M D Hill

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
  2. ncbi request reprint The high risk of stroke immediately after transient ischemic attack: a population-based study
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Canada
    Neurology 62:2015-20. 2004
  3. ncbi request reprint Simultaneous carotid endarterectomy and coronary artery bypass surgery in Canada
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 64:1435-7. 2005
  4. ncbi request reprint Factors influencing the decision to perform carotid endarterectomy
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 62:803-5. 2004
  5. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
  6. ncbi request reprint Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 34:1925-31. 2003
  7. ncbi request reprint Stroke: the dashed hopes of neuroprotection
    Michael D Hill
    Hotchkins Brain Institute, University of Calgary, Foothills Hospital, Calgary, ABT2N 2T9, Canada
    Lancet Neurol 6:2-3. 2007
  8. ncbi request reprint Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada
    Neurology 60:1525-7. 2003
  9. ncbi request reprint Using the baseline CT scan to select acute stroke patients for IV-IA therapy
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 27:1612-6. 2006
  10. pmc Stroke units in Canada
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, AB
    CMAJ 167:649-50. 2002

Detail Information

Publications97

  1. pmc Methodology of the Interventional Management of Stroke III Trial
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way ML 0525, Cincinnati, OH 45267 0525, USA
    Int J Stroke 3:130-7. 2008
    ..a.) approach to recanalization may be more effective than standard i.v. rt-PA (Activase) alone for moderate-to-large National Institutes of Health Stroke Scale (NIHSS>or=10) strokes, and with a similar safety profile...
  2. ncbi request reprint The high risk of stroke immediately after transient ischemic attack: a population-based study
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Canada
    Neurology 62:2015-20. 2004
    ..Previous prognostic models suggest that diabetes mellitus, age, and clinical symptomatology predict stroke. The authors evaluated the magnitude of risk of stroke and predictors of stroke after TIA in an entire population over time...
  3. ncbi request reprint Simultaneous carotid endarterectomy and coronary artery bypass surgery in Canada
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 64:1435-7. 2005
    ..In Canada, 0.51% of CABG procedures were combined CEA-CABG. The adjusted stroke and death rate was 2.67-fold greater in the combined CEA-CABG group compared to CABG alone. Randomized trials of the combined procedure are needed...
  4. ncbi request reprint Factors influencing the decision to perform carotid endarterectomy
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 62:803-5. 2004
    ..No differences existed by specialty. Canadian physicians in four specialties are knowledgeable about results of randomized clinical trials for carotid endarterectomy...
  5. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
    ..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
  6. ncbi request reprint Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 34:1925-31. 2003
    ....
  7. ncbi request reprint Stroke: the dashed hopes of neuroprotection
    Michael D Hill
    Hotchkins Brain Institute, University of Calgary, Foothills Hospital, Calgary, ABT2N 2T9, Canada
    Lancet Neurol 6:2-3. 2007
  8. ncbi request reprint Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alberta, Canada
    Neurology 60:1525-7. 2003
    ..Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0)...
  9. ncbi request reprint Using the baseline CT scan to select acute stroke patients for IV-IA therapy
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 27:1612-6. 2006
    ..Selecting the best patients for this therapy may be accomplished with the use of baseline neuroimaging...
  10. pmc Stroke units in Canada
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, AB
    CMAJ 167:649-50. 2002
  11. doi request reprint The albumin in acute stroke trial (ALIAS); design and methodology
    Michael D Hill
    Department of Clinical Neurosciences, Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Int J Stroke 2:214-9. 2007
    ....
  12. ncbi request reprint Hyperdense sylvian fissure MCA "dot" sign: A CT marker of acute ischemia
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Seaman Family Magnetic Research Center, Calgary, Alberta, Canada
    Stroke 32:84-8. 2001
    ..CONCLUSIONS: The MCA dot sign is an early marker of thromboembolic occlusion of the distal MCA branches seen in the sylvian fissure and is associated with better outcome than the HMCA sign...
  13. ncbi request reprint Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients
    P N Sylaja
    Calgary Stroke Program, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 68:415-9. 2007
    ..Our goal was to evaluate whether the presence of ischemic lesions of varying ages identified by DWI and apparent diffusion coefficient (ADC) suggests a higher risk of future ischemic events...
  14. pmc Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging
    P A Barber
    Seaman Family Magnetic Resonance Research Centre, University of Calgary, Calgary T2N 4N1, Canada
    J Neurol Neurosurg Psychiatry 76:1528-33. 2005
    ..Controversy exists about the optimal imaging technique in acute stroke. It was hypothesised that CT is comparable with DWI, when both are read systematically using quantitative scoring...
  15. ncbi request reprint Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator
    A M Demchuk
    Seaman Family MR Research Centre, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Stroke 32:89-93. 2001
    ..We examined whether the emergent TCD TIBI classification correlated with stroke severity and outcome in patients treated with intravenously administered tPA (IV-tPA)...
  16. doi request reprint Computed tomography and computed tomography angiography findings predict functional impairment in patients with minor stroke and transient ischaemic attack
    S B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, AB, Canada
    Int J Stroke 4:448-53. 2009
    ..We hypothesised that noncontrast computed tomography and computed tomography angiography findings in minor stroke and transient ischaemic attack patients would also predict functional outcome...
  17. pmc Building a "brain attack" team to administer thrombolytic therapy for acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Alta
    CMAJ 162:1589-93. 2000
    ..Areas for continued improvement include the door-to-needle time and broader education of the public about the symptoms of acute ischemic stroke...
  18. pmc Symptomatic hemorrhage after alteplase therapy not due to silent ischemia
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Stroke Research Office, Foothills Hospital, 1403 29th Street NW, Calgary, Alberta, Canada
    BMC Neurol 1:1. 2001
    ..Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia...
  19. ncbi request reprint Silent ischemia in minor stroke and TIA patients identified on MR imaging
    S B Coutts
    Seaman Family MR Centre, Foothills Hospital, Calgary, Alberta T2N 2T9, Canada
    Neurology 65:513-7. 2005
    ..With patients with minor stroke and TIA having a higher risk of recurrent clinical events, the authors examined whether patients with minor stroke and TIA also had a high rate of asymptomatic lesions on repeat MRI scanning...
  20. pmc Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Neurol Neurosurg Psychiatry 77:885-7. 2006
    ..To test the hypothesis that insular cortical ischaemia is associated with acute hypertension and hyperglycaemia...
  21. ncbi request reprint Outcomes after carotid angioplasty and stenting in symptomatic octogenarians
    M A Almekhlafi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 38:446-51. 2011
    ..We sought to review our experience with carotid stenting in symptomatic octogenarians with an emphasis on short-term outcomes and complications...
  22. pmc Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Alta
    CMAJ 162:1281-4. 2000
    ..The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy...
  23. doi request reprint Regional leptomeningeal score on CT angiography predicts clinical and imaging outcomes in patients with acute anterior circulation occlusions
    B K Menon
    Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 32:1640-5. 2011
    ..Efforts to determine biological determinants of collateral status are needed if techniques to alter collateral behavior and extend time windows are to succeed...
  24. ncbi request reprint Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    P A Barber
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 56:1015-20. 2001
    ..Thrombolytic therapy for acute stroke (<3 hours) will not have a major impact on death and dependency unless it is accessible to more patients...
  25. doi request reprint Subacute seizure incidence in thrombolysis-treated ischemic stroke patients
    P Couillard
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
    Neurocrit Care 16:241-5. 2012
    ..To assess the incidence of seizures in acute ischemic stroke patients treated with chemical (tPA) thrombolysis...
  26. ncbi request reprint Methodology for the Canadian Activase for Stroke Effectiveness Study (CASES). CASES Investigators
    M D Hill
    Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, AB, Canada
    Can J Neurol Sci 28:232-8. 2001
    ..CONCLUSIONS: This paper outlines the development of and methods for the CASES study. The study is an example of a multi-stakeholder collaboration to advance the care of patients with acute stroke...
  27. pmc Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts?
    M Eesa
    Department of Diagnostic Imaging, University of Calgary, Canada
    Interv Neuroradiol 17:228-34. 2011
    ..Time differences during regular and after hours should serve as a reminder to make efforts to reduce overall ischemic times in spite of staffing patterns and resource availability...
  28. ncbi request reprint Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke
    J H Pexman
    Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 22:1534-42. 2001
    ..CONCLUSION: ASPECTS is a systematic, robust, and practical method that can be applied to different axial baselines. Clinician agreement is superior to that of the 1/3 MCA rule...
  29. ncbi request reprint Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:507-11. 2005
    ..Intra-arterial thrombolysis has been reported as a potentially efficacious and safe treatment...
  30. pmc Differences in stroke outcome based on sex
    N Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T2N 2T9, Canada
    Neurology 74:767-71. 2010
    ..Stroke thrombolysis may have a differential effect by sex. We sought to examine the relationship between sex and outcome after thrombolysis...
  31. ncbi request reprint Predicting final disposition after stroke using the Orpington Prognostic Score
    C J Wright
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, and Rehabilitation Services Neurosciences Team FMC, Calgary Health Region, Calgary, AB, Canada
    Can J Neurol Sci 31:494-8. 2004
    ..In Calgary, the Orpington Prognostic Score (OPS) has been used to predict outcome as an aid to rehabilitation triage. However, the OPS has not been assessed at one week for predictive capability...
  32. ncbi request reprint Carotid stenting in asymptomatic carotid stenosis: the Calgary experience
    N Shobha
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 37:568-73. 2010
    ..We describe our experience with asymptomatic patients who underwent carotid stenting at our center in a routine clinical setting...
  33. pmc The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies
    P A Barber
    Department of Clinical Neurosciences, Calgary Stroke Program, Seaman Family Magnetic Research Centre, NW, Calgary, Canada AB T2N 4N1
    J Neurol Neurosurg Psychiatry 75:1426-30. 2004
    ..We assessed the sensitivity and specificity of the hyperdense middle cerebral artery (HMCA) and the "dot" sign using magnetic resonance angiography (MRA)...
  34. ncbi request reprint CT assessment of conjugate eye deviation in acute stroke
    J E Simon
    Calgary Stroke Programme, Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Neurology 60:135-7. 2003
    ..In an era of thrombolysis and rapid decision making in acute ischemic stroke, eye deviation on CT can help quickly direct attention to the affected hemisphere...
  35. ncbi request reprint Incidence of Guillain-Barré syndrome in Alberta, Canada: an administrative data study
    L J Hauck
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 2T9, Canada
    J Neurol Neurosurg Psychiatry 79:318-20. 2008
    ..To examine the epidemiology of Guillain-Barré syndrome (GBS) in Alberta between 1994 and 2004 with data derived from hospital administration procedures...
  36. doi request reprint Recurrent cerebral ischemia in medically treated patent foramen ovale: a meta-analysis
    M A Almekhlafi
    Room 1242A, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB, T2N 2T9 Canada
    Neurology 73:89-97. 2009
    ..Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear...
  37. ncbi request reprint Neuroprotection and neurogenesis: modulation of cornus ammonis 1 neuronal survival after transient forebrain ischemia by prior fimbria-fornix deafferentation
    Z Zhao
    Calgary Stroke Program, Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Neuroscience 140:219-26. 2006
    ..5-fold over sham lesion plus ischemia. The results indicate that fimbria-fornix deafferentation provides long-term neuroprotection in cornus ammonis 1 following forebrain ischemia and promotes neurogenesis after ischemic insults...
  38. ncbi request reprint The ASPIRE approach for TIA risk stratification
    S B Coutts
    Calgary Stroke Program, University of Calgary, Calgary Department of Clinical Neurosciences, University of Calgary, Calgary
    Can J Neurol Sci 38:78-81. 2011
    ..We assessed the ability of the ASPIRE approach to identify patients at risk for stroke...
  39. doi request reprint Role of CT angiographic plaque morphologic characteristics in addition to stenosis in predicting the symptomatic side in carotid artery disease
    M Eesa
    Department of Radiology, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 31:1254-60. 2010
    ..We evaluated carotid plaque morphologic features by using CTA in addition to stenosis in the setting of symptomatic hemispheric TIA/stroke to identify factors that may predict plaque activity...
  40. ncbi request reprint The rise and fall of NMDA antagonists for ischemic stroke
    L Hoyte
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Curr Mol Med 4:131-6. 2004
    ..We also speculate that NMDA receptor antagonism may have hindered endogenous mechanisms for neuronal survival and neuroregeneration. It remains to be proven in human stroke whether NMDA receptor antagonism can be neuroprotective...
  41. ncbi request reprint Wallerian-like degeneration after ischemic stroke revealed by diffusion--weighted imaging
    R N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 34:243-4. 2007
  42. ncbi request reprint Refractory neurosarcoidosis responding to infliximab
    J A Pettersen
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Calgary, Alberta, Canada
    Neurology 59:1660-1. 2002
  43. ncbi request reprint Unexpected posthemorrhagic hydrocephalus in patients treated with rFVIIa
    S Subramaniam
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 2T9
    Neurology 67:1096. 2006
  44. ncbi request reprint Multicenter evaluation of a self-expanding carotid stent system with distal protection in the treatment of carotid stenosis
    M D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 27:759-65. 2006
    ....
  45. ncbi request reprint Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis
    Y Zhang
    Department of Radiology, University of Calgary, Calgary, Canada
    Mult Scler 13:880-3. 2007
    ..5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study...
  46. ncbi request reprint Open labeled, uncontrolled pharmacokinetic study of a single intramuscular hCG dose in healthy male volunteers
    A W Davidoff
    Stem Cell Therapeutics Corp, Calgary, Alberta, Canada
    Int J Clin Pharmacol Ther 47:516-24. 2009
    ..Consequently, we conclude that these two drugs demonstrate no statistical significant difference with respect to the CSF...
  47. pmc Importance of leukoaraiosis on CT for tissue plasminogen activator decision making: evaluation of the NINDS rt-PA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Cerebrovasc Dis 26:120-5. 2008
    ..We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study...
  48. doi request reprint Stroke: the Elixhauser Index for comorbidity adjustment of in-hospital case fatality
    Haifeng Zhu
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Rm 1242A, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2T9
    Neurology 71:283-7. 2008
    ..Similarly, an International Classification of Diseases (ICD)-10 coding algorithm has been rarely reported for Elixhauser Index...
  49. ncbi request reprint Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients?
    Shelagh B Coutts
    Department of Clinical Neurosciences, Room C1246, Foothills Medical Centre, 1403 29th St SW, Calgary, AB, T2N 2T9, Canada
    Stroke 39:2461-6. 2008
    ..Clinical trials are needed to assess acute treatment options in these patients. We sought to evaluate the type of recurrent events and to identify which subsets of patients are at risk for recurrent events...
  50. doi request reprint Calcification and endothelialization of thrombi in acute stroke
    Mohammed A Almekhlafi
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Ann Neurol 64:344-8. 2008
    ..Thrombus composition could critically determine the success of chemical thrombolysis. Our results should stimulate the development of imaging modalities to determine thrombus composition...
  51. doi request reprint Variables associated with 7-day, 30-day, and 1-year fatality after ischemic stroke
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    Stroke 39:2318-24. 2008
    ..However, limited information is available concerning variables associated with stroke case fatality at these different points in time. We sought to identify and compare variables associated with 7-day, 30-day, and 1-year stroke fatality...
  52. pmc Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease
    Michael Eliasziw
    Department of Community Health Sciences, University of Calgary, Calgary, Alta
    CMAJ 170:1105-9. 2004
    ..Transient ischemic attacks (TIAs) often herald a stroke, but little is known about the acute natural history of TIAs. Our objective was to quantify the early risk of stroke after a TIA in patients with internal carotid artery disease...
  53. pmc The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk
    Raj S Padwal
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Can J Cardiol 24:455-63. 2008
    ..To provide updated, evidence-based recommendations for the diagnosis and assessment of adults with hypertension...
  54. doi request reprint The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Neurology 71:1080-3. 2008
    ..This nullification of the usual gender effect among rtPA-treated patients has not been confirmed...
  55. doi request reprint When to expect negative diffusion-weighted images in stroke and transient ischemic attack
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Centre, Room 1162, University of Calgary, Alberta, Canada
    Stroke 39:1898-900. 2008
    ..The frequency of DWI negative cerebral ischemia and clinical factors associated with such a circumstance is not well understood...
  56. ncbi request reprint Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial
    James Kennedy
    Acute Stroke Programme, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Lancet Neurol 6:961-9. 2007
    ..Patients with transient ischaemic attack (TIA) or minor stroke are at high immediate risk of stroke. The optimum early treatment options for these patients are not known...
  57. ncbi request reprint Combined intravenous and intra-arterial approach in acute stroke treatment
    Mohammed A Almekhlafi
    University of Calgary, Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    Expert Opin Pharmacother 8:1837-49. 2007
    ..The authors discuss the process of patient selection using clinical, as well as state of the art imaging modalities...
  58. ncbi request reprint Neurological outcome and quality of life after stroke due to vertebral artery dissection
    Diana Czechowsky
    Department of Clinical Neurosciences, University of Calgary, Foothills Hospital, Alta, Canada
    Cerebrovasc Dis 13:192-7. 2002
    ..Vertebral artery dissection is a well-recognized cause of posterior circulation stroke for which there is relatively little information on long-term outcomes. Quality of life (QOL) is an important patient-centred outcome measure...
  59. ncbi request reprint An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, AB, Canada
    Int J Stroke 3:3-10. 2008
    ..Modern imaging of the brain was not included. The present study quantified the added value of magnetic resonance imaging (MRI) factors to the ABCD(2) tool...
  60. ncbi request reprint Bedside emergency transcranial Doppler diagnosis of severe carotid disease using orbital window examination
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Canada
    J Neuroimaging 15:138-43. 2005
    ..The authors sought to evaluate the TCD orbital window for predicting cervical ICA (cICA) stenosis in the setting of acute stroke and TIA...
  61. ncbi request reprint Intra-arterial thrombolysis in acute ischemic stroke: a review of pharmacologic approaches
    Jacqueline A Pettersen
    Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Expert Rev Cardiovasc Ther 2:285-99. 2004
    ..Alteplase (Activase, Genentech Inc.) is currently the drug of choice simply because it is available and it is the current intravenous standard. Further trials and developments are anticipated...
  62. ncbi request reprint Interobserver variation of ASPECTS in real time
    Shelagh B Coutts
    Seaman Family MR Centre, Calgary Health Region, Foothills Hospital, Calgary, Alberta, Canada
    Stroke 35:e103-5. 2004
    ..We sought to assess the reliability of the score when performed in real time as compared with an expert rating performed at a later time point...
  63. ncbi request reprint ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome
    Shelagh B Coutts
    Seaman Family MR Centre, Foothills Hospital, Calgary Health Region, 1403 29th St NW, Calgary, Alberta T2N 2T9, Canada
    Stroke 35:2472-6. 2004
    ..CT angiography-source images (CTA-SI) predict final infarct volume. We examined whether the final infarct ASPECTS and clinical outcome were more related to acute CTA-SI ASPECTS than to the acute noncontrast CT (NCCT) ASPECTS...
  64. ncbi request reprint Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke
    Andrei V Alexandrov
    Stroke Treatment Team, University of Texas Houston Medical School, Houston 77030, USA
    N Engl J Med 351:2170-8. 2004
    ..Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA...
  65. ncbi request reprint Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
    Stroke 36:62-5. 2005
    ..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke...
  66. ncbi request reprint Stroke after varicella vaccination
    Elaine Wirrell
    Division of Pediatric Neurology, Alberta Children s Hospital, and the University of Calgary, Ontario, Canada
    J Pediatr 145:845-7. 2004
    ..Both children had small patent foramen ovale (PFO), and one child also had severe iron-deficiency anemia, which may have predisposed the patient to this adverse effect...
  67. ncbi request reprint Stroke prevention. MATCHing therapy to the patient with TIA
    Nicolas U Weir
    Department of Clinical Neurosciences, University of Calgary Faculty of Medicine, Foothills Medical Centre, Alberta, Canada
    Postgrad Med 117:26-30. 2005
    ..Here, the authors discuss treatment considerations, outlining the current knowledge and stressing the need for formal randomized trials to definitively establish the effectiveness of preventive therapies after minor stroke or TIA...
  68. ncbi request reprint Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 33:279-82. 2002
    ..A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke. We sought to assess the safety and feasibility of this approach...
  69. ncbi request reprint A description of Canadian and United States physician reimbursement for thrombolytic therapy administration in acute ischemic stroke
    Dawn Kleindorfer
    Department of Neurology, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0525, Cincinnati, Ohio 45267 0525, USA
    Stroke 36:682-7. 2005
    ..We describe the physician reimbursement for thrombolytic therapy for the stroke team physicians serving the Greater Cincinnati/Northern Kentucky region (GCNK), and the Alberta region...
  70. ncbi request reprint Derivation of transcranial Doppler criteria for rescue intra-arterial thrombolysis: multicenter experience from the Interventional Management of Stroke study
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Stroke 36:865-8. 2005
    ..We examined clinical utility and prognostic value of TCD flow findings in patients enrolled in an intravenous/intra-arterial rtPA pilot trial (Interventional Management of Stroke [IMS] study)...
  71. pmc Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study
    Michael D Hill
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alta
    CMAJ 172:1307-12. 2005
    ..The Canadian Alteplase for Stroke Effectiveness Study, a national prospective cohort study, was conducted to assess the effectiveness of alteplase therapy for ischemic stroke in actual practice...
  72. ncbi request reprint Safety outcomes of Alteplase among acute ischemic stroke patients with special characteristics
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Medical Center, University of Calgary, Calgary, Alberta, Canada
    Neurocrit Care 6:181-5. 2007
    ....
  73. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis
    Yuko Y Palesch
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2107-14. 2006
    ..A phase I dose-escalation study was conducted to assess the safety of ALB therapy in ischemic stroke. We analyzed the data for preliminary evidence of treatment efficacy...
  74. ncbi request reprint Intracerebral hemorrhage: outcomes and eligibility for factor VIIa treatment in a National Stroke Registry
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 22:271-5. 2006
    ..Intracerebral hemorrhage (ICH) is a devastating form of stroke for which the lack of treatment options, high mortality rate, and the tendency to severely disable result in high social and economic burden...
  75. ncbi request reprint Hyperperfusion syndrome: toward a stricter definition
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, and Seaman Family MR Research Centre, Calgary, Alberta, Canada
    Neurosurgery 53:1053-58; discussion 1058-60. 2003
    ..Hyperperfusion syndrome is a rare and potentially devastating complication of carotid endarterectomy or carotid artery angioplasty and stenting. With the advent of new imaging techniques, we reviewed our experience with this phenomenon...
  76. ncbi request reprint Is the ABCD score truly useful?
    Michael D Hill
    Stroke 37:1636. 2006
  77. ncbi request reprint Hyperacute stroke: experience essential when reading unenhanced CT scans
    J H Warwick Pexman
    AJNR Am J Neuroradiol 25:516; author reply 516-8. 2004
  78. ncbi request reprint Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study
    Andrew M Demchuk
    Department of Clinical Neurosciences, Foothills Medical Centre, Calgary, AB, Canada
    Stroke 36:2110-5. 2005
    ..We examined whether ASPECTS could be a treatment modifier by systematically reviewing the CT scans in the NINDS rtPA Stroke Study...
  79. pmc Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, Room 1242A, Calgary, AB T2N 2T9, Canada
    J Neurol Neurosurg Psychiatry 77:826-9. 2006
    ..The benefit of intravenous tissue plasminogen activator (tPA) given within 3 h of acute ischaemic stroke to patients over 80 years of age is uncertain...
  80. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
    ..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset...
  81. ncbi request reprint Mild neurological symptoms despite middle cerebral artery occlusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Alberta T2N 2T9, Canada
    Stroke 35:469-71. 2004
    ..Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy...
  82. ncbi request reprint TPA use for stroke in the Registry of the Canadian Stroke Network
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Can J Neurol Sci 32:433-9. 2005
    ..Thrombolysis for stroke with tPA is now a standard of care in North America. However, it is only used on a small percentage of patients...
  83. ncbi request reprint Hypertension and stroke: 2005 Canadian Hypertension Educational Program recommendations
    J M Boulanger
    Canadian Hypertension Educational Program, Foothills Hospital, Calgary, Alberta, Canada
    Can J Neurol Sci 32:403-8. 2005
    ..The Canadian Hypertension Educational Program, representing Canada's experts in the field of hypertension, publishes annual evidence-based recommendations on the diagnosis and treatment of hypertension...
  84. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2100-6. 2006
    ..In preclinical stroke models, high-dose human albumin confers robust neuroprotection. We investigated the safety and tolerability of this therapy in patients with acute ischemic stroke...
  85. ncbi request reprint Computed tomographic parameters predicting fatal outcome in large middle cerebral artery infarction
    Philip A Barber
    Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
    Cerebrovasc Dis 16:230-5. 2003
    ..As yet there are few guidelines to aid the selection of patients for aggressive interventional therapies, such as decompression hemicraniectomy and/or hypothermia...
  86. ncbi request reprint CT-NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:2079-84. 2007
    ..However, MRI has limited availability in many hospitals. We investigated whether mismatch between the Alberta Stroke Program Early CT Score (ASPECTS) and the NIH Stroke Scale (NIHSS) correlates with MRI diffusion-perfusion mismatch...
  87. ncbi request reprint Accuracy of serial National Institutes of Health Stroke Scale scores to identify artery status in acute ischemic stroke
    Robert Mikulik
    Department of Neurology, University of Texas Health Science Center at Houston, USA
    Circulation 115:2660-5. 2007
    ..We sought to determine the accuracy of serial National Institutes of Health Stroke Scale (NIHSS) scores to detect complete early recanalization of the middle cerebral artery...
  88. ncbi request reprint MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction
    Michael S Bristow
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Cereb Blood Flow Metab 25:1280-7. 2005
    ..This study suggests that tissue-specific analysis of perfusion and diffusion imaging is required to accurately predict tissue at risk of infarction in acute ischemic stroke...
  89. ncbi request reprint Current management of transient ischemic attack
    Padmavathy N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Am J Cardiovasc Drugs 7:67-74. 2007
    ..Endarterectomy or carotid stenting is of great benefit to patients with TIA secondary to stenosis in the extracranial carotid artery...
  90. ncbi request reprint Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging
    Shelagh B Coutts
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, Alberta, Canada
    Ann Neurol 57:848-54. 2005
    ....
  91. ncbi request reprint Association of pretreatment blood pressure with tissue plasminogen activator-induced arterial recanalization in acute ischemic stroke
    Georgios Tsivgoulis
    Neurosonology and Stroke Research Program, Barrow Neurological Institute, Phoenix, Arizona, USA
    Stroke 38:961-6. 2007
    ..We aimed to evaluate the potential relationship between pretreatment SBP and tPA-induced recanalization...
  92. ncbi request reprint Syncope and cerebral hypoperfusion
    Shelagh B Coutts
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Neurology 60:2011. 2003
  93. ncbi request reprint Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry
    Imanuel Dzialowski
    Calgary Stroke Program, Department of Clinical Neurosciences, Foothills Hospital, 1403 29th St NW, Calgary, Alberta, Canada
    Stroke 38:75-9. 2007
    ..We sought to study the relation between the type of hemorrhagic transformation on CT scans and functional outcome...
  94. ncbi request reprint Stroke due to calcific embolus following coronary angiography
    P N Sylaja
    Calgary Stroke Program, Department of Clinical Neurosciences, Foot Hills Hospital, Room 1242A, Calgary, Alberta, Canada T2N 2T9
    Neurology 67:E16. 2006
  95. ncbi request reprint "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Stroke 36:1695-9. 2005
    ..We explored this hypothesis using a combined database including 4 major clinical trials of intravenous (IV) thrombolytic therapy...
  96. ncbi request reprint Outcome after stroke upon awakening
    Janel O Nadeau
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
    Can J Neurol Sci 32:232-6. 2005
    ..An estimated 20-25% of all strokes occur during sleep and these patients wake up with their deficits. This study evaluated outcomes among patients who woke up with stroke compared to those who were awake at stroke onset...
  97. ncbi request reprint Acute ischemic stroke: accuracy of diffusion-weighted MR imaging--effects of b value and cerebrospinal fluid suppression
    Philip E Chen
    Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region, Calgary, AB, T2N 2T9, Canada
    Radiology 238:232-9. 2006
    ....