P F Halloran

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis
    P F Halloran
    Departments of Medicine, Surgery, and Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 158:215-26. 2001
  2. ncbi request reprint Immunosuppressive drugs for kidney transplantation
    Philip F Halloran
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    N Engl J Med 351:2715-29. 2004
  3. pmc Molecular phenotypes of acute kidney injury in kidney transplants
    Konrad S Famulski
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 23:948-58. 2012
  4. pmc Improving gene set analysis of microarray data by SAM-GS
    Irina Dinu
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    BMC Bioinformatics 8:242. 2007
  5. ncbi request reprint IFN-gamma alters the pathology of graft rejection: protection from early necrosis
    P F Halloran
    Departments of Medicine, Surgery, and Laboratory Medicine and Anatomical Pathology, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 166:7072-81. 2001
  6. ncbi request reprint An integrated view of molecular changes, histopathology and outcomes in kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2223-30. 2010
  7. doi request reprint T cell-mediated rejection of kidney transplants: a personal viewpoint
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 10:1126-34. 2010
  8. ncbi request reprint Immunosuppressive agents in clinical trials in transplantation
    P F Halloran
    Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Med Sci 313:283-8. 1997
  9. ncbi request reprint The molecular phenotype of kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2215-22. 2010
  10. ncbi request reprint Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B
    Philip F Halloran
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:705-12. 2004

Collaborators

Detail Information

Publications96

  1. pmc Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis
    P F Halloran
    Departments of Medicine, Surgery, and Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Pathol 158:215-26. 2001
    ..Thus IFN-gamma acting on IFN-gamma receptors in allografts promotes infiltration and MHC induction but prevents early thrombosis, congestion, and necrosis...
  2. ncbi request reprint Immunosuppressive drugs for kidney transplantation
    Philip F Halloran
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    N Engl J Med 351:2715-29. 2004
  3. pmc Molecular phenotypes of acute kidney injury in kidney transplants
    Konrad S Famulski
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 23:948-58. 2012
    ....
  4. pmc Improving gene set analysis of microarray data by SAM-GS
    Irina Dinu
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    BMC Bioinformatics 8:242. 2007
    ..We describe here some critical problems with GSEA and propose an alternative method by extending the individual-gene analysis method, Significance Analysis of Microarray (SAM), to gene-set analyses (SAM-GS)...
  5. ncbi request reprint IFN-gamma alters the pathology of graft rejection: protection from early necrosis
    P F Halloran
    Departments of Medicine, Surgery, and Laboratory Medicine and Anatomical Pathology, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 166:7072-81. 2001
    ..This is probably a local action of IFN-gamma produced in large quantities in the allograft...
  6. ncbi request reprint An integrated view of molecular changes, histopathology and outcomes in kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2223-30. 2010
    ..The active injury-repair response is the strongest correlate of organ function and future progression to failure, but should always prompt a search for the initiating injury or disease...
  7. doi request reprint T cell-mediated rejection of kidney transplants: a personal viewpoint
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 10:1126-34. 2010
    ..Thus TCMR is a cognate recognition-based process that creates local inflammation and epithelial dedifferentiation, stereotyped nephron responses, and tubulitis, and if untreated causes irreversible nephron loss...
  8. ncbi request reprint Immunosuppressive agents in clinical trials in transplantation
    P F Halloran
    Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Med Sci 313:283-8. 1997
    ..Organ transplant practice will probably change considerably as these agents become available...
  9. ncbi request reprint The molecular phenotype of kidney transplants
    P F Halloran
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2215-22. 2010
    ..Thus the molecular phenotype is best described in terms of three elements: specific diseases, including rejection; the injury-repair response and the cumulative burden of injury...
  10. ncbi request reprint Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B
    Philip F Halloran
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:705-12. 2004
    ..Together with previous graft survival studies, these results indicate that the granule-associated cytotoxic mechanisms of T cells are not the effectors of T-cell-mediated allograft rejection...
  11. ncbi request reprint Microarrays and transcriptome analysis in renal transplantation
    Philip F Halloran
    University of Alberta, Division of Nephrology and Transplantation Immunology, 250 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada
    Nat Clin Pract Nephrol 2:2-3. 2006
  12. doi request reprint NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection
    L G Hidalgo
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:1812-22. 2010
    ..Thus, the strategy of using DSASTs in the biopsy to identify mechanism-related transcripts in biopsies from patients with clinical phenotypes indicates the selective involvement of NK cells in ABMR...
  13. ncbi request reprint Tubulitis and epithelial cell alterations in mouse kidney transplant rejection are independent of CD103, perforin or granzymes A/B
    G Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 6:2109-20. 2006
    ..We suggest that alloimmune effector T cells mediate epithelial injury by contact-independent mechanisms related to delayed type hypersensitivity, followed by invasion of the altered epithelium to produce tubulitis...
  14. doi request reprint De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure
    L G Hidalgo
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2532-41. 2009
    ..We propose careful assessment of de novo DSA, particularly against class II, be performed in all late kidney transplant biopsies...
  15. doi request reprint A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 12:1168-79. 2012
    ..Thus any degree of microcirculation inflammation in late kidney transplant biopsies strongly indicates presence of DSA and predicts progression to graft failure...
  16. doi request reprint The molecular phenotype of heart transplant biopsies: relationship to histopathological and clinical variables
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 10:2105-15. 2010
    ....
  17. doi request reprint Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure
    G Einecke
    Alberta Transplant Applied Genomics Centre, Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 9:2520-31. 2009
    ..The major cause of late kidney transplant failure is antibody-mediated microcirculation injury, but detection of this phenotype requires new diagnostic criteria...
  18. ncbi request reprint IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo
    M Hobart
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Immunol 158:4260-9. 1997
    ..Thus, in vivo, IRF-1 plays a major role in basal and induced class I expression and in induction of class II by IFN-gamma, probably via CIITA induction...
  19. doi request reprint The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 11:708-18. 2011
    ..Thus while detecting T cell-mediated inflammation, the molecular phenotype of early protocol biopsies mostly reflects the injury-repair response to implantation stresses, and has little relationship to future events and outcomes...
  20. doi request reprint Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies
    J Reeve
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 13:645-55. 2013
    ..We propose new rules to integrate molecular tests and histology into a precision diagnostic system that can reduce errors, ambiguity and interpathologist disagreement...
  21. doi request reprint Interpreting NK cell transcripts versus T cell transcripts in renal transplant biopsies
    L G Hidalgo
    Department of Laboratory Medicine and Pathology, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 12:1180-91. 2012
    ....
  22. doi request reprint Cluster analysis of lesions in nonselected kidney transplant biopsies: microcirculation changes, tubulointerstitial inflammation and scarring
    B Sis
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 10:421-30. 2010
    ..Interpretation of lesions should reflect these associations...
  23. ncbi request reprint Changes in the transcriptome in allograft rejection: IFN-gamma-induced transcripts in mouse kidney allografts
    K S Famulski
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 6:1342-54. 2006
    ....
  24. ncbi request reprint Early loss of renal transcripts in kidney allografts: relationship to the development of histologic lesions and alloimmune effector mechanisms
    G Einecke
    Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 7:1121-30. 2007
    ..We conclude that loss of renal transcripts indicates an early stage of T-cell mediated alloimmune injury that later progresses to pathologic lesions such as tubulitis...
  25. ncbi request reprint The role of the class II transactivator (CIITA) in MHC class I and II regulation and graft rejection in kidney
    T N Sims
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 1:211-21. 2001
    ..Thus CIITA-deficient kidneys have no basal and induced class II expression but display intense induction of class I expression, and evoke typical rejection lesions, although some indices of infiltration are reduced at day 21...
  26. doi request reprint Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:388-99. 2012
    ..This prospective cohort indicates that many actual failures after indication biopsies manifest phenotypic features of antibody-mediated or mixed rejection and also underscores the major role of nonadherence...
  27. doi request reprint Comparing microarray versus RT-PCR assessment of renal allograft biopsies: similar performance despite different dynamic ranges
    K Allanach
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 8:1006-15. 2008
    ..The dynamic range of both platforms was sufficient to detect the relevant changes in rejection...
  28. doi request reprint FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes
    S Bunnag
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:1423-33. 2008
    ..Thus FOXP3 mRNA expression is a time-dependent feature of inflammatory infiltrates in renal tissue. We hypothesize that time-dependent entry of FOXP3-positive cells represents a mechanism for stabilizing inflammatory sites...
  29. ncbi request reprint Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets
    T F Mueller
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 7:2712-22. 2007
    ..PBTs represent a quantitative measure of the inflammatory disturbances in organ transplants, and a new window on the mechanisms of these changes...
  30. ncbi request reprint Transcriptome analysis reveals heterogeneity in the injury response of kidney transplants
    K S Famulski
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:2483-95. 2007
    ..The alloresponse strikingly and selectively increased the late IRITs but not the IRITs that peak early, indicating that rejection triggers parenchymal responses similar to those in ATN...
  31. doi request reprint Inflammation lesions in kidney transplant biopsies: association with survival is due to the underlying diseases
    J Sellares
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 11:489-99. 2011
    ..The most important predictor of outcome is the diagnosis of a progressive disease...
  32. doi request reprint Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 10:464-71. 2010
    ....
  33. doi request reprint Alternative macrophage activation-associated transcripts in T-cell-mediated rejection of mouse kidney allografts
    K S Famulski
    Alberta Transplant Applied Genomics Centre, Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 10:490-7. 2010
    ..Although the mechanisms and causal relationships remain to be determined, high AMA transcript levels in rejecting allografts are strongly associated with and may be a consequence of parenchymal deterioration similar to ATN...
  34. ncbi request reprint Ly-6 in kidney is widely expressed on tubular epithelium and vascular endothelium and is up-regulated by interferon gamma
    P G Blake
    Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 4:1140-50. 1993
    ..The renal expression of Ly-6 is similar to that of CD59 in the human kidney, supporting the suggestion that these proteins are closely related...
  35. ncbi request reprint IFN-gamma prevents early perforin-granzyme-mediated destruction of kidney allografts by inducing donor class I products in the kidney
    B Sis
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:2301-10. 2007
    ..We propose that donor class Ia or Ib products are needed to trigger inhibitory receptors on effector T cells...
  36. doi request reprint The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants
    L G Hidalgo
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:637-46. 2008
    ..Thus QCAT sets robustly measure the burden of CTL and effector memory T cells in biopsies as %CTL RNA, in a manner not achieved by measurement of individual transcripts...
  37. doi request reprint Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts
    M Mengel
    Department of Laboratory Medicine and Pathology, Alberta Transplant Applied Genomics Centre, Canada
    Am J Transplant 9:1859-67. 2009
    ..Thus, the total i-score is superior to the current Banff i-score and most diagnostic Banff categories in predicting outcome and assessing the molecular phenotype of renal allografts...
  38. doi request reprint Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts
    G Einecke
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 8:1434-43. 2008
    ..Expression of BATs and IGTs correlated with renal function, but this relationship was due to differences in early versus late biopsies: BATs and IGTs were not related to function or future function after correcting for time...
  39. doi request reprint Interferon-gamma and donor MHC class I control alternative macrophage activation and activin expression in rejecting kidney allografts: a shift in the Th1-Th2 paradigm
    K S Famulski
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:547-56. 2008
    ..Thus, Ifng may control T helper type 2 (Th2) cell inflammation by induction of class I products...
  40. doi request reprint The nature of biopsies with "borderline rejection" and prospects for eliminating this category
    D G de Freitas
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 12:191-201. 2012
    ..Both molecular measurements and histopathology offer opportunities for more precise assignment of these cases after clinical validation...
  41. doi request reprint Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts
    M Mengel
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, Edmonton, Canada
    Am J Transplant 9:169-78. 2009
    ..Scarring is associated with a distinct pattern of inflammatory molecules, including B cell/immunoglobulin but particularly mast cell-associated transcripts, which correlated with poor outcomes...
  42. doi request reprint Donor Fas is not necessary for T-cell-mediated rejection of mouse kidney allografts
    D Kayser
    Department of Medicine, Division of Nephrology, Alberta Transplant Applied Genomics Centre, Edmonton, Canada
    Am J Transplant 8:2049-55. 2008
    ..We propose that in TCMR, interstitial effector T cells mediate parenchymal injury by inflammatory mechanisms that require neither the perforin-granzyme nor the Fas-Fas ligand cytotoxic mechanisms...
  43. doi request reprint Banff 07 classification of renal allograft pathology: updates and future directions
    K Solez
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
    Am J Transplant 8:753-60. 2008
    ....
  44. doi request reprint Defining the canonical form of T-cell-mediated rejection in human kidney transplants
    K S Famulski
    Alberta Transplant Applied Genomics Centre, Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 10:810-20. 2010
    ..This combination of pathologic, clinical and molecular features constitutes the typical or canonical T-cell-mediated rejection...
  45. doi request reprint The early course of kidney allograft rejection: defining the time when rejection begins
    G Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 9:483-93. 2009
    ..Thus, in renal allografts, allorecognition by T cells occurs in perivascular sites by day 1, but alloimmune parenchymal damage begins at day 3, coinciding with the emergence of the interstitial T-cell-MMDC infiltrate...
  46. ncbi request reprint Acute renal injury in the interferon-gamma gene knockout mouse: effect on cytokine gene expression
    N Goes
    Department of Medicine, University of Alberta, Edmonton, Canada
    Transplantation 60:1560-4. 1995
    ..Therefore, local injury was equally effective in both wild-type and GKO mice with equivalent cytokine and MHC mRNA induction, proving that local tissue injury can induce MHC expression by non-IFN-gamma factors...
  47. ncbi request reprint Evidence for the in vivo role of class II transactivator in basal and IFN-gamma induced class II expression in mouse tissue
    V Ramassar
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
    Transplantation 62:1901-7. 1996
    ..CIITA induction by IFN-gamma was partially sensitive to cycloheximide, suggesting that another protein is required for CIITA induction. The data suggest that CIITA is a major regulator of basal and induced class II expression in vivo...
  48. doi request reprint Comparing molecular assessment of implantation biopsies with histologic and demographic risk assessment
    C Kreepala
    Alberta Transplant Applied Genomic Centre, Edmonton, Alberta, Canada
    Am J Transplant 13:415-26. 2013
    ..Thus, measurement of injury-induced transcripts at the time of implantation improves the prediction of early kidney dysfunction, but risk prediction may fail when old kidneys are transplanted into old recipients...
  49. pmc Banff 2011 Meeting report: new concepts in antibody-mediated rejection
    M Mengel
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 12:563-70. 2012
    ..Results are expected to be presented at the 12th Banff meeting to be held in 2013 in Brazil. No change to the Banff classification occurred in 2011...
  50. ncbi request reprint Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    K Solez
    University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 7:518-26. 2007
    ..Participation of B cells in allograft rejection and genomics markers of rejection were also major subjects addressed by the conference...
  51. ncbi request reprint Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause
    B Sis
    Laboratory Medicine and Pathology, and Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 7:1743-52. 2007
    ..The remaining 27%, mostly BD, may be a different disease or a stage in which A and C are undetectable...
  52. ncbi request reprint The unique role of interferon-gamma in the regulation of MHC expression on arterial endothelium
    N Goes
    Department of Medicine, University of Alberta, Edmonton, Canada
    Transplantation 62:1889-94. 1996
    ..The fact that MHC class I is induced in endothelium may be useful therapeutically for reduction of immune recognition in transplantation...
  53. doi request reprint The transcriptome of human cytotoxic T cells: similarities and disparities among allostimulated CD4(+) CTL, CD8(+) CTL and NK cells
    L G Hidalgo
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 8:627-36. 2008
    ..This study serves as a foundation for the interpretation of CATs in rejecting allografts and highlights the extensive sharing of CATs among CD4(+) CTL, CD8(+) CTL and effector memory T cells...
  54. doi request reprint Molecular diagnosis of antibody-mediated rejection in human kidney transplants
    J Sellares
    Alberta Transplant Applied Genomics Centre, Edmonton, Alberta, Canada
    Am J Transplant 13:971-83. 2013
    ..We conclude that microarray assessment of gene expression can assign a probability of ABMR to transplant biopsies without knowledge of HLA antibody status, histology, or C4d staining, and predicts future failure...
  55. ncbi request reprint The transcriptome of the implant biopsy identifies donor kidneys at increased risk of delayed graft function
    T F Mueller
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 8:78-85. 2008
    ..03) but not with clinical or histopathologic scores. The transcriptome reflects kidney quality and susceptibility to DGF better than available clinical and histopathological scoring systems...
  56. pmc Evidence that calcineurin is rate-limiting for primary human lymphocyte activation
    T D Batiuk
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta AB T6G 2R8, Canada
    J Clin Invest 100:1894-901. 1997
    ..Thus, the reduction of CN activity observed in CsA-treated patients is accompanied by a similar degree of reduction in lymphocyte gene activation, and accounts for the immunosuppression observed...
  57. ncbi request reprint Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma
    N Goes
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Immunol 155:4559-66. 1995
    ..The local increase in MHC class I and II in parenchymal cells in response to injury reflects both IFN-gamma and a non-IFN-gamma factor. Systemic MHC class I and II induction is almost exclusively due to IFN-gamma...
  58. ncbi request reprint Mouse class II transactivator: cDNA sequence and amino acid comparison with the human class II transactivator
    T N Sims
    Department of Medical Microbiology and Immunology, 1 41 MSB, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Immunogenetics 45:220-2. 1997
  59. ncbi request reprint SWOT analysis of Banff: strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology
    M Mengel
    Department of Medicine, Division of Nephrology and Immunology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada
    Am J Transplant 7:2221-6. 2007
    ..The threat is the degree to which the renal transplant community will participate in and support this process...
  60. ncbi request reprint Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection
    Gunilla Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 5:1827-36. 2005
    ..Expression of CATs was established before diagnostic lesions and remained remarkably consistent through day 42 despite massive alterations in the pathology, and probably reflects T cells recruited to the graft...
  61. ncbi request reprint Tissue distribution of calcineurin and its sensitivity to inhibition by cyclosporine
    L Kung
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 1:325-33. 2001
    ..Thus each cyclosporine dose produces rapid and wide-spread inhibition of calcineurin in tissues, with differences in total susceptibility of each tissue...
  62. ncbi request reprint Peritubular capillary changes and C4d deposits are associated with transplant glomerulopathy but not IgA nephropathy
    Attapong Vongwiwatana
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:124-9. 2004
    ..Transplant glomerulopathy has a serious prognosis but is less frequent in patients on newer immunosuppression, unlike recurrent IgAN...
  63. ncbi request reprint Late deterioration of organ transplants: a problem in injury and homeostasis
    Sita Gourishankar
    Division of Nephrology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada
    Curr Opin Immunol 14:576-83. 2002
    ..The most important recent advance has been the emergence of potent immunosuppressive drug combinations that have greatly reduced rejection...
  64. doi request reprint Potential Impact of Microarray Diagnosis of T Cell-Mediated Rejection in Kidney Transplants: The INTERCOM Study
    P F Halloran
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada
    Am J Transplant 13:2352-63. 2013
    ..Neither the TCMR score nor histologic TCMR was associated with graft loss. Thus the molecular TCMR score has potential to add new insight, particularly in situations where histology is ambiguous or potentially misleading. ..
  65. ncbi request reprint Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease
    B Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 71:218-26. 2007
    ..The findings suggest a role for somatic cell senescence mechanisms in progression of GD...
  66. doi request reprint Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining
    Banu Sis
    Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 9:2312-23. 2009
    ..94%) than C4d. The results were validated in independent set of 82 kidneys. High renal endothelial transcript expression in patients with alloantibody is indicator of active antibody-mediated allograft damage and poor graft outcome...
  67. ncbi request reprint Transcription factor IRF-1 in kidney transplants mediates resistance to graft necrosis during rejection
    Marjan Afrouzian
    Department of Medicine, Division of Nephrology and Immunology, and Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 13:1199-209. 2002
    ..Thus in rejecting kidney transplants, IRF-1 in the graft mediates MHC induction, but it also mediates resistance to necrosis, an effect that could be crucial to permit success in interventions against rejection...
  68. doi request reprint Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection
    Banu Sis
    Department of Laboratory Medicine and Pathology, University of Alberta, Alberta, Canada
    Curr Opin Organ Transplant 15:42-8. 2010
    ..This article reviews recent molecular studies in kidney allograft tissues that decipher molecular burden and mechanisms of ABMR, leading to discovery of a new phenotype: 'C4d-negative ABMR'...
  69. pmc Molecular correlates of renal function in kidney transplant biopsies
    Sakarn Bunnag
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 20:1149-60. 2009
    ..Thus, in biopsies performed for clinical reasons, functional disturbances are reflected in transcriptome changes representing tissue injury and dedifferentiation but not the inflammatory burden...
  70. ncbi request reprint Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 68:2667-79. 2005
    ..The molecular basis of renal aging is not completely understood...
  71. ncbi request reprint Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis
    Attapong Vongwiwatana
    Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1367-74. 2005
    ..These findings support a model in which the TEC damage induces loss of epithelial features and expression of fibroblast features, as a common pathway of deterioration by either immunologic or nonimmunologic processes...
  72. ncbi request reprint Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1375-82. 2005
    ..Thus, aging, injury and disease may share common pathways involving somatic cell senescence...
  73. pmc A molecular classifier for predicting future graft loss in late kidney transplant biopsies
    Gunilla Einecke
    Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada
    J Clin Invest 120:1862-72. 2010
    ..In an independent validation set, the molecular risk score was the only predictor of graft loss. Thus, the molecular risk score reflects active injury and is superior to either scarring or function in predicting graft failure...
  74. ncbi request reprint Alternatively spliced, germline J alpha 11-2-C alpha mRNAs are the predominant T cell receptor alpha transcripts in mouse kidney
    J Madrenas
    Department of Immunology, University of Alberta, Edmonton, Canada
    Mol Immunol 31:993-1004. 1994
    ..These results suggest that the product of this transcript may be functionally relevant...
  75. ncbi request reprint Tissue distribution of IL-10 mRNA in normal mice. Evidence that a component of IL-10 expression is T and B cell-independent and increased by irradiation
    A P Broski
    Department of Medicine, University of Alberta, Edmonton, Canada
    Transplantation 57:582-92. 1994
    ....
  76. ncbi request reprint Role of IFN-gamma in allograft rejection
    Luis G Hidalgo
    Department of Medical Microbiology, University of Alberta, Edmonton, Alberta, Canada
    Crit Rev Immunol 22:317-49. 2002
    ..Thus IFN-gamma has diverse and potentially contradictory effects on organ allograft survival, acting both on the immune system and on the graft itself, the net effect depending on the graft type and the time post-transplant...
  77. ncbi request reprint Donor tissue characteristics influence cadaver kidney transplant function and graft survival but not rejection
    Sita Gourishankar
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 14:493-9. 2003
    ..In contrast, rejection affects survival and function, but it is not primarily determined by the characteristics of the donor tissue. Graft survival reflects both of these influences...
  78. ncbi request reprint Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
    Anette Melk
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 63:2134-43. 2003
    ..We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structural and functional changes in rat kidney with age to phenomena associated with cellular senescence in vitro...
  79. ncbi request reprint The role of B cells and alloantibody in the host response to human organ allografts
    Attapong Vongwiwatana
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, 250 Heritage Medical Research Center, Edmonton, Alberta, Canada T6G 2S2
    Immunol Rev 196:197-218. 2003
    ..The diagnosis of late ongoing AMR raises the possibility of treatment to suppress the alloantibody, but efficacy of the available treatments requires further study...
  80. ncbi request reprint The stability of the glomerular filtration rate after renal transplantation is improving
    Sita Gourishankar
    Division of Nephrology and Immunology, Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 14:2387-94. 2003
    ..Despite continued calcineurin inhibitor use, late improvement in function now occurs in many cadaver kidney transplants, suggesting a previously unappreciated capacity for functional adaptation...
  81. ncbi request reprint IFN-gamma is an absolute requirement for spontaneous acceptance of liver allografts
    Tina S Mele
    Departments of Surgery, Medicine, Laboratory Medicine and Pathology, and Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 3:942-51. 2003
    ..Thus IFN-gamma mediates a direct effect on rejecting liver allografts that reduces hemorrhage and necrosis, induces MHC expression, and is absolutely required for spontaneous acceptance...
  82. doi request reprint Precision diagnostics in transplantation: from bench to bedside
    M Mengel
    Transplant Diagnostics Community of Practice of the American Society of Transplantation, USA
    Am J Transplant 13:562-8. 2013
    ....
  83. ncbi request reprint Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
    Anette Melk
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 65:510-20. 2004
    ..In the present study, we evaluated the relationship between renal age in humans and a number of phenomena associated with cellular senescence in vitro...
  84. ncbi request reprint Differential usage of class II transactivator promoters PI and PIV during inflammation and injury in kidney
    Oki Takeuchi
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 14:2823-32. 2003
    ....
  85. ncbi request reprint Long-term deterioration of kidney allograft function
    Bertram L Kasiske
    Department of Medicine, University of Minnesota, Minneapolis, USA
    Am J Transplant 5:1405-14. 2005
    ..78 (0.64-0.95), p = 0.0110 during 1999-2002 (compared to 1984-1989). We conclude that the rate of decline in allograft function after kidney transplantation has improved, suggesting that stable, long-term function may be achievable...
  86. ncbi request reprint Reduced exposure to calcineurin inhibitors in renal transplantation
    Henrik Ekberg
    Lund University, Malmo, Sweden
    N Engl J Med 357:2562-75. 2007
    ..Immunosuppressive regimens with the fewest possible toxic effects are desirable for transplant recipients. This study evaluated the efficacy and relative toxic effects of four immunosuppressive regimens...
  87. ncbi request reprint Banff 2003 meeting report: new diagnostic insights and standards
    Lorraine C Racusen
    Department of Pathology, The Johns Hopkins University School of Medicine, USA
    Am J Transplant 4:1562-6. 2004
    ..Future meetings are planned for 2005 (Edmonton), 2007 and 2009, with active ongoing Internet discussion between meetings...
  88. ncbi request reprint Heterogeneity in the evolution and mechanisms of the lesions of kidney allograft rejection in mice
    Wolfram J Jabs
    1st Department of Internal Medicine, University of Luebeck School of Medicine, Luebeck, Germany
    Am J Transplant 3:1501-9. 2003
    ....
  89. ncbi request reprint Call for revolution: a new approach to describing allograft deterioration
    Philip F Halloran
    Am J Transplant 2:195-200. 2002
    ..The level of function and the slope of the loss of function should be separately determined. This approach can be applied both in research and in clinical practice, and can be adapted to other organ transplants...
  90. ncbi request reprint Costimulation blockade with belatacept in renal transplantation
    Flavio Vincenti
    University of California, San Francisco, San Francisco, USA
    N Engl J Med 353:770-81. 2005
    ..The use of potentially less toxic agents, such as belatacept, a selective blocker of T-cell activation, may improve outcomes...
  91. ncbi request reprint Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support
    Florian Grabellus
    Institute of Pathology, University of Essen, Essen, Germany
    J Pathol 197:230-7. 2002
    ..This supports the concept that restoration of cardiac normoxia by mechanical unloading, particularly in the subendocardium, may be in part responsible for the phenomenon of 'reverse remodelling'...
  92. ncbi request reprint IFN-gamma decreases CTL generation by limiting IL-2 production: A feedback loop controlling effector cell production
    Luis G Hidalgo
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 5:651-61. 2005
    ..This creates a feedback loop in which effectors produce IFN-gamma that limits IL-2 production which in turn limits CTL generation...
  93. ncbi request reprint Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection
    Lorraine C Racusen
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 3:708-14. 2003
    ..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...
  94. ncbi request reprint Assessing long-term nephron loss: is it time to kick the CAN grading system?
    Philip F Halloran
    Am J Transplant 4:1729-30. 2004
  95. ncbi request reprint A uniform clinical trial registration policy for journals of kidney diseases, dialysis and transplantation
    William G Couser
    Journal of the American Society of Nephrology
    Am J Transplant 5:643. 2005
  96. ncbi request reprint The clinical importance of alloantibody-mediated rejection
    Philip F Halloran
    Am J Transplant 3:639-40. 2003