Vladimir Hachinski

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Stroke thrombolysis in the elderly: risk or benefit?
    Vadim Beletsky
    Neurology 67:183-4; author reply 183-4. 2006
  2. ncbi The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approach
    Vladimir Hachinski
    University of Western Ontario, London, Ontario, Canada
    Stroke 38:1396. 2007
  3. doi Shifts in thinking about dementia
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Rd, London, ON, N6A 3K7 Canada
    JAMA 300:2172-3. 2008
  4. ncbi Predictors of major neurologic improvement after thrombolysis in acute stroke
    Gustavo Saposnik
    Department of Clinical Neurological Sciences, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Neurology 65:1169-74. 2005
  5. doi Is stroke history reliably reported by elderly with cognitive impairment? A community-based study
    Ya Ping Jin
    Department of Clinical Neurological Sciences, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Neuroepidemiology 35:215-20. 2010
  6. doi Optimizing the Hachinski Ischemic Scale
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada
    Arch Neurol 69:169-75. 2012
  7. doi Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic stroke
    Fiona Webster
    Department of Surgery, University of Toronto, Toronto, Ontario, M5G 1V7, Canada
    Stroke 42:3176-82. 2011
  8. doi Vascular risk factors and Alzheimer's disease
    David F Cechetto
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Expert Rev Neurother 8:743-50. 2008
  9. ncbi Optimizing discharge planning: clinical predictors of longer stay after recombinant tissue plasminogen activator for acute stroke
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences and Southwestern Ontario Coordinated Stroke Strategy, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Stroke 36:147-50. 2005
  10. ncbi Weekends: a dangerous time for having a stroke?
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, London, ON, Canada
    Stroke 38:1211-5. 2007

Detail Information

Publications57

  1. ncbi Stroke thrombolysis in the elderly: risk or benefit?
    Vadim Beletsky
    Neurology 67:183-4; author reply 183-4. 2006
  2. ncbi The 2005 Thomas Willis Lecture: stroke and vascular cognitive impairment: a transdisciplinary, translational and transactional approach
    Vladimir Hachinski
    University of Western Ontario, London, Ontario, Canada
    Stroke 38:1396. 2007
    ..No one's work is so exalted that it cannot be improved, nor so humble that it has no value. We can all make a difference...
  3. doi Shifts in thinking about dementia
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Rd, London, ON, N6A 3K7 Canada
    JAMA 300:2172-3. 2008
  4. ncbi Predictors of major neurologic improvement after thrombolysis in acute stroke
    Gustavo Saposnik
    Department of Clinical Neurological Sciences, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Neurology 65:1169-74. 2005
    ..Major neurologic improvement at 24 hours after administration of recombinant tissue plasminogen activator (rt-PA) in acute stroke may predict good outcome at 3 months...
  5. doi Is stroke history reliably reported by elderly with cognitive impairment? A community-based study
    Ya Ping Jin
    Department of Clinical Neurological Sciences, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada
    Neuroepidemiology 35:215-20. 2010
    ..We tested the validity of response to a stroke questionnaire versus clinical diagnosis of stroke among elderly people with and without cognitive impairment...
  6. doi Optimizing the Hachinski Ischemic Scale
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, London, Ontario, Canada
    Arch Neurol 69:169-75. 2012
    ..Vascular causes and factors remain the most significant preventable component of cognitive disorders of elderly individuals. The Hachinski Ischemic Score (HIS) is the questionnaire most commonly used for diagnosis of vascular dementia...
  7. doi Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic stroke
    Fiona Webster
    Department of Surgery, University of Toronto, Toronto, Ontario, M5G 1V7, Canada
    Stroke 42:3176-82. 2011
    ..We compared 1-year mortality and stroke readmission in patients with transient ischemic attack or ischemic stroke referred versus not referred to an SPC...
  8. doi Vascular risk factors and Alzheimer's disease
    David F Cechetto
    Department of Anatomy and Cell Biology, University of Western Ontario, London, ON, Canada
    Expert Rev Neurother 8:743-50. 2008
    ....
  9. ncbi Optimizing discharge planning: clinical predictors of longer stay after recombinant tissue plasminogen activator for acute stroke
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences and Southwestern Ontario Coordinated Stroke Strategy, London Health Science Center, The University of Western Ontario, London, Ontario, Canada
    Stroke 36:147-50. 2005
    ..Although studies have identified variables associated with LOS, few have analyzed predictors of longer stay after receiving thrombolytic therapy for acute stroke...
  10. ncbi Weekends: a dangerous time for having a stroke?
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, London, ON, Canada
    Stroke 38:1211-5. 2007
    ..However, limited information is available concerning the "weekend effect" on stroke mortality. Our aim was to evaluate the impact of weekend admissions on stroke mortality in different settings...
  11. ncbi The impact of lesion side on acute stroke treatment
    Silvia Di Legge
    Department of Clinical Neurological Sciences, London Health Science Centre, University of Western Ontario, Canada
    Neurology 65:81-6. 2005
    ..Only a small percentage of patients with acute stroke are treated with recombinant tissue plasminogen activator (rt-PA)...
  12. doi Antihypertensive treatment can prevent stroke and cognitive decline
    Peter Soros
    Department of Clinical Neurological Sciences, London Health Sciences Centre, 339 Windermere Road, London, ON N6A 5A5, Canada
    Nat Rev Neurol 9:174-8. 2013
    ..In this article we argue that, in patients of all ages, not treating hypertension is a missed opportunity to prevent some of the most prevalent brain diseases...
  13. doi Thrombolysis in patients with marked clinical fluctuations in neurologic status due to cerebral ischemia
    Ozcan Ozdemir
    Department of Neurological Sciences, London Health Science Centre, University of Western Ontario, London, Ontario, Canada
    Arch Neurol 65:1041-3. 2008
    ..It is unclear whether thrombolysis benefits patients with fluctuating neurologic symptoms...
  14. ncbi Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat
    Guanliang Cheng
    Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Neurobiol Dis 23:140-51. 2006
    ..The potential of PDTC for reducing cognitive and neuropathological deficits may provide preliminary evidence for a new approach of AD treatment...
  15. doi Therapeutic benefit of internet-based lifestyle counselling for hypertension
    Robert P Nolan
    Behavioural Cardiology Research Unit, University Health Network, Toronto, Ontario, Canada
    Can J Cardiol 28:390-6. 2012
    ..We incorporated key features of an established behavioural therapy, motivational interviewing, to help standardize e-counselling in order to reduce blood pressure in patients with hypertension...
  16. ncbi Hyperdense internal carotid artery sign: a CT sign of acute ischemia
    Ozcan Ozdemir
    Department of Clinical Neurological Sciences, University of Western Ontario, London Health Sciences, University Campus, London, Ontario, Canada
    Stroke 39:2011-6. 2008
    ..The purpose of this study was to define the hyperdense ICA sign (HICAS) and determine its prevalence, diagnostic and prognostic value, and its reliability as a marker for ischemia...
  17. doi Hypertension, executive dysfunction, and progression to dementia: the canadian study of health and aging
    Shahram Oveisgharan
    Department of Clinical Neurological Sciences, University Hospital, University of Western Ontario, 339 Windermere Street, London, Ontario, Canada
    Arch Neurol 67:187-92. 2010
    ..Midlife hypertension has long been established as a risk factor for dementia, but the role of late-life hypertension remains unclear...
  18. ncbi Carotid endarterectomy for ophthalmic manifestations: what do we do?
    David Nicolle
    Department of Ophthalmology DN, University of Western Ontario, London, Ontario, Canada
    J Neuroophthalmol 25:303. 2005
  19. pmc Stroke: working toward a prioritized world agenda
    Vladimir Hachinski
    University of Western Ontario, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5, USA
    Stroke 41:1084-99. 2010
    ..The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke...
  20. ncbi Impact of disability status on ischemic stroke costs in Canada in the first year
    Nicole Mittmann
    Research Centre, Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre, 2075 Bayview Aveune, E240, Toronto, Ontario, M4N 3M5, Canada
    Can J Neurol Sci 39:793-800. 2012
    ..The objectives of this analysis were to calculate costs for the first year post-stroke and determine the impact of disability on costs...
  21. doi Proof-of-principle pilot study of oropharyngeal air-pulse application in individuals with dysphagia after hemispheric stroke
    Julie A Theurer
    Faculty of Health Sciences, School of Communication Sciences and Disorders, The University of Western Ontario, London, Ontario, Canada
    Arch Phys Med Rehabil 94:1088-94. 2013
    ..To test the hypothesis that oropharyngeal air-pulse application is associated with increased swallowing rates in individuals with dysphagia secondary to stroke...
  22. doi Genetic determinants of "cognitive impairment, no dementia"
    Joseph B Dubé
    Department of Biochemistry, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada
    J Alzheimers Dis 33:831-40. 2013
    ..35; p = 0.044). We identified a potential association between the ZNF608/GRAMD3 locus and CIND status, although AD-related variants were not associated with CIND. Additional replication of this association signal is invited...
  23. pmc Stuttered swallowing: electric stimulation of the right insula interferes with water swallowing. A case report
    Peter Soros
    School of Communication Sciences and Disorders, University of Western Ontario, London, Ontario, Canada
    BMC Neurol 11:20. 2011
    ..However, the exact location of insular activation during swallowing and its functional significance remain unclear...
  24. doi Comprehensive cardiac rehabilitation for secondary prevention after transient ischemic attack or mild stroke: I: feasibility and risk factors
    Peter L Prior
    London Health Sciences Centre Cardiac Rehabilitation and Secondary Prevention Program, London, Ontario, Canada
    Stroke 42:3207-13. 2011
    ..This article presents risk factors. A future article will discuss psychological outcomes...
  25. doi Statins and intracerebral hemorrhage: a retrospective cohort study
    Daniel G Hackam
    Stroke Prevention and Atherosclerosis Research Centre, Siebens Drake Research Bldg, Room 100K, 1400 Western Rd, London, ON N6G 2V2, Canada
    Arch Neurol 69:39-45. 2012
    ..A recent post hoc analysis of a large randomized trial in patients with cerebrovascular disease suggested that statins may increase the risk of intracerebral hemorrhage (ICH)...
  26. doi Cardiovascular and neurological causes of sudden death after ischaemic stroke
    Peter Soros
    Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, ON, Canada
    Lancet Neurol 11:179-88. 2012
    ..The exact mechanisms leading to sudden death remain incompletely understood. Further research is needed to investigate the autonomic consequences of acute stroke and to identify patients at high risk of sudden death...
  27. ncbi Does a birthday predispose to vascular events?
    Gustavo Saposnik
    Stroke Team, Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Ontario, Canada
    Neurology 67:300-4. 2006
    ..To examine the influence of birthdays on the onset and course of vascular events such as stroke, TIA, and acute myocardial infarction (AMI)...
  28. doi Association between weekend hospital presentation and stroke fatality
    Jiming Fang
    Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada
    Neurology 75:1589-96. 2010
    ..Previous studies have found higher stroke case fatality in patients admitted to the hospital on weekends compared to weekdays, but the reasons for this association are not known...
  29. ncbi Lack of improvement in patients with acute stroke after treatment with thrombolytic therapy: predictors and association with outcome
    Gustavo Saposnik
    Stroke Program, Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, London, Canada
    JAMA 292:1839-44. 2004
    ..Few studies have analyzed outcome at 24 hours. An early and reliable prediction of poor outcome has implications for clinical management and discharge planning...
  30. ncbi Intra-arterial thrombolysis for basilar artery thrombosis and stenting for asymptomatic carotid disease: implications and future directions
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, London Health Sciences Center, University Hospital, London, Ontario, Canada
    Stroke 38:721-2. 2007
  31. ncbi Cerebral cortical processing of swallowing in older adults
    Ruth Martin
    School of Communication Sciences and Disorders, Faculty of Health Sciences, Elborn College, Room 2568, University of Western Ontario, London, ON, Canada
    Exp Brain Res 176:12-22. 2007
    ..This task-specific activation pattern may represent a compensatory response to the demands of the water swallow in the face of age-related diminution of oral sensorimotor function...
  32. ncbi Cerebrovascular events on awakening, patent foramen ovale and obstructive sleep apnea syndrome
    Ozcan Ozdemir
    London Health Science Centre, Department of Neurological Sciences, University of Western Ontario, London, ON, Canada
    J Neurol Sci 268:193-4. 2008
    ..The possibility of patent foramen ovale and an obstructive sleep apnea syndrome may be considered in patients with cryptogenic strokes-on-awakening. Further studies are needed to support our observation...
  33. ncbi Prospects for prevention and treatment of vascular cognitive impairment
    Silvia Di Legge
    Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, N6A 5A5 London, Ontario, Canada
    Curr Opin Investig Drugs 4:1082-7. 2003
    ....
  34. ncbi National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  35. ncbi Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: II. Effects of triflusal
    Shawn Whitehead
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Canada
    Stroke 36:1782-9. 2005
    ..Thus, anti-inflammatory agents such as Triflusal, a nonsteroidal anti-inflammatory agent (NSAID), may provide neuroprotection for susceptible neurons in AD and cerebral ischemia...
  36. ncbi Advances in stroke 2003: introduction
    Vladimir Hachinski
    London Sciences Health Centre, University of Western Ontario, London, Ontario, Canada
    Stroke 35:341. 2004
  37. pmc Stroke: working toward a prioritized world agenda
    Vladimir Hachinski
    Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, and St Joseph s Healthcare London, Ontario, Canada
    Cerebrovasc Dis 30:127-47. 2010
    ..The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke...
  38. ncbi Stroke-related dementia
    Jose G Merino
    Department of Neurology, University of Florida, Shands Jacksonville, 580 West 8th Street, Plaza I, 9th Floor, Jacksonville, FL 32209, USA
    Curr Atheroscler Rep 4:285-90. 2002
    ..To be clinically useful, a broader concept of cognitive impairment in the setting of vascular disease needs to be developed based on data collected prospectively using cohorts of stroke patients...
  39. ncbi Idiopathic free-floating thrombus of the common carotid artery
    Brian Silver
    Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA
    Can J Neurol Sci 29:97-9. 2002
    ..To our knowledge, there are no previous reports of a free-floating thrombus in the common carotid artery...
  40. ncbi Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery disease
    Jonathan Y Streifler
    Neurology Unit, Rabin Medical Center, Golda Campus, 7 Keren Kayemet St, Petach Tikva 49372, Israel
    Stroke 34:1913-6. 2003
    ..The aim of the study was to seek development and progression of LA and associated risk factors in patients with symptomatic carotid artery disease...
  41. ncbi Extending tissue plasminogen activator use to community and rural stroke patients
    Jose G Merino
    Department of Neurology, University of Florida, Jacksonville 32217, USA
    Stroke 33:141-6. 2002
    ..This prospective case series set out to evaluate the safety of tPA use in patients referred from rural communities to a tertiary center...
  42. ncbi Reporting clinical trials: full access to all the data
    Roger N Rosenberg
    Brain 125:i-ii. 2002
  43. ncbi [Unblocking arteries to save brains: thrombolysis in patients with stroke]
    Jose G Merino
    Med Clin (Barc) 120:17-8. 2003
  44. ncbi The population approach to stroke prevention: a Canadian perspective
    T Kue Young
    Department of Public Health Sciences, University of Toronto, Toronto, Ont
    Clin Invest Med 26:78-86. 2003
    ..To contrast the population and clinical approaches to stroke prevention and to review Canadian data relevant to estimating disease burden, assessing risk factors, designing preventive strategies and organizing health services...
  45. ncbi Stroke: the next 30 years
    Vladimir Hachinski
    Stroke 33:1-4. 2002
  46. ncbi Genetics of vascular cognitive impairment: the opportunity and the challenges
    Gabrielle G Leblanc
    The Neurogenetics Group, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Stroke 37:248-55. 2006
    ..This review considers the current state of knowledge of genetic factors underlying vascular cognitive impairment (VCI)...
  47. ncbi CT assessment of conjugate eye deviation in acute stroke
    Silvia Di Legge
    Neurology 62:523; author reply 523. 2004
  48. ncbi A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers
    Maria J Bullido
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Neurobiol Aging 28:519-23. 2007
    ..These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD...
  49. ncbi ASPECT scoring to estimate >1/3 middle cerebral artery territory infarction
    Bart M Demaerschalk
    Mayo Clinic College of Medicine, Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Can J Neurol Sci 33:200-4. 2006
    ....
  50. ncbi Neglecting the difference: does right or left matter in stroke outcome after thrombolysis?
    Silvia Di Legge
    Stroke Unit, Università of Tor Vergata, Viale Oxford 81 00133 Rome, Italy
    Stroke 37:2066-9. 2006
    ..We analyzed outcomes after IV rt-PA with respect to the side of the affected hemisphere...
  51. ncbi Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease
    Ale Algra
    Department of Neurology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:2871-5. 2003
    ..Current publications suggest increased risk of sudden death in experimental animals with acute right insular lesions and in patients with recent right-sided brain infarction, particularly if the insula is involved...
  52. ncbi Re: tPA use for stroke in the registry of the Canadian Stroke Network. Can J Neurol Sci. 2005;32:433-9
    Miguel Bussière
    Can J Neurol Sci 33:433. 2006
  53. ncbi Vascular behavioral and cognitive disorders
    Vladimir Hachinski
    Stroke 34:2775. 2003
  54. pmc Effects of thrombolysis for acute stroke in patients with pre-existing disability
    R Blaine Taylor Foell
    London Health Sciences Centre, Department of Clinical Neurological Sciences, and the University of Western Ontario, London, Ont
    CMAJ 169:193-7. 2003
    ..Because clinical trials generally exclude patients with pre-existing disability, this subgroup of patients has not been studied. We examined the outcomes after thrombolysis of patients with and without disability before their stroke...
  55. ncbi Escalating levels of access to in-hospital care and stroke mortality
    Gustavo Saposnik
    Stroke Research Unit, Division of Neurology, Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, M5C 1R6, Canada
    Stroke 39:2522-30. 2008
    ..However, limited information is available comparing different levels of organized care. Our aim was to determine whether escalating levels of organized care can improve stroke outcomes...
  56. doi World Stroke Day 2008: "little strokes, big trouble"
    Vladimir Hachinski
    Stroke 39:2407-20. 2008
  57. ncbi Alzheimer's disease with and without cerebral infarcts
    Teodoro Del Ser
    Seccion de Neurologia, Hospital Severo Ochoa, Avda Orellana s n, Leganes, 28911 Madrid, Spain
    J Neurol Sci 231:3-11. 2005
    ..To compare the clinical and pathological features of Alzheimer's disease (AD) patients with and without associated cerebral infarcts (CI)...