Gideon M Hirschfield

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Primary biliary cirrhosis: one disease with many faces
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Isr Med Assoc J 13:55-9. 2011
  2. doi request reprint Preventative hepatology: minimising symptoms and optimising care
    Gideon M Hirschfield
    Toronto Western Hospital, University Health Network, University of Toronto, ON, Canada
    Liver Int 28:922-34. 2008
  3. doi request reprint Progress in the genetics of primary biliary cirrhosis
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital and Department of Medicine, University of Toronto, Ontario, Canada
    Semin Liver Dis 31:147-56. 2011
  4. ncbi request reprint Cholestasis and cholestatic syndromes
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 25:175-9. 2009
  5. pmc Current status of therapy in autoimmune liver disease
    Gideon M Hirschfield
    Toronto Western Hospital, Toronto, Canada
    Therap Adv Gastroenterol 2:11-28. 2009
  6. doi request reprint Diagnosis of primary biliary cirrhosis
    Gideon M Hirschfield
    Department of Medicine, University of Toronto, Canada
    Best Pract Res Clin Gastroenterol 25:701-12. 2011
  7. pmc Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    Xiangdong Liu
    University Health Network, Toronto, Ontario, Canada
    Nat Genet 42:658-60. 2010
  8. pmc Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Nat Genet 42:655-7. 2010
  9. doi request reprint Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis
    Teru Kumagi
    Liver Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
    Am J Gastroenterol 105:2186-94. 2010
  10. doi request reprint CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population
    Erin J Walker
    University of Toronto, Toronto General Hospital, and Mount Sinai Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 60:931-7. 2009

Detail Information

Publications24

  1. ncbi request reprint Primary biliary cirrhosis: one disease with many faces
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Isr Med Assoc J 13:55-9. 2011
    ..In this review we highlight these features of PBC in comparison to other autoimmune diseases...
  2. doi request reprint Preventative hepatology: minimising symptoms and optimising care
    Gideon M Hirschfield
    Toronto Western Hospital, University Health Network, University of Toronto, ON, Canada
    Liver Int 28:922-34. 2008
    ....
  3. doi request reprint Progress in the genetics of primary biliary cirrhosis
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital and Department of Medicine, University of Toronto, Ontario, Canada
    Semin Liver Dis 31:147-56. 2011
    ..Identification of risk loci associated with disease has the potential to aid development of rational, disease-specific, therapies in the future...
  4. ncbi request reprint Cholestasis and cholestatic syndromes
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 25:175-9. 2009
    ..Cholestatic liver injury is encountered across a wide variety of clinical scenarios ranging from toxin-induced, genetic, to autoimmune in nature. This review summarizes recent findings from what is a burgeoning clinical field...
  5. pmc Current status of therapy in autoimmune liver disease
    Gideon M Hirschfield
    Toronto Western Hospital, Toronto, Canada
    Therap Adv Gastroenterol 2:11-28. 2009
    ..With better biological understanding, more specific interventions are expected that will benefit all those with autoimmune liver diseases...
  6. doi request reprint Diagnosis of primary biliary cirrhosis
    Gideon M Hirschfield
    Department of Medicine, University of Toronto, Canada
    Best Pract Res Clin Gastroenterol 25:701-12. 2011
    ....
  7. pmc Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
    Xiangdong Liu
    University Health Network, Toronto, Ontario, Canada
    Nat Genet 42:658-60. 2010
    ..9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38)...
  8. pmc Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Nat Genet 42:655-7. 2010
    ..Fine-mapping studies showed that a single variant accounts for the IRF5-TNPO3 association. As these loci are implicated in other autoimmune conditions, these findings confirm genetic overlap among such diseases...
  9. doi request reprint Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosis
    Teru Kumagi
    Liver Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
    Am J Gastroenterol 105:2186-94. 2010
    ..We sought to develop clinically meaningful markers for those with predominantly early disease at risk of progressive liver damage...
  10. doi request reprint CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population
    Erin J Walker
    University of Toronto, Toronto General Hospital, and Mount Sinai Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 60:931-7. 2009
    ..We undertook this study to examine whether CTLA4 and ICOS influence RA and PBC susceptibility by testing CTLA4/ICOS polymorphisms for association with these diseases in Canadian subjects...
  11. doi request reprint Patients with autoimmune hepatitis who have antimitochondrial antibodies need long-term follow-up to detect late development of primary biliary cirrhosis
    Amreen M Dinani
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Gastroenterol Hepatol 10:682-4. 2012
    ....
  12. doi request reprint Pathogenesis of cholestatic liver disease and therapeutic approaches
    Gideon M Hirschfield
    Liver Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Gastroenterology 139:1481-96. 2010
    ..These discoveries will hopefully lead to new therapeutic approaches for patients with cholestatic liver disease...
  13. doi request reprint Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus
    Darryl Huang
    Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, Ontario, Canada
    J Rheumatol 39:254-61. 2012
    ....
  14. doi request reprint The spectrum of sclerosing cholangitis and the relevance of IgG4 elevations in routine practice
    Khalid Alswat
    Liver Centre, Toronto Western Hospital, Ontario, Canada
    Am J Gastroenterol 107:56-63. 2012
    ..American Association for the Study of Liver Diseases (AASLD) guidance recommends measurement of IgG4 in patients with sclerosing cholangitis (SC). The objective of this study was to evaluate this by analyzing our SC practice...
  15. doi request reprint The specificity of fatigue in primary biliary cirrhosis: evaluation of a large clinic practice
    Nadya Al-Harthy
    Liver Centre, Toronto Western Hospital, University Health Network and Department of MEdicine, University of Toronto, Toronto, Canada
    Hepatology 52:562-70. 2010
    ..Biochemical response to UDCA was not associated with lower fatigue scores. Conclusion: Attempts at defining the biological basis of fatigue in patients with PBC, and improving its treatment, must account for its multifactoral causes...
  16. doi request reprint Improvement of ischemic cholangiopathy in three patients with hereditary hemorrhagic telangiectasia following treatment with bevacizumab
    Paraskevi A Vlachou
    Department of Diagnostic Imaging, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8
    J Hepatol 59:186-9. 2013
    ....
  17. pmc Wilson disease: Canadian perspectives on presentation and outcomes from an adult ambulatory setting
    A Moores
    Toronto Western Hospital, Toronto, Ontario
    Can J Gastroenterol 26:333-9. 2012
    ..Wilson disease (WD) is a rare disorder of copper metabolism...
  18. doi request reprint IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations
    Paraskevi A Vlachou
    Department of Medical Imaging and Pathology, University of Toronto, Toronto, Canada
    Radiographics 31:1379-402. 2011
    ..It is important to recognize multiorgan involvement of IgG4-related sclerosing disease and be familiar with its clinical and imaging features because it demonstrates a favorable response to treatment...
  19. doi request reprint The phenotypic expression of inflammatory bowel disease in patients with primary sclerosing cholangitis differs in the distribution of colitis
    David F Schaeffer
    Department of Laboratory Medicine and Pathology, Toronto General Hospital, University of Toronto, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada
    Dig Dis Sci 58:2608-14. 2013
    ..However, no dedicated studies evaluating patterns of presentation of liver disease with respect to IBD are available...
  20. doi request reprint Identifying opportunities to improve management of autoimmune hepatitis: evaluation of drug adherence and psychosocial factors
    Sanjeev Sockalingam
    University Health Network, Program in Medical Psychiatry, Canada
    J Hepatol 57:1299-304. 2012
    ..We sought to determine the association between anxiety, depressive symptoms, and avoidant relationship style on self-reported immunosuppressant medication adherence and treatment response in patients with AIH...
  21. doi request reprint Biliary atresia and survival into adulthood without transplantation: a collaborative multicentre clinic review
    Teru Kumagi
    Toronto Western Hospital, Toronto, Canada
    Liver Int 32:510-8. 2012
    ..Biliary atresia is a progressive biliary injury which occurs only in infants...
  22. pmc Autoantibodies and liver disease: uses and abuses
    Marilyn V Zeman
    Liver Centre, Toronto Western Hospital University Health Network and the Department of Medicine, University of Toronto, Ontario
    Can J Gastroenterol 24:225-31. 2010
    ....
  23. pmc Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants
    Gideon M Hirschfield
    University of Toronto and Liver Center, Toronto Western Hospital, Toronto, ON, Canada
    N Engl J Med 360:2544-55. 2009
    ..Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown...
  24. ncbi request reprint New insights into autoimmune liver diseases
    Teru Kumagi
    Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Hepatol Res 38:745-61. 2008
    ..The challenges remain to treat patients before liver injury becomes permanent and to prevent the development of organ failure...