Research Topics
| D G HackamSummaryAffiliation: University of Western Ontario Country: Canada Publications
| Collaborators
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Detail Information
Publications
Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque areaJonathan H Klein
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
Arterioscler Thromb Vasc Biol 28:1851-6. 2008..We studied relationships of Lp(a) with carotid stenosis, occlusion, and total plaque area, distinct phenotypes of atherosclerosis that may be differentially affected by cardiovascular risk factors...- The 2013 canadian hypertension education program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertensionDaniel G Hackam
Division of Clinical Pharmacology, Departments of Medicine, Clinical Neurological Sciences, and Epidemiology and Biostatistics, Western University, London, Ontario, Canada Electronic address
Can J Cardiol 29:528-42. 2013..However, both of these issues will be examined on an ongoing basis, in particular as new evidence emerges... - Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysisDaniel G Hackam
Stroke Prevention and Atherosclerosis Research Centre SPARC, Western University, London, Canada
Neurology 79:1862-5. 2012..We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage... 
Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertensionDaniel G Hackam
Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
Hypertension 50:998-1003. 2007
Missed opportunities for the secondary prevention of cardiovascular disease in CanadaDaniel G Hackam
Department of Medicine, University of Western Ontario, London, Canada
Can J Cardiol 23:1124-30. 2007....- Angiotensin inhibition in renovascular disease: a population-based cohort studyDaniel G Hackam
Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
Am Heart J 156:549-55. 2008.... - Vascular protection in peripheral artery disease: systematic review and modelling studyD G Hackam
Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario N6G 2V2, Canada
Heart 95:1098-102. 2009..To ascertain the effectiveness of medical therapy for reducing risk in peripheral artery disease (PAD) and to model the potential impact of combining multiple efficacious approaches... - The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapyDaniel G Hackam
Department of Medicine and Epidemiology, Division of Clinical Pharmacology and Clinical Neurological Sciences, University of Western Ontario, London, Ontario
Can J Cardiol 26:249-58. 2010..To update the evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010... - Statins and renovascular disease in the elderly: a population-based cohort studyDaniel G Hackam
Stroke Prevention and Atherosclerosis Research Centre, University of Western Ontario, Siebens Drake Research Institute, London, Ontario, Canada
Eur Heart J 32:598-610. 2011..More than 90% of cases of renovascular disease (RVD) are caused by atherosclerosis; thus patients with this condition are at high risk for vascular events. We examined the association of statins with prognosis in patients with RVD... - Influence of noninvasive cardiovascular imaging in primary prevention: systematic review and meta-analysis of randomized trialsDaniel G Hackam
Department of Medicine, University of Western Ontario, London, ON, Canada
Arch Intern Med 171:977-82. 2011..Despite extensive use in practice, the impact of noninvasive cardiovascular imaging in primary prevention remains unclear... - Statins and intracerebral hemorrhage: a retrospective cohort studyDaniel G Hackam
Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Research Bldg, Room 100K, 1400 Western Rd, London, ON N6G 2V2, Canada
Arch Neurol 69:39-45. 2012..A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH)... - Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysisDaniel G Hackam
University of Western Ontario, London, Canada
Circulation 124:2233-42. 2011..Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data... - Discordance between physicians' estimation of patient cardiovascular risk and use of evidence-based medical therapyJennifer L Y Tsang
Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
Am J Cardiol 102:1142-5. 2008.... - Trapped renal arteries: functional renal artery stenosis due to occlusion of the aorta in the arch and below the kidneysD G Hackam
Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Canada
Can J Cardiol 17:587-92. 2001..The literature on suprarenal aortic occlusion is reviewed to determine the manner of presentation, prevalent risk factors and physical findings that typify this unique clinical entity... - How does the prognosis of diabetes compare with that of established vascular disease? Insights from the Canadian Vascular Protection (VP) RegistryDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Hospital, University of Toronto, Toronto, Ontario, Canada
Am Heart J 148:1028-33. 2004.... - Cardiovascular risk prevention in peripheral artery diseaseDaniel G Hackam
Division of Clinical Pharmacology and Toxicology and the Clinical Epidemiology Health Care Research Program, Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, Canada
J Vasc Surg 41:1070-3. 2005.... - Perioperative beta-blocker therapy in vascular surgery: clinical updateDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
J Vasc Surg 43:632-4. 2006..This article reviews the available evidence concerning beta-blockers and provides guidance for their use in the perioperative setting... - Commentary: cardiovascular implications of the epidemiological transition for the developing world: Thailand as a case in pointDaniel G Hackam
Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada L8L 2X2
Int J Epidemiol 32:468-9. 2003 - Prognostic implications of warfarin cessation after major trauma: a population-based cohort analysisDaniel G Hackam
Division of Clinical Pharmacology, University of Toronto, Toronto, ON, Canada
Circulation 111:2250-6. 2005..CONCLUSIONS: Cessation of warfarin in elderly patients after major trauma was not associated with an increased risk of arterial thrombotic events but was associated with a significantly increased risk of venous thromboembolism... - Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling studyDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Stroke 38:1881-5. 2007..We sought to calculate the cumulative benefit of combining multiple strategies for preventing recurrent events in patients with a history of ischemic stroke or transient ischemic attack... - Intensive reduction of low-density lipoprotein-cholesterol: implications of recent trialsDaniel G Hackam
Cardiac Rehabilitation and Secondary Prevention Program, Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada
Am J Cardiovasc Drugs 6:367-71. 2006..This article summarizes the results of randomized trials comparing these two strategies in patients with a history of coronary artery disease... - Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosisJ David Spence
Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario, Canada
Arch Neurol 67:180-6. 2010..To assess the effect of more intensive medical therapy on the rate of transcranial Doppler (TCD) microemboli and cardiovascular events in patients with asymptomatic carotid stenosis (ACS)... - Progress in clinical neurosciences: pharmacotherapies for the secondary prevention of strokeDaniel G Hackam
From the Division of Clinical Pharmacology, University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Can J Neurol Sci 31:295-303. 2004..We review the literature to determine the clinical significance of these therapies, and provide recommendations regarding their use in the prevention of recurrent stroke... - Contemporary management of dyslipidemia in high-risk patients: targets still not metAndrew T Yan
Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, Toronto, Ontario, Canada
Am J Med 119:676-83. 2006..There remains an important opportunity to improve the quality of care for these high-risk patients... - Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysisDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Canada
Lancet 367:413-8. 2006..95; 0.75-1.22). IMPLICATIONS: Use of statins in patients with atherosclerosis is associated with a reduced risk of subsequent sepsis. Randomised trials of statins for prevention of sepsis are warranted... - Supporting a call to action for peripheral artery disease: insights from two prospective clinical registriesDaniel G Hackam
Canadian Heart Research Center, Toronto, Canada
J Vasc Surg 44:776-81. 2006.... - Do hypertensive patients with average cholesterol levels benefit from atorvastatin therapy?Daniel G Hackam
St Joseph s Healthcare, Department of Medicine, McMaster University Hamilton, Ont
CMAJ 168:1689. 2003 - Statins: panacea for sepsis?Marius Terblanche
Interdepartmental Division of Critical Care Medicine, Sunnybrook and Women s College Health Science Centre, Toronto, Canada
Lancet Infect Dis 6:242-8. 2006.... - Drug treatment of hypertension. Conclusion of editorial is somewhat flawedDaniel G Hackam
BMJ 326:764. 2003 - Carotid plaque area: a tool for targeting and evaluating vascular preventive therapyJ David Spence
Robarts Research Institute and University of Western Ontario, London
Stroke 33:2916-22. 2002..Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death... - Aldosterone blockade after myocardial infarctionDaniel G Hackam
Clinical Pharmacology, University of Toronto, ON
CMAJ 169:444. 2003 - ACE inhibition in stable coronary artery diseaseDaniel G Hackam
Clinical Pharmacology, University of Toronto, Toronto, Ont
CMAJ 169:939. 2003 - C-reactive protein for the prediction of cardiovascular risk: ready for prime-time?Daniel G Hackam
Institute for Clinical Evaluative Sciences and Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
CMAJ 170:1563-5. 2004 - Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control studyDaniel G Hackam
Clinical Epidemiology and Health Care Research Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
Lancet 368:659-65. 2006..Angiotensin-converting enzyme (ACE) inhibitors prevent the expansion and rupture of aortic aneurysms in animals. We investigated the association between ACE inhibitors and rupture in patients with abdominal aortic aneurysms... - Predicting stroke risk in patients with atrial fibrillationDaniel G Hackam
Stroke 38:2409. 2007 - Statins and sepsis: multiple modifications at multiple levelsMarius Terblanche
Department of Critical Care Medicine, St Thomas Hospital, London, UK
Lancet Infect Dis 7:358-68. 2007..This work establishes the biological plausibility needed for future trials of statins in critical illness... - Antithrombotic treatment for peripheral arterial diseaseDaniel G Hackam
Division of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, Canada
Heart 93:303-8. 2007..In addition, this disorder is associated with a systemic milieu characterised by ongoing platelet activation and heightened thrombogenesis...