J Q He

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 166:323-8. 2002
  2. ncbi request reprint Association of Hck genetic polymorphisms with gene expression and COPD
    Xiaozhu Zhang
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 166, Vancouver, BC, Canada
    Hum Genet 120:681-90. 2007
  3. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  4. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006
  5. doi request reprint Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 32:755-62. 2008
  6. ncbi request reprint Recent developments in the genetics of asthma
    J Q He
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Pharmacogenomics 2:329-39. 2001
  7. ncbi request reprint Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 123:438S. 2003
  8. ncbi request reprint Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers
    G Tanaka
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Eur Respir J 29:34-41. 2007
  9. ncbi request reprint Polymorphisms of interleukin-10 and its receptor and lung function in COPD
    J Q He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 29:1120-6. 2007
  10. doi request reprint Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Eur Respir J 32:25-34. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 166:323-8. 2002
    ..20; p = 0.01). However, due to the multiple comparisons that were made, these associations may represent type 1 error. There was no association between HMOX1 (GT)n alleles and the rate of decline in lung function in smokers...
  2. ncbi request reprint Association of Hck genetic polymorphisms with gene expression and COPD
    Xiaozhu Zhang
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 166, Vancouver, BC, Canada
    Hum Genet 120:681-90. 2007
    ..These data suggest that the insertion/deletion polymorphism could be a functional polymorphism of the Hck gene, may contribute to COPD pathogenesis and modify COPD-related phenotypes...
  3. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  4. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006
    ....
  5. doi request reprint Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 32:755-62. 2008
    ....
  6. ncbi request reprint Recent developments in the genetics of asthma
    J Q He
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Pharmacogenomics 2:329-39. 2001
    ..In the future, knowledge of an individual's genotype may help us tailor treatment to make it the most appropriate form for that asthmatic individual...
  7. ncbi request reprint Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 123:438S. 2003
  8. ncbi request reprint Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers
    G Tanaka
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Eur Respir J 29:34-41. 2007
    ..In conclusion, these results support the findings of previous studies in late-onset chronic obstructive pulmonary disease in Caucasian populations...
  9. ncbi request reprint Polymorphisms of interleukin-10 and its receptor and lung function in COPD
    J Q He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 29:1120-6. 2007
    ....
  10. doi request reprint Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Eur Respir J 32:25-34. 2008
    ..No association was found for CSF2 SNPs and lung function, nor was there evidence of epistasis. In conclusion, genetic variation in colony-stimulating factor 3 is associated with cross-sectionally measured lung function in smokers...
  11. ncbi request reprint Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children
    J Q He
    McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, University of British Columbia, Canada
    Genes Immun 4:385-9. 2003
    ..006) and with atopy (P=0.009). Our data suggest that the IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T were associated with the development of atopy and atopic dermatitis at 24 months of age...
  12. pmc Associations of IL6 polymorphisms with lung function decline and COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Thorax 64:698-704. 2009
    ..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers...
  13. ncbi request reprint Microarray genotyping resource to determine population stratification in genetic association studies of complex disease
    Scott J Tebbutt
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Biotechniques 37:977-85. 2004
    ..Based on 1141 known genotypes from other research groups, our GC SNP chip has an accuracy of 98.5%, including non-calls...
  14. ncbi request reprint The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    Ladina Joos
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Hum Mol Genet 11:569-76. 2002
    ..0007). These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms...
  15. ncbi request reprint Promoter polymorphism and expression of beta-arrestin 2 in neutrophils
    Xiaozhu Zhang
    Clin Chim Acta 385:79-80. 2007
  16. ncbi request reprint Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 28:379-85. 2003
    ..Haplotypes consisting of alleles from the IL13 polymorphisms or from the IL4RA polymorphisms were not associated with rate of decline in lung function in smokers...
  17. ncbi request reprint Genetic variants of the hemostatic system and development of transplant coronary artery disease
    Jian Qing He
    Puget Sound Blood Center, Seattle, Washington, USA
    J Heart Lung Transplant 21:629-36. 2002
    ..The clinical setting of heart transplantation provides a unique opportunity to examine the relative contribution of circulating (i.e., recipient) vs local vascular (i.e., donor) hemostatic components to the occurrence of CAD...
  18. ncbi request reprint Glutathione S-transferase variants and their interaction with smoking on lung function
    Jian Qing He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 170:388-94. 2004
    ..49 (95% CI, 1.48-8.39, p = 0.005) in mild smokers (< or = 25 pack years). We conclude that GST genotypes are risk factors for rapid decline or low lung function in smokers with mild to moderate airflow obstruction...
  19. ncbi request reprint Interferon gamma polymorphisms and their interaction with smoking are associated with lung function
    Jian Qing He
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Hum Genet 119:365-75. 2006
    ..No association was found in the rate of decline study. There was an association between IFNG genotype and baseline of lung function and this association was modified by cigarette smoking...