Tony J C Harris

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3)
    Cao Guo Yu
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e86412. 2014
  2. pmc A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium
    Wei Shao
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9938. 2010
  3. pmc Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions
    Melanie A McGill
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S3G5, Canada
    J Cell Biol 185:787-96. 2009
  4. pmc Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila
    Gabrielle Goldenberg
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e79613. 2013
  5. doi request reprint An introduction to adherens junctions: from molecular mechanisms to tissue development and disease
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, M5S 3G5, Toronto, ON, Canada
    Subcell Biochem 60:1-5. 2012
  6. doi request reprint Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
  7. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
  8. doi request reprint Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism
    R F Andrew McKinley
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    J Cell Sci 125:1177-90. 2012
  9. doi request reprint The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Development 137:1645-55. 2010
  10. doi request reprint Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Development 140:4719-29. 2013

Collaborators

Detail Information

Publications23

  1. pmc Peptide binding properties of the three PDZ domains of Bazooka (Drosophila Par-3)
    Cao Guo Yu
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 9:e86412. 2014
    ..Thus, the peptide binding pockets of each PDZ domain in Baz are not obviously affected by the presence of neighbouring PDZ domains, but act as isolated modules with specific in vitro peptide binding preferences. ..
  2. pmc A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium
    Wei Shao
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9938. 2010
    ..We sought to identify additional proteins that function with Baz to regulate epithelial structure in the Drosophila embryo...
  3. pmc Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions
    Melanie A McGill
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S3G5, Canada
    J Cell Biol 185:787-96. 2009
    ..Our data implicate cell protrusions in initial cadherin-catenin clustering in the Drosophila melanogaster embryo. Then, independent Baz clusters appear to engage the cadherin-catenin clusters to assemble SAJs...
  4. pmc Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila
    Gabrielle Goldenberg
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e79613. 2013
    ..Overall, we propose that new synthesis, lateral diffusion, and endocytosis play overlapping roles to populate elongating cell-cell contacts with evenly distributed AJs in this in vivo system. ..
  5. doi request reprint An introduction to adherens junctions: from molecular mechanisms to tissue development and disease
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, M5S 3G5, Toronto, ON, Canada
    Subcell Biochem 60:1-5. 2012
    ..to assemble AJs and mediate adhesion? How do AJs interface with other cellular machinery to couple adhesion with the whole cell? How do AJs affect cell behaviour and multicellular development? How can abnormal AJ activity lead to disease?..
  6. doi request reprint Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
    ..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis...
  7. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
    ..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...
  8. doi request reprint Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism
    R F Andrew McKinley
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    J Cell Sci 125:1177-90. 2012
    ..We also identified specific downstream effects, including the promotion of epithelial structure, a positive-feedback loop that recruits aPKC, PAR-6 and Crumbs, and a negative-feedback loop that regulates Baz...
  9. doi request reprint The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Development 137:1645-55. 2010
    ..These results identify the mechanics of actomyosin contractility that drive amnioserosa apical constriction and how specific steps of the contractile mechanism are regulated by the PAR complex...
  10. doi request reprint Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Development 140:4719-29. 2013
    ..This later impact of aPKC inhibition is supported by mathematical modelling of the system. Overall, this work illustrates how shifting chemical signals can tune actomyosin network behaviour during development...
  11. doi request reprint Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila
    Karen L Pope
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    Development 135:2227-38. 2008
    ..Genetic analysis revealed that Myosin II and Bazooka cooperate to properly position adherens junctions. These results identify a specific cellular mechanism of squamous tissue morphogenesis and molecular interactions involved...
  12. pmc Displacement of basolateral Bazooka/PAR-3 by regulated transport and dispersion during epithelial polarization in Drosophila
    R F Andrew McKinley
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    Mol Biol Cell 23:4465-71. 2012
    ..Our work complements recent findings in Caenorhabditis elegans and thus suggests the coupling of transport and dispersion is a common protein polarization strategy...
  13. pmc Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial development
    Cao Guo Yu
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Mol Biol Cell 23:3743-53. 2012
    ..Bazooka polarity landmarks may be conglomerates of proteins and plasma membrane lipids that modify each other's activities for an integrated effect on cell polarity...
  14. ncbi request reprint An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development
    Donghoon M Lee
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    Curr Biol 23:2110-20. 2013
    ..Endocytosis also regulates the PM and can be promoted or inhibited by cytoskeletal networks. However, endocytic regulation of the general membrane cytoskeleton is undocumented...
  15. doi request reprint Adherens junction assembly and function in the Drosophila embryo
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Canada
    Int Rev Cell Mol Biol 293:45-83. 2012
    ....
  16. doi request reprint Live imaging of Drosophila embryos: quantifying protein numbers and dynamics at subcellular locations
    Daryl J V David
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 839:1-17. 2012
    ..These techniques can help reveal the structure and dynamics of protein complexes in live cells...
  17. doi request reprint How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Curr Top Dev Biol 89:55-85. 2009
    ..These events provide models for uncovering the cell biological basis of morphogenesis...
  18. ncbi request reprint Regulation of cell-cell adhesion during Dictyostelium development
    Chi Hung Siu
    Banting and Best Department of Medical Research and Department of Biochemistry, University of Toronto, 112 College Street, Toronto, Ont, Canada M5G 1L6
    Semin Cell Dev Biol 15:633-41. 2004
    ..Studies on gp80 have led to a model for the rapid assembly of adhesion complexes via lipid rafts...
  19. ncbi request reprint Cytoskeleton interactions involved in the assembly and function of glycoprotein-80 adhesion complexes in dictyostelium
    Tony J C Harris
    Banting and Best Department of Medical Research, University of Toronto, Ontario M5G 1L6, Canada
    J Biol Chem 278:2614-23. 2003
    ..We propose that such nascent gp80 adhesion complexes produce expanded raftlike domains that recruit ponticulin and thereby establish stable cytoskeleton interactions to complete the assembly process...
  20. ncbi request reprint Reciprocal raft-receptor interactions and the assembly of adhesion complexes
    Tony J C Harris
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Bioessays 24:996-1003. 2002
    ..Finally, the enlarged and stabilized rafts acquire enhanced abilities to recruit the cytoskeleton and induce signaling. This process exemplifies how the domain structure of the plasma membrane can impact the function of its receptors...
  21. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  22. pmc Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 167:135-47. 2004
    ..Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues...
  23. ncbi request reprint Decisions, decisions: beta-catenin chooses between adhesion and transcription
    Tony J C Harris
    Dept of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Trends Cell Biol 15:234-7. 2005
    ..Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription...