Research Topics
Species | P W HochachkaSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
The metabolic implications of intracellular circulationP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, BC Canada V6T 1Z4
Proc Natl Acad Sci U S A 96:12233-9. 1999..The ease with which this hypothesis explains the [s] stability paradox is one of its most compelling features...
Going malignant: the hypoxia-cancer connection in the prostateP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
Bioessays 24:749-57. 2002..Recognition and understanding of these redox balancing and hypoxia defense functions may lead to new intervention strategies by developing new intracellular targets for prostate cancer therapy...- Adaptation and conservation of physiological systems in the evolution of human hypoxia toleranceP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, Canada
Comp Biochem Physiol A Mol Integr Physiol 124:1-17. 1999.... - Mechanism and evolution of hypoxia-tolerance in humansP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Exp Biol 201:1243-54. 1998..More recent evidence indicating that our species evolved under 'colder, drier and higher' conditions suggests that these adaptations may represent the 'ancestral' physiological condition for humans... - Pinniped diving response mechanism and evolution: a window on the paradigm of comparative biochemistry and physiologyP W Hochachka
Department of Zoology, University of British Columbia, BC, V6T 1Z4, Vancouver, Canada
Comp Biochem Physiol A Mol Integr Physiol 126:435-58. 2000.... - Effects on regional brain metabolism of high-altitude hypoxia: a study of six US marinesP W Hochachka
Department of Zoology and Sports Medicine Division, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
Am J Physiol 277:R314-9. 1999..The observed short-term hypoxia acclimation responses in these lowlanders clearly differ from the long-term hypoxia adaptations found in brain metabolism of people indigenous to high-altitude environments... - Two research paths for probing the roles of oxygen in metabolic regulationP W Hochachka
Department of Zoology, Radiology, University of British Columbia, Vancouver, Canada
Braz J Med Biol Res 32:661-72. 1999.... - Beta-fibrinogen allele frequencies in Peruvian Quechua, a high-altitude native populationJ L Rupert
Department of Zoology, University of British Columbia, Vancouver, Canada
Am J Phys Anthropol 109:181-6. 1999..Frequencies in the Na-Dene, a Native American group unrelated to the Quechua, were not significantly different from those in Caucasians... - Carbohydrate utilization during exercise after high-altitude acclimation: a new perspectiveG B McClelland
Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Proc Natl Acad Sci U S A 95:10288-93. 1998.... - Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in ratsG B McClelland
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Am J Physiol 277:E1095-102. 1999.... - Effect of brood size manipulation on offspring physiology: an experiment with passerine birdsG P Burness
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
J Exp Biol 203:3513-20. 2000..These individuals also had decreased activity of cardiac 3-hydroxyacyl CoA dehydrogenase, suggesting a decreased capacity for oxidation of fatty acids. How these characters affect survival or the future adult phenotype remains unknown... - Selective pressure has not acted against hypercoagulability alleles in high-altitude AmerindiansJ L Rupert
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, B C, Canada
Ann Hum Genet 67:426-32. 2003..These data do not support the hypothesis that selection has acted to eliminate alleles associated with hypercoagulability in Andean highlanders... - Methylenetetrahydrofolate reductase (MTHFR) allele frequencies in AmerindiansM V Monsalve
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, B C Canada
Ann Hum Genet 67:367-71. 2003.... - Angiotensin-converting enzyme (ACE) alleles in the Quechua, a high altitude South American native populationJ L Rupert
Department of Zoology, University of British Columbia, Vancouver, Canada
Ann Hum Biol 26:375-80. 1999.... - Cellular metabolic homeostasis during large-scale change in ATP turnover rates in musclesP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, Canada
J Exp Biol 200:381-6. 1997..The central regulatory question is how such homeostasis of key intermediates in pathways of energy supply and energy demand is achieved... - Energy turnover in the normoxic and anoxic turtle heartP G Arthur
Department of Zoology, University of British Columbia, Vancouver, Canada
Comp Biochem Physiol A Physiol 117:121-6. 1997..We conclude that long-term cardiac tolerance of hypoxia in this species is more likely related to metabolic depression rather than to an exceptional anaerobic performance... - Cardiovascular adaptations in Andean natives after 6 wk of exposure to sea levelD C McKenzie
Department of Sport Science, Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, Canada
J Appl Physiol 70:2650-5. 1991..01). The results indicate that the removal of these high-altitude-adapted natives from 4,300 m to sea level for 6 wk results in only minor changes to the cardiac structure and function as measured by these noninvasive techniques... - Genetic polymorphisms in the Renin-Angiotensin system in high-altitude and low-altitude Native American populationsJ L Rupert
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
Ann Hum Genet 67:17-25. 2003..There was no evidence for an over-representation of the RAS alleles associated with cardiovascular fitness in the high-altitude Amerindian population when compared to the lowland Amerindian population... - The evidence for hereditary factors contributing to high altitude adaptation in Andean natives: a reviewJ L Rupert
Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
High Alt Med Biol 2:235-56. 2001.... - Mechanism, origin, and evolution of anoxia tolerance in animalsP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, Canada V6T 1Z4
Comp Biochem Physiol B Biochem Mol Biol 130:435-59. 2001..adaptable features in the evolution of the above hypoxia-response physiology in these two specific animal lineages... - Allometric scaling of RNA, DNA, and enzyme levels: an intraspecific studyG P Burness
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4
Am J Physiol 277:R1164-70. 1999..This was supported by a positive correlation between MyoD and PK mRNA levels (r(2) = 0.17, P < 0.05)... - High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exerciseG B McClelland
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Am J Physiol Endocrinol Metab 281:E537-44. 2001.... - Catecholamine stimulation of hepatic glycogenolysis during anoxia in the turtle Chrysemys pictaK M Keiver
Department of Zoology, University of British Columbia, Vancouver, Canada
Am J Physiol 261:R1341-5. 1991..Hepatic glycogen mobilization during anoxia appeared to be stimulated via beta-adrenergic receptors, as propranolol was effective in blocking the stimulation, whereas phentolamine, an alpha-receptor antagonist, was not... - Genetic approaches to understanding human adaptation to altitude in the AndesJ L Rupert
Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, Canada V6T 2B5
J Exp Biol 204:3151-60. 2001..The principles and assumptions underlying the various approaches, as well as some of the inherent strengths and weaknesses of each, are briefly discussed... - Effects of forced diving on the spleen and hepatic sinus in northern elephant seal pupsS J Thornton
Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Proc Natl Acad Sci U S A 98:9413-8. 2001.... - Intracellular convection, homeostasis and metabolic regulationP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
J Exp Biol 206:2001-9. 2003.... - The lactate paradox in human high-altitude physiological performanceP W Hochachka
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
News Physiol Sci 17:122-6. 2002..This paradoxical situation may be caused mainly by upregulated metabolic control contributions from cell ATP demand and ATP supply pathways... - Physiological and biochemical correlates of brood size and energy expenditure in tree swallowsG P Burness
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1S6
J Exp Biol 204:1491-501. 2001..There was no correlation between either brood size or DEE and the mass of any internal organ or the metabolic capacity of the pectoral muscle... - An (1)H-MRS evaluation of the phosphocreatine/creatine pool (tCr) in human muscleM E Trump
Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T-1Z4
Am J Physiol Regul Integr Comp Physiol 280:R889-96. 2001..In addition, these data suggest that in (1)H-MRS studies whose goals include quantitative estimates of tCr pool sizes, standardized metabolic conditions or careful T(2) evaluations will be required... - Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native populationJ L Rupert
Department of Zoology, University of British Columbia, Vancouver, Canada
Ann Hum Genet 64:135-43. 2000..In addition, we sequenced the coding region of the gene in three unrelated Quechua to determine if there were any other polymorphisms common in this population. None were detected...