Ahmed Hasbi

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
    Ahmed Hasbi
    Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
    Mol Brain 4:26. 2011
  2. pmc Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2
    Vaneeta Verma
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:35092-103. 2010
  3. pmc The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia
    Melissa L Perreault
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:36625-34. 2010
  4. pmc Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
    Ahmed Hasbi
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 106:21377-82. 2009
  5. pmc The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia
    Melissa L Perreault
    Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Neuroanat 5:31. 2011
  6. pmc Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance
    Melissa L Perreault
    1 Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada 2 Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 39:156-68. 2014
  7. pmc Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010

Detail Information

Publications7

  1. pmc Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
    Ahmed Hasbi
    Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
    Mol Brain 4:26. 2011
    ..Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance...
  2. pmc Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2
    Vaneeta Verma
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:35092-103. 2010
    ..These results indicated that desensitization of the dopamine D1-D2 receptor heteromer-mediated signal can occur by agonist occupancy even without activation and is dually regulated by both the catalytic and RGS domains of GRK2...
  3. pmc The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia
    Melissa L Perreault
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:36625-34. 2010
    ....
  4. pmc Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth
    Ahmed Hasbi
    Centre for Addiction and Mental Health, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 106:21377-82. 2009
    ..This dopaminergic pathway regulating neuronal growth and maturation through BDNF may have considerable significance in disorders such as drug addiction, schizophrenia, and depression...
  5. pmc The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia
    Melissa L Perreault
    Centre for Addiction and Mental Health, University of Toronto Toronto, ON, Canada
    Front Neuroanat 5:31. 2011
    ....
  6. pmc Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance
    Melissa L Perreault
    1 Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada 2 Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 39:156-68. 2014
    ....
  7. pmc Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms
    Ahmed Hasbi
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Pharmacol 10:93-9. 2010
    ..These novel receptor heteromeric complexes, for the first time, establish the link between dopamine action and rapid calcium signaling...