Affiliation: University of Western Ontario
- Stroke thrombolysis in the elderly: risk or benefit?Vadim Beletsky
Neurology 67:183-4; author reply 183-4. 2006
- The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approachVladimir Hachinski
University of Western Ontario, London, Ontario, Canada
Stroke 38:1396. 2007..No one's work is so exalted that it cannot be improved, nor so humble that it has no value. We can all make a difference...
- Shifts in thinking about dementiaVladimir Hachinski
Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Rd, London, ON, N6A 3K7 Canada
JAMA 300:2172-3. 2008
- Predictors of major neurologic improvement after thrombolysis in acute strokeGustavo Saposnik
Department of Clinical Neurological Sciences, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
Neurology 65:1169-74. 2005..Major neurologic improvement at 24 hours after administration of recombinant tissue plasminogen activator (rt-PA) in acute stroke may predict good outcome at 3 months...
- Is stroke history reliably reported by elderly with cognitive impairment? A community-based studyYa Ping Jin
Department of Clinical Neurological Sciences, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
Neuroepidemiology 35:215-20. 2010..We tested the validity of response to a stroke questionnaire versus clinical diagnosis of stroke among elderly people with and without cognitive impairment...
- Optimizing the Hachinski Ischemic ScaleVladimir Hachinski
Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada
Arch Neurol 69:169-75. 2012..Vascular causes and factors remain the most significant preventable component of cognitive disorders of elderly individuals. The Hachinski Ischemic Score (HIS) is the questionnaire most commonly used for diagnosis of vascular dementia...
- Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic strokeFiona Webster
Department of Surgery, University of Toronto, Toronto, Ontario, M5G 1V7, Canada
Stroke 42:3176-82. 2011..We compared 1-year mortality and stroke readmission in patients with transient ischemic attack or ischemic stroke referred versus not referred to an SPC...
- Vascular risk factors and Alzheimer's diseaseDavid F Cechetto
Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
Expert Rev Neurother 8:743-50. 2008....
- Optimizing discharge planning: clinical predictors of longer stay after recombinant tissue plasminogen activator for acute strokeGustavo Saposnik
Stroke Program, Department of Clinical Neurological Sciences and Southwestern Ontario Coordinated Stroke Strategy, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
Stroke 36:147-50. 2005..Although studies have identified variables associated with LOS, few have analyzed predictors of longer stay after receiving thrombolytic therapy for acute stroke...
- Weekends: a dangerous time for having a stroke?Gustavo Saposnik
Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, London, ON, Canada
Stroke 38:1211-5. 2007..However, limited information is available concerning the "weekend effect" on stroke mortality. Our aim was to evaluate the impact of weekend admissions on stroke mortality in different settings...
- The impact of lesion side on acute stroke treatmentSilvia Di Legge
Department of Clinical Neurological Sciences, London Health Science Centre, University of Western Ontario, Canada
Neurology 65:81-6. 2005..Only a small percentage of patients with acute stroke are treated with recombinant tissue plasminogen activator (rt-PA)...
- Antihypertensive treatment can prevent stroke and cognitive declinePeter Soros
Department of Clinical Neurological Sciences, London Health Sciences Centre, 339 Windermere Road, London, ON N6A 5A5, Canada
Nat Rev Neurol 9:174-8. 2013..In this article we argue that, in patients of all ages, not treating hypertension is a missed opportunity to prevent some of the most prevalent brain diseases...
- Thrombolysis in patients with marked clinical fluctuations in neurologic status due to cerebral ischemiaOzcan Ozdemir
Department of Neurological Sciences, London Health Science Centre, University of Western Ontario, London, Ontario, Canada
Arch Neurol 65:1041-3. 2008..It is unclear whether thrombolysis benefits patients with fluctuating neurologic symptoms...
- Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the ratGuanliang Cheng
Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
Neurobiol Dis 23:140-51. 2006..The potential of PDTC for reducing cognitive and neuropathological deficits may provide preliminary evidence for a new approach of AD treatment...
- Therapeutic benefit of internet-based lifestyle counselling for hypertensionRobert P Nolan
Behavioural Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada
Can J Cardiol 28:390-6. 2012..We incorporated key features of an established behavioural therapy, motivational interviewing, to help standardize e-counselling in order to reduce blood pressure in patients with hypertension...
- Hyperdense internal carotid artery sign: a CT sign of acute ischemiaOzcan Ozdemir
Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences, University Campus, London, Ontario, Canada
Stroke 39:2011-6. 2008..The purpose of this study was to define the hyperdense ICA sign (HICAS) and determine its prevalence, diagnostic and prognostic value, and its reliability as a marker for ischemia...
- Hypertension, executive dysfunction, and progression to dementia: the canadian study of health and agingShahram Oveisgharan
Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, 339 Windermere Street, London, Ontario, Canada
Arch Neurol 67:187-92. 2010..Midlife hypertension has long been established as a risk factor for dementia, but the role of late-life hypertension remains unclear...
- Carotid endarterectomy for ophthalmic manifestations: what do we do?David Nicolle
Department of Ophthalmology DN, University of Western Ontario, London, Ontario, Canada
J Neuroophthalmol 25:303. 2005
- Stroke: working toward a prioritized world agendaVladimir Hachinski
University of Western Ontario, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5, USA
Stroke 41:1084-99. 2010..The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke...
- Impact of disability status on ischemic stroke costs in Canada in the first yearNicole Mittmann
Research Centre, Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre, 2075 Bayview Aveune, E240, Toronto, Ontario, M4N 3M5, Canada
Can J Neurol Sci 39:793-800. 2012..The objectives of this analysis were to calculate costs for the first year post-stroke and determine the impact of disability on costs...
- Proof-of-principle pilot study of oropharyngeal air-pulse application in individuals with dysphagia after hemispheric strokeJulie A Theurer
Faculty of Health Sciences, School of Communication Sciences and Disorders, The University of Western Ontario, London, Ontario, Canada
Arch Phys Med Rehabil 94:1088-94. 2013..To test the hypothesis that oropharyngeal air-pulse application is associated with increased swallowing rates in individuals with dysphagia secondary to stroke...
- Genetic determinants of "cognitive impairment, no dementia"Joseph B Dubé
Department of Biochemistry, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
J Alzheimers Dis 33:831-40. 2013..35; p = 0.044). We identified a potential association between the ZNF608/GRAMD3 locus and CIND status, although AD-related variants were not associated with CIND. Additional replication of this association signal is invited...
- Stuttered swallowing: electric stimulation of the right insula interferes with water swallowing. A case reportPeter Soros
School of Communication Sciences and Disorders, University of Western Ontario, London, Ontario, Canada
BMC Neurol 11:20. 2011..However, the exact location of insular activation during swallowing and its functional significance remain unclear...
- Comprehensive cardiac rehabilitation for secondary prevention after transient ischemic attack or mild stroke: I: feasibility and risk factorsPeter L Prior
London Health Sciences Centre Cardiac Rehabilitation and Secondary Prevention Program, London, Ontario, Canada
Stroke 42:3207-13. 2011..This article presents risk factors. A future article will discuss psychological outcomes...
- Statins and intracerebral hemorrhage: a retrospective cohort studyDaniel G Hackam
Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Research Bldg, Room 100K, 1400 Western Rd, London, ON N6G 2V2, Canada
Arch Neurol 69:39-45. 2012..A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH)...
- Cardiovascular and neurological causes of sudden death after ischaemic strokePeter Soros
Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, ON, Canada
Lancet Neurol 11:179-88. 2012..The exact mechanisms leading to sudden death remain incompletely understood. Further research is needed to investigate the autonomic consequences of acute stroke and to identify patients at high risk of sudden death...
- Does a birthday predispose to vascular events?Gustavo Saposnik
Stroke Team, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Ontario, Canada
Neurology 67:300-4. 2006..To examine the influence of birthdays on the onset and course of vascular events such as stroke, TIA, and acute myocardial infarction (AMI)...
- Association between weekend hospital presentation and stroke fatalityJiming Fang
Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
Neurology 75:1589-96. 2010..Previous studies have found higher stroke case fatality in patients admitted to the hospital on weekends compared to weekdays, but the reasons for this association are not known...
- Lack of improvement in patients with acute stroke after treatment with thrombolytic therapy: predictors and association with outcomeGustavo Saposnik
Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, Canada
JAMA 292:1839-44. 2004..Few studies have analyzed outcome at 24 hours. An early and reliable prediction of poor outcome has implications for clinical management and discharge planning...
- Intra-arterial thrombolysis for basilar artery thrombosis and stenting for asymptomatic carotid disease: implications and future directionsVladimir Hachinski
Department of Clinical Neurological Sciences, London Health Sciences Center, University Hospital, London, Ontario, Canada
Stroke 38:721-2. 2007
- Cerebral cortical processing of swallowing in older adultsRuth Martin
School of Communication Sciences and Disorders, Faculty of Health Sciences, Elborn College, Room 2568, University of Western Ontario, London, ON, Canada
Exp Brain Res 176:12-22. 2007..This task-specific activation pattern may represent a compensatory response to the demands of the water swallow in the face of age-related diminution of oral sensorimotor function...
- Cerebrovascular events on awakening, patent foramen ovale and obstructive sleep apnea syndromeOzcan Ozdemir
London Health Science Centre, Department of Neurological Sciences, University of Western Ontario, London, ON, Canada
J Neurol Sci 268:193-4. 2008..The possibility of patent foramen ovale and an obstructive sleep apnea syndrome may be considered in patients with cryptogenic strokes-on-awakening. Further studies are needed to support our observation...
- Prospects for prevention and treatment of vascular cognitive impairmentSilvia Di Legge
Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, N6A 5A5 London, Ontario, Canada
Curr Opin Investig Drugs 4:1082-7. 2003....
- National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standardsVladimir Hachinski
London Health Sciences Centre, University Campus, London, Ontario, Canada
Stroke 37:2220-41. 2006....
- Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: II. Effects of triflusalShawn Whitehead
Department of Anatomy and Cell Biology, University of Western Ontario, London, Canada
Stroke 36:1782-9. 2005..Thus, anti-inflammatory agents such as Triflusal, a nonsteroidal anti-inflammatory agent (NSAID), may provide neuroprotection for susceptible neurons in AD and cerebral ischemia...
- Advances in stroke 2003: introductionVladimir Hachinski
London Sciences Health Centre, University of Western Ontario, London, Ontario, Canada
Stroke 35:341. 2004
- Stroke: working toward a prioritized world agendaVladimir Hachinski
Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, and St Joseph s Healthcare London, Ontario, Canada
Cerebrovasc Dis 30:127-47. 2010..The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke...
- Stroke-related dementiaJose G Merino
Department of Neurology, University of Florida, Shands Jacksonville, 580 West 8th Street, Plaza I, 9th Floor, Jacksonville, FL 32209, USA
Curr Atheroscler Rep 4:285-90. 2002..To be clinically useful, a broader concept of cognitive impairment in the setting of vascular disease needs to be developed based on data collected prospectively using cohorts of stroke patients...
- Idiopathic free-floating thrombus of the common carotid arteryBrian Silver
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
Can J Neurol Sci 29:97-9. 2002..To our knowledge, there are no previous reports of a free-floating thrombus in the common carotid artery...
- Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery diseaseJonathan Y Streifler
Neurology Unit, Rabin Medical Center, Golda Campus, 7 Keren Kayemet St, Petach Tikva 49372, Israel
Stroke 34:1913-6. 2003..The aim of the study was to seek development and progression of LA and associated risk factors in patients with symptomatic carotid artery disease...
- Extending tissue plasminogen activator use to community and rural stroke patientsJose G Merino
Department of Neurology, University of Florida, Jacksonville 32217, USA
Stroke 33:141-6. 2002..This prospective case series set out to evaluate the safety of tPA use in patients referred from rural communities to a tertiary center...
- Reporting clinical trials: full access to all the dataRoger N Rosenberg
Brain 125:i-ii. 2002
- [Unblocking arteries to save brains: thrombolysis in patients with stroke]Jose G Merino
Med Clin (Barc) 120:17-8. 2003
- The population approach to stroke prevention: a Canadian perspectiveT Kue Young
Department of Public Health Sciences, University of Toronto, Toronto, Ont
Clin Invest Med 26:78-86. 2003..To contrast the population and clinical approaches to stroke prevention and to review Canadian data relevant to estimating disease burden, assessing risk factors, designing preventive strategies and organizing health services...
- Stroke: the next 30 yearsVladimir Hachinski
Stroke 33:1-4. 2002
- Genetics of vascular cognitive impairment: the opportunity and the challengesGabrielle G Leblanc
The Neurogenetics Group, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
Stroke 37:248-55. 2006..This review considers the current state of knowledge of genetic factors underlying vascular cognitive impairment (VCI)...
- CT assessment of conjugate eye deviation in acute strokeSilvia Di Legge
Neurology 62:523; author reply 523. 2004
- A TAP2 genotype associated with Alzheimer's disease in APOE4 carriersMaria J Bullido
Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Neurobiol Aging 28:519-23. 2007..These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD...
- ASPECT scoring to estimate >1/3 middle cerebral artery territory infarctionBart M Demaerschalk
Mayo Clinic College of Medicine, Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
Can J Neurol Sci 33:200-4. 2006....
- Neglecting the difference: does right or left matter in stroke outcome after thrombolysis?Silvia Di Legge
Stroke Unit, Università of Tor Vergata, Viale Oxford 81 00133 Rome, Italy
Stroke 37:2066-9. 2006..We analyzed outcomes after IV rt-PA with respect to the side of the affected hemisphere...
- Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid diseaseAle Algra
Department of Neurology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Stroke 34:2871-5. 2003..Current publications suggest increased risk of sudden death in experimental animals with acute right insular lesions and in patients with recent right-sided brain infarction, particularly if the insula is involved...
- Re: tPA use for stroke in the registry of the Canadian Stroke Network. Can J Neurol Sci. 2005;32:433-9Miguel Bussière
Can J Neurol Sci 33:433. 2006
- Vascular behavioral and cognitive disordersVladimir Hachinski
Stroke 34:2775. 2003
- Effects of thrombolysis for acute stroke in patients with pre-existing disabilityR Blaine Taylor Foell
London Health Sciences Centre, Department of Clinical Neurological Sciences, and the University of Western Ontario, London, Ont
CMAJ 169:193-7. 2003..Because clinical trials generally exclude patients with pre-existing disability, this subgroup of patients has not been studied. We examined the outcomes after thrombolysis of patients with and without disability before their stroke...
- Escalating levels of access to in-hospital care and stroke mortalityGustavo Saposnik
Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, M5C 1R6, Canada
Stroke 39:2522-30. 2008..However, limited information is available comparing different levels of organized care. Our aim was to determine whether escalating levels of organized care can improve stroke outcomes...
- World Stroke Day 2008: "little strokes, big trouble"Vladimir Hachinski
Stroke 39:2407-20. 2008
- Alzheimer's disease with and without cerebral infarctsTeodoro Del Ser
Seccion de Neurologia, Hospital Severo Ochoa, Avda Orellana s n, Leganes, 28911 Madrid, Spain
J Neurol Sci 231:3-11. 2005..To compare the clinical and pathological features of Alzheimer's disease (AD) patients with and without associated cerebral infarcts (CI)...