Michael D Hill

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
    Amanda V Tyndall
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    BMC Geriatr 13:21. 2013
  2. ncbi request reprint Tissue Window in Stroke Thrombolysis study (TWIST): a safety study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 40:17-20. 2013
  3. doi request reprint Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial
    Michael D Hill
    Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Lancet Neurol 11:942-50. 2012
  4. pmc The Albumin in Acute Stroke Part 1 Trial: an exploratory efficacy analysis
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Room 1242A, 1403 29th St NW, Calgary, Alberta, T2N 2T9, Canada
    Stroke 42:1621-5. 2011
  5. pmc Final 2 year results of the vascular imaging of acute stroke for identifying predictors of clinical outcome and recurrent ischemic eveNts (VISION) study
    Shelagh B Coutts
    Department of Clinical Neurosciences and Radiology, University of Calgary, Calgary, AB, T2N 2T9, Canada
    BMC Cardiovasc Disord 11:18. 2011
  6. ncbi request reprint Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry
    Imanuel Dzialowski
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
    Stroke 38:75-9. 2007
  7. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
  8. doi request reprint Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
    Volker Puetz
    University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
    Int J Stroke 3:230-6. 2008
  9. doi request reprint Frequency and clinical course of stroke and transient ischemic attack patients with intracranial nonocclusive thrombus on computed tomographic angiography
    Volker Puetz
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Calgary, Canada
    Stroke 40:193-9. 2009
  10. doi request reprint Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke
    Bijoy K Menon
    Calgary Stroke Program, University of Calgary, Calgary, AB, Canada
    Neuroradiology 53:261-6. 2011

Detail Information

Publications104 found, 100 shown here

  1. pmc The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
    Amanda V Tyndall
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    BMC Geriatr 13:21. 2013
    ....
  2. ncbi request reprint Tissue Window in Stroke Thrombolysis study (TWIST): a safety study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 40:17-20. 2013
    ....
  3. doi request reprint Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial
    Michael D Hill
    Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Lancet Neurol 11:942-50. 2012
    ..Neuroprotection with NA-1 (Tat-NR2B9c), an inhibitor of postsynaptic density-95 protein, has been shown in a primate model of stroke. We assessed whether NA-1 could reduce ischaemic brain damage in human beings...
  4. pmc The Albumin in Acute Stroke Part 1 Trial: an exploratory efficacy analysis
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Room 1242A, 1403 29th St NW, Calgary, Alberta, T2N 2T9, Canada
    Stroke 42:1621-5. 2011
    ..ALIAS Part 2 is a new, reformulated trial with more-stringent exclusion criteria. Our aim was to explore the efficacy of ALB in the ALIAS Part 1 data and to assess the statistical assumptions underlying the ALIAS Part 2 Trial...
  5. pmc Final 2 year results of the vascular imaging of acute stroke for identifying predictors of clinical outcome and recurrent ischemic eveNts (VISION) study
    Shelagh B Coutts
    Department of Clinical Neurosciences and Radiology, University of Calgary, Calgary, AB, T2N 2T9, Canada
    BMC Cardiovasc Disord 11:18. 2011
    ..We assessed the role of MR imaging in predicting stroke progression, recurrent stroke, and death within 2 years of symptom onset...
  6. ncbi request reprint Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry
    Imanuel Dzialowski
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
    Stroke 38:75-9. 2007
    ..We sought to study the relation between the type of hemorrhagic transformation on CT scans and functional outcome...
  7. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
    ..We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study...
  8. doi request reprint Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score
    Volker Puetz
    University of Calgary, Department of Clinical Neurosciences, Calgary Stroke Program, Canada
    Int J Stroke 3:230-6. 2008
    ..In ischemic stroke, functional outcomes vary depending on site of intracranial occlusion. We tested the prognostic value of a semiquantitative computed tomography angiography-based clot burden score...
  9. doi request reprint Frequency and clinical course of stroke and transient ischemic attack patients with intracranial nonocclusive thrombus on computed tomographic angiography
    Volker Puetz
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Calgary, Canada
    Stroke 40:193-9. 2009
    ..We sought to determine the frequency and clinical course of patients with acute ischemic stroke or transient ischemic attack (TIA) who had intracranial nonocclusive thrombus (iNOT) on CT angiography (CTA)...
  10. doi request reprint Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke
    Bijoy K Menon
    Calgary Stroke Program, University of Calgary, Calgary, AB, Canada
    Neuroradiology 53:261-6. 2011
    ..The Penumbra system is a newly approved mechanical device for the treatment of acute stroke designed for better and faster recanalization. We describe our initial experience with the use of this device...
  11. ncbi request reprint Cerebral perfusion and blood pressure do not affect perihematoma edema growth in acute intracerebral hemorrhage
    Rebecca McCourt
    From the Division of Neurology R M, B G, L G, M K, T J, B B, K B and Department of Diagnostic Imaging D E, University of Alberta, Edmonton, Canada Division of Neurology, University of British Columbia, Vancouver, Canada N A Division of Neurology, University of Ottawa, Ottawa, Canada D D and Department of Clinical Neurosciences, University of Calgary, Calgary, Canada S B C, M D H, A M D
    Stroke 45:1292-8. 2014
    ..Using ICH ADAPT data, we tested the hypotheses that edema growth is associated with reduced CBF and lower systolic BP...
  12. doi request reprint Venous phase of computed tomography angiography increases spot sign detection, but intracerebral hemorrhage expansion is greater in spot signs detected in arterial phase
    David Rodriguez-Luna
    From the Stroke Unit, Department of Neurology, Vall d Hebron University Hospital and Vall d Hebron Research Institute, Barcelona, Spain D R L, C A M Calgary Stroke Program, Department of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada D R L, T S, M D H, A M D Departments of Medicine Neurology D D and Diagnostic Imaging, Neuroradiology Section C L, The Ottawa Hospital, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada Division of Neuroradiology, Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada R I A, T J H Department of Neurology, Dr Josep Trueta University Hospital, Institut d Investigació Biomèdica Girona IDIBGI Foundation, Girona, Spain Y S Department of Neurology, University of Dresden, Dresden, Germany I D 2nd Department of Neurology, Institute of Psychiatry and Neurology of Warsaw, Warsaw, Poland A C Department of Neurology, Charles LeMoyne Hospital, University of Sherbrooke
    Stroke 45:734-9. 2014
    ..This study aimed to determine the frequency of the spot sign in intracerebral hemorrhage and its relationship with hematoma expansion depending on the phase of image acquisition...
  13. doi request reprint Outcomes among 3.5 million newly diagnosed hypertensive Canadians
    Hude Quan
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 29:592-7. 2013
    ..This population-based study assessed rates of all-cause mortality, myocardial infarction, heart failure, and stroke for up to 12 years of follow-up in 3.5 million Canadian adults newly diagnosed with hypertension...
  14. ncbi request reprint Mild neurological symptoms despite middle cerebral artery occlusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
    Stroke 35:469-71. 2004
    ..Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy...
  15. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
    ..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset...
  16. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
    ..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
  17. doi request reprint Does intravenous rtPA benefit patients in the absence of CT angiographically visible intracranial occlusion?
    P N Sylaja
    Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Alberta, Canada
    Neurol India 57:739-43. 2009
    ..In patients with acute stroke receiving intravenous tissue plasminogen activator (tPA), we postulated that the presence of intracranial occlusion on CT angiography (CTA) modifies the benefit of thrombolysis...
  18. pmc Alberta Stroke Program early computed tomography score to select patients for endovascular treatment: Interventional Management of Stroke (IMS)-III Trial
    Michael D Hill
    From the Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Stroke 45:444-9. 2014
    ..A predefined secondary hypothesis was that subjects with significant early ischemic change on the baseline scan would not respond to endovascular therapy...
  19. ncbi request reprint An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, AB, Canada
    Int J Stroke 3:3-10. 2008
    ..Modern imaging of the brain was not included. The present study quantified the added value of magnetic resonance imaging (MRI) factors to the ABCD(2) tool...
  20. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
    ..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
  21. ncbi request reprint Intracerebral hemorrhage: outcomes and eligibility for factor VIIa treatment in a National Stroke Registry
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 22:271-5. 2006
    ..Intracerebral hemorrhage (ICH) is a devastating form of stroke for which the lack of treatment options, high mortality rate, and the tendency to severely disable result in high social and economic burden...
  22. doi request reprint Malignant emboli on transcranial Doppler during carotid stenting predict postprocedure diffusion-weighted imaging lesions
    Mohammed A Almekhlafi
    Departments of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Stroke 44:1317-22. 2013
    ..We evaluated CAS safety by correlating the findings of procedural transcranial Doppler with postprocedure diffusion-weighted imaging (DWI) lesions...
  23. ncbi request reprint Interobserver variation of ASPECTS in real time
    Shelagh B Coutts
    Seaman Family MR Centre, Calgary Health Region, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 35:e103-5. 2004
    ..We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point...
  24. doi request reprint Thrombolysis at 3-4.5 hours after acute ischemic stroke onset--evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) registry
    Nandavar Shobha
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada
    Cerebrovasc Dis 31:223-8. 2011
    ..ECASS III examined a 3-4.5-hour window and showed a benefit to treated patients. We examined the experience in Canadian centres using intravenous tPA treatment in the 3-4.5-hour time window...
  25. ncbi request reprint Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Ann Neurol 57:848-54. 2005
    ....
  26. doi request reprint Incidence, cardiovascular complications and mortality of hypertension by sex and ethnicity
    Hude Quan
    Department of Community Health Sciences, University of Calgary, 3280 Hospital Dr NW, Calgary, Alberta, Canada T2N 4Z6
    Heart 99:715-21. 2013
    ..To compare ethnic and sex difference in the incidence of newly diagnosed hypertension, and subsequent risk of cardiovascular disease outcomes among South Asian, Chinese and white patients...
  27. ncbi request reprint Outcome after stroke upon awakening
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:232-6. 2005
    ..An estimated 20-25% of all strokes occur during sleep and these patients wake up with their deficits. This study evaluated outcomes among patients who woke up with stroke compared to those who were awake at stroke onset...
  28. pmc Weather and chinook winds in relation to spontaneous pneumothoraces
    Colin Schieman
    Division of Thoracic Surgery, Faculty of Medicine, University of Calgary, Calgary, Alta
    Can J Surg 52:E151-5. 2009
    ..Rapid changes in weather may precipitate this process. The city of Calgary is well suited to examine the effects of weather and specifically the rapid changes in weather associated with a chinook event and the occurrence of SP...
  29. doi request reprint Identifying lesion growth with MR imaging in acute ischemic stroke
    Michael S Bristow
    Department of Radiology, University of Calgary, Calgary, Alberta, Canada
    J Magn Reson Imaging 28:837-46. 2008
    ..To determine whether different MR diffusion- and perfusion-weighted imaging (DWI and PWI) parameters are important in distinguishing lesion growth from the acute lesion and from oligemia...
  30. doi request reprint Calcification and endothelialization of thrombi in acute stroke
    Mohammed A Almekhlafi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 64:344-8. 2008
    ..Thrombus composition could critically determine the success of chemical thrombolysis. Our results should stimulate the development of imaging modalities to determine thrombus composition...
  31. doi request reprint Stroke: the Elixhauser Index for comorbidity adjustment of in-hospital case fatality
    Haifeng Zhu
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm 1242A, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2T9
    Neurology 71:283-7. 2008
    ..Similarly, an International Classification of Diseases (ICD)-10 coding algorithm has been rarely reported for Elixhauser Index...
  32. pmc Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis
    Alexandre Y Poppe
    University of Calgary, Calgary, Alberta, Canada
    Diabetes Care 32:617-22. 2009
    ....
  33. ncbi request reprint MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction
    Michael S Bristow
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Cereb Blood Flow Metab 25:1280-7. 2005
    ..This study suggests that tissue-specific analysis of perfusion and diffusion imaging is required to accurately predict tissue at risk of infarction in acute ischemic stroke...
  34. ncbi request reprint MR angiography compared to conventional selective angiography in acute stroke
    Anna I Tomanek
    Seaman Family MR Research Centre, University of Calgary, Calgary, AB Canada
    Can J Neurol Sci 33:58-62. 2006
    ..The purpose of this study was to determine the accuracy of MRA in evaluation of intracranial vessels in acute stroke and transient ischemic attack (TIA) patients..
  35. doi request reprint Perfusion MR predicts outcome in high-risk transient ischemic attack/minor stroke: a derivation-validation study
    Negar Asdaghi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 44:2486-92. 2013
    ..Transient or minor ischemic stroke is associated with an early risk of deterioration. Baseline perfusion-diffusion mismatch may predict clinical deterioration and infarct growth in this population...
  36. ncbi request reprint Acute ischemic stroke: accuracy of diffusion-weighted MR imaging--effects of b value and cerebrospinal fluid suppression
    Philip E Chen
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, AB, T2N 2T9, Canada
    Radiology 238:232-9. 2006
    ....
  37. ncbi request reprint Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients?
    Shelagh B Coutts
    Department of Clinical Neurosciences, Room C1246, Foothills Medical Centre, 1403 29th St SW, Calgary, AB, T2N 2T9, Canada
    Stroke 39:2461-6. 2008
    ..Clinical trials are needed to assess acute treatment options in these patients. We sought to evaluate the type of recurrent events and to identify which subsets of patients are at risk for recurrent events...
  38. doi request reprint When to expect negative diffusion-weighted images in stroke and transient ischemic attack
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Alberta, Canada
    Stroke 39:1898-900. 2008
    ..The frequency of DWI negative cerebral ischemia and clinical factors associated with such a circumstance is not well understood...
  39. ncbi request reprint TPA use for stroke in the Registry of the Canadian Stroke Network
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 32:433-9. 2005
    ..Thrombolysis for stroke with tPA is now a standard of care in North America. However, it is only used on a small percentage of patients...
  40. ncbi request reprint Derivation of power M-mode transcranial Doppler criteria for angiographic proven MCA occlusion
    Maher Saqqur
    Department of Medicine, University of Alberta, Alberta, Canada
    J Neuroimaging 16:323-8. 2006
    ..Stringent transcranial Doppler (TCD) criteria for diagnosing occlusion are needed for more reliable TCD performance at bedside in the acute stroke setting...
  41. ncbi request reprint Derivation of transcranial Doppler criteria for rescue intra-arterial thrombolysis: multicenter experience from the Interventional Management of Stroke study
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Stroke 36:865-8. 2005
    ..We examined clinical utility and prognostic value of TCD flow findings in patients enrolled in an intravenous/intra-arterial rtPA pilot trial (Interventional Management of Stroke [IMS] study)...
  42. ncbi request reprint Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 34:1925-31. 2003
    ....
  43. doi request reprint Anterior temporal artery sign in CT angiography predicts reduced fatal brain edema and mortality in acute M1 middle cerebral artery occlusions
    Bijoy K Menon
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 22:145-8. 2012
    ..We identify a vascular imaging sign, presence of "prominent anterior temporal artery" on computed tomography (CT) angiography (CTA) and investigate whether it predicts mortality in acute M1-MCA occlusions...
  44. doi request reprint Impact of a stroke unit on length of hospital stay and in-hospital case fatality
    Hai Feng Zhu
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm 1242A, 1403 29 Street NW, Calgary, Alberta, T2N 2T9, Canada
    Stroke 40:18-23. 2009
    ..In 2001, a multidisciplinary stroke unit was opened at our institution. We observed whether a stroke unit reduces length of stay and in-hospital case fatality when compared to admission to a general neurology/medical ward...
  45. ncbi request reprint The Intracerebral Haemorrhage Acutely Decreasing Arterial Pressure Trial: ICH ADAPT
    Kenneth Butcher
    Division of Neurology, University of Alberta, Edmonton, AB, Canada
    Int J Stroke 5:227-33. 2010
    ..A study of this type is critical to establishing the safety of early blood pressure treatment and is necessary for planning larger efficacy trials in a rational manner. This trial is registered with clinicaltrials.gov (NCT00963976)...
  46. ncbi request reprint Recombinant factor VIIa plus surgery for intracerebral hemorrhage
    Christina S Sutherland
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 35:567-72. 2008
    ..The peri-operative administration of rFVIIa to patients with intracerebral hemorrhage may decrease the frequency of post-operative hemorrhage, and improve outcome...
  47. doi request reprint Prognostic value of CT angiography in patients with suspected vertebrobasilar ischemia
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neuroimaging 18:46-9. 2008
    ..The aim of our study was to analyze the CT angiography (CTA) predictors of outcome in patients with suspected vertebrobasilar ischemia...
  48. ncbi request reprint Combined intravenous and intra-arterial approach in acute stroke treatment
    Mohammed A Almekhlafi
    University of Calgary, Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    Expert Opin Pharmacother 8:1837-49. 2007
    ..The authors discuss the process of patient selection using clinical, as well as state of the art imaging modalities...
  49. doi request reprint The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy
    Doreen M Rabi
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 27:415-433.e1-2. 2011
    ..We also discussed the recent analyses that examined the association between angiotensin II receptor blockers (ARBs) and cancer...
  50. doi request reprint Cost of spontaneous intracerebral hemorrhage in Canada during 1 decade
    Adrian V Specogna
    From the Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 45:284-6. 2014
    ..Currently there is no clear understanding of the cost of treatment in Canada and thus no way of understanding how to manage ICH spending in this country...
  51. pmc Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease
    Michael Eliasziw
    Department of Community Health Sciences, University of Calgary, Calgary, Alta
    CMAJ 170:1105-9. 2004
    ..Transient ischemic attacks (TIAs) often herald a stroke, but little is known about the acute natural history of TIAs. Our objective was to quantify the early risk of stroke after a TIA in patients with internal carotid artery disease...
  52. ncbi request reprint Is intravenous recombinant tissue plasminogen activator (rt-PA) safe for use in patients over 80 years old with acute ischaemic stroke? - The Calgary experience
    Jessica E Simon
    Department of Clinical Neurosciences, University of Calgary and Foothills Hospital, Alberta, Canada
    Age Ageing 33:143-9. 2004
    ..Acute ischaemic stroke is common in older people. There is one licensed acute treatment, intravenous recombinant tissue plasminogen activator, but little information is available on its safety in over 80 year olds...
  53. doi request reprint Carotid angioplasty and stenting is safe in women
    Nandavar Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can Assoc Radiol J 63:S18-22. 2012
    ..Results of randomized controlled trials have shown that carotid endarterectomy poses greater perioperative risks to women than to men. There are limited studies regarding sex differences in carotid angioplasty and stenting...
  54. doi request reprint Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study
    Andrew M Demchuk
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Lancet Neurol 11:307-14. 2012
    ..Proper selection of patients at high risk for haematoma expansion seems crucial to improve outcomes. In this study, we aimed to prospectively validate the CT-angiography (CTA) spot sign for prediction of haematoma expansion...
  55. doi request reprint What causes disability after transient ischemic attack and minor stroke?: Results from the CT and MRI in the Triage of TIA and minor Cerebrovascular Events to Identify High Risk Patients (CATCH) Study
    Shelagh B Coutts
    Department of Clinical Nuerosciences, University of Calgary, Foothills Hospital, C1261, 1403 29 Street NW, Calgary, AB, T2N 2T9, Canada
    Stroke 43:3018-22. 2012
    ..We sought to assess the relative impact of these mechanisms on disability in a population of patients with transient ischemic attack and minor stroke...
  56. doi request reprint Acute corticospinal tract Wallerian degeneration is associated with stroke outcome
    Giselle DeVetten
    Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Alberta, Canada
    Stroke 41:751-6. 2010
    ..In this study we test the hypothesis that early diffusion changes also occur in the corticospinal tract (CST) of adults after stroke and that these lesions are associated with poor outcome...
  57. pmc Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, Room 1242A, Calgary, AB T2N 2T9, Canada
    J Neurol Neurosurg Psychiatry 77:826-9. 2006
    ..The benefit of intravenous tissue plasminogen activator (tPA) given within 3 h of acute ischaemic stroke to patients over 80 years of age is uncertain...
  58. ncbi request reprint Current management of transient ischemic attack
    Padmavathy N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiovasc Drugs 7:67-74. 2007
    ..Endarterectomy or carotid stenting is of great benefit to patients with TIA secondary to stenosis in the extracranial carotid artery...
  59. ncbi request reprint Safety outcomes of Alteplase among acute ischemic stroke patients with special characteristics
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada
    Neurocrit Care 6:181-5. 2007
    ....
  60. ncbi request reprint Perfusion MRI abnormalities in speech or motor transient ischemic attack patients
    Andrea L Krol
    Seaman Family MR Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Stroke 36:2487-9. 2005
    ..One possible mechanism of neurological worsening is the presence of perfusion abnormalities. We sought to identify what proportion of TIA patients had evidence of perfusion abnormalities on MRI...
  61. doi request reprint The albumin in acute stroke trial (ALIAS); design and methodology
    Michael D Hill
    Department of Clinical Neurosciences, Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Int J Stroke 2:214-9. 2007
    ....
  62. doi request reprint Does the application of X-ray contrast agents impair the clinical effect of intravenous recombinant tissue-type plasminogen activator in acute ischemic stroke patients?
    Imanuel Dzialowski
    Department of Clinical Neurosciences, University of Calgary, Calgary Stroke Program, Canada
    Stroke 43:1567-71. 2012
    ..We hypothesized that the application of a contrast agent before intravenous thrombolysis with rtPA reduces its clinical efficacy in acute ischemic stroke...
  63. doi request reprint CT/CT angiography and MRI findings predict recurrent stroke after transient ischemic attack and minor stroke: results of the prospective CATCH study
    Shelagh B Coutts
    Departments of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 43:1013-7. 2012
    ..MRI can identify patients at high risk for a recurrent stroke. However, MRI is not commonly available as an emergency. If similarly clinically predictive, a CT/CT angiographic (CTA) imaging strategy would be more widely applicable...
  64. doi request reprint Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: real-world experience and a call for action
    Rohit Bhatia
    Department of Clinical Neurosciences, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada
    Stroke 41:2254-8. 2010
    ..We aimed to study acute recanalization rates of IV rt-PA in CT angiogram-proven proximal (internal carotid artery [ICA], M1 middle cerebral artery [MCA], M2-MCA, and basilar artery) occlusions and their effects on outcome. Materials and..
  65. doi request reprint How accurate is ICD coding for epilepsy?
    Nathalie Jette
    Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Epilepsia 51:62-9. 2010
    ..Assess the validity of ICD-9-CM and ICD-10 epilepsy coding from an emergency visit (ER) and a hospital discharge abstract database (DAD)...
  66. ncbi request reprint ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome
    Shelagh B Coutts
    Seaman Family MR Centre, Foothills Hospital, Calgary Health Region, 1403 29th St NW, Calgary, Alberta T2N 2T9, Canada
    Stroke 35:2472-6. 2004
    ..CT angiography-source images (CTA-SI) predict final infarct volume. We examined whether the final infarct ASPECTS and clinical outcome were more related to acute CTA-SI ASPECTS than to the acute noncontrast CT (NCCT) ASPECTS...
  67. ncbi request reprint 3-Tesla versus 1.5-Tesla magnetic resonance diffusion and perfusion imaging in hyperacute ischemic stroke
    Robert K Kosior
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alta, Canada
    Cerebrovasc Dis 24:361-8. 2007
    ..5-tesla and 3-tesla imaging for the assessment of hyperacute ischemic stroke (<6 h from symptom onset). Our objective was to compare 1.5-tesla and 3-tesla diffusion and perfusion imaging for hyperacute stroke using optimized protocols...
  68. ncbi request reprint Fluid-attenuated inversion recovery preparation: not an improvement over conventional diffusion-weighted imaging at 3T in acute ischemic stroke
    Jessica E Simon
    Seaman Family MR Research Centre, University of Calgary, Rm 1162, Foothills Medical Centre, 1403 29th St NW, Calgary, AB T2N 2T9 Canada
    AJNR Am J Neuroradiol 25:1653-8. 2004
    ..We compared the signal intensity-to-noise ratio (SNR) and contrast-to-noise-ratio (CNR) between ischemic and normal tissues by using these two sequences...
  69. pmc Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alta
    CMAJ 172:1307-12. 2005
    ..The Canadian Alteplase for Stroke Effectiveness Study, a national prospective cohort study, was conducted to assess the effectiveness of alteplase therapy for ischemic stroke in actual practice...
  70. ncbi request reprint Intravenous thrombolysis for acute ischaemic stroke in young adult patients
    Alexandre Y Poppe
    Calgary Stroke Program, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada
    Can J Neurol Sci 36:161-7. 2009
    ....
  71. ncbi request reprint Rapid evaluation after high-risk TIA is associated with lower stroke risk
    Caren M Wu
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 36:450-5. 2009
    ..We describe the clinical outcomes and costs for high risk TIA patients who received care in a 'rapid evaluation unit', and compare these to a historical 'high-risk' cohort...
  72. ncbi request reprint Intra-arterial thrombolysis in acute ischemic stroke: a review of pharmacologic approaches
    Jacqueline A Pettersen
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Expert Rev Cardiovasc Ther 2:285-99. 2004
    ..Alteplase (Activase, Genentech Inc.) is currently the drug of choice simply because it is available and it is the current intravenous standard. Further trials and developments are anticipated...
  73. ncbi request reprint How well does ASPECTS predict the outcome of acute stroke treated with IV tPA?
    Nicolas U Weir
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Neurology 67:516-8. 2006
    ..Except perhaps when early ischemic change is extensive, clinicians should not estimate prognosis using ASPECTS alone...
  74. doi request reprint Quantomo: validation of a computer-assisted methodology for the volumetric analysis of intracerebral haemorrhage
    Jayme C Kosior
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB, Canada
    Int J Stroke 6:302-5. 2011
    ....
  75. ncbi request reprint Routine CT angiography in acute stroke does not delay thrombolytic therapy
    Simerpreet Bal
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 39:499-501. 2012
    ..We compare interval times during a CTA based acute ischemic stroke protocol with an earlier non-CTA based protocol at our center...
  76. doi request reprint Cardiovascular risk profiles and outcomes of Chinese living inside and outside China
    John F Chiu
    University of Alberta, Edmonton, Alberta, Canada
    Eur J Cardiovasc Prev Rehabil 17:668-75. 2010
    ..To assess whether cardiovascular risk differs among the Chinese living inside and outside mainland China...
  77. doi request reprint Effect of baseline CT scan appearance and time to recanalization on clinical outcomes in endovascular thrombectomy of acute ischemic strokes
    Mayank Goyal
    Department of Clinical Neuroscience, University of Calgary, Alberta, Canada
    Stroke 42:93-7. 2011
    ..We evaluated the association of a favorable initial noncontrast CT and a short time to recanalization in predicting good outcome...
  78. pmc A smartphone client-server teleradiology system for primary diagnosis of acute stroke
    J Ross Mitchell
    Imaging Informatics Lab, Department of Radiology, University of Calgary, Calgary, AB, Canada
    J Med Internet Res 13:e31. 2011
    ..Instead, a server loads and renders the patient images, then transmits a rendered frame to the remote device...
  79. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
    ..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach...
  80. ncbi request reprint Sex differences in adult cerebral venous sinus thrombosis: a 10-year experience
    Claire Hinnell
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 39:74-77. 2012
    ..The proportion of patients on hormonal therapy who develop CVST varies widely. We describe the clinical features, risk factors and outcome by sex and by hormone-related risk factors among a large cohort of patients...
  81. doi request reprint Risks and benefits of thrombolysis in the elderly
    Negar Asdaghi
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Int J Stroke 7:142-9. 2012
    ..Despite this, there is no evidence to suggest that the risk benefit ratio of thrombolysis treatment is substantially different in the elderly than in younger ischemic stroke patients...
  82. doi request reprint Validation of a case definition to define hypertension using administrative data
    Hude Quan
    Department of Community Health Sciences, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada
    Hypertension 54:1423-8. 2009
    ..These results provide evidence that administrative data can be used as a relatively valid source of data to define cases of hypertension for surveillance and research purposes...
  83. pmc The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk
    Robert R Quinn
    Division of Nephrology, University of Calgary, Alberta
    Can J Cardiol 26:241-8. 2010
    ..To provide updated, evidence-based recommendations for the diagnosis and assessment of adults with hypertension...
  84. doi request reprint Treatment of stroke after carotid endarterectomy using intravenous abciximab
    P N Sylaja
    Calgary Stroke Program, Division of Neurosurgery and Department of Clinical, Neurosciences, University of Calgary, Alberta, Canada
    Neurol India 57:780-2. 2009
    ..Transcranial Doppler ultrasonography revealed very frequent microembolization in the left middle cerebral artery territory. The patient was successfully treated with intravenous abciximab with complete neurological recovery...
  85. ncbi request reprint Reliability of measuring lesion volumes in transient ischemic attack and minor stroke
    Nikolai Steffenhagen
    Department of Clinical Neurosciences, Foothills Medical Centre, 1403 29th Street SW, Calgary, AB, T2N 2T9, Canada
    Stroke 41:814-6. 2010
    ....
  86. ncbi request reprint Neurological outcome and quality of life after stroke due to vertebral artery dissection
    Diana Czechowsky
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alta, Canada
    Cerebrovasc Dis 13:192-7. 2002
    ..Vertebral artery dissection is a well-recognized cause of posterior circulation stroke for which there is relatively little information on long-term outcomes. Quality of life (QOL) is an important patient-centred outcome measure...
  87. ncbi request reprint Coding of stroke and stroke risk factors using international classification of diseases, revisions 9 and 10
    Rae A Kokotailo
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Alberta, Canada
    Stroke 36:1776-81. 2005
    ..Our purpose was to compare hospital discharge abstract coding using ICD-9 and ICD-10 for stroke and its risk factors...
  88. doi request reprint Anesthetic management and outcome in patients during endovascular therapy for acute stroke
    Melinda J Davis
    Department of Anesthesiology, University of Calgary, Calgary, Alberta, Canada
    Anesthesiology 116:396-405. 2012
    ..This retrospective study attempts to identify modifiable factors associated with poor outcome, while adjusting for baseline stroke severity, in patients receiving general anesthesia...
  89. doi request reprint Stroke prevention treatment of patients with atrial fibrillation: old and new
    Simerpreet Bal
    Departments of Clinical Neurosciences, Calgary Stroke Program, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Curr Neurol Neurosci Rep 11:15-27. 2011
    ..New, safer and more effective chronic therapy is on the horizon. However, many issues surrounding the management of stroke prevention after an acute stroke and during the course of chronic anticoagulant therapy remain to be resolved...
  90. ncbi request reprint Patients with transient ischemic attack or minor stroke should be admitted to hospital: for
    Geoffrey A Donnan
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:1137-8. 2006
  91. ncbi request reprint A comparison of images generated from diffusion-weighted and diffusion-tensor imaging data in hyper-acute stroke
    Ashley D Harris
    Department of Radiology, University of Calgary, Calgary, Alberta, Canada
    J Magn Reson Imaging 20:193-200. 2004
    ....
  92. pmc Do all ischemic stroke subtypes benefit from organized inpatient stroke care?
    E E Smith
    Calgary Stroke Program, Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 2T9
    Neurology 75:456-62. 2010
    ..We analyzed the effect of organized stroke care in all stroke subtypes in a longitudinal cohort study using data from the Registry of the Canadian Stroke Network...
  93. pmc 2009 Canadian Hypertension Education Program recommendations: the scientific summary--an annual update
    Norman R C Campbell
    Department of Medicine, University of Calgary, Calgary, Canada
    Can J Cardiol 25:271-7. 2009
    ....
  94. ncbi request reprint Reliability of point-of-care testing of INR in acute stroke
    Theresa L Green
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm C1101A, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    Can J Neurol Sci 35:348-51. 2008
    ..The objective of this study was to evaluate the reliability, validity, and impact on clinical decision-making of a POCT device for INR testing in the setting of acute ischemic stroke (AIS)...
  95. ncbi request reprint Complications in MS patients after CCSVI procedures abroad (Calgary, AB)
    Jodie M Burton
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 38:741-6. 2011
    ..Such procedures include angioplasty or stent placement in jugular and azygous veins. The safety and efficacy of these procedures is unknown, but not without risk...
  96. ncbi request reprint Relationship between supra-annual trends in influenza rates and stroke occurrence
    Thalia S Field
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 2T9, Canada
    Neuroepidemiology 23:228-35. 2004
    ..Recent attention in atherosclerotic disease etiology has focused on infectious and inflammatory mechanisms. Influenza is one such infection that may influence stroke occurrence...
  97. ncbi request reprint Acute ischaemic stroke in patients aged 80 years and older: focus on the tolerability of thrombolytic agents
    Alexandre Y Poppe
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Drugs Aging 25:95-103. 2008
    ..Thrombolysis can be safely offered to acute ischaemic stroke patients aged > or = 80 years, although robust data from randomized clinical trials are relatively scarce...
  98. ncbi request reprint Stroke due to calcific embolus following coronary angiography
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foot Hills Hospital, Room 1242A, Calgary, Alberta, Canada T2N 2T9
    Neurology 67:E16. 2006
  99. ncbi request reprint Successful endovascular therapy for acute basilar thrombosis in an adolescent
    Adam Kirton
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Pediatrics 112:e248-51. 2003
    ..This case highlights the underrecognition and subsequent delay in diagnosis of pediatric stroke and how acute intervention may cure otherwise catastrophic strokes in children...
  100. ncbi request reprint Hypertension and stroke: 2005 Canadian Hypertension Educational Program recommendations
    J M Boulanger
    Canadian Hypertension Educational Program, Foothills Hospital, Calgary, Alberta, Canada
    Can J Neurol Sci 32:403-8. 2005
    ..The Canadian Hypertension Educational Program, representing Canada's experts in the field of hypertension, publishes annual evidence-based recommendations on the diagnosis and treatment of hypertension...
  101. doi request reprint Meta-analysis of the effectiveness and safety of catheter ablation of atrial fibrillation in patients with versus without left ventricular systolic dysfunction
    Stephen B Wilton
    Libin Cardiovascular Institute of Alberta, University of Calgary, Canada
    Am J Cardiol 106:1284-91. 2010
    ..Significant improvements in left ventricular ejection fractions after ablation were observed in those with LVSD. Randomized trials are needed given the limitations of present data...