Richard P Hill

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
    T Kalliomaki
    Experimental Therapeutics Division, Ontario Cancer Institute Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Br J Cancer 90:1842-9. 2004
  2. pmc Investigations into the role of inflammation in normal tissue response to irradiation
    Richard Peter Hill
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 101:73-9. 2011
  3. pmc Studies of the in vivo radiosensitivity of human skin fibroblasts
    Richard P Hill
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Ave, Toronto, Ont, Canada M5G 2M9
    Radiother Oncol 84:75-83. 2007
  4. ncbi request reprint "Destemming" cancer stem cells
    Richard P Hill
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, and Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Canada M5G2M9
    J Natl Cancer Inst 99:1435-40. 2007
  5. ncbi request reprint Identifying cancer stem cells in solid tumors: case not proven
    Richard P Hill
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 66:1891-5; discussion 1890. 2006
  6. ncbi request reprint Is there a relationship between repopulation and hypoxia/reoxygenation? Results from human carcinoma of the cervix
    R P Hill
    Department of Research, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Canada
    Int J Radiat Biol 79:487-94. 2003
  7. ncbi request reprint Cancer stem cells, hypoxia and metastasis
    Richard P Hill
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Semin Radiat Oncol 19:106-11. 2009
  8. doi request reprint Effects of genistein following fractionated lung irradiation in mice
    Andrea E Para
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
    Radiother Oncol 92:500-10. 2009
  9. doi request reprint Interstitial permeability and elasticity in human cervix cancer
    Michael Milosevic
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Microvasc Res 75:381-90. 2008
  10. ncbi request reprint Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity
    John M Akudugu
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ont, Canada
    Radiother Oncol 78:17-26. 2006

Collaborators

Detail Information

Publications86

  1. pmc Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
    T Kalliomaki
    Experimental Therapeutics Division, Ontario Cancer Institute Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Br J Cancer 90:1842-9. 2004
    ..This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines...
  2. pmc Investigations into the role of inflammation in normal tissue response to irradiation
    Richard Peter Hill
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 101:73-9. 2011
    ..Radiation-induced inflammation and production of reactive oxygen species (ROS) play a critical role in normal tissue response. In this study we have examined some aspects of these effects in lung and skin...
  3. pmc Studies of the in vivo radiosensitivity of human skin fibroblasts
    Richard P Hill
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Ave, Toronto, Ont, Canada M5G 2M9
    Radiother Oncol 84:75-83. 2007
    ....
  4. ncbi request reprint "Destemming" cancer stem cells
    Richard P Hill
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, and Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, Canada M5G2M9
    J Natl Cancer Inst 99:1435-40. 2007
    ....
  5. ncbi request reprint Identifying cancer stem cells in solid tumors: case not proven
    Richard P Hill
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 66:1891-5; discussion 1890. 2006
    ..The case that a small proportion of cells in solid tumors are specific cancer stem cells and that these cells can be successfully identified and isolated has not yet been proven...
  6. ncbi request reprint Is there a relationship between repopulation and hypoxia/reoxygenation? Results from human carcinoma of the cervix
    R P Hill
    Department of Research, Princess Margaret Hospital Ontario Cancer Institute, Toronto, Canada
    Int J Radiat Biol 79:487-94. 2003
    ..There was also no evidence that a combination of kinetic and reoxygenation measurements could be predictive of treatment outcome...
  7. ncbi request reprint Cancer stem cells, hypoxia and metastasis
    Richard P Hill
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Semin Radiat Oncol 19:106-11. 2009
    ....
  8. doi request reprint Effects of genistein following fractionated lung irradiation in mice
    Andrea E Para
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
    Radiother Oncol 92:500-10. 2009
    ..This study investigated protection of lung injury by genistein following fractionated doses of radiation and its effect on tumor response...
  9. doi request reprint Interstitial permeability and elasticity in human cervix cancer
    Michael Milosevic
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Canada
    Microvasc Res 75:381-90. 2008
    ..Serial evaluation of these parameters may provide a means of clinically monitoring response to treatments that specifically target the tumor microenvironment...
  10. ncbi request reprint Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity
    John M Akudugu
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ont, Canada
    Radiother Oncol 78:17-26. 2006
    ....
  11. doi request reprint Increased expression of metastasis-related genes in hypoxic cells sorted from cervical and lymph nodal xenograft tumors
    Naz Chaudary
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, ON, Canada
    Lab Invest 89:587-96. 2009
    ..The technique can be applied to identify other potential 'hypoxia-related' genes of interest for tumor growth and metastasis...
  12. pmc Genistein can mitigate the effect of radiation on rat lung tissue
    Victoria L Calveley
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, M5G 2M9, Canada
    Radiat Res 173:602-11. 2010
    ....
  13. ncbi request reprint Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapy
    John M Akudugu
    Division of Experimental Therapeutics, Ontario Cancer Institute Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Radiother Oncol 72:103-12. 2004
    ..To evaluate the clonogenic and cytokinesis-blocked assays in skin fibroblast cultures for their utility as tools for predicting normal tissue responses in soft tissue sarcoma (STS) patients treated with preoperative radiotherapy...
  14. doi request reprint Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin
    Salomeh Jelveh
    Ontario Cancer Institute, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
    Int J Radiat Biol 89:618-27. 2013
    ..These antioxidants were studied because they have been previously reported to protect or mitigate against radiation-induced skin reactions...
  15. ncbi request reprint Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX
    Vladimir V Iakovlev
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada
    Lab Invest 87:1206-17. 2007
    ..However, CAIX was inferior to pO2 measurements as a tool for patient stratification. Improved analytical methods to account for intratumoral heterogeneity are needed to provide reliable measurements of molecular markers...
  16. ncbi request reprint Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma
    Kårstein Måseide
    Ontario Cancer Institute Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 10:4464-71. 2004
    ..The aim of this study was to quantify the extent of CA IX expression and to investigate whether CA IX is a marker for poor prognosis in soft tissue sarcoma patients at high risk of developing metastasis...
  17. ncbi request reprint Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3
    Hilda Mujcic
    Authors Affiliations Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network Departments of Laboratory Medicine and Pathobiology, Radiation Oncology, and Medical Biophysics Radiation Medicine Program, Department of Biostatistics, Princess Margaret Cancer Centre, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Maastricht Radiation Oncology MaastRO Lab, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht and Departments of Radiation Oncology and Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 19:6126-37. 2013
    ..Here, the importance of this pathway in the metastasis of human cervix carcinoma was investigated...
  18. ncbi request reprint Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 70:126-33. 2008
    ....
  19. doi request reprint Late residual gamma-H2AX foci in murine skin are dose responsive and predict radiosensitivity in vivo
    Nirmal Bhogal
    Applied Molecular Oncology and Radiation Medicine Program, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Radiat Res 173:1-9. 2010
    ..This technique may be a useful biodosimeter to determine dose at times up to 1 week after accidental or catastrophic radiation exposure in vivo...
  20. doi request reprint Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcoma
    Kårstein Måseide
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    Pathol Res Pract 204:175-83. 2008
    ..This suggests that TMAs can be used to detect even heterogeneous and sparse markers, but the sampling strategy should be validated for the marker under investigation...
  21. ncbi request reprint Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma
    Michelle L Gervais
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Lab Invest 87:1252-64. 2007
    ..These findings provide the first evidence of aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, and suggest potential prognostic value of VHL and E-cadherin in CC-RCC...
  22. ncbi request reprint Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion
    Li Zhang
    Research Division, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer Res 67:7789-97. 2007
    ..However, this effect was not due to down-regulation of hypoxia-inducible factor-1alpha, a mechanism of action of this drug reported by previous studies. Further detailed studies of the mechanisms of action of the drug are needed...
  23. doi request reprint Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer
    Michael Milosevic
    Radiation Medicine Program, Princess Margaret Hospital and Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    Clin Cancer Res 18:2108-14. 2012
    ..The aim of this study was to determine the effect of hypoxia in patients with prostate cancer treated with radiotherapy...
  24. pmc Effects of lipopolysaccharide on the response of C57BL/6J mice to whole thorax irradiation
    Asif Zaidi
    Ontario Cancer Institute, Toronto, Ontario, Canada
    Radiother Oncol 105:341-9. 2012
    ..The aim of the present study was to examine whether additive LPS exposure in the lung (to simulate respiratory infection) would affect pneumonitis or fibrosis associated with lung irradiation...
  25. ncbi request reprint Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic
    Aimée R Langan
    Research Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ont, Canada
    Radiother Oncol 79:231-8. 2006
    ..The particular focus of these studies was the efficacy of EUK-189 when given after irradiation (mitigation)...
  26. doi request reprint Biodosimetry using radiation-induced micronuclei in skin fibroblasts
    Pavel Kaspler
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network and Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
    Int J Radiat Biol 87:824-38. 2011
    ..We assessed micronuclei in dermal fibroblasts as a local biodosimeter for estimating accidental in vivo radiation exposure...
  27. pmc Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours
    Sarah Jane Lunt
    Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
    BMC Cancer 8:2. 2008
    ....
  28. ncbi request reprint Hypoxia-regulated p53 and its effect on radiosensitivity in cancer cells
    Li Zhang
    Research Division, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Int J Radiat Biol 83:443-56. 2007
    ..To determine the response of tumor suppressor p53 to hypoxia in different tumor cell lines and the involvement of p53 activity regulation in the effect of hypoxia on tumor cell sensitivity to radiation and hyperthermia...
  29. ncbi request reprint Progression and metastasis in a transgenic mouse breast cancer model: effects of exposure to in vivo hypoxia
    Tuula M Kalliomäki
    Applied Molecular Oncology Division, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada
    Cancer Lett 282:98-108. 2009
    ....
  30. ncbi request reprint Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation
    Naz Chaudary
    Ontario Cancer Institute Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
    Cancer 118:3105-15. 2012
    ....
  31. doi request reprint Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53
    Stephane Supiot
    Princess Margaret Hospital University Health Network, Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Mol Cancer Ther 7:993-9. 2008
    ..Nutlin-3 may be a useful adjunct to improve the therapeutic ratio using precision radiotherapy targeted to hypoxic cells and warrants further study in vivo...
  32. ncbi request reprint Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis
    Sarah Jane Lunt
    Division of Applied Molecular Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Future Oncol 4:793-802. 2008
    ..Pretreatment interstitial fluid pressure and the change in pressure during treatment may provide important predictive information that in the future will be used to optimize therapy in individual patients...
  33. ncbi request reprint Gold nanoparticles as radiation sensitizers in cancer therapy
    Devika B Chithrani
    STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada
    Radiat Res 173:719-28. 2010
    ..The outcome of this research will enable the optimization of gold nanoparticle-based sensitizers for use in therapy...
  34. doi request reprint Graded hypoxia modulates the invasive potential of HT1080 fibrosarcoma and MDA MB231 carcinoma cells
    Patrick Subarsky
    Applied Molecular Oncology Division, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Clin Exp Metastasis 25:253-64. 2008
    ..This study demonstrates cell line specific effects of graded oxygen levels on invasive potential and suggests that intermediate levels of low oxygen may increase metastatic dissemination...
  35. pmc Beta-catenin is a mediator of the response of fibroblasts to irradiation
    Ananta Gurung
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Canada
    Am J Pathol 174:248-55. 2009
    ..beta-Catenin mediates the effects of ionizing radiation in fibroblasts, and its modulation has the potential to decrease the severity of radiation-induced soft tissue complications...
  36. ncbi request reprint Pretreatment proliferation parameters do not add predictive power to clinical factors in cervical cancer treated with definitive radiation therapy
    Richard W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, M5G 2M9 Canada
    Clin Cancer Res 9:4387-95. 2003
    ..We report an update of a prospective study focusing on whether pretreatment proliferation parameters are associated with clinical outcome, relative to other established clinical factors...
  37. ncbi request reprint Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer
    Anthony Fyles
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, Canada
    Radiother Oncol 80:132-7. 2006
    ..Using data from our prospective trial, we updated a cohort of patients treated with definitive radiation alone without chemotherapy, to assess the long-term prognostic impact of these microenvironmental features...
  38. ncbi request reprint Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    Robert G Bristow
    Departments of Medical Biophysics and Radiation Oncology, University of Toronto and Ontario Cancer Institute and Princess Margaret Hospital University Health Network, 610 University Avenue, Toronto, Ontario, M5G2M9, Canada
    Nat Rev Cancer 8:180-92. 2008
    ..Acute and chronic hypoxia might lead to different biology within the tumour and this might have a direct effect on the design of new therapies for the treatment of hypoxic tumours...
  39. doi request reprint Heterogeneity and power in clinical biomarker studies
    Melania Pintilie
    Department of Biostatistics, Radiation Medicine Program, and the Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Canada
    J Clin Oncol 27:1517-21. 2009
    ..Due to this heterogeneous distribution of the biomarker, the association sought may appear weak or nonexistent. Thus, there is a wide range of conclusions in the literature on the association between a biomarker and an outcome...
  40. ncbi request reprint Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation
    Pavel Kaspler
    Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, 610, University Ave, Toronto, Ontario, Canada, M5G2M9
    Health Phys 98:228-33. 2010
    ..Percentage of multimicronucleated cells may be useful as a substitute of total MN at the higher doses, but total percentage of micronucleated cells is of limited value as a substitute...
  41. pmc MicroRNA-196b regulates the homeobox B7-vascular endothelial growth factor axis in cervical cancer
    Christine How
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e67846. 2013
    ....
  42. ncbi request reprint Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis
    Li Zhang
    Research Division, Ontario Cancer Institute Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Cancer Res 64:4180-9. 2004
    ..These data suggest that hypoxia can increase tumor cell metastatic efficiency by rendering the tumor cells less sensitive to stress-induced cell death, e.g., through modifying the levels of Mdm2 and p53...
  43. ncbi request reprint Partial volume rat lung irradiation: temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation
    Victoria L Calveley
    Research Division, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Canada
    Int J Radiat Biol 81:887-99. 2005
    ..We examined temporal fluctuations in DNA damage, cytokine expression and macrophage activation during 16 weeks post-irradiation...
  44. pmc Mitigation of radiation-induced lung injury by genistein and EUK-207
    Javed Mahmood
    Ontario Cancer Institute Princess Margaret Hospital, University Health Network, and the Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
    Int J Radiat Biol 87:889-901. 2011
    ..We examined the effects of genistein and/or Eukarion (EUK)-207 on radiation-induced lung damage and investigated whether treatment for 0-14 weeks (wks) post-irradiation (PI) would mitigate late lung injury...
  45. pmc Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model
    Tuula M Kalliomäki
    Applied Molecular Oncology Division, Ontario Cancer Institute Princess Margaret Hospital, Canada
    BMC Cancer 8:151. 2008
    ..Both of these features are commonly found in many cancer types, but their relationship and association with tumour progression has not been examined in the same model...
  46. ncbi request reprint Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors
    Julia V Skliarenko
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer Res 66:2074-80. 2006
    ..The higher cell survival in high IFP tumors may reflect greater microregional blood flow limitations in these tumors and reduced access of the drug to the target endothelial cells...
  47. ncbi request reprint Estimating hypoxic status in human tumors: a simulation using Eppendorf oxygen probe data in cervical cancer patients
    Corinne M Doll
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 55:1239-46. 2003
    ..To define the minimal number of pO(2) measurements, with 90% sensitivity and 90% specificity, needed to categorize cervical tumors as either hypoxic or oxic...
  48. doi request reprint The tumor microenvironment and metastatic disease
    Sarah Jane Lunt
    Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, OCI PMH, Toronto, ON, Canada
    Clin Exp Metastasis 26:19-34. 2009
    ....
  49. doi request reprint PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status
    Stephane Supiot
    Princess Margaret Hospital University Health Network, Toronto, Canada
    Radiother Oncol 86:407-11. 2008
    ..Radiosensitization was observed in PC3 (p53Null) cells, even under hypoxia. In certain circumstances, PRIMA-1(met) may therefore act independently of MTp53 status and WTp53 transactivation...
  50. ncbi request reprint High tumor interstitial fluid pressure identifies cervical cancer patients with improved survival from radiotherapy plus cisplatin versus radiotherapy alone
    Michael F Milosevic
    Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, Toronto, Canada Department of Radiation Oncology, University of Toronto, Toronto, Canada
    Int J Cancer 135:1692-9. 2014
    ..This may reflect high tumor cell proliferation, which is known to influence IFP, local tumor control and patient survival. ..
  51. ncbi request reprint Effect of radiation and cell implantation on wound healing in a rat model
    Dale Dantzer
    The Samuel Lunenfeld Research Institute, Sinai Hospital, Toronto, Ontario, Canada
    J Surg Oncol 83:185-90. 2003
    ..Having shown that intra-dermal injection of fibroblasts decreases the effect of radiation on healing of superficial wounds, we now test the effect of fibroblasts and syngeneic marrow stromal cells on irradiated deep and superficial wounds...
  52. ncbi request reprint Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer
    Chris Parker
    Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 58:750-7. 2004
    ..To describe the oxygenation of clinically localized prostate cancer...
  53. doi request reprint Tumor-stroma interaction in orthotopic primary pancreatic cancer xenografts during hedgehog pathway inhibition
    Qing Chang
    Ontario Cancer Institute Princess Margaret Hospital, ON, Canada
    Int J Cancer 133:225-34. 2013
    ..In contrast to some recent reports, growth inhibition does not involve attenuation of the tumor stroma, pointing to additional effects of Hh signaling in pancreatic cancer...
  54. ncbi request reprint Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers
    Mohammed A Khan
    Research Division, Ontario Cancer Institute Princess Margaret Hospital, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Radiother Oncol 66:95-102. 2003
    ..They also determined whether superoxide dismutase (SOD) and nitro-L-arginine methyl ester (L-NAME) protected against this damage...
  55. ncbi request reprint Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosis
    Aileen M Davis
    Research Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario M5G 2A2, Canada
    Int J Radiat Oncol Biol Phys 60:286-94. 2004
    ....
  56. ncbi request reprint Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage
    Javed Mahmood
    Ontario Cancer Institute and the Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada Radiation Medicine Program, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 89:722-8. 2014
    ..To investigate the outcome of suppression of the renin angiotensin system using captopril combined with an antioxidant (Eukarion [EUK]-207) for mitigation of radiation-induced lung damage in rats...
  57. doi request reprint Orthotopic xenograft model of cervical cancer for studying microenvironmental effects on metastasis formation and response to drug treatment
    Naz Chaudary
    Ontario Cancer Institute Princess Margaret Hospital, Campbell Family Institute for Cancer Research and University of Toronto, Toronto, Ontario, Canada
    Curr Protoc Pharmacol . 2011
    ..Described in this unit is a surgical technique for orthotopic implantation and the use of this model for investigating the effects of novel agents as inhibitors of tumor growth and metastasis...
  58. ncbi request reprint The hypoxic tumour microenvironment and metastatic progression
    Patrick Subarsky
    Experimental Therapeutics Divison, Ontario Cancer Institute Princess Margaret Hospital, Department of Medical Biophysics, University of Toronto, Canada
    Clin Exp Metastasis 20:237-50. 2003
    ..Here we review the epigenetic control of gene expression by the hypoxic microenvironment and its potential contribution to metastatic progression...
  59. doi request reprint Suppression of vascular endothelial growth factor receptor 3 (VEGFR3) and vascular endothelial growth factor C (VEGFC) inhibits hypoxia-induced lymph node metastases in cervix cancer
    Naz Chaudary
    The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada
    Gynecol Oncol 123:393-400. 2011
    ..Our previous studies showed that growth of these tumors under conditions of cyclic hypoxia increased nodal metastasis...
  60. ncbi request reprint Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    Rob A Cairns
    Experimental Therapeutics Division, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Cancer Res 64:2054-61. 2004
    ..These results suggest that fluctuating oxygenation in cervical carcinoma tumors may reduce tumor growth rate, but it may also enhance the ability of tumor cells to metastasize to local lymph nodes...
  61. ncbi request reprint A fluorescent orthotopic model of metastatic cervical carcinoma
    Rob A Cairns
    Experimental Therapeutics Division, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Clin Exp Metastasis 21:275-81. 2004
    ..This model should allow for a more relevant investigation of the factors that affect the metastasis of cervical carcinoma and presents an opportunity to evaluate potential therapeutic strategies designed to prevent the spread of disease...
  62. ncbi request reprint Relations between non-protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma
    David W Hedley
    Department of Medical Oncology and Hematology, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 61:137-44. 2005
    ..The levels of NPSH in the nucleus are predicted to be more important than those in cytoplasm. We, therefore, investigated the relation between nuclear NPSH and the clinical outcome of radical radiotherapy (RT)...
  63. doi request reprint Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models
    Nhu An Pham
    Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada
    Int J Cancer 124:280-6. 2009
    ..These results show that signaling pathways are responsive to tumor hypoxia in vivo, although the effects appear to differ between individual tumor types...
  64. ncbi request reprint Hypoxia and metastasis in breast cancer
    Naz Chaudary
    Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Breast Dis 26:55-64. 2006
    ..An understanding of the molecular pathways in hypoxia-induced breast cancer metastasis promises potential useful prognostic and therapeutic information...
  65. ncbi request reprint The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy
    R G Bristow
    Department of Radiation Oncology, University of Toronto, Canada
    Radiother Oncol 40:197-223. 1996
    ....
  66. ncbi request reprint Normal tissue radiobiology: from the laboratory to the clinic
    R P Hill
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 49:353-65. 2001
    ..The symposium highlights the complexities of the radiobiology of late normal tissue responses, yet provides evidence and ideas about how the clinical problem of such responses may be modified or alleviated...
  67. pmc Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    Kathrin Zaugg
    The Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Ontario, Canada
    Genes Dev 25:1041-51. 2011
    ..Our results indicate that cells can use a novel mechanism involving CPT1C and FA metabolism to protect against metabolic stress. CPT1C may thus be a new therapeutic target for the treatment of hypoxic tumors...
  68. ncbi request reprint Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53
    Robert G Bristow
    Department of Radiation Oncology, University of Toronto, The Princess Margaret Hospital UHN Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Oncogene 22:2960-6. 2003
    ..Our results support the concept that gain of MTp53pro193 function leads to the selection of dominant clones, which may exhibit cellular resistance following cancer therapy...
  69. ncbi request reprint Hypoxia and metastasis
    Naz Chaudary
    Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 13:1947-9. 2007
  70. pmc pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development
    Natalie H Stickle
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Cell Biol 24:3251-61. 2004
    ..These results suggest that NEDD8 modification of pVHL plays an important role in fibronectin matrix assembly and that in the absence of such regulation, an intact HIF pathway is insufficient to prevent VHL-associated tumorigenesis...
  71. ncbi request reprint Expression of hypoxia-inducible factor-1alpha in cervical carcinomas: correlation with tumor oxygenation
    Hans Kristian Haugland
    Department of Medical Biophysics, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 53:854-61. 2002
    ..To investigate the relations between hypoxia-inducible factor-1 (HIF-1), tumor oxygenation, and clinical correlates in patients with locally advanced carcinoma of the uterine cervix...
  72. pmc High-resolution in-vivo analysis of normal brain response to cranial irradiation
    Kelly Burrell
    Brain Tumor Research Centre, SickKids Research Institute, Toronto, Canada
    PLoS ONE 7:e38366. 2012
    ....
  73. pmc A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines
    J A Chiarotto
    Research Department, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Canada
    Br J Cancer 80:1518-24. 1999
    ..Stirring in suspension culture was found to induce VEGF mRNA in SiHa cells. The presence of VEGF mRNA may be a marker for radiobiologic hypoxia...
  74. ncbi request reprint Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo
    Katherine A Vallis
    Department of Radiation Oncology, University of Toronto, Ontario M5G 2M9, Canada
    Radiat Res 157:8-18. 2002
    ..Similar strategies may facilitate the discovery and characterization of genes involved in other cellular stress responses...
  75. ncbi request reprint pH, hypoxia and metastasis
    R P Hill
    Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto, Canada
    Novartis Found Symp 240:154-65; discussion 165-8. 2001
    ..Recent studies have implicated a number of genes, such as vascular endothelial growth factor and interleukin 8, in the effect of hypoxic and acid pH on metastasis...
  76. ncbi request reprint The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis
    M F Milosevic
    Department of Radiation Oncology and Experimental Therapeutics, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Int J Radiat Oncol Biol Phys 43:1111-23. 1999
    ..To examine the hypothesis that elevated interstitial fluid pressure (IFP) is a cause of reduced blood flow in tumors...
  77. ncbi request reprint Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    R A Cairns
    Experimental Therapeutics Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, M5G 2M9 Canada
    Cancer Res 61:8903-8. 2001
    ..This study describes a novel method for studying the effects of hypoxia in solid tumors and demonstrates that acute and chronic hypoxia can have different effects on tumor cell behavior in vivo...
  78. pmc Dynamics of micronuclei in rat skin fibroblasts after X irradiation
    P Kaspler
    Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Department of Medical Biophysics and Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Radiat Res 172:106-13. 2009
    ..Further studies are needed to define the dose-response relationship in detail...
  79. pmc Radiation sensitivity of tumour cells stained in vitro or in vivo with the bisbenzimide fluorochrome Hoechst 33342
    S D Young
    Physics Division, Ontario Cancer Institute, Toronto, Canada
    Br J Cancer 60:715-21. 1989
    ....
  80. ncbi request reprint Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    A Fyles
    Department of Radiation Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 20:680-7. 2002
    ..This prospective clinical study was begun in 1994 to validate the independent prognostic impact of tumor hypoxia in patients with cervix cancer treated with definitive radiation therapy...
  81. ncbi request reprint Partial volume rat lung irradiation: an evaluation of early DNA damage
    M A Khan
    The Ontario Cancer Institute Princess Margaret Hospital and the Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 40:467-76. 1998
    ..2. To determine the variation in DNA damage in different lung regions. 3. To investigate the possible mechanisms associated with early DNA damage after lung irradiation...
  82. ncbi request reprint Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice
    W Cruz-Munoz
    Ontario Cancer Research, University of Toronto, Toronto, Ontario, Canada
    Oncogene 25:6489-96. 2006
    ..TIMP-3 regulates MMP-2 activation to limit tumor cell extravasation and subsequent colonization of the lung, without augmenting inflammatory cell response...
  83. ncbi request reprint Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain
    Martijn P Lolkema
    Department of Medical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 280:22205-11. 2005
    ..We propose that phosphorylation of the acidic domain plays a role in the regulation of proper fibronectin matrix deposition and that this may be relevant for the development of VHL-associated malignancies...
  84. ncbi request reprint Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    James L Tatum
    National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852 7440, USA
    Int J Radiat Biol 82:699-757. 2006
    ....
  85. ncbi request reprint Targeted treatment: insights from studies of osteopontin and hypoxia
    Richard P Hill
    Lancet Oncol 6:733-4. 2005
  86. doi request reprint Low-dose radiation effects on human health with implications to radioprotection and cancer radiotherapy
    K P Mishra
    United Research Institute for Science and Technology URIST, Naini, Allahabad, Uttar Pradesh, India and United Institute of Technology, Naini
    Int J Radiat Biol 84:441-4. 2008