Ikuko Hayashi

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
    Ikuko Hayashi
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Biol 9:101-6. 2002
  2. ncbi Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, Toronto, Ontario, Canada
    J Mol Biol 372:918-26. 2007
  3. ncbi Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:36430-4. 2003
  4. ncbi [Structural basis of microtubule plus-end-tracking proteins]
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute
    Tanpakushitsu Kakusan Koso 49:1274-9. 2004
  5. ncbi Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Mol Cell 19:449-60. 2005
  6. ncbi CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Nat Struct Mol Biol 14:980-1. 2007
  7. ncbi Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    J Am Chem Soc 130:14918-9. 2008
  8. ncbi [Molecular mechanism of microtubule plus-end tracking proteins]
    Ikuko Hayashi
    International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
    Seikagaku 80:521-30. 2008

Detail Information

Publications8

  1. ncbi The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
    Ikuko Hayashi
    Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Struct Biol 9:101-6. 2002
    ....
  2. ncbi Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, Toronto, Ontario, Canada
    J Mol Biol 372:918-26. 2007
    ..We propose a molecular mechanism for green-to-red photoconversion, which is assisted by the water molecule...
  3. ncbi Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:36430-4. 2003
    ..We propose that, like other actin-binding CH domains, EB1 employs the hydrophobic interaction to bind to microtubules...
  4. ncbi [Structural basis of microtubule plus-end-tracking proteins]
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute
    Tanpakushitsu Kakusan Koso 49:1274-9. 2004
  5. ncbi Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex
    Ikuko Hayashi
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Mol Cell 19:449-60. 2005
    ..We, therefore, propose that EB1 possesses an auto-inhibited conformation, which is relieved by p150Glued as an allosteric activator...
  6. ncbi CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Nat Struct Mol Biol 14:980-1. 2007
    ..Our data thus demonstrate that regulation of microtubule dynamics by plus end-tracking proteins (+TIPs) occurs through direct competition between homologous binding interfaces...
  7. ncbi Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    J Am Chem Soc 130:14918-9. 2008
    ..The OH/pi interaction is part of a TxFxxxxW motif that comprises a conserved "threonine clasp" that defines function in CAP-Gly domains...
  8. ncbi [Molecular mechanism of microtubule plus-end tracking proteins]
    Ikuko Hayashi
    International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan
    Seikagaku 80:521-30. 2008