D G Hackam

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area
    Jonathan H Klein
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 28:1851-6. 2008
  2. pmc Shift work and vascular events: systematic review and meta-analysis
    Manav V Vyas
    Department of Epidemiology and Biostatistics, Western University, London, ON, Canada
    BMJ 345:e4800. 2012
  3. doi request reprint The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada
    Can J Cardiol 29:528-42. 2013
  4. doi request reprint Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre SPARC, Western University, London, Canada
    Neurology 79:1862-5. 2012
  5. ncbi request reprint Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hypertension 50:998-1003. 2007
  6. pmc Missed opportunities for the secondary prevention of cardiovascular disease in Canada
    Daniel G Hackam
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Cardiol 23:1124-30. 2007
  7. doi request reprint Angiotensin inhibition in renovascular disease: a population-based cohort study
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 156:549-55. 2008
  8. doi request reprint Vascular protection in peripheral artery disease: systematic review and modelling study
    D G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario N6G 2V2, Canada
    Heart 95:1098-102. 2009
  9. pmc The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Daniel G Hackam
    Department of Medicine and Epidemiology, Division of Clinical Pharmacology and Clinical Neurological Sciences, University of Western Ontario, London, Ontario
    Can J Cardiol 26:249-58. 2010
  10. pmc Statins and renovascular disease in the elderly: a population-based cohort study
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, University of Western Ontario, Siebens Drake Research Institute, London, Ontario, Canada
    Eur Heart J 32:598-610. 2011

Detail Information

Publications38

  1. doi request reprint Lipoprotein(a) is associated differentially with carotid stenosis, occlusion, and total plaque area
    Jonathan H Klein
    Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada
    Arterioscler Thromb Vasc Biol 28:1851-6. 2008
    ..We studied relationships of Lp(a) with carotid stenosis, occlusion, and total plaque area, distinct phenotypes of atherosclerosis that may be differentially affected by cardiovascular risk factors...
  2. pmc Shift work and vascular events: systematic review and meta-analysis
    Manav V Vyas
    Department of Epidemiology and Biostatistics, Western University, London, ON, Canada
    BMJ 345:e4800. 2012
    ..To synthesise the association of shift work with major vascular events as reported in the literature...
  3. doi request reprint The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada
    Can J Cardiol 29:528-42. 2013
    ..However, both of these issues will be examined on an ongoing basis, in particular as new evidence emerges...
  4. doi request reprint Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre SPARC, Western University, London, Canada
    Neurology 79:1862-5. 2012
    ..We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage...
  5. ncbi request reprint Role of renin-angiotensin system blockade in atherosclerotic renal artery stenosis and renovascular hypertension
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Hypertension 50:998-1003. 2007
  6. pmc Missed opportunities for the secondary prevention of cardiovascular disease in Canada
    Daniel G Hackam
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Cardiol 23:1124-30. 2007
    ....
  7. doi request reprint Angiotensin inhibition in renovascular disease: a population-based cohort study
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada
    Am Heart J 156:549-55. 2008
    ....
  8. doi request reprint Vascular protection in peripheral artery disease: systematic review and modelling study
    D G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario N6G 2V2, Canada
    Heart 95:1098-102. 2009
    ..To ascertain the effectiveness of medical therapy for reducing risk in peripheral artery disease (PAD) and to model the potential impact of combining multiple efficacious approaches...
  9. pmc The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Daniel G Hackam
    Department of Medicine and Epidemiology, Division of Clinical Pharmacology and Clinical Neurological Sciences, University of Western Ontario, London, Ontario
    Can J Cardiol 26:249-58. 2010
    ..To update the evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010...
  10. pmc Statins and renovascular disease in the elderly: a population-based cohort study
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, University of Western Ontario, Siebens Drake Research Institute, London, Ontario, Canada
    Eur Heart J 32:598-610. 2011
    ..More than 90% of cases of renovascular disease (RVD) are caused by atherosclerosis; thus patients with this condition are at high risk for vascular events. We examined the association of statins with prognosis in patients with RVD...
  11. doi request reprint Influence of noninvasive cardiovascular imaging in primary prevention: systematic review and meta-analysis of randomized trials
    Daniel G Hackam
    Department of Medicine, University of Western Ontario, London, ON, Canada
    Arch Intern Med 171:977-82. 2011
    ..Despite extensive use in practice, the impact of noninvasive cardiovascular imaging in primary prevention remains unclear...
  12. doi request reprint Statins and intracerebral hemorrhage: a retrospective cohort study
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Research Bldg, Room 100K, 1400 Western Rd, London, ON N6G 2V2, Canada
    Arch Neurol 69:39-45. 2012
    ..A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH)...
  13. doi request reprint Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis
    Daniel G Hackam
    University of Western Ontario, London, Canada
    Circulation 124:2233-42. 2011
    ..Accordingly, we systematically reviewed the association of statins with intracerebral hemorrhage in randomized and observational data...
  14. doi request reprint Discordance between physicians' estimation of patient cardiovascular risk and use of evidence-based medical therapy
    Jennifer L Y Tsang
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 102:1142-5. 2008
    ....
  15. ncbi request reprint Trapped renal arteries: functional renal artery stenosis due to occlusion of the aorta in the arch and below the kidneys
    D G Hackam
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Canada
    Can J Cardiol 17:587-92. 2001
    ..The literature on suprarenal aortic occlusion is reviewed to determine the manner of presentation, prevalent risk factors and physical findings that typify this unique clinical entity...
  16. ncbi request reprint Cardiovascular risk prevention in peripheral artery disease
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology and the Clinical Epidemiology Health Care Research Program, Institute for Clinical Evaluative Sciences, University of Toronto, Ontario, Canada
    J Vasc Surg 41:1070-3. 2005
    ....
  17. ncbi request reprint How does the prognosis of diabetes compare with that of established vascular disease? Insights from the Canadian Vascular Protection (VP) Registry
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:1028-33. 2004
    ....
  18. ncbi request reprint Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Stroke 38:1881-5. 2007
    ..We sought to calculate the cumulative benefit of combining multiple strategies for preventing recurrent events in patients with a history of ischemic stroke or transient ischemic attack...
  19. ncbi request reprint Perioperative beta-blocker therapy in vascular surgery: clinical update
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    J Vasc Surg 43:632-4. 2006
    ..This article reviews the available evidence concerning beta-blockers and provides guidance for their use in the perioperative setting...
  20. ncbi request reprint Commentary: cardiovascular implications of the epidemiological transition for the developing world: Thailand as a case in point
    Daniel G Hackam
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Int J Epidemiol 32:468-9. 2003
  21. ncbi request reprint Prognostic implications of warfarin cessation after major trauma: a population-based cohort analysis
    Daniel G Hackam
    Division of Clinical Pharmacology, University of Toronto, Toronto, ON, Canada
    Circulation 111:2250-6. 2005
    ..We studied whether stopping warfarin after trauma is associated with a higher risk of subsequent adverse cardiovascular events...
  22. ncbi request reprint Progress in clinical neurosciences: pharmacotherapies for the secondary prevention of stroke
    Daniel G Hackam
    From the Division of Clinical Pharmacology, University of Toronto, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Can J Neurol Sci 31:295-303. 2004
    ..We review the literature to determine the clinical significance of these therapies, and provide recommendations regarding their use in the prevention of recurrent stroke...
  23. doi request reprint Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis
    J David Spence
    Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, Ontario, Canada
    Arch Neurol 67:180-6. 2010
    ..To assess the effect of more intensive medical therapy on the rate of transcranial Doppler (TCD) microemboli and cardiovascular events in patients with asymptomatic carotid stenosis (ACS)...
  24. ncbi request reprint Intensive reduction of low-density lipoprotein-cholesterol: implications of recent trials
    Daniel G Hackam
    Cardiac Rehabilitation and Secondary Prevention Program, Toronto Rehabilitation Institute, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiovasc Drugs 6:367-71. 2006
    ..This article summarizes the results of randomized trials comparing these two strategies in patients with a history of coronary artery disease...
  25. ncbi request reprint Contemporary management of dyslipidemia in high-risk patients: targets still not met
    Andrew T Yan
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, Toronto, Ontario, Canada
    Am J Med 119:676-83. 2006
    ..Our objective was to evaluate treatment patterns and the attainment of current National Cholesterol Education Program (NCEP)-recommended lipid targets in unselected high-risk ambulatory patients...
  26. ncbi request reprint Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, Toronto, Canada
    Lancet 367:413-8. 2006
    ..The relation between statins and risk of sepsis in patients with atherosclerosis is unknown...
  27. ncbi request reprint Supporting a call to action for peripheral artery disease: insights from two prospective clinical registries
    Daniel G Hackam
    Canadian Heart Research Center, Toronto, Canada
    J Vasc Surg 44:776-81. 2006
    ....
  28. ncbi request reprint Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy
    J David Spence
    Robarts Research Institute and University of Western Ontario, London
    Stroke 33:2916-22. 2002
    ..Carotid plaque area measured by ultrasound (cross-sectional area of longitudinal views of all plaques seen) was studied as a way of identifying patients at increased risk of stroke, myocardial infarction, and vascular death...
  29. pmc Drug treatment of hypertension. Conclusion of editorial is somewhat flawed
    Daniel G Hackam
    BMJ 326:764. 2003
  30. pmc Do hypertensive patients with average cholesterol levels benefit from atorvastatin therapy?
    Daniel G Hackam
    St Joseph s Healthcare, Department of Medicine, McMaster University Hamilton, Ont
    CMAJ 168:1689. 2003
  31. pmc Aldosterone blockade after myocardial infarction
    Daniel G Hackam
    Clinical Pharmacology, University of Toronto, ON
    CMAJ 169:444. 2003
  32. pmc ACE inhibition in stable coronary artery disease
    Daniel G Hackam
    Clinical Pharmacology, University of Toronto, Toronto, Ont
    CMAJ 169:939. 2003
  33. pmc C-reactive protein for the prediction of cardiovascular risk: ready for prime-time?
    Daniel G Hackam
    Institute for Clinical Evaluative Sciences and Division of Clinical Pharmacology and Toxicology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont
    CMAJ 170:1563-5. 2004
  34. ncbi request reprint Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study
    Daniel G Hackam
    Clinical Epidemiology and Health Care Research Program, Department of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada
    Lancet 368:659-65. 2006
    ..Angiotensin-converting enzyme (ACE) inhibitors prevent the expansion and rupture of aortic aneurysms in animals. We investigated the association between ACE inhibitors and rupture in patients with abdominal aortic aneurysms...
  35. pmc Antithrombotic treatment for peripheral arterial disease
    Daniel G Hackam
    Division of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Heart 93:303-8. 2007
    ..In addition, this disorder is associated with a systemic milieu characterised by ongoing platelet activation and heightened thrombogenesis...
  36. ncbi request reprint Statins and sepsis: multiple modifications at multiple levels
    Marius Terblanche
    Department of Critical Care Medicine, St Thomas Hospital, London, UK
    Lancet Infect Dis 7:358-68. 2007
    ..This work establishes the biological plausibility needed for future trials of statins in critical illness...
  37. ncbi request reprint Predicting stroke risk in patients with atrial fibrillation
    Daniel G Hackam
    Stroke 38:2409. 2007
  38. ncbi request reprint Statins: panacea for sepsis?
    Marius Terblanche
    Interdepartmental Division of Critical Care Medicine, Sunnybrook and Women s College Health Science Centre, Toronto, Canada
    Lancet Infect Dis 6:242-8. 2006
    ....