Sadayuki Hashioka

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    Cent Nerv Syst Agents Med Chem 9:12-9. 2009
  2. ncbi request reprint Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Biol Med 42:945-54. 2007
  3. ncbi request reprint Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Exp Neurol 206:33-42. 2007
  4. ncbi request reprint Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Neurochem Int 50:499-506. 2007
  5. ncbi request reprint Antidepressants and neuroinflammation: Can antidepressants calm glial rage down?
    S Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, B C, Canada
    Mini Rev Med Chem 11:555-64. 2011
  6. ncbi request reprint Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
    Hideki Horikawa
    Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, Fukuoka 812 8582, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1306-16. 2010
  7. doi request reprint Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia
    Takahiro A Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Schizophr Res 129:172-82. 2011
  8. ncbi request reprint Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro
    Takahiro Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurochem 106:815-25. 2008
  9. ncbi request reprint Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro
    Takahiro Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Schizophr Res 92:108-15. 2007
  10. pmc Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat
    Motohide Furuya
    Department of Psychiatry, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    J Neuroinflammation 10:145. 2013

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Vancouver, Canada
    Cent Nerv Syst Agents Med Chem 9:12-9. 2009
    ....
  2. ncbi request reprint Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Free Radic Biol Med 42:945-54. 2007
    ..These results suggest that PS/PC liposomes have both neuroprotective and antioxidative properties through the inhibition of microglial activation, thus supporting the nootropic and antidementia effect of PS...
  3. ncbi request reprint Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Exp Neurol 206:33-42. 2007
    ..On the other hand, the mood stabilizer and anti-manic agent lithium chloride has mixed effects on IFN-gamma-induced microglial activation...
  4. ncbi request reprint Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Neurochem Int 50:499-506. 2007
    ..Therefore, PS/PC liposomes appear to have both neuroprotective and anti-oxidative properties through the inhibition of microglial activation...
  5. ncbi request reprint Antidepressants and neuroinflammation: Can antidepressants calm glial rage down?
    S Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, B C, Canada
    Mini Rev Med Chem 11:555-64. 2011
    ..One of the most plausible mechanisms of such anti-neuroinflammatory efficacy of the drugs, as well as their antidepressant actions, seems to involve elevated intracellular cAMP levels. But the exact mechanism has still to be elucidated...
  6. ncbi request reprint Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
    Hideki Horikawa
    Department of Neuropsychiatry, Graduate School of Medicine, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka City, Fukuoka 812 8582, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1306-16. 2010
    ..Our results suggest that the inhibitory effect of paroxetine and sertraline on microglial activation may not be a prerequisite for antidepressant function, but an additional beneficial effect...
  7. doi request reprint Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia
    Takahiro A Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Schizophr Res 129:172-82. 2011
    ..Our results imply that aripiprazole may have psychotropic effects by reducing the microglial oxidative reactions and following neuronal reactions, which puts forward a novel therapeutic hypothesis in schizophrenia research...
  8. ncbi request reprint Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro
    Takahiro Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurochem 106:815-25. 2008
    ..Antipsychotics may therefore have a potentially useful therapeutic effect on patients with schizophrenia by reducing the microglial inflammatory reactions...
  9. ncbi request reprint Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro
    Takahiro Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Schizophr Res 92:108-15. 2007
    ....
  10. pmc Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat
    Motohide Furuya
    Department of Psychiatry, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    J Neuroinflammation 10:145. 2013
    ..Although certain ingredients of YKS have potent anti-inflammatory activity, no study has determined if YKS has anti-inflammatory properties...
  11. doi request reprint Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia
    Yoshito Mizoguchi
    Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    J Immunol 183:7778-86. 2009
    ....
  12. ncbi request reprint Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia
    Jian Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 172:112-20. 2006
    ....
  13. ncbi request reprint Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurochem Int 47:369-76. 2005
    ..These results suggest that Abeta fibril formation is not necessarily required for microglial activation by the peptides...
  14. doi request reprint Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity
    Sadayuki Hashioka
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, The University of British Columbia, Vancouver, BC, Canada
    Exp Neurol 217:177-83. 2009
    ..They suggest that PPIs combined with NSAIDs may be effective in the treatment of a broad spectrum of neurodegenerative diseases associated with activated microglia...
  15. ncbi request reprint The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma
    Qian Bian
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka, 812 8582, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:42-8. 2008
    ....
  16. ncbi request reprint Glia: an important target for anti-inflammatory and antidepressant activity
    Sadayuki Hashioka
    Department of Psychiatry, Faculty of Medicine, Shimane University, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    Curr Drug Targets 14:1322-8. 2013
    ..Moreover, antidepressants have the possibility to be useful treatment, not only for depression, but for a broad spectrum of neuroinflammatory and neurodegenerative disorders where the pathogenesis is associated with glial activation. ..
  17. doi request reprint Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, B C, V6T 2A1 Canada
    Neuropharmacology 63:685-91. 2012
    ..L-type CCBs, especially NDP, might be a useful treatment option for a broad spectrum of neurodegenerative diseases, including Alzheimer disease, where the pathology is believed to be exacerbated by neurotoxic glial activation...
  18. ncbi request reprint Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1W5 Canada
    Neurobiol Aging 30:1924-35. 2009
    ..These findings suggest that activated astrocytes may become neurotoxic when stimulated by IFN-gamma and may therefore exacerbate the pathology in a spectrum of neurodegenerative diseases...
  19. ncbi request reprint Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Neuroimmunol 225:91-9. 2010
    ....
  20. doi request reprint Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia
    Zhou Wu
    Faculty of Dental Sciences, Department of Aging Science and Pharmacology, Kyushu University, Fukuoka, Japan Electronic address
    Neurobiol Aging 34:2715-25. 2013
    ..These observations indicate differential pathways for the microglial IL-1β production by CGA and fAβ, which may aid in better understanding of the pathological significance of neuroinflammation in AD. ..
  21. doi request reprint Proton pump inhibitors reduce interferon-γ-induced neurotoxicity and STAT3 phosphorylation of human astrocytes
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Kinsmen Laboratory of Neurological Research, Vancouver, B C, Canada
    Glia 59:833-40. 2011
    ..PPIs that possess antineurotoxic properties may be a useful treatment option for Alzheimer's disease and other neuroinflammatory disorders associated with activated astrocytes...
  22. ncbi request reprint Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 14:345-52. 2008
    ..These results suggest that human microglial cells are capable of adhering to and phagocytosing post mortem AD plaque material but activation may be necessary. Astrocytes may further enhance the process...
  23. ncbi request reprint The effects of combine treatment of memantine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow in the prefrontal area
    Tomoko Araki
    Department of Psychiatry, Shimane University Faculty of Medicine, Izumo, Japan
    Int J Geriatr Psychiatry 29:881-9. 2014
    ..Furthermore, with near-infrared spectroscopy (NIRS), we examined the association between effect of memantine and brain blood flow...
  24. ncbi request reprint Different SPECT findings before and after Capgras' syndrome in interictal psychosis
    Hideki Horikawa
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Epilepsy Behav 9:189-92. 2006
    ..The enhanced hypoperfusion demonstrated by SPECT in the present case seems to indicate a right interhemispheric disconnection resulting in the occurrence of Capgras' syndrome...
  25. doi request reprint STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Neurobiol Dis 41:299-307. 2011
    ....
  26. ncbi request reprint A patient with Cotard syndrome who showed an improvement in single photon emission computed tomography findings after successful treatment with antidepressants
    Sadayuki Hashioka
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Neuropharmacol 25:276-9. 2002
    ..These differences suggest that the mechanism of Cotard syndrome is still not well understood at the present time...
  27. ncbi request reprint Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides
    Akira Monji
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Life Sci 70:833-41. 2002
    ..These results thus demonstrate that A beta(25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides...
  28. pmc Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC Canada
    BMC Neurosci 15:18. 2014
    ..RT-PCR was also performed to confirm human astrocyte expression of specific purinoceptors which were indicated from imaging studies...
  29. pmc The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    J Neuroinflammation 9:113. 2012
    ..It is tempting to evaluate the potential of SAHA as a therapeutic agent in various neuroinflammatory and neurodegenerative disorders...
  30. doi request reprint Pyrazole compound 2-MBAPA as a novel inhibitor of microglial activation and neurotoxicity in vitro and in vivo
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 27:531-41. 2011
    ....
  31. ncbi request reprint Carbamazepine may trigger new-onset epileptic seizures in an individual with autism spectrum disorders: a case report
    Akira Monji
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Eur Psychiatry 19:322-3. 2004
    ..We clinicians should bear in mind the possibility that epileptic seizures may possibly be either precipitated or exacerbated by carbamazepine especially in individuals with ASD...
  32. ncbi request reprint Activation of mu-calpain in developing cortical neurons following methylmercury treatment
    Jian Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Brain Res Dev Brain Res 142:105-10. 2003
    ..Our results indicate that mu-calpain activation and mu-calpain-mediated proteolysis of alpha-spectrin preceded neuronal damage in the developing cerebral cortex induced by chronic treatment of MeHg...
  33. doi request reprint Yokukansan (TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: an open-label study
    Tsuyoshi Miyaoka
    Department of Psychiatry, Shimane University School of Medicine, Izumo, Japan
    Phytomedicine 20:654-8. 2013
    ....
  34. doi request reprint Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity
    Andis Klegeris
    Unit of Biology and Physical Geography, Barber School of Arts and Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    Glia 56:675-85. 2008
    ..We found both to be partially protective in a concentration-dependent manner. Inhibition of PEP may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases...