Affiliation: University of Toronto
- Dysplasia in barrett's esophagus. New techniques and markersMaha Guindi
Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Pathology, Toronto General Hospital, Toronto, Ontario, Canada
Chest Surg Clin N Am 12:59-68, viii-ix. 2002..The histologic problems in the diagnosis and grading of dysplasia are discussed. Techniques that can serve as aids to the histologic diagnosis of dysplasia, such as flow cytometry and molecular markers, are reviewed...
- Histology of autoimmune hepatitis and its variantsMaha Guindi
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
Clin Liver Dis 14:577-90. 2010..Overlap syndromes with primary biliary cirrhosis and primary sclerosing cholangitis are described. The role of the pathologist in reporting the biopsies is discussed...
- Histology of Barrett's esophagus and dysplasiaMaha Guindi
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada
Gastrointest Endosc Clin N Am 13:349-68, viii. 2003..Biomarkers and their role in the diagnosis of dysplasia and stratification of risk are summarized...
- Indeterminate colitisM Guindi
Department of Laboratory Medicine and Pathobiology, University of Toronto, and Department of Pathology, University Health Network, Toronto, Ontario, Canada, M5G 2C4
J Clin Pathol 57:1233-44. 2004..This review offers some personal observations and viewpoints, and proposes an approach to some of the relatively more esoteric combinations of findings...
- Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional studyJohane P Allard
The University of Toronto and The University Health Network, The Toronto General Hospital, 200 Elizabeth Street, 9N 973, Toronto, Ont, Canada M5G 2C4
J Hepatol 48:300-7. 2008..Low hepatic n-6 and n-3 polyunsaturated fatty acid (PUFA) may contribute to steatosis and steatohepatitis and can be affected by diet and oxidative stress...
- A case of small bowel obstruction due to intraluminal metastases from metastatic renal cell cancerSrikala S Sridhar
Department of Medicine, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada
Oncologist 13:95-7. 2008..Furthermore, these patients can now be treated with a new class of antiangiogenic agents that are showing impressive response rates, which may also translate into improved overall survival...
- Non-alcoholic fatty liver disease in HIV infection associated with altered hepatic fatty acid compositionBianca M Arendt
University Health Network, Dept of Medicine, Toronto, Ontario, Canada
Curr HIV Res 9:128-35. 2011..Changes may be due to impaired FA metabolism or suboptimal n-3 PUFA intake. The potential role of n-3 PUFA (e.g. fish oil) to treat or prevent HIV/NAFLD warrants further investigation...
- Intrahepatic bile duct dilatation due to liver metastases from colorectal carcinomaKartik S Jhaveri
Abdominal Imaging Division, Department of Medical Imaging, University of Toronto, University Health Network and Mount Sinai Hospital, 610 University Ave, 3 957, Toronto, ON M5G 2M9, Canada
AJR Am J Roentgenol 193:752-6. 2009....
- Chemotherapy-induced liver injury in metastatic colorectal cancer: semiquantitative histologic analysis of 334 resected liver specimens shows that vascular injury but not steatohepatitis is associated with preoperative chemotherapyPaul Ryan
Department of Pathology, Mount Sinai Hospital, Toronto, ON
Am J Surg Pathol 34:784-91. 2010..Semiquantitative measurement enables reproducible assessment of vascular injuries, allows comparison between studies, and may help inform future treatment decisions in patients with limited hepatic reserve...
- Phase 2 trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by surgery for esophageal cancerJennifer J Knox
Department of Medical Oncology, Princess Margaret and Toronto General Hospitals of the University Health Network, Toronto, Ontario, Canada
Cancer 116:4023-32. 2010..Newer regimens may impact these poor outcomes. This phase 2 trial assessed the feasibility and efficacy of induction chemoradiotherapy with cisplatin and irinotecan followed by esophagectomy...
- Imaging features of sclerosed hemangiomaDeirdre J Doyle
Department of Medical Imaging, University Health Network and Mount Sinai Hospital, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada
AJR Am J Roentgenol 189:67-72. 2007..The purpose of this study was to review the imaging features of sclerosed hemangioma...
- Oxidative stress and nutritional factors in hepatitis C virus-positive liver recipients, controls, and hepatitis C virus-positive nontransplant patientsJ Madill
University of Toronto, Lung Transplant Program, University Health Network, Toronto, Ontario, Canada
Transplant Proc 42:1744-9. 2010..Oxidative stress (OxS) is involved in the pathogenesis of HCV, but little is known about its presence prior to disease recurrence...
- Hepatic lipid peroxidation and antioxidant micronutrients in hepatitis virus C liver recipients with and without disease recurrenceJ Madill
Multi Organ Transplant Department, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
Transplant Proc 41:3800-5. 2009..Several risk factors are associated with progression. Oxidative stress may be involved because it has a role in the pathogenesis of HCV...
- Radiotherapy as a bridge to liver transplantation for hepatocellular carcinomaCharbel Sandroussi
Multiorgan Transplant Department, Toronto General Hospital, Toronto, ON, USA
Transpl Int 23:299-306. 2010..CRT is a safe and efficacious local bridging therapy for patients with advanced HCC who are on the waiting list for LT. Further studies are warranted to compare the effectiveness of CRT to other local treatment regimens for HCC...
- MR imaging correlates of intratumoral tissue types within colorectal liver metastases: a high-spatial-resolution fresh ex vivo radiologic-pathologic correlation studyLaurent Milot
Joint Department of Medical Imaging and Department of Radiation Oncology, Princess Margaret Hospital, Department of Pathology, and Division of General Surgery, University Health Network and Mount Sinai Hospital, University of Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9
Radiology 254:747-54. 2010..This SI pattern is unusual for common benign liver lesions and may be helpful in the MR imaging diagnosis of colorectal liver metastases. (c) RSNA, 2010...
- Liver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlationO Adeyi
University Health Network University of Toronto, Ontario, Canada
J Clin Pathol 63:47-74. 2010..This review provides a practical approach to the interpretation of these challenging biopsies. Selected difficult scenarios or conundrums are identified and discussed in the relevant sections...
- HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patientsSaira S Mohammed
Department of Medicine, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada
J Acquir Immune Defic Syndr 45:432-8. 2007..To determine whether the clinical and metabolic features associated with nonalcoholic fatty liver disease (NAFLD) are similar between HIV-positive and HIV-negative male subjects...
- Hepatic fatty acid composition differs between chronic hepatitis C patients with and without steatosisBianca M Arendt
University Health Network, Department of Medicine, Toronto, M5G 2C4 Ontario, Canada
J Nutr 139:691-5. 2009..Oxidative stress or nutritional status does not seem to play a predominant role for development of steatosis in CHC...
- Health-related quality of life in esophageal cancer: effect of neoadjuvant chemoradiotherapy followed by surgical interventionNajib Safieddine
Division of Thoracic Surgery, Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 137:36-42. 2009..We sought to determine the effect of neoadjuvant chemoradiotherapy followed by surgical intervention on health-related quality of life in patients with esophageal cancer...
- Distinguishing nonalcoholic steatohepatitis from fatty liver: serum-free fatty acids, insulin resistance, and serum lipoproteinsIan D Bookman
Department of Medicine, University of Toronto, Toronto, Canada
Liver Int 26:566-71. 2006....
- Long-term follow-up of antimitochondrial antibody-positive autoimmune hepatitisConor O'Brien
Department of Medicine, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Canada
Hepatology 48:550-6. 2008....
- Intestinal epithelial lesions associated with signet ring cell carcinoma of the colon and small intestineKien T Mai
Division of Anatomical Pathology, Department of Laboratory Medicine, Ottawa Civic Hospital, Ontario, Canada
Pathology 34:51-6. 2002..The purpose of this study was to investigate the epithelial lesions associated with signet ring cell carcinoma (SRCC) of the colon and small intestine and the possible mechanism of tumour development...
- Ramipril-associated hepatotoxicityElaine Yeung
Departments of Medicine, Toronto General Hospital, Toronto, Ontario, Canada
Arch Pathol Lab Med 127:1493-7. 2003..Adverse hepatic events, especially cholestasis, have rarely been reported with captopril, enalapril, lisinopril, and fosinopril. To date, hepatic injury associated with ramipril has not been reported...
- Baseline ductopenia and treatment response predict long-term histological progression in primary biliary cirrhosisTeru Kumagi
Liver Centre, Toronto Western Hospital, University Health Network, Ontario, Canada
Am J Gastroenterol 105:2186-94. 2010..We sought to develop clinically meaningful markers for those with predominantly early disease at risk of progressive liver damage...
- Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivorsSean P Cleary
Department of Surgery, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 2X5
J Am Coll Surg 198:722-31. 2004..We then sought to determine clinical and histopathologic features of 5-year survivors to determine factors associated with a favorable prognosis...
- Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infectionLimin Chen
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
Gastroenterology 138:1123-33.e1-3. 2010..We here study how the nonresponder gene expression phenotype is influenced by clinical factors and uncover the cellular basis of the phenotype through ISG15 protein expression...
- Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acidLimin Chen
Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada
Liver Int 28:997-1010. 2008....
- Gene expression profiling of acute liver stress during living donor liver transplantationI Borozan
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
Am J Transplant 6:806-24. 2006..This study has identified a set of genes whose expression is altered in acute, but not chronic, liver stress, likely to play a central role in the pathogenesis of acute liver injury of liver transplantation...
- The lighter side of myeloma: an easily overlooked diagnosisJ J Feld
Department of Gastroenterology, University of Toronto, Canada
Gut 54:1376, 1401. 2005
- The management of dysplasia associated with ulcerative colitis: colectomy versus continued surveillanceMartin S Friedlich
Department of Surgery, University of Ottawa, Ottawa, Ont
Can J Surg 47:212-4. 2004
- Impact of regional lymph node evaluation in staging patients with periampullary tumorsShishir K Maithel
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Stoneman 9, 330 Brookline Avenue, Boston, Massachusetts, 02215, USA
Ann Surg Oncol 14:202-10. 2007..We examined whether radiographical enlargement of either lymph node predicts tumor resectability, nodal metastasis, or patient survival...