Mitchell L Halperin

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Potassium
    M L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Lancet 352:135-40. 1998
  2. ncbi request reprint Control of potassium excretion: a Paleolithic perspective
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Nephrol Hypertens 15:430-6. 2006
  3. ncbi request reprint A new look at an old problem: therapy of chronic hyponatremia
    Mitchell L Halperin
    University of Toronto, Toronto, ON, Canada
    Nat Clin Pract Nephrol 3:2-3. 2007
  4. ncbi request reprint Effect of fasting for two days on the excretion of ammonium in dogs with chronic metabolic acidosis
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ont, Canada
    Nephron 91:695-700. 2002
  5. ncbi request reprint Physiology of acid-base balance: links with kidney stone prevention
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Semin Nephrol 26:441-6. 2006
  6. ncbi request reprint Clinical approach to disorders of salt and water balance. Emphasis on integrative physiology
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, St Michael s Hospital Annex, 38 Shuter Street, Toronto, Ontario, M5B 1A6, Canada
    Crit Care Clin 18:249-72. 2002
  7. ncbi request reprint Integrative physiology of basal water permeability in the distal nephron: implications for the syndrome of inappropriate secretion of antidiuretic hormone
    M L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Ontario, Canada
    Clin Nephrol 56:339-45. 2001
  8. ncbi request reprint Properties permitting the renal cortex to be the oxygen sensor for the release of erythropoietin: clinical implications
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin J Am Soc Nephrol 1:1049-53. 2006
  9. doi request reprint Mechanisms to concentrate the urine: an opinion
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 17:416-22. 2008
  10. ncbi request reprint Dynamic interactions between integrative physiology and molecular medicine: the key to understand the mechanism of action of aldosterone in the kidney
    M L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Ontario, Canada
    Can J Physiol Pharmacol 78:587-94. 2000

Collaborators

  • Kamel S Kamel
  • Shih Hua Lin
  • Gregory M T Hare
  • C David Mazer
  • Man S Oh
  • Carlos G Carlotti
  • E J Hoorn
  • Surinder Cheema-Dhadli
  • Namhee Kim
  • Ana P C P Carlotti
  • Chee Kiong Chong
  • Chee Keong Chong
  • Manjula Gowrishankar
  • Daniel G Bichet
  • Mohammad A Shafiee
  • Desmond Bohn
  • Sheila Singh
  • Mogamat Razeen Davids
  • Laura Voicu
  • Stephen K W Chan
  • Mohammad Alazmi
  • Chee Keong-Chong
  • Elena Semenova
  • Asheer Sharman
  • Jamshid Roozbeh
  • Olga Napolova
  • Andre F Charest
  • Daniel N Glick
  • Yeouda Edoute
  • Michael Cusimano
  • Jean Pierre Mallie
  • James T Rutka

Detail Information

Publications36

  1. ncbi request reprint Potassium
    M L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Lancet 352:135-40. 1998
    ..This analysis provides the basis for diagnosis and may indicate where non-emergency therapy should then be directed...
  2. ncbi request reprint Control of potassium excretion: a Paleolithic perspective
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Nephrol Hypertens 15:430-6. 2006
    ....
  3. ncbi request reprint A new look at an old problem: therapy of chronic hyponatremia
    Mitchell L Halperin
    University of Toronto, Toronto, ON, Canada
    Nat Clin Pract Nephrol 3:2-3. 2007
  4. ncbi request reprint Effect of fasting for two days on the excretion of ammonium in dogs with chronic metabolic acidosis
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ont, Canada
    Nephron 91:695-700. 2002
    ..The source of glutamine for renal ammonium production is ultimately dietary protein in the fed state and body proteins in fasting...
  5. ncbi request reprint Physiology of acid-base balance: links with kidney stone prevention
    Mitchell L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Semin Nephrol 26:441-6. 2006
    ..Formation of this precipitate requires medullary alkalinization; K(+) -depletion and augmented medullary H(+)/K(+) -ATPase may be predisposing factors...
  6. ncbi request reprint Clinical approach to disorders of salt and water balance. Emphasis on integrative physiology
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, St Michael s Hospital Annex, 38 Shuter Street, Toronto, Ontario, M5B 1A6, Canada
    Crit Care Clin 18:249-72. 2002
    ..In contrast, the objective in the patient with chronic hyponatremia is to prevent ODS. An even slower rate of rise of the PNa is required in patients who are malnourished and/or K+ depleted...
  7. ncbi request reprint Integrative physiology of basal water permeability in the distal nephron: implications for the syndrome of inappropriate secretion of antidiuretic hormone
    M L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Ontario, Canada
    Clin Nephrol 56:339-45. 2001
    ..These patients may develop osmotic demyelination if a large solute load leads to a very rapid excretion of electrolyte-free water...
  8. ncbi request reprint Properties permitting the renal cortex to be the oxygen sensor for the release of erythropoietin: clinical implications
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin J Am Soc Nephrol 1:1049-53. 2006
    ..This suggests that the GFR and the renal blood flow rate should be examined in patients with unexplained anemia or erythrocytosis...
  9. doi request reprint Mechanisms to concentrate the urine: an opinion
    Mitchell L Halperin
    Division of Nephrology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 17:416-22. 2008
    ..Our goal is to suggest how the renal concentrating mechanism is regulated in vivo...
  10. ncbi request reprint Dynamic interactions between integrative physiology and molecular medicine: the key to understand the mechanism of action of aldosterone in the kidney
    M L Halperin
    Renal Division, St Michael s Hospital, University of Toronto, Ontario, Canada
    Can J Physiol Pharmacol 78:587-94. 2000
    ..Using a similar approach, it is possible to understand how the risk of the formation of kidney stones can be minimized...
  11. pmc Requirements for a high rate of potassium excretion in rats consuming a low electrolyte diet
    Surinder Cheema-Dhadli
    Renal Division, St Michael s Hospital, University of Toronto, Canada
    J Physiol 572:493-501. 2006
    ..Thus, to understand which of the potential control mechanisms are operating, one must look very closely at the conditions imposed by the experimental setting...
  12. ncbi request reprint Studies to identify the basis for an alkaline urine pH in patients with calcium hydrogen phosphate kidney stones
    Kamel S Kamel
    University of Toronto, St Michael s Hospital, Division of Nephrology, 61 Queen Street, Toronto, Ontario M5B 1A6, Canada
    Nephrol Dial Transplant 22:424-31. 2007
    ..Patients with CaHPO(4) kidney stones belong to a diagnostic category that has a high urine pH as its common feature. Our objective was to provide a new clinical approach to examine the basis for this high pH...
  13. ncbi request reprint Mechanisms used to dispose of progressively increasing alkali load in rats
    Surinder Cheema-Dhadli
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada M5B 1A6
    Am J Physiol Renal Physiol 282:F1049-55. 2002
    ..This provides a way of limiting changes in urine pH without sacrificing acid-base balance, a process that might lessen the risk of kidney stone formation...
  14. ncbi request reprint Bartter's, Gitelman's, and Gordon's syndromes. From physiology to molecular biology and back, yet still some unanswered questions
    Kamel S Kamel
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ont, Canada
    Nephron 92:18-27. 2002
    ..Our objective is to integrate these new insights into an understanding of the pathophysiology of renal potassium handling. We also propose different ways to think about some of the unresolved issues in this area...
  15. ncbi request reprint Dogmas and controversies in the handling of nitrogenous wastes: excretion of nitrogenous wastes in human subjects
    Kamel S Kamel
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, M5B 1A6 Canada
    J Exp Biol 207:1985-91. 2004
    ..0 must be maintained in order to reduce the risk of precipitating uric acid in the urine. Possible ways of resolving these conundrums require novel physiological interpretations...
  16. doi request reprint Response of the renal inner medulla to hypoxia: possible defense mechanisms
    Namhee Kim
    Department of Anesthesia, Keenan Research Centre of Li Ka Shing Knowledge Institute, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Nephron Physiol 121:p1-7. 2012
    ..Owing to the precarious blood supply to the renal medulla and the high metabolic requirement of the medullary thick ascending limb of Henle's loop, this nephron segment should be especially vulnerable when its supply of O(2) declines...
  17. doi request reprint Non-natriuretic doses of furosemide: potential use for decreasing the workload of the renal outer medulla with minimal magnesium wasting in the rat
    Namhee Kim
    Department of Anesthesia, Division of Nephrology, University of Toronto, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute, Toronto, Ont, Canada
    Nephron Physiol 122:7-12. 2012
    ..Mg(2+) is important because the ATP needed to perform work must have bound Mg(2+) to it...
  18. doi request reprint Intrarenal urea recycling leads to a higher rate of renal excretion of potassium: an hypothesis with clinical implications
    Kamel S Kamel
    Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Division of Nephrology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Nephrol Hypertens 20:547-54. 2011
    ..This review aims to illustrate why urea recycling may play an important role in potassium (K⁺) excretion and to emphasize its potential clinical implications...
  19. ncbi request reprint Acute hyponatremia related to intravenous fluid administration in hospitalized children: an observational study
    Ewout J Hoorn
    Department of Critical Care Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 113:1279-84. 2004
    ..The objective of this study was to identify risk factors for the development of hospital-acquired, acute hyponatremia in a tertiary care hospital using a retrospective analysis...
  20. pmc Influence of hypernatraemia and urea excretion on the ability to excrete a maximally hypertonic urine in the rat
    Surinder Cheema-Dhadli
    Renal Division, St Michael s Hospital, University of Toronto, Canada M5B 1A6
    J Physiol 541:929-36. 2002
    ..Thus hypernatraemia was the most important factor associated with a higher urine tonicity...
  21. ncbi request reprint Defining conditions that lead to the retention of water: the importance of the arterial sodium concentration
    Mohammad A Shafiee
    Renal Division, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 67:613-21. 2005
    ..Nevertheless, water conservation is required to provide a source of water for evaporative heat dissipation throughout the day. Therefore, the objective was to define conditions that permit the retention of ingested water...
  22. ncbi request reprint Studies on the pathophysiology of the low urine pH in patients with uric acid stones
    Kamel S Kamel
    Renal Division, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1A6
    Kidney Int 61:988-94. 2002
    ..A very low urine pH is the major risk factor for uric acid stone formation...
  23. pmc Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?
    Surinder Cheema-Dhadli
    Renal Divisions, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Electrolyte Blood Press 8:10-7. 2010
    ..05). One explanation for this difference is that the rats escaped from the renal action of vasopressin. Nevertheless, based on a quantitative analysis, other possibilities will be considered...
  24. ncbi request reprint Cerebral salt wasting: truths, fallacies, theories, and challenges
    Sheila Singh
    Department of Pediatric Neurosurgery, Hospital for Sick Children, Toronto, Canada
    Crit Care Med 30:2575-9. 2002
    ..The reported prevalence of cerebral salt wasting has increased in the past three decades. A cerebral lesion and a large natriuresis without a known stimulus to excrete so much sodium (Na ) constitute its essential two elements...
  25. pmc Importance of Residual Water Permeability on the Excretion of Water during Water Diuresis in Rats
    Surinder Cheema-Dhadli
    Renal Divisions, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Electrolyte Blood Press 8:1-9. 2010
    ..The enormous osmotic driving force for the reabsorption of water in the inner medullary collecting duct may play a role in this reabsorption of water. Possible clinical implications are illustrated in the discussion of a case example...
  26. ncbi request reprint Strategies to diminish the danger of cerebral edema in a pediatric patient presenting with diabetic ketoacidosis
    Mitchell L Halperin
    Pediatr Diabetes 7:191-5. 2006
  27. ncbi request reprint Laboratory tests to determine the cause of hypokalemia and paralysis
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan
    Arch Intern Med 164:1561-6. 2004
    ..Failure to make a distinction between HPP and non-HPP may lead to improper management. Therefore, we evaluated the diagnostic value of spot urine tests in patients with hypokalemia and paralysis during 3 years...
  28. ncbi request reprint A brain protein centered view of H+ buffering
    Manjula Gowrishankar
    Stollery Children s Hospital, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 18:2278-80. 2007
    ..This article provides a "brain protein-centered" view, which leads to different conclusions concerning the way H(+) are removed physiologically...
  29. ncbi request reprint Hypercalcaemia and metabolic alkalosis with betel nut chewing: emphasis on its integrative pathophysiology
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Nephrol Dial Transplant 17:708-14. 2002
    ....
  30. ncbi request reprint Body compartment volumes and composition after giving a vasopressin antagonist: changes are revealed by a tonicity balance
    Mogamat Razeen Davids
    Nephrology Unit, University of Stellenbosch, Cape Town, South Africa
    Nephrol Dial Transplant 17:300-3. 2002
  31. ncbi request reprint Hypokalemia: a practical approach to diagnosis and its genetic basis
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Curr Med Chem 14:1551-65. 2007
    ..Recent molecular advances in inherited hypokalemic disorders affecting transcellular K+ shift, gastrointestinal and renal K+ excretion are also discussed...
  32. ncbi request reprint Preventing a drop in effective plasma osmolality to minimize the likelihood of cerebral edema during treatment of children with diabetic ketoacidosis
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Pediatr 150:467-73. 2007
    ....
  33. ncbi request reprint Minimizing the risk of developing cerebral edema during therapy for diabetic ketoacidosis
    Ana P C P Carlotti
    Crit Care Med 35:1450; author reply 1450-1. 2007
  34. ncbi request reprint An unusual cause of hypokalemic paralysis: chronic licorice ingestion
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, Nationa Defense Medical Center, Taipei, Taiwan
    Am J Med Sci 325:153-6. 2003
    ..Long-term licorice ingestion should be kept in mind as a cause of paralysis with an extreme degree of hypokalemia to avoid missing this recognizable and curable medical disorder...
  35. ncbi request reprint Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium/chloride cotransporter
    Shih Hua Lin
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Am J Kidney Dis 43:304-12. 2004
    ..Although the severity of symptoms may vary in patients who have the same mutations, a markedly different clinical presentation in family members with identical mutations is truly rare...
  36. ncbi request reprint Hyponatremia in marathon runners
    Mitchell L Halperin
    N Engl J Med 353:427-8; author reply 427-8. 2005