Research Topics
Genomes and GenesSpecies | Tony J C HarrisSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
An introduction to adherens junctions: from molecular mechanisms to tissue development and diseaseTony J C Harris
Department of Cell and Systems Biology, University of Toronto, M5S 3G5, Toronto, ON, Canada
Subcell Biochem 60:1-5. 2012..to assemble AJs and mediate adhesion? How do AJs interface with other cellular machinery to couple adhesion with the whole cell? How do AJs affect cell behaviour and multicellular development? How can abnormal AJ activity lead to disease?..- Adherens junctions: from molecules to morphogenesisTony J C Harris
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
Nat Rev Mol Cell Biol 11:502-14. 2010..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis... 
aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during developmentTony J C Harris
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Dev Cell 12:727-38. 2007..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...- The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in DrosophilaDaryl J V David
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Development 137:1645-55. 2010..These results identify the mechanics of actomyosin contractility that drive amnioserosa apical constriction and how specific steps of the contractile mechanism are regulated by the PAR complex... - Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in DrosophilaKaren L Pope
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
Development 135:2227-38. 2008..Genetic analysis revealed that Myosin II and Bazooka cooperate to properly position adherens junctions. These results identify a specific cellular mechanism of squamous tissue morphogenesis and molecular interactions involved... - A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epitheliumWei Shao
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 5:e9938. 2010..We sought to identify additional proteins that function with Baz to regulate epithelial structure in the Drosophila embryo... - Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanismR F Andrew McKinley
Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
J Cell Sci 125:1177-90. 2012..We also identified specific downstream effects, including the promotion of epithelial structure, a positive-feedback loop that recruits aPKC, PAR-6 and Crumbs, and a negative-feedback loop that regulates Baz... - Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctionsMelanie A McGill
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S3G5, Canada
J Cell Biol 185:787-96. 2009..Our data implicate cell protrusions in initial cadherin-catenin clustering in the Drosophila melanogaster embryo. Then, independent Baz clusters appear to engage the cadherin-catenin clusters to assemble SAJs... - Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial developmentCao Guo Yu
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Mol Biol Cell 23:3743-53. 2012..Bazooka polarity landmarks may be conglomerates of proteins and plasma membrane lipids that modify each other's activities for an integrated effect on cell polarity... - Adherens junction assembly and function in the Drosophila embryoTony J C Harris
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada
Int Rev Cell Mol Biol 293:45-83. 2012.... - Live imaging of Drosophila embryos: quantifying protein numbers and dynamics at subcellular locationsDaryl J V David
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Methods Mol Biol 839:1-17. 2012..These techniques can help reveal the structure and dynamics of protein complexes in live cells... - How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from DrosophilaTony J C Harris
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
Curr Top Dev Biol 89:55-85. 2009..These events provide models for uncovering the cell biological basis of morphogenesis... 
Regulation of cell-cell adhesion during Dictyostelium developmentChi Hung Siu
Banting and Best Department of Medical Research and Department of Biochemistry, University of Toronto, 112 College Street, Toronto, Ont, Canada M5G 1L6
Semin Cell Dev Biol 15:633-41. 2004..Studies on gp80 have led to a model for the rapid assembly of adhesion complexes via lipid rafts...- Cytoskeleton interactions involved in the assembly and function of glycoprotein-80 adhesion complexes in dictyosteliumTony J C Harris
Banting and Best Department of Medical Research, University of Toronto, Ontario M5G 1L6, Canada
J Biol Chem 278:2614-23. 2003..We propose that such nascent gp80 adhesion complexes produce expanded raftlike domains that recruit ponticulin and thereby establish stable cytoskeleton interactions to complete the assembly process... - Reciprocal raft-receptor interactions and the assembly of adhesion complexesTony J C Harris
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
Bioessays 24:996-1003. 2002..Finally, the enlarged and stabilized rafts acquire enhanced abilities to recruit the cytoskeleton and induce signaling. This process exemplifies how the domain structure of the plasma membrane can impact the function of its receptors... - Displacement of basolateral Bazooka/PAR-3 by regulated transport and dispersion during epithelial polarization in DrosophilaR F Andrew McKinley
Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
Mol Biol Cell 23:4465-71. 2012..Our work complements recent findings in Caenorhabditis elegans and thus suggests the coupling of transport and dispersion is a common protein polarization strategy... - The positioning and segregation of apical cues during epithelial polarity establishment in DrosophilaTony J C Harris
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 170:813-23. 2005..These results reveal key steps in the assembly of the apical domain in Drosophila... - Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in DrosophilaTony J C Harris
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 167:135-47. 2004..Thus, although epithelial polarity develops in the absence of AJs, AJs play specific roles in maintaining epithelial architecture and segregating basolateral cues... - Decisions, decisions: beta-catenin chooses between adhesion and transcriptionTony J C Harris
Dept of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA
Trends Cell Biol 15:234-7. 2005..Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription...