Research Topics
Genomes and Genes
| Richard P HillSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Investigations into the role of inflammation in normal tissue response to irradiationRichard Peter Hill
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
Radiother Oncol 101:73-9. 2011..Radiation-induced inflammation and production of reactive oxygen species (ROS) play a critical role in normal tissue response. In this study we have examined some aspects of these effects in lung and skin...- Studies of the in vivo radiosensitivity of human skin fibroblastsRichard P Hill
Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Ave, Toronto, Ont, Canada M5G 2M9
Radiother Oncol 84:75-83. 2007.... 
Identifying cancer stem cells in solid tumors: case not provenRichard P Hill
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Cancer Res 66:1891-5; discussion 1890. 2006..The case that a small proportion of cells in solid tumors are specific cancer stem cells and that these cells can be successfully identified and isolated has not yet been proven...- Is there a relationship between repopulation and hypoxia/reoxygenation? Results from human carcinoma of the cervixR P Hill
Department of Research, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Canada
Int J Radiat Biol 79:487-94. 2003..There was also no evidence that a combination of kinetic and reoxygenation measurements could be predictive of treatment outcome... - "Destemming" cancer stem cellsRichard P Hill
Ontario Cancer Institute Princess Margaret Hospital, University Health Network, and Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Canada M5G2M9
J Natl Cancer Inst 99:1435-40. 2007.... 
Cancer stem cells, hypoxia and metastasisRichard P Hill
Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Semin Radiat Oncol 19:106-11. 2009....- Effects of genistein following fractionated lung irradiation in miceAndrea E Para
Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
Radiother Oncol 92:500-10. 2009..This study investigated protection of lung injury by genistein following fractionated doses of radiation and its effect on tumor response... - Interstitial permeability and elasticity in human cervix cancerMichael Milosevic
Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
Microvasc Res 75:381-90. 2008..Serial evaluation of these parameters may provide a means of clinically monitoring response to treatments that specifically target the tumor microenvironment... - Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activityJohn M Akudugu
Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ont, Canada
Radiother Oncol 78:17-26. 2006..TGF-beta levels in culture do not predict WHC, suggesting that the role of TGF-beta in wound healing is likely controlled by other in vivo factors... - Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumorsNaz Chaudary
Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, ON, Canada
Lab Invest 89:587-96. 2009..The technique can be applied to identify other potential 'hypoxia-related' genes of interest for tumor growth and metastasis... - Genistein can mitigate the effect of radiation on rat lung tissueVictoria L Calveley
Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2M9, Canada
Radiat Res 173:602-11. 2010.... - Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IXVladimir V Iakovlev
Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
Lab Invest 87:1206-17. 2007..However, CAIX was inferior to pO2 measurements as a tool for patient stratification. Improved analytical methods to account for intratumoral heterogeneity are needed to provide reliable measurements of molecular markers... - Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcomaKårstein Måseide
Ontario Cancer Institute Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Clin Cancer Res 10:4464-71. 2004..The aim of this study was to quantify the extent of CA IX expression and to investigate whether CA IX is a marker for poor prognosis in soft tissue sarcoma patients at high risk of developing metastasis... - Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapyJohn M Akudugu
Division of Experimental Therapeutics, Ontario Cancer Institute/Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Canada
Radiother Oncol 72:103-12. 2004.... - Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancerMichael Milosevic
Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9
Clin Cancer Res 18:2108-14. 2012..The aim of this study was to determine the effect of hypoxia in patients with prostate cancer treated with radiotherapy... - Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivoNirmal Bhogal
Applied Molecular Oncology and Radiation Medicine Program, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Radiat Res 173:1-9. 2010..This technique may be a useful biodosimeter to determine dose at times up to 1 week after accidental or catastrophic radiation exposure in vivo... - Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcomaKårstein Måseide
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9
Pathol Res Pract 204:175-83. 2008..This suggests that TMAs can be used to detect even heterogeneous and sparse markers, but the sampling strategy should be validated for the marker under investigation... - Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinomaMichelle L Gervais
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Lab Invest 87:1252-64. 2007..These findings provide the first evidence of aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, and suggest potential prognostic value of VHL and E-cadherin in CC-RCC... - Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasionLi Zhang
Research Division, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Cancer Res 67:7789-97. 2007..However, this effect was not due to down-regulation of hypoxia-inducible factor-1alpha, a mechanism of action of this drug reported by previous studies. Further detailed studies of the mechanisms of action of the drug are needed... - Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimeticAimée R Langan
Research Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
Radiother Oncol 79:231-8. 2006..The particular focus of these studies was the efficacy of EUK-189 when given after irradiation (mitigation)... - Biodosimetry using radiation-induced micronuclei in skin fibroblastsPavel Kaspler
Ontario Cancer Institute Princess Margaret Hospital, University Health Network and Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
Int J Radiat Biol 87:824-38. 2011..We assessed micronuclei in dermal fibroblasts as a local biodosimeter for estimating accidental in vivo radiation exposure... - Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumoursSarah Jane Lunt
Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
BMC Cancer 8:2. 2008.... - Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxiaKaren Lim
Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
Int J Radiat Oncol Biol Phys 70:126-33. 2008.... - Hypoxia-regulated p53 and its effect on radiosensitivity in cancer cellsLi Zhang
Research Division, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Ontario, Canada
Int J Radiat Biol 83:443-56. 2007..To determine the response of tumor suppressor p53 to hypoxia in different tumor cell lines and the involvement of p53 activity regulation in the effect of hypoxia on tumor cell sensitivity to radiation and hyperthermia... - Progression and metastasis in a transgenic mouse breast cancer model: effects of exposure to in vivo hypoxiaTuula M Kalliomäki
Applied Molecular Oncology Division, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada
Cancer Lett 282:98-108. 2009.... - Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiationNaz Chaudary
Ontario Cancer Institute Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
Cancer 118:3105-15. 2012.... - Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesisSarah Jane Lunt
Division of Applied Molecular Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada
Future Oncol 4:793-802. 2008..Pretreatment interstitial fluid pressure and the change in pressure during treatment may provide important predictive information that in the future will be used to optimize therapy in individual patients... - Gold nanoparticles as radiation sensitizers in cancer therapyDevika B Chithrani
STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada
Radiat Res 173:719-28. 2010..The outcome of this research will enable the optimization of gold nanoparticle-based sensitizers for use in therapy... - Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53Stephane Supiot
Princess Margaret Hospital University Health Network, Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Mol Cancer Ther 7:993-9. 2008..Nutlin-3 may be a useful adjunct to improve the therapeutic ratio using precision radiotherapy targeted to hypoxic cells and warrants further study in vivo... - Pretreatment proliferation parameters do not add predictive power to clinical factors in cervical cancer treated with definitive radiation therapyRichard W Tsang
Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, M5G 2M9 Canada
Clin Cancer Res 9:4387-95. 2003..We report an update of a prospective study focusing on whether pretreatment proliferation parameters are associated with clinical outcome, relative to other established clinical factors... - Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiationPavel Kaspler
Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, 610, University Ave, Toronto, Ontario, Canada, M5G2M9
Health Phys 98:228-33. 2010..Percentage of multimicronucleated cells may be useful as a substitute of total MN at the higher doses, but total percentage of micronucleated cells is of limited value as a substitute... - Heterogeneity and power in clinical biomarker studiesMelania Pintilie
Department of Biostatistics, Radiation Medicine Program, and the Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Canada
J Clin Oncol 27:1517-21. 2009..Due to this heterogeneous distribution of the biomarker, the association sought may appear weak or nonexistent. Thus, there is a wide range of conclusions in the literature on the association between a biomarker and an outcome... - Beta-catenin is a mediator of the response of fibroblasts to irradiationAnanta Gurung
Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada
Am J Pathol 174:248-55. 2009..beta-Catenin mediates the effects of ionizing radiation in fibroblasts, and its modulation has the potential to decrease the severity of radiation-induced soft tissue complications... - Hypoxia and metabolism. Hypoxia, DNA repair and genetic instabilityRobert G Bristow
Departments of Medical Biophysics and Radiation Oncology, University of Toronto and Ontario Cancer Institute and Princess Margaret Hospital University Health Network, 610 University Avenue, Toronto, Ontario, M5G2M9, Canada
Nat Rev Cancer 8:180-92. 2008..Acute and chronic hypoxia might lead to different biology within the tumour and this might have a direct effect on the design of new therapies for the treatment of hypoxic tumours... - Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancerAnthony Fyles
Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, Canada
Radiother Oncol 80:132-7. 2006..Using data from our prospective trial, we updated a cohort of patients treated with definitive radiation alone without chemotherapy, to assess the long-term prognostic impact of these microenvironmental features... - Mitigation of radiation-induced lung injury by genistein and EUK-207Javed Mahmood
Ontario Cancer Institute Princess Margaret Hospital, University Health Network, and the Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
Int J Radiat Biol 87:889-901. 2011..We examined the effects of genistein and/or Eukarion (EUK)-207 on radiation-induced lung damage and investigated whether treatment for 0-14 weeks (wks) post-irradiation (PI) would mitigate late lung injury... - Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiationVictoria L Calveley
Research Division, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Canada
Int J Radiat Biol 81:887-99. 2005..We examined temporal fluctuations in DNA damage, cytokine expression and macrophage activation during 16 weeks post-irradiation... - Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer modelTuula M Kalliomäki
Applied Molecular Oncology Division, Ontario Cancer Institute Princess Margaret Hospital, Canada
BMC Cancer 8:151. 2008..Both of these features are commonly found in many cancer types, but their relationship and association with tumour progression has not been examined in the same model... - Estimating hypoxic status in human tumors: a simulation using Eppendorf oxygen probe data in cervical cancer patientsCorinne M Doll
Department of Radiation Oncology, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 55:1239-46. 2003..The results of this study will serve as a guide for research clinicians in the use of this and other systems in the assessment of tumor oxygenation in humans... - The tumor microenvironment and metastatic diseaseSarah Jane Lunt
Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, OCI PMH, Toronto, ON, Canada
Clin Exp Metastasis 26:19-34. 2009.... - PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-statusStephane Supiot
Princess Margaret Hospital University Health Network, Toronto, Canada
Radiother Oncol 86:407-11. 2008..Radiosensitization was observed in PC3 (p53Null) cells, even under hypoxia. In certain circumstances, PRIMA-1(met) may therefore act independently of MTp53 status and WTp53 transactivation... - Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cellsPatrick Subarsky
Applied Molecular Oncology Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
Clin Exp Metastasis 25:253-64. 2008..This study demonstrates cell line specific effects of graded oxygen levels on invasive potential and suggests that intermediate levels of low oxygen may increase metastatic dissemination... - Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumorsJulia V Skliarenko
Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
Cancer Res 66:2074-80. 2006..The higher cell survival in high IFP tumors may reflect greater microregional blood flow limitations in these tumors and reduced access of the drug to the target endothelial cells... - Polarographic electrode study of tumor oxygenation in clinically localized prostate cancerChris Parker
Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada
Int J Radiat Oncol Biol Phys 58:750-7. 2004..HP(5), as determined in this study, should adequately discriminate among patients with prostate cancer and allow the independent prognostic significance of oxygenation to be evaluated once the study matures... - Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengersMohammed A Khan
Research Division, Ontario Cancer Institute/Princess Margaret Hospital, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Radiother Oncol 66:95-102. 2003.... - Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosisLi Zhang
Research Division, Ontario Cancer Institute/Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
Cancer Res 64:4180-9. 2004..These data suggest that hypoxia can increase tumor cell metastatic efficiency by rendering the tumor cells less sensitive to stress-induced cell death, e.g., through modifying the levels of Mdm2 and p53... - Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosisAileen M Davis
Research Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario M5G 2A2, Canada
Int J Radiat Oncol Biol Phys 60:286-94. 2004.... - Orthotopic xenograft model of cervical cancer for studying microenvironmental effects on metastasis formation and response to drug treatmentNaz Chaudary
Ontario Cancer Institute Princess Margaret Hospital, Campbell Family Institute for Cancer Research and University of Toronto, Toronto, Ontario, Canada
Curr Protoc Pharmacol . 2011..Described in this unit is a surgical technique for orthotopic implantation and the use of this model for investigating the effects of novel agents as inhibitors of tumor growth and metastasis... - A fluorescent orthotopic model of metastatic cervical carcinomaRob A Cairns
Experimental Therapeutics Division, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada
Clin Exp Metastasis 21:275-81. 2004..This model should allow for a more relevant investigation of the factors that affect the metastasis of cervical carcinoma and presents an opportunity to evaluate potential therapeutic strategies designed to prevent the spread of disease... - Hypoxia and metastasis in breast cancerNaz Chaudary
Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada
Breast Dis 26:55-64. 2006..An understanding of the molecular pathways in hypoxia-induced breast cancer metastasis promises potential useful prognostic and therapeutic information... - Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinomaRob A Cairns
Experimental Therapeutics Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Cancer Res 64:2054-61. 2004..These results suggest that fluctuating oxygenation in cervical carcinoma tumors may reduce tumor growth rate, but it may also enhance the ability of tumor cells to metastasize to local lymph nodes... - Suppression of vascular endothelial growth factor receptor 3 (VEGFR3) and vascular endothelial growth factor C (VEGFC) inhibits hypoxia-induced lymph node metastases in cervix cancerNaz Chaudary
The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
Gynecol Oncol 123:393-400. 2011..Our previous studies showed that growth of these tumors under conditions of cyclic hypoxia increased nodal metastasis... - The hypoxic tumour microenvironment and metastatic progressionPatrick Subarsky
Experimental Therapeutics Divison, Ontario Cancer Institute/Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Canada
Clin Exp Metastasis 20:237-50. 2003..Here we review the epigenetic control of gene expression by the hypoxic microenvironment and its potential contribution to metastatic progression... - Relations between non-protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinomaDavid W Hedley
Department of Medical Oncology and Hematology, Toronto, ON, Canada
Int J Radiat Oncol Biol Phys 61:137-44. 2005..The levels of NPSH in the nucleus are predicted to be more important than those in cytoplasm. We, therefore, investigated the relation between nuclear NPSH and the clinical outcome of radical radiotherapy (RT)... - Effect of radiation and cell implantation on wound healing in a rat modelDale Dantzer
The Samuel Lunenfeld Research Institute, Sinai Hospital, Toronto, Ontario, Canada
J Surg Oncol 83:185-90. 2003..CONCLUSIONS: Cell implantation holds promise for decreasing the effect of radiation on healing of irradiated wounds... - Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft modelsNhu An Pham
Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada
Int J Cancer 124:280-6. 2009..These results show that signaling pathways are responsive to tumor hypoxia in vivo, although the effects appear to differ between individual tumor types... - The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapyR G Bristow
Department of Radiation Oncology, University of Toronto, Canada
Radiother Oncol 40:197-223. 1996.... - Normal tissue radiobiology: from the laboratory to the clinicR P Hill
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 49:353-65. 2001..The symposium highlights the complexities of the radiobiology of late normal tissue responses, yet provides evidence and ideas about how the clinical problem of such responses may be modified or alleviated... - Effects of lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiationAsif Zaidi
Ontario Cancer Institute, Toronto, Ontario, Canada
Radiother Oncol 105:341-9. 2012..The aim of the present study was to examine whether additive LPS exposure in the lung (to simulate respiratory infection) would affect pneumonitis or fibrosis associated with lung irradiation... - Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stressKathrin Zaugg
The Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Ontario, Canada
Genes Dev 25:1041-51. 2011..Our results indicate that cells can use a novel mechanism involving CPT1C and FA metabolism to protect against metabolic stress. CPT1C may thus be a new therapeutic target for the treatment of hypoxic tumors... - pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor developmentNatalie H Stickle
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Mol Cell Biol 24:3251-61. 2004..These results suggest that NEDD8 modification of pVHL plays an important role in fibronectin matrix assembly and that in the absence of such regulation, an intact HIF pathway is insufficient to prevent VHL-associated tumorigenesis... - Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenationHans Kristian Haugland
Department of Medical Biophysics, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 53:854-61. 2002..CONCLUSION: Our results suggest that HIF-1alpha expression may represent a useful biologic marker for hypoxia in uterine cervical cancer... - Hypoxia and metastasisNaz Chaudary
Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Clin Cancer Res 13:1947-9. 2007 - Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53Robert G Bristow
Department of Radiation Oncology, University of Toronto, The Princess Margaret Hospital UHN Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
Oncogene 22:2960-6. 2003..Our results support the concept that gain of MTp53pro193 function leads to the selection of dominant clones, which may exhibit cellular resistance following cancer therapy... - High-resolution in-vivo analysis of normal brain response to cranial irradiationKelly Burrell
Brain Tumor Research Centre, SickKids Research Institute, Toronto, Canada
PLoS ONE 7:e38366. 2012.... - A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell linesJ A Chiarotto
Research Department, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Canada
Br J Cancer 80:1518-24. 1999..Stirring in suspension culture was found to induce VEGF mRNA in SiHa cells. The presence of VEGF mRNA may be a marker for radiobiologic hypoxia... - Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivoKatherine A Vallis
Department of Radiation Oncology, University of Toronto, Ontario M5G 2M9, Canada
Radiat Res 157:8-18. 2002..Similar strategies may facilitate the discovery and characterization of genes involved in other cellular stress responses... - Dynamics of micronuclei in rat skin fibroblasts after X irradiationP Kaspler
Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Department of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Radiat Res 172:106-13. 2009..Further studies are needed to define the dose-response relationship in detail... - pH, hypoxia and metastasisR P Hill
Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, Canada
Novartis Found Symp 240:154-65; discussion 165-8. 2001..Recent studies have implicated a number of genes, such as vascular endothelial growth factor and interleukin 8, in the effect of hypoxic and acid pH on metastasis... - Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumorsR A Cairns
Experimental Therapeutics Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 Canada
Cancer Res 61:8903-8. 2001..This study describes a novel method for studying the effects of hypoxia in solid tumors and demonstrates that acute and chronic hypoxia can have different effects on tumor cell behavior in vivo... - Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342S D Young
Physics Division, Ontario Cancer Institute, Toronto, Canada
Br J Cancer 60:715-21. 1989.... - The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysisM F Milosevic
Department of Radiation Oncology and Experimental Therapeutics, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
Int J Radiat Oncol Biol Phys 43:1111-23. 1999..To examine the hypothesis that elevated interstitial fluid pressure (IFP) is a cause of reduced blood flow in tumors... - Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- miceW Cruz-Munoz
Ontario Cancer Research, University of Toronto, Toronto, Ontario, Canada
Oncogene 25:6489-96. 2006..TIMP-3 regulates MMP-2 activation to limit tumor cell extravasation and subsequent colonization of the lung, without augmenting inflammatory cell response... - Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell linesT Kalliomaki
Experimental Therapeutics Division, Ontario Cancer Institute Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Br J Cancer 90:1842-9. 2004..This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines... - Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancerA Fyles
Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
J Clin Oncol 20:680-7. 2002..This prospective clinical study was begun in 1994 to validate the independent prognostic impact of tumor hypoxia in patients with cervix cancer treated with definitive radiation therapy... - Partial volume rat lung irradiation: an evaluation of early DNA damageM A Khan
The Ontario Cancer Institute Princess Margaret Hospital and the Department of Medical Biophysics, University of Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 40:467-76. 1998..2. To determine the variation in DNA damage in different lung regions. 3. To investigate the possible mechanisms associated with early DNA damage after lung irradiation... - Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapyJames L Tatum
National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
Int J Radiat Biol 82:699-757. 2006.... - Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domainMartijn P Lolkema
Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Biol Chem 280:22205-11. 2005..We propose that phosphorylation of the acidic domain plays a role in the regulation of proper fibronectin matrix deposition and that this may be relevant for the development of VHL-associated malignancies... - Targeted treatment: insights from studies of osteopontin and hypoxiaRichard P Hill
Lancet Oncol 6:733-4. 2005 - Low-dose radiation effects on human health with implications to radioprotection and cancer radiotherapyK P Mishra
United Research Institute for Science and Technology (URIST, Naini, Allahabad, Uttar Pradesh, India and United Institute of Technology, Naini
Int J Radiat Biol 84:441-4. 2008