Paul E Grundy
Affiliation: University of Alberta
- Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study GroupPaul E Grundy
Department of Pediatrics, Roswell Park Cancer Institute, Taipei
J Clin Oncol 23:7312-21. 2005..To determine if tumor-specific loss of heterozygosity (LOH) for chromosomes 1p or 16q is associated with a poorer prognosis for children with favorable-histology (FH) Wilms tumor entered on the fifth National Wilms Tumor Study (NWTS-5)...
- Early discontinuation of intravenous antimicrobial therapy in pediatric oncology patients with febrile neutropeniaHeather Hodgson-Viden
Department of Pediatrics, Stollery Children s Hospital, Edmonton, Alberta, Canada
BMC Pediatr 5:10. 2005..The purpose of this study was to evaluate the outcome of a large cohort of children with FN who had IVAMT discontinued with an ANC < or = 500/mm3..
- Treatment of Wilms tumor relapsing after initial treatment with vincristine and actinomycin D: a report from the National Wilms Tumor Study GroupDaniel M Green
Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Pediatr Blood Cancer 48:493-9. 2007..A uniform approach to the treatment of patients with relapse was employed...
- Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor StudyJeffrey S Dome
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 24:2352-8. 2006..An objective of the fifth National Wilms' Tumor Study (NWTS-5) was to evaluate the efficacy of treatment regimens for anaplastic histology Wilms' tumor (AH)...
- Decreased E-cadherin expression correlates with higher stage of Wilms' tumorsShawn D Safford
Division of Pediatric Surgery, Department of Surgery, Duke University Medical Center, PO Box 3815, Durham, NC 27710, USA
J Pediatr Surg 40:341-8. 2005..The aim of this study was to examine the association between E-cadherin expression and markers of Wilms' tumor aggression, including metastasis and recurrence...
- Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumorsRachael Natrajan
Paediatric Oncology, Institute of Cancer Research Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
Clin Cancer Res 12:7284-93. 2006..We have previously shown a link between genomic gain of chromosome 1q and tumor relapse and sought to further elucidate the role of genes on 1q in treatment failure...
- Treatment of recurrent clear cell sarcoma of the kidney with brain metastasisVlad C Radulescu
East Tennessee State University, Johnson City, Tennessee, USA
Pediatr Blood Cancer 50:246-9. 2008..This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain...
- Effect of duration of treatment on treatment outcome for patients with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study GroupNita L Seibel
Department of Hematology Oncology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
J Clin Oncol 22:468-73. 2004....
- Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhoodStephen J Qualman
Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio 43205, USA
Arch Pathol Lab Med 127:1280-9. 2003
- Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study GroupMarcio Malogolowkin
Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California, USA
Pediatr Blood Cancer 50:236-41. 2008....
- Increased microvascular density predicts relapse in Wilms' tumorLisa P Abramson
Division of Pediatric Surgery, Children s Memorial Hospital, Department of Biostatistics, Northwestern University Medical School, Chicago, Illinois 60611, USA
J Pediatr Surg 38:325-30; discussion 325-30. 2003..The authors postulated that increased microvascular density (MVD), a hallmark for angiogenesis, could identify patients at risk for relapse...
- Fine mapping of Wilms' tumors with 16q loss of heterozygosity localizes the putative tumor suppressor gene to a region of 6.7 megabasesShawn D Safford
Department of Surgery, Division of Pediatric Surgery, Duke University Medical Center, Durham, North Carolina, USA
Ann Surg Oncol 10:136-43. 2003..The aim of this study was to more precisely map the region of 16q loss of heterozygosity (LOH) in Wilms' tumors and to examine the expression of putative tumor suppressor...
- Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumorsRichard R Desrosiers
Departement de Chimie Biochimie, Universite du Quebec a Montreal, Quebec, Canada
Pediatr Blood Cancer 46:40-9. 2006..However, the disruption of normal WT1 protein function cannot solely explain WT growth. The aim of the present study is to identify new molecular players that regulate the invasive character of WT...
- Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGHRachael Natrajan
Paediatric Oncology, Institute of Cancer Research Royal Marsden NHS Trust, Sutton, UK
Genes Chromosomes Cancer 46:607-15. 2007..This study highlights the power of fine-tiling oligonucleotide arrays to delineate breakpoint regions identified by genome-wide screens...
- Blastemal expression of type I insulin-like growth factor receptor in Wilms' tumors is driven by increased copy number and correlates with relapseRachael Natrajan
Paediatric Oncology, Institute of Cancer Research Royal Marsden National Health Service Trust, Sutton, UK
Cancer Res 66:11148-55. 2006..These findings suggest the possibility of use of targeted agents in the therapy of these children...
- Children with idiopathic hemihypertrophy and beckwith-wiedemann syndrome have different constitutional epigenotypes associated with wilms tumorEmily L Niemitz
Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Hum Genet 77:887-91. 2005..0028). These results indicate that children with IH and Wilms tumor have different constitutional epigenotypes from those of children with BWS and Wilms tumor...
- Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificityGalina N Filippova
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 62:48-52. 2002..These observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific "change of function" rather than complete "loss of function."..
- Prognostic value of quantifying apoptosis factor expression in favorable histology wilms tumorsMichal A Miller
Department of Surgery, University of Iowa, Iowa City, Iowa 52242, USA
J Pediatr Hematol Oncol 27:11-4. 2005..Although survivin mRNA was present at markedly greater levels than in normal kidney, none of the factors assayed independently or as a ratio was associated with stage of disease or risk for tumor recurrence in this group of tumors...
- CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumorsChi Ming Li
Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, New York, USA
Am J Pathol 165:1943-53. 2004..Beta-Catenin stabilization can initiate tumorigenesis in other systems, and this mechanism is likely critical in tumor formation after loss of WT1...
- Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidneyMichael S Anglesio
Department of Pathology, British Columbia Research Institute for Children s and Women s Health, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada
Hum Mol Genet 13:2061-74. 2004..Our findings implicate Hace1 as a novel ubiquitin-protein ligase and demonstrate that its expression is very low in primary Wilms' tumors...
- The Simpson-Golabi-Behmel gene, GPC3, is not involved in sporadic Wilms tumorigenesisTanya L Gillan
Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada
Am J Med Genet A 122:30-6. 2003..Surprisingly, we did not find evidence of functional mutations of GPC3 in sporadic Wilms tumor suggesting that GPC3 is not often directly involved in Wilms tumorigenesis...
- A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16Marianne K H Kim
Division of Hematology Oncology, Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
Neoplasia 10:69-78. 2008..These data suggest that IFI16 and WT1, in certain cellular context including sporadic Wilms tumors, may support cell survival...