S B Harris

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi The prevalence of NIDDM and associated risk factors in native Canadians
    S B Harris
    Department of Family Medicine, University of Western Ontario, London, Canada
    Diabetes Care 20:185-7. 1997
  2. ncbi The epidemiology of diabetes in pregnant Native Canadians. A risk profile
    S B Harris
    Department of Family Medicine, University of Western Ontario, London, Canada
    Diabetes Care 20:1422-5. 1997
  3. ncbi Gender, obesity, hepatic nuclear factor-1alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    John P Robarts Research Institute, London, Ontario, Canada
    Int J Obes Relat Metab Disord 24:1062-4. 2000
  4. ncbi Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins
    R A Hegele
    Department of Medicine, St Michael s Hospital, London, Canada
    Arterioscler Thromb Vasc Biol 17:2753-8. 1997
  5. ncbi Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 85:2014-9. 2000
  6. ncbi Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians
    R A Hegele
    John P Robarts Research Institute, Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Physiol Genomics 3:39-44. 2000
  7. ncbi Absence of association between genetic variation of the beta 3-adrenergic receptor and metabolic phenotypes in Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Diabetes Care 21:851-4. 1998
  8. ncbi Clinical utility of HNF1A genotyping for diabetes in aboriginal Canadians
    R A Hegele
    John P Robarts Research Institute, and Department of Medicine, University of Western Ontario, London, Canada
    Diabetes Care 23:775-8. 2000
  9. ncbi NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Pharmacogenetics 10:233-8. 2000
  10. ncbi G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    Robarts Research Institute and Department of Medicine, Thames Valley Family Practice Research Unit, University of Western Ontario, London, Ontario, Canada
    Hypertension 32:688-92. 1998

Detail Information

Publications23

  1. ncbi The prevalence of NIDDM and associated risk factors in native Canadians
    S B Harris
    Department of Family Medicine, University of Western Ontario, London, Canada
    Diabetes Care 20:185-7. 1997
    ..To determine the true prevalence of impaired glucose tolerance (IGT), NIDDM, and associated risk factors by age and sex in an isolated native community...
  2. ncbi The epidemiology of diabetes in pregnant Native Canadians. A risk profile
    S B Harris
    Department of Family Medicine, University of Western Ontario, London, Canada
    Diabetes Care 20:1422-5. 1997
    ....
  3. ncbi Gender, obesity, hepatic nuclear factor-1alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    John P Robarts Research Institute, London, Ontario, Canada
    Int J Obes Relat Metab Disord 24:1062-4. 2000
    ..One factor that might account for the gender difference in the onset of HNF1A S319-associated type 2 diabetes is the greater prevalence and severity, and earlier onset of, obesity among female Oji-Cree...
  4. ncbi Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins
    R A Hegele
    Department of Medicine, St Michael s Hospital, London, Canada
    Arterioscler Thromb Vasc Biol 17:2753-8. 1997
    ..However, the associations could also have resulted from linkage disequilibrium with other functional variants in APOC3 or the closely linked APOA1 and/or APOA4 genes...
  5. ncbi Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 85:2014-9. 2000
    ....
  6. ncbi Genetic variation in LMNA modulates plasma leptin and indices of obesity in aboriginal Canadians
    R A Hegele
    John P Robarts Research Institute, Centre for Studies in Family Medicine, University of Western Ontario, London, Ontario N6A 5K8, Canada
    Physiol Genomics 3:39-44. 2000
    ..The results suggest that common genetic variation in LMNA may be an important determinant of plasma leptin and obesity-related quantitative traits...
  7. ncbi Absence of association between genetic variation of the beta 3-adrenergic receptor and metabolic phenotypes in Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Diabetes Care 21:851-4. 1998
    ..To assess the association between the common missense variant, Y64R, in the gene encoding the beta 3-adrenergic receptor, ADRB3, and intermediate phenotypes related to obesity and NIDDM in Canadian Oji-Cree...
  8. ncbi Clinical utility of HNF1A genotyping for diabetes in aboriginal Canadians
    R A Hegele
    John P Robarts Research Institute, and Department of Medicine, University of Western Ontario, London, Canada
    Diabetes Care 23:775-8. 2000
    ..To determine the diagnostic performance characteristics of HNF1A genotyping for diabetes and impaired glucose tolerance (IGT) in Canadian Oji-Cree Indians...
  9. ncbi NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Pharmacogenetics 10:233-8. 2000
    ..However, NAT2 might be a 'modifier gene' affecting the level of glycaemia in non-diabetic subjects...
  10. ncbi G protein beta3 subunit gene variant and blood pressure variation in Canadian Oji-Cree
    R A Hegele
    Robarts Research Institute and Department of Medicine, Thames Valley Family Practice Research Unit, University of Western Ontario, London, Ontario, Canada
    Hypertension 32:688-92. 1998
    ..571 versus 0.496; P=NS), although this young sample had relatively few subjects with hypertension. The findings support an association of variation in this gene with variation in blood pressure...
  11. ncbi Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Department of Medicine, London, Ont, Canada
    Atherosclerosis 146:153-60. 1999
    ....
  12. ncbi Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, London, Ontario, Canada
    Clin Biochem 32:143-8. 1999
    ....
  13. ncbi Variable association between genetic variation in the CYP7 gene promoter and plasma lipoproteins in three Canadian populations
    R A Hegele
    Department of Medicine, Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, University of Western Ontario, 406 100 Perth Drive, Ont, N6A 5K8, London, Canada
    Atherosclerosis 154:579-87. 2001
    ..The inconsistencies could be due to differences in genetic background or to unspecified environmental or genetic factors...
  14. ncbi Genetic variation in paraoxonase-2 is associated with variation in plasma lipoproteins in Canadian Oji-Cree
    R A Hegele
    John P Robarts Research Institute, University of Western Ontario, London, Canada
    Clin Genet 54:394-9. 1998
    ..01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3-22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism...
  15. ncbi Association between AGT codon 235 polymorphism and variation in serum concentrations of creatinine and urea in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Clin Genet 55:438-43. 1999
    ..The findings suggest that the AGT T235 allele is a determinant of intermediate traits related to renal function in these aboriginal Canadians...
  16. ncbi Disparity between association and linkage analysis for HNF1A G319S in type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Roberts Research Institute, London, Ontario, Canada
    J Hum Genet 45:184-7. 2000
    ..Furthermore, our experience confirms the value of using several complementary strategies to identify susceptibility genes for a complex disease...
  17. ncbi Association between AGT T235 variant and microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada
    Clin Biochem 32:201-5. 1999
    ..To assess the association between the common variation in the gene encoding angiotensinogen, AGT, and the presence of microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus...
  18. ncbi Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population
    R L Pollex
    Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute and University of Western Ontario, London, Ontario, Canada
    Int J Obes (Lond) 30:484-91. 2006
    ....
  19. ncbi Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers
    R A Hegele
    Blackburn Cardiovascular Genetics Laboratory, John P Robarts Research Institute, London, Ontario, Canada
    J Hum Genet 44:10-4. 1999
    ..Thus, different marker sets will likely be required for different ethnic groups in order to maximize their information content for linkage calculations...
  20. ncbi Common and rare ABCA1 variants affecting plasma HDL cholesterol
    J Wang
    John P Robarts Research Institute, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 20:1983-9. 2000
    ....
  21. ncbi The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree
    R A Hegele
    Robarts Research Institute, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 84:1077-82. 1999
    ..Also, G319S is associated with a distinct form of type 2 diabetes, characterized by onset at an earlier age, lower body mass, and a higher postchallenge plasma glucose...
  22. ncbi Increased rates of adverse outcomes for gestational diabetes and pre-pregnancy diabetes in on-reserve First Nations Women in Ontario, Canada
    S L Liu
    Resident Research Career Development Program, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
    Diabet Med 29:e180-3. 2012
    ..To compare the prevalence of diabetes in pregnancy, pregnancy care and adverse pregnancy outcomes in on-reserve First Nations women vs. non-First Nations women in Ontario, Canada...
  23. ncbi Insulin resistance in latent autoimmune diabetes of adulthood
    M T Behme
    Lawson Health Research Institute, Robarts Research Institute, London Health Sciences Centre, and St Joseph s Health Care, University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1005:374-7. 2003
    ..LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age...