Kevin A Hildebrand

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Intramuscular myxoid lipoma in the proximal forearm presenting as an olecranon mass with superficial radial nerve palsy: a case report
    Peter Lewkonia
    Division of Orthopedic Surgery, Department of Surgery, University of Calgary, NW Calgary, Alberta T2N 4Z6, Canada
    J Med Case Reports 5:321. 2011
  2. ncbi request reprint Posttraumatic elbow joint contractures: defining pathologic capsular mechanisms and potential future treatment paradigms
    Kevin A Hildebrand
    Department of Surgery, University of Calgary and Alberta Health Services Calgary Zone, Calgary, Alberta, Canada Electronic address
    J Hand Surg Am 38:2227-33. 2013
  3. pmc Interprosthetic humeral fracture revision using a tibial allograft total elbow prosthetic composite in a patient with hemophilia A : a case report
    Justin Leblanc
    Department of Surgery, Section of Orthopedic Surgery, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada
    J Med Case Rep 6:319. 2012
  4. pmc Joint capsule mast cells and neuropeptides are increased within four weeks of injury and remain elevated in chronic stages of posttraumatic contractures
    Kevin A Hildebrand
    McCaig Centre, Bone and Joint Institute, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
    J Orthop Res 26:1313-9. 2008
  5. pmc Cellular, matrix, and growth factor components of the joint capsule are modified early in the process of posttraumatic contracture formation in a rabbit model
    Kevin A Hildebrand
    McCaig Centre, Bone and Joint Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Acta Orthop 79:116-25. 2008
  6. pmc Myofibroblast upregulators are elevated in joint capsules in posttraumatic contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 456:85-91. 2007
  7. pmc Joint capsule matrix turnover in a rabbit model of chronic joint contractures: Correlation with human contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 24:1036-43. 2006
  8. pmc High rate of joint capsule matrix turnover in chronic human elbow contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 439:228-34. 2005
  9. pmc A new method to measure post-traumatic joint contractures in the rabbit knee
    Kevin A Hildebrand
    Department of Surgery, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Biomech Eng 125:887-92. 2003
  10. pmc Exogenous transforming growth factor beta 1 alone does not improve early healing of medial collateral ligament in rabbits
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alta
    Can J Surg 45:330-6. 2002

Collaborators

Detail Information

Publications26

  1. pmc Intramuscular myxoid lipoma in the proximal forearm presenting as an olecranon mass with superficial radial nerve palsy: a case report
    Peter Lewkonia
    Division of Orthopedic Surgery, Department of Surgery, University of Calgary, NW Calgary, Alberta T2N 4Z6, Canada
    J Med Case Reports 5:321. 2011
    ..abstract:..
  2. ncbi request reprint Posttraumatic elbow joint contractures: defining pathologic capsular mechanisms and potential future treatment paradigms
    Kevin A Hildebrand
    Department of Surgery, University of Calgary and Alberta Health Services Calgary Zone, Calgary, Alberta, Canada Electronic address
    J Hand Surg Am 38:2227-33. 2013
    ....
  3. pmc Interprosthetic humeral fracture revision using a tibial allograft total elbow prosthetic composite in a patient with hemophilia A : a case report
    Justin Leblanc
    Department of Surgery, Section of Orthopedic Surgery, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada
    J Med Case Rep 6:319. 2012
    ..abstract:..
  4. pmc Joint capsule mast cells and neuropeptides are increased within four weeks of injury and remain elevated in chronic stages of posttraumatic contractures
    Kevin A Hildebrand
    McCaig Centre, Bone and Joint Institute, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
    J Orthop Res 26:1313-9. 2008
    ..Approaches designed to manipulate this axis, such as preventing degranulation of mast cells, warrant further investigation...
  5. pmc Cellular, matrix, and growth factor components of the joint capsule are modified early in the process of posttraumatic contracture formation in a rabbit model
    Kevin A Hildebrand
    McCaig Centre, Bone and Joint Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Acta Orthop 79:116-25. 2008
    ..To understand the initiation of the process, we evaluated the cellular, matrix, and growth factor changes in the joint capsule in the early stages of the animal model, which would not be possible in humans...
  6. pmc Myofibroblast upregulators are elevated in joint capsules in posttraumatic contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 456:85-91. 2007
    ..The rabbit knee model correlated well with the human post traumatic elbow contractures...
  7. pmc Joint capsule matrix turnover in a rabbit model of chronic joint contractures: Correlation with human contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 24:1036-43. 2006
    ..Many of the changes observed in this animal model are similar to those observed in human joint capsules from posttraumatic elbow contractures, supporting the value of this rabbit model...
  8. pmc High rate of joint capsule matrix turnover in chronic human elbow contractures
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, Canada
    Clin Orthop Relat Res 439:228-34. 2005
    ..The results indicate that joint capsule matrix molecule mRNA levels are altered in the chronic stages of posttraumatic elbow contractures in humans, potentially creating an environment with high matrix turnover rates...
  9. pmc A new method to measure post-traumatic joint contractures in the rabbit knee
    Kevin A Hildebrand
    Department of Surgery, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Biomech Eng 125:887-92. 2003
    ..The custom gripping device coupled to a materials testing machine will serve as a measurement test for future studies characterizing a rabbit knee model of post-traumatic joint contractures...
  10. pmc Exogenous transforming growth factor beta 1 alone does not improve early healing of medial collateral ligament in rabbits
    Kevin A Hildebrand
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alta
    Can J Surg 45:330-6. 2002
    ..To determine whether transforming growth factor beta 1 (TGF-beta1) improves early ligament healing...
  11. ncbi request reprint Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts
    Kevin A Hildebrand
    Department of Surgery, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    J Orthop Res 22:313-20. 2004
    ..The initial decrease in severity followed by stabilization of motion loss and the association of motion loss with myofibroblasts mimics the human scenario of permanent post-traumatic joint contractures...
  12. pmc The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures
    Michael J Monument
    Division of Orthopaedic Surgery, Faculty of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada
    Inflamm Res 61:285-92. 2012
    ..Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis...
  13. pmc The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures
    Michael J Monument
    McCaig Institute for Bone and Joint Health, Faculty of Medicine, University of Calgary, Calgary, Canada
    J Bone Joint Surg Am 92:1468-77. 2010
    ..We hypothesized that mast cell inhibition after skeletal injury would lessen contracture severity and reduce myofibroblast hyperplasia within the joint capsule...
  14. doi request reprint Wound healing differences between Yorkshire and red Duroc porcine medial collateral ligaments identified by biomechanical assessment of scars
    Niccole M Germscheid
    Department of Surgery, McCaig Institute for Bone and Joint Health, Health Research Innovation Centre, University of Calgary, Calgary, AB, Canada
    Clin Biomech (Bristol, Avon) 27:91-8. 2012
    ..This study assessed medial collateral ligament healing in Yorkshire and red Duroc pigs at the functional (biomechanical) level...
  15. ncbi request reprint Triceps tendon fascia for collateral ligament reconstruction about the elbow: a clinical and biomechanical evaluation
    C Ryan Martin
    University of Calgary, Canada
    Am J Orthop (Belle Mead NJ) 40:E163-9. 2011
    ..It is unclear whether the statistically significant 0.8-mm difference in creep translates into clinical relevance. Clinically, patients reported good functional outcomes, motion, strength, and stability...
  16. pmc Regional variation is present in elbow capsules after injury
    Niccole M Germscheid
    McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Clin Orthop Relat Res 450:219-24. 2006
    ..These results suggest elevated myofibroblast numbers occur throughout the whole joint capsule in posttraumatic elbow contractures, although there is some regional variation...
  17. doi request reprint The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs
    Corrie L Gallant-Behm
    Departments of Surgery, Medicine, and Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Wound Repair Regen 16:226-33. 2008
    ..These results suggest that ketotifen may be an effective treatment for the reduction of excessive wound contraction and fibrosis in human cutaneous injuries, without affecting the normal healing process...
  18. doi request reprint A retrospective cohort study of displaced segmental radial head fractures: is 2 mm of articular displacement an indication for surgery?
    Matthew J Furey
    Section of Orthopaedic Surgery, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Shoulder Elbow Surg 22:636-41. 2013
    ..We hypothesized there would be no difference between conservatively treated radial head fractures with greater 2 mm of displacement and those with less than 2 mm of displacement in terms of patient-reported or clinical outcomes...
  19. doi request reprint Does the source of hemarthrosis influence posttraumatic joint contracture and biomechanical properties of the joint?
    Monika Horisberger
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Clin Biomech (Bristol, Avon) 26:790-5. 2011
    ..The purpose of this investigation was to determine whether the source of the hemarthrosis (peripheral blood vs. bleeding from the bone marrow) affects the amount of contracture and its reversibility and biomechanical properties...
  20. ncbi request reprint Tissue repair in rheumatoid arthritis: challenges and opportunities in the face of a systemic inflammatory disease
    David A Hart
    Department of Surgery, McCaig Centre for Joint Injury and Arthritis Research, University of Calagary, 3330 Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Best Pract Res Clin Rheumatol 18:187-202. 2004
    ..These include growth factors, gene therapy, and bioengineered tissues, alone or in combination to augment endogenous repair or replace tissue damaged beyond such repair capabilities...
  21. pmc Chronic volar distal radioulnar joint instability: joint capsular plication to restore function
    Kelly Johnston
    University of Calgary and the Calgary Health Region, Calgary, Alta
    Can J Surg 52:112-8. 2009
    ..The purpose of this study is to describe a new procedure to treat volar DRUJ instability and to present the outcomes of patients who received this unique surgical repair at a minimum of 1 year follow-up...
  22. ncbi request reprint Distal humerus internal fixation: a biomechanical comparison of 90° and parallel constructs
    Carrie M Kollias
    Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada
    Am J Orthop (Belle Mead NJ) 39:440-4. 2010
    ..However, our findings are consistent with a trend in the biomechanical literature supporting use of a parallel construct...
  23. doi request reprint A biomechanical assessment to evaluate breed differences in normal porcine medial collateral ligaments
    Niccole M Germscheid
    Department of Surgery, McCaig Institute for Bone and Joint Health, Health Research Innovation Centre, University of Calgary, 3280 Hospital Drive NW, Calgary, AB T2N4Z6, Canada
    J Biomech 44:725-31. 2011
    ..In conclusion, the pig serves as a suitable large animal model for genetic-related connective tissue studies...
  24. ncbi request reprint Simple dislocations of the elbow: evaluation and treatment
    David M Sheps
    Division of Orthopaedics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Hand Clin 20:389-404. 2004
    ....
  25. ncbi request reprint Supracondylar femur fracture after endoscopic anterior cruciate reconstruction using an EndoButton
    David M Sheps
    University of Calgary, Alberta, Canada
    Clin J Sport Med 16:428-9. 2006
  26. ncbi request reprint Response of donor and recipient cells after transplantation of cells to the ligament and tendon
    Kevin A Hildebrand
    Alberta Heritage Foundation for Medical Research, University of Calgary, Calgary, Canada T2N 4N1
    Microsc Res Tech 58:34-8. 2002
    ..Even though these early results are encouraging, more work is required regarding the response of the recipient site to donor cells or vectors...