B B Hasinoff

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Anticancer Drugs 13:255-8. 2002
  2. doi request reprint The dual-targeted HER1/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada
    Cardiovasc Toxicol 13:33-47. 2013
  3. pmc The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba R3E 0T5, Canada
    Biochem Pharmacol 84:1617-26. 2012
  4. ncbi request reprint Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 53:1843-53. 1997
  5. ncbi request reprint The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    Mol Pharmacol 64:670-8. 2003
  6. pmc The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada R3T 2N2
    Bioorg Med Chem 16:3959-68. 2008
  7. ncbi request reprint Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Cardiovasc Toxicol 3:89-99. 2003
  8. ncbi request reprint A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors
    Hong Liang
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Mol Pharmacol 73:686-96. 2008
  9. ncbi request reprint Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada
    Cardiovasc Toxicol 7:140-4. 2007
  10. ncbi request reprint Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada, R3T 2N2
    Cancer Chemother Pharmacol 57:221-33. 2006

Collaborators

Detail Information

Publications60

  1. ncbi request reprint The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Anticancer Drugs 13:255-8. 2002
    ..It was concluded that dexrazoxane interfered with cell division in cardiac myocytes by virtue of its ability to inhibit topoisomerase II...
  2. doi request reprint The dual-targeted HER1/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada
    Cardiovasc Toxicol 13:33-47. 2013
    ..These results suggest that the clinical use of concurrent doxorubicin and lapatinib should be approached with care due to the possibility of lapatinib increasing doxorubicin cardiotoxicity...
  3. pmc The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba R3E 0T5, Canada
    Biochem Pharmacol 84:1617-26. 2012
    ....
  4. ncbi request reprint Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 53:1843-53. 1997
    ..It was concluded that the DZR cell line acquired its resistance to dexrazoxane mainly through an alteration in the topoisomerase II target...
  5. ncbi request reprint The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    Mol Pharmacol 64:670-8. 2003
    ....
  6. pmc The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada R3T 2N2
    Bioorg Med Chem 16:3959-68. 2008
    ..In conclusion, a novel group of bisintercalating anthrapyrazole compounds have been designed, synthesized and biologically evaluated as possible anticancer agents...
  7. ncbi request reprint Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Cardiovasc Toxicol 3:89-99. 2003
    ..These results suggest that doxorubicin may be cardiotoxic by damaging the mitochondria and dexrazoxane may be protective by preventing iron-based oxidative damage...
  8. ncbi request reprint A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors
    Hong Liang
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Mol Pharmacol 73:686-96. 2008
    ..For the hydrogen bond donor field, para- and meta-substituted hydroxyl groups favored inhibition. Hydrophobic substituents on the bridge atoms disfavored inhibition...
  9. ncbi request reprint Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada
    Cardiovasc Toxicol 7:140-4. 2007
    ..However, it cannot be ruled out that dexrazoxane may also be protective through its ability to inhibit topoisomerase II...
  10. ncbi request reprint Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada, R3T 2N2
    Cancer Chemother Pharmacol 57:221-33. 2006
    ..Quantitative structure-activity studies were performed on a series of benzoquinone mustard (BM) bifunctional alkylating agents to determine whether DNA topoisomerase II (topo II) inhibition was responsible for cell growth inhibition...
  11. ncbi request reprint The cytotoxicity of celecoxib towards cardiac myocytes is cyclooxygenase-2 independent
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, R3T 2N2 Winnipeg, MB, Canada
    Cardiovasc Toxicol 7:19-27. 2007
    ..The evidence supports the conclusion that celecoxib exerts its cytotoxicity towards myocytes through COX-2-independent mediated pathways...
  12. ncbi request reprint The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada
    Free Radic Res 40:974-8. 2006
    ..These results also suggest that selection of patients for treatment with RH1 based on their expression levels of NQO1 may be problematic...
  13. ncbi request reprint Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Mol Pharmacol 67:937-47. 2005
    ....
  14. ncbi request reprint Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Anticancer Drugs 17:825-37. 2006
    ....
  15. ncbi request reprint Dexrazoxane use in the prevention of anthracycline extravasation injury
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Future Oncol 2:15-20. 2006
    ..Dexrazoxane is a prodrug analog of the metal chelator EDTA that most likely acts by removing iron from the iron-doxorubicin complex, thus preventing formation of damaging reactive oxygen species...
  16. ncbi request reprint The intracellular iron sensor calcein is catalytically oxidatively degraded by iron(II) in a hydrogen peroxide-dependent reaction
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    J Inorg Biochem 95:157-64. 2003
    ..Thus, the use of calcein as an intracellular iron-sensing indicator may yield misleading results due to its degradation under certain conditions...
  17. doi request reprint Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Pharmacol 74:1722-8. 2008
    ....
  18. ncbi request reprint The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Pharmacol 59:453-61. 2001
    ..The ability of dexrazoxane to induce differentiation and apoptosis suggests that bisdioxopiperazines may be useful in treating some types of leukemia...
  19. ncbi request reprint Stereoselective metabolism of dexrazoxane (ICRF-187) and levrazoxane (ICRF-186)
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    Chirality 11:286-90. 1999
    ..However, given the relatively small difference in elimination of the two enantiomers, it would be difficult to predict from this study whether or not dexrazoxane or levrazoxane might be more efficacious in reducing cardiotoxicity...
  20. ncbi request reprint The displacement of iron(III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotective agent dexrazoxane
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    J Inorg Biochem 77:257-9. 1999
    ..This study provides a basis for utilizing dexrazoxane for the clinical prevention of anthrapyrazole cardiotoxicity...
  21. ncbi request reprint The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces endopolyploidy in Chinese hamster ovary cells
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Pharmacol Exp Ther 295:474-83. 2000
    ..It is concluded that dexrazoxane inhibits CHO cytokinesis in cells by virtue of its ability to inhibit topoisomerase II...
  22. doi request reprint The use of dexrazoxane for the prevention of anthracycline extravasation injury
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Expert Opin Investig Drugs 17:217-23. 2008
    ..The use of the anthracycline anticancer drugs doxorubicin, daunorubicin, epirubicin and idarubicin sometimes results in accidental extravasation injury and can be a serious complication of their use...
  23. doi request reprint Mechanisms of myocyte cytotoxicity induced by the multikinase inhibitor sorafenib
    Brian B Hasinoff
    Apotex Centre, University of Manitoba, Winnipeg, Canada
    Cardiovasc Toxicol 10:1-8. 2010
    ..In conclusion, given the extreme lack of kinase selectivity that sorafenib exhibits, it is likely that inhibition of kinases other than RAF, or combinations of kinases, contributes to the cardiotoxic effects of sorafenib...
  24. doi request reprint The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba R3E0T5, Canada
    Toxicol Appl Pharmacol 249:132-9. 2010
    ..Thus, myocyte damage may be multifactorial in nature with the inhibition of a number of kinases involved in producing kinase inhibitor-induced myocyte damage...
  25. doi request reprint The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity
    Brian B Hasinoff
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0T5
    Toxicol Appl Pharmacol 244:190-5. 2010
    ..Finally, strength of TKI binding to colony-stimulating factor 1 receptor (CSF1R) was highly correlated with myocyte damage, thus possibly implicating this kinase in contributing to TKI-induced cardiotoxicity...
  26. doi request reprint The iron chelator Dp44mT does not protect myocytes against doxorubicin
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Inorg Biochem 103:1093-101. 2009
    ..In conclusion Dp44mT is unlikely to be useful as an anthracycline cardioprotective agent...
  27. ncbi request reprint The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    Anticancer Drugs 10:47-54. 1999
    ..It is concluded that dexrazoxane and camptothecin analogs should be used with caution in combination chemotherapy...
  28. ncbi request reprint Deferiprone protects against doxorubicin-induced myocyte cytotoxicity
    Norman Barnabé
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB, Canada
    Free Radic Biol Med 33:266-75. 2002
    ....
  29. doi request reprint The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Bioorg Med Chem 17:4575-82. 2009
    ..In conclusion, a novel group of amide-coupled bisintercalating anthrapyrazole compounds were designed, synthesized, and evaluated for their physico-chemical and biologic properties as potential anticancer agents...
  30. ncbi request reprint Synthesis and biological activity of a photoaffinity etoposide probe
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
    Bioorg Med Chem 9:1765-71. 2001
    ..These results suggest that the photoactivated form of etoposide is a more effective topoisomerase II poison either by interacting directly with the enzyme or with DNA subsequent to topoisomerase II-mediated strand cleavage...
  31. pmc Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F
    Kimberley A O'Hara
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2
    Free Radic Biol Med 43:1132-44. 2007
    ..In conclusion, the results indicated that kinamycin F cytotoxicity may be due to reductive and/or peroxidative activation to produce DNA-and protein-damaging species...
  32. ncbi request reprint The antitumor anthracyclines doxorubicin and daunorubicin do not inhibit cell growth through the formation of iron-mediated reactive oxygen species
    Xing Wu
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Anticancer Drugs 16:93-9. 2005
    ..In conclusion, the anthracyclines do not inhibit the growth of DZR cells through the generation of iron-mediated formation of ROS...
  33. ncbi request reprint Prevention of doxorubicin-induced damage to rat heart myocytes by arginine analog nitric oxide synthase inhibitors and their enantiomers
    Norman Barnabé
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Nitric Oxide 9:211-6. 2003
    ..Thus, some caution must be exercised in their use. NO may exert its protective effects either by directly acting as an antioxidant or through some other NO-dependent pathway...
  34. ncbi request reprint A structure-based 3D-QSAR study of anthrapyrazole analogues of the anticancer agents losoxantrone and piroxantrone
    Hong Liang
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    J Chem Inf Model 46:1827-35. 2006
    ..The 3D-QSAR analyses showed that hydrogen-bond donor interactions and electrostatic interactions with the protonated amino side chains of the anthrapyrazoles led to high cell growth inhibitory activity...
  35. ncbi request reprint The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925
    Patricia E Schroeder
    Faculty of Pharmacy, 50 Sifton Road, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Cancer Chemother Pharmacol 50:509-13. 2002
    ..The metabolism of dexrazoxane (ICRF-187) to its one-ring open hydrolysis products and its rings-opened metal-chelating product ADR-925 was determined in a rat model in order to identify the mechanism by which dexrazoxane acts...
  36. ncbi request reprint The iron chelating cardioprotective prodrug dexrazoxane does not affect the cell growth inhibitory effects of bleomycin
    Xing Wu
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2
    J Inorg Biochem 98:1818-23. 2004
    ..These results suggest that dexrazoxane may be clinically used in combination with bleomycin as a pulmonary protective agent without adversely affecting the antitumor activity of bleomycin...
  37. doi request reprint Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha
    Xing Wu
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, R3T 2N2, Canada
    Chem Res Toxicol 21:483-93. 2008
    ..In conclusion, these studies have elucidated some of the chemistry and biological activities of the interaction of thimerosal with topoisomerase II alpha and protein and nonprotein thiols and with DNA...
  38. ncbi request reprint High-throughput fluorescence flow-injection topoisomerase II inhibition assay
    N Barnabe
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    J Chromatogr B Biomed Sci Appl 760:263-9. 2001
    ....
  39. ncbi request reprint Relative plasma levels of the cardioprotective drug dexrazoxane and its two active ring-opened metabolites in the rat
    B B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
    Drug Metab Dispos 27:265-8. 1999
    ..These results are consistent with the hypothesis that dihydropyrimidine amidohydrolase in the liver and kidney is responsible for the metabolism of dexrazoxane in the rat...
  40. doi request reprint Cell lysis with dimethyl sulphoxide produces stable homogeneous solutions in the dichlorofluorescein oxidative stress assay
    GuQi Wang
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Free Radic Res 42:435-41. 2008
    ..In conclusion this study describes a more convenient and accurate method for measuring cellular oxidative stress that also makes it possible to assay cells treated in large culture plates...
  41. ncbi request reprint Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada
    Drug Metab Dispos 33:1367-72. 2005
    ..These studies showed that the two one-ring open metabolites of dexrazoxane were rapidly metabolized in the rat to ADR-925, and thus, these results provide a mechanism by which dexrazoxane is activated to its active metal-binding form...
  42. doi request reprint The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Drug Metab Dispos 36:1780-5. 2008
    ..Together these results indicate that the metabolism of dexrazoxane and of B and C is mediated by DHOase. These results provide a mechanistic basis for the antioxidant cardioprotective activity of dexrazoxane...
  43. pmc Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents
    Rui Zhang
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0T5
    Bioorg Med Chem 18:3974-84. 2010
    ..In conclusion, a novel group of compounds combining DNA intercalating anthrapyrazole groups and minor groove binding netropsin analogs have been designed, synthesized and biologically evaluated as possible novel anticancer agents...
  44. pmc A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II
    Gaik Lean Chee
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0T5
    Bioorg Med Chem 18:830-8. 2010
    ....
  45. ncbi request reprint Structure-activity studies with cytotoxic anthrapyrazoles
    Asher Begleiter
    Manitoba Institute of Cell Biology, CancerCare Manitoba, Departments of Internal Medicine, and Pharmacology and Therapeutics, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9, Canada
    Oncol Rep 15:1575-80. 2006
    ..There was no significant correlation between the cytotoxic activity of the anthrapyrazole analogues and their ability to inhibit decatenation by topoisomerase II...
  46. ncbi request reprint Role of NADPH cytochrome P450 reductase in activation of RH1
    Asher Begleiter
    Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Internal Medicine, University of Manitoba, 675 McDermot Avenue, R3E 0V9 Winnipeg, MB, Canada
    Cancer Chemother Pharmacol 60:713-23. 2007
    ..8 nmol min(-1) mg prot(-1), while the mean NQO1 activity in these cell lines is 199.5 nmol min(-1) mg prot(-1). Thus, we investigated whether P450 Red could play a role in activating RH1...
  47. ncbi request reprint Dexrazoxane (ICRF-187) protects cardiac myocytes against hypoxia-reoxygenation damage
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2 Canada B_
    Cardiovasc Toxicol 2:111-8. 2002
    ..Thus, dexrazoxane or its analogs may have some clinical utility in preventing tissue damage that occurs after a stroke or heart attack...
  48. ncbi request reprint The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Free Radic Biol Med 35:1469-79. 2003
    ....
  49. ncbi request reprint Synthesis and characterization of the biological activity of the cisplatin analogs, cis-PtCl(2)(dexrazoxane) and cis-PtCl(2)(levrazoxane), of the topoisomerase II inhibitors dexrazoxane (ICRF-187) and levrazoxane (ICRF-186)
    Brian B Hasinoff
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Man Canada R3T 2N2
    J Inorg Biochem 98:616-24. 2004
    ..Neither of the platinum complexes were able to cross-link DNA. Thus the cell growth inhibitory activity of these complexes was also not likely due to any cisplatin-type cross-linking activity...
  50. ncbi request reprint Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, R3T 2N2, Winnipeg, Manitoba, Canada
    Cancer Chemother Pharmacol 52:167-74. 2003
    ..In this phase I/II trial dexrazoxane was used as a rescue agent to reduce the extracerebral toxicity of etoposide...
  51. doi request reprint Kinamycin F downregulates cyclin D3 in human leukemia K562 cells
    Kimberley A O'Hara
    Faculty of Pharmacy, Apotex Centre, University of Manitoba, 750 McDermot Ave, Winnipeg, Manitoba R3E 0T5, Canada
    Chem Biol Interact 184:396-402. 2010
    ..Thus cyclin D3 is a potential target of kinamycin F...
  52. ncbi request reprint Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    Drug Metab Dispos 33:719-25. 2005
    ..In conclusion, these studies provide a nearly complete description of the metabolism of dexrazoxane by myocytes and hepatocytes to its presumably active form, ADR-925...
  53. ncbi request reprint Dihydroorotase catalyzes the ring opening of the hydrolysis intermediates of the cardioprotective drug dexrazoxane (ICRF-187)
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Drug Metab Dispos 30:1431-5. 2002
    ..The ADR-925 thus formed may either remove iron from the iron-doxorubicin complex, or bind free iron, thus preventing oxygen radical formation...
  54. ncbi request reprint Pharmacokinetics of etoposide in cancer patients treated with high-dose etoposide and with dexrazoxane (ICRF-187) as a rescue agent
    Patricia E Schroeder
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2
    Cancer Chemother Pharmacol 53:91-3. 2004
    ....
  55. pmc Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells
    Hongming Qiu
    Department of Pathology, Faculty of Medicine, and the Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 162:403-12. 2003
    ....
  56. ncbi request reprint Expression of a stress-induced hemoglobin affects NO levels produced by alfalfa root cultures under hypoxic stress
    Christos Dordas
    Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
    Plant J 35:763-70. 2003
    ..These results lead us to hypothesize that NO is involved in the response of plants to hypoxia and that hemoglobin modulates the levels of NO in the hypoxic cell...
  57. ncbi request reprint Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures
    Christos Dordas
    Department of Plant Science, University of Manitoba, MB R3T 2N2, Winnipeg, Canada
    Planta 219:66-72. 2004
    ..The results demonstrate that NO is produced in plant tissues grown under low oxygen tensions and suggest that class-1 hemoglobins have a significant function in regulating NO levels...
  58. ncbi request reprint A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs
    Lars H Jensen
    TopoTarget A S, Copenhagen, Denmark
    Mol Pharmacol 70:1503-13. 2006
    ..These results suggest that topoisomerase IIalpha is a functional cellular target for most of these substituted purine compounds and that these compounds do not display MDR1 liability...
  59. ncbi request reprint Total synthesis of isoprekinamycin: structural evidence for enhanced diazonium ion character and growth inhibitory activity toward cancer cells
    Wei Liu
    Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada
    Org Lett 9:2915-8. 2007
    ....
  60. ncbi request reprint Evaluation of relative DNA binding affinities of anthrapyrazoles by electrospray ionization mass spectrometry
    Suncerae I Smith
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    J Mass Spectrom 42:681-8. 2007
    ..However, for complexes containing AP2 or mitoxantrone, strand separation with the ligand remaining on one of the single strands was observed, indicative of a different binding mode or stronger binding...