
    PLoS ONE 3:e3205. 2008
    ..Most analyses of SAGE data aimed at identifying co-expressed genes have been accomplished using various versions of clustering approaches that often result in a number of false positives...
  5. pmc The transcription factor Myt3 acts as a pro-survival factor in β-cells
    Bryan R Tennant
    Child and Family Research Institute, British Columbia Children s Hospital and Sunny Hill Health Centre, Vancouver, British Columbia, Canada
    PLoS ONE 7:e51501. 2012
    ..Here, we sought to determine the expression and regulation of Myt3 in islets and to determine its significance in regulating islet function and survival...
  6. pmc Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation
    Peter T W Kim
    Department of Surgery, University of British Columbia, Vancouver, Canada
    PLoS ONE 5:e14146. 2010
    ..1. This protocol using all-trans-retinoic acid, DBcAMP, in the absence of embryoid bodies, generated cells that have features of definitive endoderm that may serve as pancreatic endocrine precursors...
  7. pmc Identification of transcripts with enriched expression in the developing and adult pancreas
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, West 10th Ave, Vancouver, BC V5Z 1L3, Canada
    Genome Biol 9:R99. 2008
    ....
  8. doi request reprint Genome-wide identification of DNA-protein interactions using chromatin immunoprecipitation coupled with flow cell sequencing
    Brad G Hoffman
    Department of Cancer Endocrinology, BC Cancer Research Center, 675 West 10th Avenue, Vancouver, BC, Canada
    J Endocrinol 201:1-13. 2009
    ..However, to date, this technology has been applied only to a small number of cell types, and even fewer tissues, suggesting a huge potential for novel discovery in this field...
  9. ncbi request reprint SAGE reveals expression of Wnt signalling pathway members during mouse prostate development
    Tian Jiao Zhang
    Department of Cancer Endocrinology, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
    Gene Expr Patterns 6:310-24. 2006
    ..These studies provide the first evidence that Wnt pathway members are expressed in the developing prostate. Functional analyses are now required to establish the biological significance of this observation...