A K Ho

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes
    A K Ho
    Department of Physiology, University of Alberta, Edmonton, Alta, Canada T6G 2H7
    Biochem Pharmacol 70:1840-50. 2005
  2. ncbi request reprint Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, 7 26 Medical Sciences Building, T6G 2H7, Edmonton, Alberta, Canada
    Biochem Pharmacol 62:1605-11. 2001
  3. ncbi request reprint The role of inducible repressor proteins in the adrenergic induction of arylalkylamine-N-acetyltransferase and mitogen-activated protein kinase phosphatase-1 in rat pinealocytes
    A K Ho
    Department of Medicine, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 148:743-51. 2007
  4. ncbi request reprint Diurnal variation in p42/44 mitogen-activated protein kinase in the rat pineal gland
    A K Ho
    Department of Physiology, Faculty of Medicine, 7 26 Medical Sciences Building, University of Alberta, Edmonton, Alta, Canada T6G 2H7
    Mol Cell Endocrinol 208:23-30. 2003
  5. ncbi request reprint Adrenergic regulation of mitogen-activated protein kinase in rat pinealocytes: opposing effects of protein kinase A and protein kinase G
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Endocrinology 141:4496-502. 2000
  6. ncbi request reprint Intracellular pH on translocation of protein kinase C isozymes in rat pinealocytes
    A K Ho
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 75:1845-51. 2000
  7. ncbi request reprint Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes
    A K Ho
    Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 148:4592-600. 2007
  8. ncbi request reprint Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Chronobiol Int 23:361-7. 2006
  9. ncbi request reprint Timing of mitogen-activated protein kinase (MAPK) activation in the rat pineal gland
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, 7 26 Medical Sciences Building, Edmonton, Alta T6G 2H7, Canada
    Mol Cell Endocrinol 252:34-9. 2006
  10. ncbi request reprint Regulation of 90-kilodalton ribosomal S6 kinase phosphorylation in the rat pineal gland
    A K Ho
    Departments of Physiology and Medicine, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 144:3344-50. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Role of protein turnover in the activation of p38 mitogen-activated protein kinase in rat pinealocytes
    A K Ho
    Department of Physiology, University of Alberta, Edmonton, Alta, Canada T6G 2H7
    Biochem Pharmacol 70:1840-50. 2005
    ..The synthesis of an activator upstream of MKK3/6 is required for the NE-activation of p38MAPK...
  2. ncbi request reprint Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, 7 26 Medical Sciences Building, T6G 2H7, Edmonton, Alberta, Canada
    Biochem Pharmacol 62:1605-11. 2001
    ..These results suggest that the commonly used p38MAPK inhibitors can modulate cyclic nucleotide responses through phosphodiesterase inhibition, a mechanism that appears to be independent of p38MAPK inhibition...
  3. ncbi request reprint The role of inducible repressor proteins in the adrenergic induction of arylalkylamine-N-acetyltransferase and mitogen-activated protein kinase phosphatase-1 in rat pinealocytes
    A K Ho
    Department of Medicine, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 148:743-51. 2007
    ....
  4. ncbi request reprint Diurnal variation in p42/44 mitogen-activated protein kinase in the rat pineal gland
    A K Ho
    Department of Physiology, Faculty of Medicine, 7 26 Medical Sciences Building, University of Alberta, Edmonton, Alta, Canada T6G 2H7
    Mol Cell Endocrinol 208:23-30. 2003
    ..These results indicate the presence of a diurnal difference in MEK1/2 and p42/44(MAPK) phosphorylation in the rat pineal gland that is under adrenergic control...
  5. ncbi request reprint Adrenergic regulation of mitogen-activated protein kinase in rat pinealocytes: opposing effects of protein kinase A and protein kinase G
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Endocrinology 141:4496-502. 2000
    ..These results indicate that the effect of NE on MAPK phosphorylation represents mainly the integration of two signaling mechanisms, protein kinase A and protein kinase G, each having an opposite effect on MAPK phosphorylation...
  6. ncbi request reprint Intracellular pH on translocation of protein kinase C isozymes in rat pinealocytes
    A K Ho
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 75:1845-51. 2000
    ..However, PKC translocation stimulated directly by PMA does not appear to be sensitive to changes in intracellular pH...
  7. ncbi request reprint Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes
    A K Ho
    Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 148:4592-600. 2007
    ..Moreover, both inhibitory and enhancing effects appear to be mediated through specific modification of promoter-bound histones during gene transcription...
  8. ncbi request reprint Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Chronobiol Int 23:361-7. 2006
    ..The effects of the proteasome inhibitors on NE-stimulated Aanat induction appear to be mediated by accumulation of a protein repressor...
  9. ncbi request reprint Timing of mitogen-activated protein kinase (MAPK) activation in the rat pineal gland
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, 7 26 Medical Sciences Building, Edmonton, Alta T6G 2H7, Canada
    Mol Cell Endocrinol 252:34-9. 2006
    ..Taken together, our studies on the timing of MAPK activation and regulation of AA-NAT by MAPKs add to the importance of MAPKs in regulating the circadian biology of the pineal gland...
  10. ncbi request reprint Regulation of 90-kilodalton ribosomal S6 kinase phosphorylation in the rat pineal gland
    A K Ho
    Departments of Physiology and Medicine, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 144:3344-50. 2003
    ..These results indicate that the adrenergically regulated nocturnal increase in p90RSK phosphorylation is mainly mediated through a cGMP-->p42/44(MAPK)-dependent mechanism...
  11. ncbi request reprint Ceramide inhibits L-type calcium channel currents in rat pinealocytes
    C L Chik
    Department of Physiology and Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Endocrinology 140:5682-90. 1999
    ..These results indicate that the sphingomyelin pathway is another important signaling mechanism that regulates the L-type Ca2+ channel, and tyrosine kinase appears to be involved in the effect of ceramide...
  12. ncbi request reprint cGMP inhibits L-type Ca2+ channel currents through protein phosphorylation in rat pinealocytes
    C L Chik
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Neurosci 15:3104-9. 1995
    ....
  13. ncbi request reprint The role of protein turnover in regulating MKP-1 levels in rat pinealocytes
    D M Price
    Department of Physiology, University of Alberta, 7 26 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
    Mol Cell Endocrinol 263:134-41. 2007
    ....
  14. doi request reprint Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription
    R Kanyo
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 150:4221-30. 2009
    ..These findings support a role for SIK1 in framing the temporal expression profile of Aa-nat and other adrenergic-regulated genes in the rat pineal gland...
  15. ncbi request reprint Histone H3 phosphorylation in the rat pineal gland: adrenergic regulation and diurnal variation
    C L Chik
    Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 148:1465-72. 2007
    ..This transient histone H3 phosphorylation probably reflects the nocturnal activation of multiple adrenergic-regulated genes in the rat pineal gland...
  16. doi request reprint Nocturnal activation of aurora C in rat pineal gland: its role in the norepinephrine-induced phosphorylation of histone H3 and gene expression
    D M Price
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 150:2334-41. 2009
    ..This phenomenon suggests that activation of this mitotic kinase can be induced by extracellular signals to participate in the transcriptional induction of a subset of genes in the rat pineal gland...
  17. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase enhances adrenergic-stimulated arylalkylamine N-acetyltransferase activity in rat pinealocytes
    J R Man
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada T6G 2H7
    Endocrinology 145:1167-74. 2004
    ..The lack of effect on NE-stimulated MT accumulation by p38(MAPK) inhibitors in the absence of 5-methoxytryptamine could be secondary to a lack of substrate, or alternatively, hydroxyindole-O-methyltransferase may become limiting...
  18. ncbi request reprint Adrenergic regulation and diurnal rhythm of p38 mitogen-activated protein kinase phosphorylation in the rat pineal gland
    C L Chik
    Department of Physiology, 7 26 Medical Sciences Building, Edmonton, Alberta, Canada
    Endocrinology 145:5194-201. 2004
    ..Together, our results indicate that activation of p38MAPK is under photoneural control in the rat pineal gland and that protein kinase A and intracellular Ca(2+) signaling pathways are involved in NE regulation of p38MAPK...
  19. doi request reprint Adrenergic regulation of the distribution of transducer of regulated cAMP-response element-binding protein (TORC2) in rat pinealocytes
    R Kanyo
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 152:3440-50. 2011
    ....
  20. doi request reprint Sustained adrenergic stimulation is required for the nuclear retention of TORC1 in male rat pinealocytes
    J McTague
    Department of Physiology, 7 26 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 154:3240-50. 2013
    ..Together, these results demonstrate that, in the rat pineal gland, different mechanisms are involved in regulating the nuclear entry and exit of TORC1 and that the SIK1-mediated phosphorylation of TORC1 may not lead to its nuclear exit...
  21. ncbi request reprint The role of repressor proteins in the adrenergic induction of type II iodothyronine deiodinase in rat pinealocytes
    C L Chik
    Department of Physiology, Faculty of Medicine and Dentistry, 7 26 Medical Sciences Building, Edmonton, University of Alberta, Canada T6G 2H7
    Endocrinology 148:3523-31. 2007
    ..Together, our results support Fra-2 as an important transcriptional repressor that helps shape the time profile of the adrenergic induction of Dio2 expression in the rat pineal gland...
  22. ncbi request reprint Thapsigargin modulates agonist-stimulated cyclic AMP responses through cytosolic calcium-dependent and -independent mechanisms in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Mol Pharmacol 49:1104-12. 1996
    ....
  23. doi request reprint Different signaling mechanisms are involved in the norepinephrine-stimulated TORC1 and TORC2 nuclear translocation in rat pinealocytes
    J McTague
    Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Endocrinology 153:3839-49. 2012
    ..Together these results highlight different intracellular signaling pathways that are involved in the NE-stimulated dephosphorylation and translocation of TORC1 and TORC2 in rat pinealocytes...
  24. ncbi request reprint Ceramide inhibits the outward potassium current in rat pinealocytes
    C L Chik
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 79:339-48. 2001
    ..Moreover, protein kinase C appears to be the main kinase involved in the ceramide inhibition of I(KCa)...
  25. ncbi request reprint 3',5'-cyclic guanosine monophosphate activates mitogen-activated protein kinase in rat pinealocytes
    A K Ho
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    J Neurochem 73:598-604. 1999
    ..Our results indicate that, in this neuroendocrine tissue, the cGMP/PKG signaling pathway is an important mechanism used by hormones and neurotransmitters in activating MAPK...
  26. ncbi request reprint Ceramide inhibits L-type calcium channel currents in GH3 cells
    C L Chik
    Department of Medicine, 7 33 Medical Sciences Building, Edmonton, Alta, Canada T6G 2H7
    Mol Cell Endocrinol 218:175-83. 2004
    ..These results indicate that ceramide, a lipid messenger of the sphingomyelin pathway, is an important regulator of the L-channel in GH3 cells and both tyrosine kinase and PKC are involved in this effect of ceramide...
  27. ncbi request reprint L-type Ca(2+) channel regulation by pituitary adenylate cyclase-activating polypeptide in vascular myocytes from spontaneously hypertensive rats
    B Li
    Departments of Physiology and Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Endocrinology 142:2865-73. 2001
    ..This difference in PACAP response appears to be predominately secondary to an increased PKC sensitivity...
  28. pmc Activation of bovine tracheal chloride channels by amino group-specific reagents
    M Duszyk
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Physiol 512:129-36. 1998
    ..These residues may present an important target for site-directed mutagenesis and pharmacological activation of Cl- channels in epithelial cells...
  29. ncbi request reprint Ceramide enhances growth hormone (GH)-releasing hormone-stimulated cyclic adenosine 3',5'-monophosphate accumulation but inhibits GH release in rat anterior pituitary cells
    T Negishi
    Department of Physiology, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Endocrinology 140:5691-7. 1999
    ..By reducing GH secretion while enhancing cAMP accumulation, ceramide may promote the synthesis and storage of GH in rat anterior pituitary cells...
  30. ncbi request reprint Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase
    W Zheng
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore MD 21205, USA
    Chem Biol 8:379-89. 2001
    ....
  31. ncbi request reprint Development and regulation of rhodopsin kinase in rat pineal and retina
    A K Ho
    J Neurochem 46:1176-9. 1986
    ..The finding of neural control of pineal rhodopsin kinase in the pineal gland of adult rats is consistent with a function of the enzyme in the neural regulation of pineal function...