Douglas W Hamilton

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair
    Linda Jackson-Boeters
    CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1
    J Cell Commun Signal 3:125-33. 2009
  2. pmc Functional role of periostin in development and wound repair: implications for connective tissue disease
    Douglas W Hamilton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Cell Commun Signal 2:9-17. 2008
  3. pmc Migration of periodontal ligament fibroblasts on nanometric topographical patterns: influence of filopodia and focal adhesions on contact guidance
    Douglas W Hamilton
    Graduate Program of Biomedical Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    PLoS ONE 5:e15129. 2010
  4. doi The differential regulation of osteoblast and osteoclast activity by surface topography of hydroxyapatite coatings
    Daniel O Costa
    Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada
    Biomaterials 34:7215-26. 2013
  5. pmc Functional significance of periostin in excisional skin repair: is the devil in the detail?
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON Canada
    Cell Adh Migr 6:319-26. 2012
  6. pmc Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies
    Paul D H Prowse
    Department of Anatomy, Graduate Program of Biomedical Engineering, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e58898. 2013
  7. doi Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St, London, Ontario N6A 5C1, Canada
    Matrix Biol 43:71-84. 2015
  8. doi Large area periodic, systematically changing, multishape nanostructures by laser interference lithography and cell response to these topographies
    Erden Ertorer
    Biomedical Engineering Program, University of Western Ontario Western University, 1151 Richmond Street, London, Ontario N6A 3K7, Canada
    J Biomed Opt 18:035002. 2013
  9. doi Directional change produced by perpendicularly-oriented microgrooves is microtubule-dependent for fibroblasts and epithelium
    Douglas W Hamilton
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada
    Cell Motil Cytoskeleton 66:260-71. 2009
  10. pmc Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    J Cell Sci 125:121-32. 2012

Collaborators

Detail Information

Publications15

  1. pmc Periostin localizes to cells in normal skin, but is associated with the extracellular matrix during wound repair
    Linda Jackson-Boeters
    CIHR Group in Skeletal Development and Remodeling, Division of Oral Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, Dental Sciences Building, London, ON, Canada, N6A 5C1
    J Cell Commun Signal 3:125-33. 2009
    ..Periostin may represent a new therapeutic target for modulating the wound repair process...
  2. pmc Functional role of periostin in development and wound repair: implications for connective tissue disease
    Douglas W Hamilton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, Dental Sciences Building, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Cell Commun Signal 2:9-17. 2008
    ..In this review, the functional role of periostin is discussed in the context of connective tissue physiology, in development, disease, and wound repair...
  3. pmc Migration of periodontal ligament fibroblasts on nanometric topographical patterns: influence of filopodia and focal adhesions on contact guidance
    Douglas W Hamilton
    Graduate Program of Biomedical Engineering, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    PLoS ONE 5:e15129. 2010
    ..We conclude that periodontal ligament fibroblasts are sensitive to nanotopographical depths of 85-100 µm, which could be utilized in regeneration of the periodontal ligament...
  4. doi The differential regulation of osteoblast and osteoclast activity by surface topography of hydroxyapatite coatings
    Daniel O Costa
    Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada
    Biomaterials 34:7215-26. 2013
    ..Thus, it may be possible to design HA coatings that induce optimal rates of bone formation and degradation specifically tailored for different applications in orthopedics and dentistry...
  5. pmc Functional significance of periostin in excisional skin repair: is the devil in the detail?
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON Canada
    Cell Adh Migr 6:319-26. 2012
    ..The aim of this commentary is to compare and contrast the three studies performed to date in an attempt to decipher the role of periostin in the repair of full-thickness skin wounds...
  6. pmc Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies
    Paul D H Prowse
    Department of Anatomy, Graduate Program of Biomedical Engineering, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e58898. 2013
    ....
  7. doi Inflammatory microenvironment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond St, London, Ontario N6A 5C1, Canada
    Matrix Biol 43:71-84. 2015
    ..We conclude that variations in the expression of periostin and CCN2, are related to an inflammatory microenvironment and the presence of TNFα in human chronic wounds. ..
  8. doi Large area periodic, systematically changing, multishape nanostructures by laser interference lithography and cell response to these topographies
    Erden Ertorer
    Biomedical Engineering Program, University of Western Ontario Western University, 1151 Richmond Street, London, Ontario N6A 3K7, Canada
    J Biomed Opt 18:035002. 2013
    ..The effect of the different periodicities and transition structures can be studied on a single substrate to reduce the number of samples significantly...
  9. doi Directional change produced by perpendicularly-oriented microgrooves is microtubule-dependent for fibroblasts and epithelium
    Douglas W Hamilton
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada
    Cell Motil Cytoskeleton 66:260-71. 2009
    ..We conclude that MT may be the prime determinant of fibroblast and epithelial cell conformation to conflicting topographies...
  10. pmc Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair
    Christopher G Elliott
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    J Cell Sci 125:121-32. 2012
    ..We propose that periostin promotes wound contraction by facilitating myofibroblast differentiation and contraction...
  11. pmc Regulation of matrix remodelling phenotype in gingival fibroblasts by substratum topography
    Shawna S Kim
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada
    J Cell Mol Med 19:1183-96. 2015
    ..We conclude that topographical features that reduce focal adhesion stability could be applied to inhibit myofibroblast differentiation in gingival fibroblasts. ..
  12. doi The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces
    Richard J Miron
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Biomaterials 31:449-60. 2010
    ..We conclude that coating of titanium with EMD enhances the proliferation and differentiation of osteoblasts irrespective of the titanium substratum topography...
  13. pmc Deconstructing fibrosis research: do pro-fibrotic signals point the way for chronic dermal wound regeneration?
    Christopher G Elliott
    Department of Anatomy and Cell Biology, The University of Western Ontario, Medical Sciences Building, London, Ontario, N6A 5C1, Canada
    J Cell Commun Signal 5:301-15. 2011
    ....
  14. doi Reinforcement of resin based cement with titania nanotubes
    S M Z Khaled
    Department of Chemical and Biochemical Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada N6A 5B9
    Dent Mater 26:169-78. 2010
    ..The long term objective is to add these fillers as reinforcement to dental resin cements and flowable composites in combination with existing fillers...
  15. ncbi Detection of galectin-3 and localization of advanced glycation end products (AGE) in human chronic skin wounds
    Daniel Pepe
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Histol Histopathol 29:251-8. 2014
    ..The results from our study demonstrate an inverse correlation between Gal-3 and AGEs localization, suggesting that Gal-3 may protect against accumulation of AGEs in wound healing. ..