M D Hill

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Rate of stroke recurrence in patients with primary intracerebral hemorrhage
    M D Hill
    Toronto Western Hospital, University of Toronto, Division of Neurology, Ontario, Canada
    Stroke 31:123-7. 2000
  2. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
  3. pmc Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
    BMC Neurol 1:1. 2001
  4. pmc Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Alta
    CMAJ 162:1589-93. 2000
  5. pmc Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Alta
    CMAJ 162:1281-4. 2000
  6. ncbi request reprint Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemia
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
    Stroke 32:84-8. 2001
  7. ncbi request reprint Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator
    A M Demchuk
    Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Stroke 32:89-93. 2001
  8. pmc Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
    P A Barber
    Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
    J Neurol Neurosurg Psychiatry 76:1528-33. 2005
  9. ncbi request reprint Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients
    P N Sylaja
    Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 68:415-9. 2007
  10. doi request reprint Computed tomography and computed tomography angiography findings predict functional impairment in patients with minor stroke and transient ischaemic attack
    S B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, AB, Canada
    Int J Stroke 4:448-53. 2009

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Rate of stroke recurrence in patients with primary intracerebral hemorrhage
    M D Hill
    Toronto Western Hospital, University of Toronto, Division of Neurology, Ontario, Canada
    Stroke 31:123-7. 2000
    ..We sought to determine the rate of recurrence of ICH or cerebral ischemia in a cohort of PICH patients at the Toronto Hospital, Toronto, Canada...
  2. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
    ..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach...
  3. pmc Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
    BMC Neurol 1:1. 2001
    ..One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia...
  4. pmc Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Alta
    CMAJ 162:1589-93. 2000
    ..Areas for continued improvement include the door-to-needle time and broader education of the public about the symptoms of acute ischemic stroke...
  5. pmc Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Alta
    CMAJ 162:1281-4. 2000
    ..The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy...
  6. ncbi request reprint Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemia
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
    Stroke 32:84-8. 2001
    ..CONCLUSIONS: The MCA dot sign is an early marker of thromboembolic occlusion of the distal MCA branches seen in the sylvian fissure and is associated with better outcome than the HMCA sign...
  7. ncbi request reprint Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator
    A M Demchuk
    Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Stroke 32:89-93. 2001
    ..We examined whether the emergent TCD TIBI classification correlated with stroke severity and outcome in patients treated with intravenously administered tPA (IV-tPA)...
  8. pmc Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
    P A Barber
    Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
    J Neurol Neurosurg Psychiatry 76:1528-33. 2005
    ..Controversy exists about the optimal imaging technique in acute stroke. It was hypothesised that CT is comparable with DWI, when both are read systematically using quantitative scoring...
  9. ncbi request reprint Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients
    P N Sylaja
    Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 68:415-9. 2007
    ..Our goal was to evaluate whether the presence of ischemic lesions of varying ages identified by DWI and apparent diffusion coefficient (ADC) suggests a higher risk of future ischemic events...
  10. doi request reprint Computed tomography and computed tomography angiography findings predict functional impairment in patients with minor stroke and transient ischaemic attack
    S B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, AB, Canada
    Int J Stroke 4:448-53. 2009
    ..We hypothesised that noncontrast computed tomography and computed tomography angiography findings in minor stroke and transient ischaemic attack patients would also predict functional outcome...
  11. ncbi request reprint Outcomes after carotid angioplasty and stenting in symptomatic octogenarians
    M A Almekhlafi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 38:446-51. 2011
    ..We sought to review our experience with carotid stenting in symptomatic octogenarians with an emphasis on short-term outcomes and complications...
  12. ncbi request reprint Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 56:1015-20. 2001
    ..Thrombolytic therapy for acute stroke (<3 hours) will not have a major impact on death and dependency unless it is accessible to more patients...
  13. pmc Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neurol Neurosurg Psychiatry 77:885-7. 2006
    ..To test the hypothesis that insular cortical ischaemia is associated with acute hypertension and hyperglycaemia...
  14. ncbi request reprint Silent ischemia in minor stroke and TIA patients identified on MR imaging
    S B Coutts
    Seaman Family MR Centre, Foothills Hospital, Calgary, Alberta T2N 2T9, Canada
    Neurology 65:513-7. 2005
    ..With patients with minor stroke and TIA having a higher risk of recurrent clinical events, the authors examined whether patients with minor stroke and TIA also had a high rate of asymptomatic lesions on repeat MRI scanning...
  15. ncbi request reprint Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada
    Neurology 60:1525-7. 2003
    ..Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0)...
  16. doi request reprint Regional leptomeningeal score on CT angiography predicts clinical and imaging outcomes in patients with acute anterior circulation occlusions
    B K Menon
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 32:1640-5. 2011
    ..Efforts to determine biological determinants of collateral status are needed if techniques to alter collateral behavior and extend time windows are to succeed...
  17. pmc The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies
    P A Barber
    Department of Clinical Neurosciences, Calgary Stroke Program, Seaman Family Magnetic Research Centre, NW, Calgary, Canada AB T2N 4N1
    J Neurol Neurosurg Psychiatry 75:1426-30. 2004
    ..We assessed the sensitivity and specificity of the hyperdense middle cerebral artery (HMCA) and the "dot" sign using magnetic resonance angiography (MRA)...
  18. doi request reprint Subacute seizure incidence in thrombolysis-treated ischemic stroke patients
    P Couillard
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
    Neurocrit Care 16:241-5. 2012
    ..To assess the incidence of seizures in acute ischemic stroke patients treated with chemical (tPA) thrombolysis...
  19. ncbi request reprint Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:507-11. 2005
    ..Intra-arterial thrombolysis has been reported as a potentially efficacious and safe treatment...
  20. pmc Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts?
    M Eesa
    Department of Diagnostic Imaging, University of Calgary, Canada
    Interv Neuroradiol 17:228-34. 2011
    ..Time differences during regular and after hours should serve as a reminder to make efforts to reduce overall ischemic times in spite of staffing patterns and resource availability...
  21. ncbi request reprint Using the baseline CT scan to select acute stroke patients for IV-IA therapy
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 27:1612-6. 2006
    ..Selecting the best patients for this therapy may be accomplished with the use of baseline neuroimaging...
  22. ncbi request reprint Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke
    J H Pexman
    Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 22:1534-42. 2001
    ..CONCLUSION: ASPECTS is a systematic, robust, and practical method that can be applied to different axial baselines. Clinician agreement is superior to that of the 1/3 MCA rule...
  23. ncbi request reprint Simultaneous carotid endarterectomy and coronary artery bypass surgery in Canada
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 64:1435-7. 2005
    ..In Canada, 0.51% of CABG procedures were combined CEA-CABG. The adjusted stroke and death rate was 2.67-fold greater in the combined CEA-CABG group compared to CABG alone. Randomized trials of the combined procedure are needed...
  24. ncbi request reprint Methodology for the Canadian Activase for Stroke Effectiveness Study (CASES). CASES Investigators
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, AB, Canada
    Can J Neurol Sci 28:232-8. 2001
    ..CONCLUSIONS: This paper outlines the development of and methods for the CASES study. The study is an example of a multi-stakeholder collaboration to advance the care of patients with acute stroke...
  25. ncbi request reprint Carotid stenting in asymptomatic carotid stenosis: the Calgary experience
    N Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 37:568-73. 2010
    ..We describe our experience with asymptomatic patients who underwent carotid stenting at our center in a routine clinical setting...
  26. pmc Differences in stroke outcome based on sex
    N Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T2N 2T9, Canada
    Neurology 74:767-71. 2010
    ..Stroke thrombolysis may have a differential effect by sex. We sought to examine the relationship between sex and outcome after thrombolysis...
  27. ncbi request reprint Incidence of Guillain-Barré syndrome in Alberta, Canada: an administrative data study
    L J Hauck
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    J Neurol Neurosurg Psychiatry 79:318-20. 2008
    ..To examine the epidemiology of Guillain-Barré syndrome (GBS) in Alberta between 1994 and 2004 with data derived from hospital administration procedures...
  28. doi request reprint Recurrent cerebral ischemia in medically treated patent foramen ovale: a meta-analysis
    M A Almekhlafi
    Room 1242A, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB, T2N 2T9 Canada
    Neurology 73:89-97. 2009
    ..Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear...
  29. ncbi request reprint Neuroprotection and neurogenesis: modulation of cornus ammonis 1 neuronal survival after transient forebrain ischemia by prior fimbria-fornix deafferentation
    Z Zhao
    Calgary Stroke Program, Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Neuroscience 140:219-26. 2006
    ..5-fold over sham lesion plus ischemia. The results indicate that fimbria-fornix deafferentation provides long-term neuroprotection in cornus ammonis 1 following forebrain ischemia and promotes neurogenesis after ischemic insults...
  30. doi request reprint Role of CT angiographic plaque morphologic characteristics in addition to stenosis in predicting the symptomatic side in carotid artery disease
    M Eesa
    Department of Radiology, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 31:1254-60. 2010
    ..We evaluated carotid plaque morphologic features by using CTA in addition to stenosis in the setting of symptomatic hemispheric TIA/stroke to identify factors that may predict plaque activity...
  31. ncbi request reprint The ASPIRE approach for TIA risk stratification
    S B Coutts
    Calgary Stroke Program, University of Calgary, Calgary Department of Clinical Neurosciences, University of Calgary, Calgary
    Can J Neurol Sci 38:78-81. 2011
    ..We assessed the ability of the ASPIRE approach to identify patients at risk for stroke...
  32. ncbi request reprint Predicting final disposition after stroke using the Orpington Prognostic Score
    C J Wright
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, and Rehabilitation Services Neurosciences Team FMC, Calgary Health Region, Calgary, AB, Canada
    Can J Neurol Sci 31:494-8. 2004
    ..In Calgary, the Orpington Prognostic Score (OPS) has been used to predict outcome as an aid to rehabilitation triage. However, the OPS has not been assessed at one week for predictive capability...
  33. ncbi request reprint Wallerian-like degeneration after ischemic stroke revealed by diffusion--weighted imaging
    R N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 34:243-4. 2007
  34. ncbi request reprint The rise and fall of NMDA antagonists for ischemic stroke
    L Hoyte
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Curr Mol Med 4:131-6. 2004
    ..We also speculate that NMDA receptor antagonism may have hindered endogenous mechanisms for neuronal survival and neuroregeneration. It remains to be proven in human stroke whether NMDA receptor antagonism can be neuroprotective...
  35. ncbi request reprint CT assessment of conjugate eye deviation in acute stroke
    J E Simon
    Calgary Stroke Programme, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 60:135-7. 2003
    ..In an era of thrombolysis and rapid decision making in acute ischemic stroke, eye deviation on CT can help quickly direct attention to the affected hemisphere...
  36. ncbi request reprint The high risk of stroke immediately after transient ischemic attack: a population-based study
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Canada
    Neurology 62:2015-20. 2004
    ..Previous prognostic models suggest that diabetes mellitus, age, and clinical symptomatology predict stroke. The authors evaluated the magnitude of risk of stroke and predictors of stroke after TIA in an entire population over time...
  37. ncbi request reprint Unexpected posthemorrhagic hydrocephalus in patients treated with rFVIIa
    S Subramaniam
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 67:1096. 2006
  38. ncbi request reprint The spectrum of electrophysiological abnormalities in Bell's palsy
    M D Hill
    Division of Neurology, St. Michael's Hospital, ON, Canada
    Can J Neurol Sci 28:130-3. 2001
    ..Blink reflex latencies may be under-utilized in the assessment of the facial nerve in Bell's palsy. Facial EMG is not generally useful in routine assessment...
  39. ncbi request reprint Multicenter evaluation of a self-expanding carotid stent system with distal protection in the treatment of carotid stenosis
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 27:759-65. 2006
    ....
  40. ncbi request reprint Open labeled, uncontrolled pharmacokinetic study of a single intramuscular hCG dose in healthy male volunteers
    A W Davidoff
    Stem Cell Therapeutics Corp, Calgary, Alberta, Canada
    Int J Clin Pharmacol Ther 47:516-24. 2009
    ..Consequently, we conclude that these two drugs demonstrate no statistical significant difference with respect to the CSF...
  41. ncbi request reprint Radiation-induced glioma presenting as diffuse leptomeningeal gliomatosis: a case report
    M D Hill
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Neurooncol 55:113-6. 2001
    ..Our patient's course is novel in that symptomatic relief was achieved with CSF diversion and a combination of chemotherapy and focal radiation allowed prolonged survival...
  42. ncbi request reprint Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis
    Y Zhang
    Department of Radiology, University of Calgary, Calgary, Canada
    Mult Scler 13:880-3. 2007
    ..5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study...
  43. ncbi request reprint Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke
    V Palumbo
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neurology 68:1020-4. 2007
    ..To evaluate whether the presence of leukoaraiosis or multiple lacunes is associated with symptomatic intracerebral hemorrhage (ICH) and 90-day outcome after thrombolytic treatment with tissue plasminogen activator (tPA)...
  44. ncbi request reprint Predictors of good outcome after intravenous tPA for acute ischemic stroke
    A M Demchuk
    Stroke Unit, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Neurology 57:474-80. 2001
    ..CONCLUSIONS: Several factors were independently predictive of good outcome among patients with acute ischemic stroke treated with alteplase. These results require further confirmation before clinical implementation...
  45. ncbi request reprint Trends in hospital admission for stroke in Calgary
    T S Field
    Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 31:387-93. 2004
    ..Poisson and simple linear regression was used to model time trends of occurrence by stroke type and age-group and to extrapolate future time trends...
  46. ncbi request reprint The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report
    M D Ginsberg
    Department of Neurology, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Biochem Soc Trans 34:1323-6. 2006
    ..Approx. 60 North American clinical sites will participate. Subject enrollment is expected to commence in July 2006...
  47. ncbi request reprint Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy
    S R Martini
    Department of Neurology, Baylor College of Medicine and the Michael E DeBakey Veterans Affairs Medical Center Stroke Program, Houston, TX 77030, USA
    Neurology 67:700-2. 2006
    ..We found that ultrasound's benefit on 90-day outcome was primarily apparent at higher glucose levels, suggesting that ultrasound therapy may improve outcome following hyperglycemic stroke...