Clement Hamani

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Neuromodulation: a more comprehensive concept beyond deep brain stimulation
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int Rev Neurobiol 107:1-3. 2012
  2. ncbi request reprint Deep brain stimulation effects on memory
    A W Laxton
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    J Neurosurg Sci 56:341-4. 2012
  3. doi request reprint Preclinical studies modeling deep brain stimulation for depression
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 72:916-23. 2012
  4. doi request reprint Deep brain stimulation for psychiatric disease: contributions and validity of animal models
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Sci Transl Med 4:142rv8. 2012
  5. doi request reprint Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto Western Hospital, 250 College Street, Toronto, Ontario, Canada
    Biol Psychiatry 71:30-5. 2012
  6. doi request reprint Deep brain stimulation in clinical trials and animal models of depression
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Eur J Neurosci 32:1109-17. 2010
  7. doi request reprint Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Exp Neurol 232:100-4. 2011
  8. doi request reprint The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
  9. doi request reprint Anterior thalamus deep brain stimulation at high current impairs memory in rats
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Exp Neurol 225:154-62. 2010
  10. doi request reprint Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    Biol Psychiatry 67:117-24. 2010

Collaborators

Detail Information

Publications68

  1. doi request reprint Neuromodulation: a more comprehensive concept beyond deep brain stimulation
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Int Rev Neurobiol 107:1-3. 2012
    ..As the number of indications and studies increases, so does research in associated fields. This chapter provides a brief introduction and discusses the overall contents of this volume of the International Review of Neurobiology...
  2. ncbi request reprint Deep brain stimulation effects on memory
    A W Laxton
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    J Neurosurg Sci 56:341-4. 2012
    ..In this article, we review the scientific literature to address some of the mechanisms by which DBS may impact memory and cognition. We then summarize the results of recent clinical experience with DBS in AD and Parkinsonian dementia...
  3. doi request reprint Preclinical studies modeling deep brain stimulation for depression
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 72:916-23. 2012
    ....
  4. doi request reprint Deep brain stimulation for psychiatric disease: contributions and validity of animal models
    Clement Hamani
    Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
    Sci Transl Med 4:142rv8. 2012
    ....
  5. doi request reprint Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factor
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto Western Hospital, 250 College Street, Toronto, Ontario, Canada
    Biol Psychiatry 71:30-5. 2012
    ..We have studied the effects of ventromedial prefrontal cortex (vmPFC) stimulation in a chronic model of depression and assessed the involvement of the serotonergic system and brain derived neurotrophic factor (BDNF) in a DBS response...
  6. doi request reprint Deep brain stimulation in clinical trials and animal models of depression
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
    Eur J Neurosci 32:1109-17. 2010
    ..Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats...
  7. doi request reprint Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Exp Neurol 232:100-4. 2011
    ....
  8. doi request reprint The subcallosal cingulate gyrus in the context of major depression
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Biol Psychiatry 69:301-8. 2011
    ..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...
  9. doi request reprint Anterior thalamus deep brain stimulation at high current impairs memory in rats
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    Exp Neurol 225:154-62. 2010
    ..Though translating data from animals to humans has to be considered with caution, our study underscores the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of AN DBS...
  10. doi request reprint Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
    Biol Psychiatry 67:117-24. 2010
    ..We report on the effects of ventromedial prefrontal cortex (vmPFC) DBS in rats, focusing on possible mechanisms involved in an antidepressant-like response in the forced swim test (FST)...
  11. doi request reprint Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats
    Clement Hamani
    Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
    J Psychiatr Res 44:683-7. 2010
    ..In summary, vmPFC DBS at high frequency and moderate intensity led to a maximal response in the FST...
  12. doi request reprint Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei
    Meaghan C Creed
    Department of Pharmacology and Toxicology, Toronto Western Hospital, University of Toronto, Ontario M5T 1R8, Canada
    J Neurosci 32:9574-81. 2012
    ..While decreasing 5-HT function is sufficient to suppress HAL-induced VCMs, 5-HT decrease is not necessary for the beneficial motor effects of DBS in this model...
  13. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
    ....
  14. doi request reprint A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
    Adrian W Laxton
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 68:521-34. 2010
    ..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits...
  15. doi request reprint Pedunculopontine nucleus microelectrode recordings in movement disorder patients
    Moran Weinberger
    Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
    Exp Brain Res 188:165-74. 2008
    ..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...
  16. doi request reprint Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease
    Bogdan Neagu
    Toronto Western Research Institute, University Health Network, University of Toronto, Canada
    Exp Neurol 250:221-7. 2013
    ..These results demonstrate a functional connection between the STN and the PPNR. It likely involves direct projections between the STN and PPNR or polysynaptic pathways with thalamic or cortical relays. ..
  17. doi request reprint Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease
    Akihiro Yugeta
    Division of Neurology, Toronto Western Research Institute, and the Edmond J Safra Program in Parkinson s Disease, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 33:6895-904. 2013
    ..Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction...
  18. doi request reprint Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movements
    Eric W Tsang
    Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
    J Neurol Neurosurg Psychiatry 83:91-7. 2012
    ..To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements...
  19. doi request reprint Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:110-4. 2009
    ..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114...
  20. doi request reprint Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivation
    Meaghan C Creed
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Eur Neuropsychopharmacol 22:506-17. 2012
    ..The divergent effects of STN vs. EPN manipulations on HAL-induced zif268 changes suggest that similar behavioral outcomes of DBS in these two areas may involve different neuroanatomical mechanisms...
  21. doi request reprint Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET study
    Benedicte Ballanger
    Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
    Hum Brain Mapp 30:3901-9. 2009
    ..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements...
  22. doi request reprint Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's disease
    Elena Moro
    Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
    Brain 134:2096-105. 2011
    ..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series...
  23. ncbi request reprint Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Res 78:117-23. 2008
    ..As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE)...
  24. doi request reprint The nature and time course of cortical activation following subthalamic stimulation in Parkinson's disease
    Renju Kuriakose
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
    Cereb Cortex 20:1926-36. 2010
    ..Cortical activation may be related to the clinical effects of STN DBS in PD...
  25. doi request reprint A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Canada
    J Neurosurg 116:315-22. 2012
    ..They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression...
  26. doi request reprint Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
    J Neurosurg 111:1209-15. 2009
    ..Based on the location of the active contacts used for long-term stimulation in responders, the authors suggest a standardized method of targeting the SCG in patients with MDD...
  27. doi request reprint Neural stimulation successfully treats depression in patients with prior ablative cingulotomy
    Joseph S Neimat
    Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
    Am J Psychiatry 165:687-93. 2008
  28. doi request reprint Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
    I Jin Yeh
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Mov Disord 25:2076-83. 2010
    ..Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins...
  29. doi request reprint Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression
    Andres M Lozano
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Biol Psychiatry 64:461-7. 2008
    ..We now report the results of these and an additional 14 patients with extended follow-up...
  30. doi request reprint Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
    Lili Naz Hazrati
    Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Mov Disord 27:1304-7. 2012
    ..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)...
  31. doi request reprint Unilateral pedunculopontine stimulation improves falls in Parkinson's disease
    Elena Moro
    Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
    Brain 133:215-24. 2010
    ..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required...
  32. ncbi request reprint Comparison of 2-dimensional magnetic resonance imaging and 3-planar reconstruction methods for targeting the subthalamic nucleus in Parkinson disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8, Canada
    Surg Neurol 63:357-62; discussion 362-3. 2005
    ....
  33. doi request reprint The dominant-STN phenomenon in bilateral STN DBS for Parkinson's disease
    Anna Castrioto
    Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada
    Neurobiol Dis 41:131-7. 2011
    ..In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery...
  34. doi request reprint Memory enhancement induced by hypothalamic/fornix deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 63:119-23. 2008
    ..This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions...
  35. doi request reprint The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation
    Hiroki Toda
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 108:132-8. 2008
    ..To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model...
  36. doi request reprint Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task
    Lily R Aleksandrova
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Behav Brain Res 245:76-82. 2013
    ..These results suggest that STN-DBS in the absence of parkinsonism may not lead to a general loss of inhibitory control, but may instead affect impulsivity under specific conditions...
  37. doi request reprint Neuronal coding of implicit emotion categories in the subcallosal cortex in patients with depression
    Adrian W Laxton
    Department of Neurosurgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina Department of Surgery, Toronto Western Hospital, Institute of Medical Science, University of Toronto, Toronto, Canada Electronic address
    Biol Psychiatry 74:714-9. 2013
    ..On the basis of imaging studies, it is unclear whether the SCC predominantly processes 1) negatively valenced affective content, 2) affective arousal, or 3) category-specific affective information...
  38. doi request reprint The pedunculopontine nucleus as a target for deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
    J Neural Transm 118:1461-8. 2011
    ..In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials...
  39. ncbi request reprint Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus procedures
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada
    Surg Neurol 63:249-53; discussion 253. 2005
    ..Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease...
  40. doi request reprint Basal ganglia physiology and deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
    Mov Disord 25:S71-5. 2010
    ..In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease...
  41. ncbi request reprint Deep brain stimulation for the treatment of epilepsy
    Clement Hamani
    Division of Neurosurgery Toronto Western Hospital University of Toronto, Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada
    Int J Neural Syst 19:213-26. 2009
    ..We review the published literature on DBS, cortical and cerebellar stimulation for the treatment of epilepsy focusing predominantly on the rationale and clinical outcome in each target...
  42. doi request reprint Dravet syndrome and deep brain stimulation: seizure control after 10 years of treatment
    Danielle M Andrade
    Division of Neurology, Toronto Western Hospital, Krembil Neuroscience Centre, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 51:1314-6. 2010
    ..We speculate that the results of DBS for epilepsy in patients with Dravet syndrome may be related to age at initiation of DBS treatment and seizure type...
  43. doi request reprint Effects of repeated deep brain stimulation on depressive- and anxiety-like behavior in rats: comparing entopeduncular and subthalamic nuclei
    Meaghan C Creed
    Department of Pharmacology and Toxicology, University of Toronto, Canada
    Brain Stimul 6:506-14. 2013
    ..However, DBS may be associated with adverse psychiatric effects, such as depression, anxiety and impulsivity...
  44. ncbi request reprint Special lecture: Brain stimulation: perspectives for the future
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    Clin Neurosurg 51:271-4. 2004
  45. pmc Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human pons
    Andrew S Lim
    Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
    Sleep 30:823-7. 2007
    ..We sought to identify and characterize human PGO waves...
  46. doi request reprint Location of active contacts in patients with primary dystonia treated with globus pallidus deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
    Neurosurgery 62:217-23; discussion 223-5. 2008
    ..We compared the location of the contacts being used for stimulation (active contacts) in patients with cervical dystonia, generalized dystonia, and Parkinson's disease and correlated the results with clinical outcome...
  47. ncbi request reprint The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulation
    Clement Hamani
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital Research Institute, University of Toronto, Toronto, Canada
    Parkinsonism Relat Disord 13:S276-80. 2007
    ..We review the anatomical features of the PPN, its role in motor control, and its potential role as a target for PD surgery, including the results of recently published clinical studies...
  48. ncbi request reprint Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's disease
    Yuri M Andrade-Souza
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 56:360-8; discussion 360-8. 2005
    ....
  49. ncbi request reprint Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 54:191-5; discussion 195-7. 2004
    ..The aim of the present study was to investigate the influence of anterior thalamic nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats...
  50. doi request reprint Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial
    Nir Lipsman
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
    Lancet 381:1361-70. 2013
    ..We aimed to assess the safety of DBS to modulate the activity of limbic circuits and to examine how this might affect the clinical features of anorexia nervosa...
  51. ncbi request reprint Saccade-related potentials recorded from human subthalamic nucleus
    Adrian P Fawcett
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Clin Neurophysiol 118:155-63. 2007
    ..To investigate an ocular motor role for the STN in Parkinson's disease (PD) patients...
  52. doi request reprint Deep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesia
    Meaghan Creed
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
    Eur Neuropsychopharmacol 21:393-400. 2011
    ..The chronic HAL VCM model preparation may be useful to explore mechanisms underlying DBS effects in drug-induced dyskinesias...
  53. ncbi request reprint Bilateral subthalamic nucleus stimulation for Parkinson's disease: a systematic review of the clinical literature
    Clement Hamani
    Division of Neurosurgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Neurosurgery 56:1313-21; discussion 1321-4. 2005
    ..To evaluate the benefits and adverse effects of bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease (PD) by systematically reviewing the published literature...
  54. ncbi request reprint The motor thalamus in neurosurgery
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 58:146-58; discussion 146-58. 2006
    ..The aim of the present article is to briefly review the major anatomic and physiological aspects of the motor thalamus as well as the electrophysiological findings described in humans undergoing surgical procedures...
  55. doi request reprint Deep brain stimulation: current and future perspectives
    Nasir Raza Awan
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Canada
    Neurosurg Focus 27:E2. 2009
    ..This review will discuss some of the areas of current investigation and potential new applications of DBS...
  56. pmc Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors
    Abhiram Pushparaj
    Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health CAMH, Toronto, ON, Canada
    Neuropsychopharmacology 38:690-8. 2013
    ..Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored...
  57. ncbi request reprint Surgery for other movement disorders: dystonia, tics
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, UHN, Toronto, Ontario, Canada
    Curr Opin Neurol 20:470-6. 2007
    ..We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation...
  58. ncbi request reprint Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effect
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ont, Canada
    Pain 125:188-96. 2006
    ..The relatively low efficacy of DBS for the treatment of neuropathic pain stresses the need for further investigation and the exploration of new surgical targets...
  59. ncbi request reprint Deep brain stimulation for treatment-resistant depression
    Helen S Mayberg
    Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
    Neuron 45:651-60. 2005
    ....
  60. ncbi request reprint The subthalamic nucleus in the context of movement disorders
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
    Brain 127:4-20. 2004
    ..The aim of the present article is to review briefly the major anatomical, pharmacological and physiological aspects of the STN, as well as its involvement in the pathophysiology and treatment of Parkinson's disease...
  61. ncbi request reprint The future of deep brain stimulation
    Andres M Lozano
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Neurophysiol 21:68-9. 2004
    ..This will act as a driving force to increase the efforts to improve the technology applied to design and manufacture new hardware...
  62. ncbi request reprint Neural stimulation for Parkinson's disease: current therapies and future directions
    Joseph S Neimat
    Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    Expert Rev Neurother 6:101-9. 2006
    ....
  63. doi request reprint Treatment options for epileptic myoclonus and epilepsy syndromes associated with myoclonus
    Danielle M Andrade
    Division of Neurology, Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Canada
    Expert Opin Pharmacother 10:1549-60. 2009
    ..Myoclonus is a brief shock-like movement that has many different etiologies. The degree to which it disturbs quality of life is extremely variable, as is its response to treatment...
  64. ncbi request reprint Deep brain stimulation in the treatment of dyskinesia and dystonia
    Hiroki Toda
    Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Ontario, Cananda
    Neurosurg Focus 17:E2. 2004
    ..Discrimination between the diverse forms of dystonia and a better understanding of the pathophysiological features of this condition will serve as a platform for improved outcomes...
  65. ncbi request reprint Tremor cells in the human thalamus: differences among neurological disorders
    Jason A Brodkey
    Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
    J Neurosurg 101:43-7. 2004
    ....
  66. ncbi request reprint Hardware-related complications of deep brain stimulation: a review of the published literature
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Stereotact Funct Neurosurg 84:248-51. 2006
    ..3% of the patients). Refinements in surgical technique, technological improvements, and a greater experience with the procedures will likely decrease the incidence of hardware-related side effects in the future...
  67. ncbi request reprint Longevity of batteries in internal pulse generators used for deep brain stimulation
    Mohammed Bin-Mahfoodh
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Stereotact Funct Neurosurg 80:56-60. 2003
    ..In our series of patients who needed battery replacement, battery longevity varied with stimulation parameters but was longer than expected from the manufacturer's specifications...
  68. ncbi request reprint Physiology and pathophysiology of Parkinson's disease
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Ann N Y Acad Sci 991:15-21. 2003
    ..With this abnormal neuronal activity neutralized, normal movements can in many cases be restored...