Paul Grof

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint "Mood-stabilizers: the archeology of the concept"--by M Harris, S Chandran, N Chakraborty and D Healy: a commentary
    Paul Grof
    University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Bipolar Disord 5:453-5. 2003
  2. ncbi request reprint Protective effect of pregnancy in women with lithium-responsive bipolar disorder
    P Grof
    Department of Psychiatry, University of Ottawa, Ottawa, Canada
    J Affect Disord 61:31-9. 2000
  3. doi request reprint Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009
  4. doi request reprint Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study
    Anne Duffy
    Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
    J Affect Disord 142:57-64. 2012
  5. ncbi request reprint A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder
    Glenda M MacQueen
    McMaster University, Hamilton, Ontario, Canada
    Bipolar Disord 6:374-8. 2004
  6. pmc BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
    Michael Tseng
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canda
    J Psychiatry Neurosci 33:449-53. 2008
  7. doi request reprint Findings from bipolar offspring studies: methodology matters
    Anne Duffy
    Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
    Early Interv Psychiatry 5:181-91. 2011
  8. doi request reprint Early stages in the development of bipolar disorder
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 121:127-35. 2010
  9. pmc Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Psychiatry 9:4. 2009
  10. ncbi request reprint The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Bipolar Disord 9:828-38. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint "Mood-stabilizers: the archeology of the concept"--by M Harris, S Chandran, N Chakraborty and D Healy: a commentary
    Paul Grof
    University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Bipolar Disord 5:453-5. 2003
  2. ncbi request reprint Protective effect of pregnancy in women with lithium-responsive bipolar disorder
    P Grof
    Department of Psychiatry, University of Ottawa, Ottawa, Canada
    J Affect Disord 61:31-9. 2000
    ..Our retrospective study statistically examines the clinical course of 28 women with RDC typical bipolar disorder, type I, who became pregnant prior to receiving successful lithium prophylaxis...
  3. doi request reprint Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009
    ..The current study investigated whether or not deficits in early information processing were present before the onset and/or during the early stages of bipolar disorder...
  4. doi request reprint Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study
    Anne Duffy
    Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada
    J Affect Disord 142:57-64. 2012
    ..We studied this relationship in a prospectively assessed cohort of high-risk offspring...
  5. ncbi request reprint A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder
    Glenda M MacQueen
    McMaster University, Hamilton, Ontario, Canada
    Bipolar Disord 6:374-8. 2004
    ..A high-risk paradigm would clarify the temporal relation of cognitive dysfunction to clinical course...
  6. pmc BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
    Michael Tseng
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canda
    J Psychiatry Neurosci 33:449-53. 2008
    ..The objective of our study was to analyze BDNF in lithium-responsive patients with bipolar disorder (BD) to further understand the role of BDNF in the pathophysiology of BD...
  7. doi request reprint Findings from bipolar offspring studies: methodology matters
    Anne Duffy
    Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
    Early Interv Psychiatry 5:181-91. 2011
    ..In this review, we compare different methods of ascertainment and assessment, and their impact on study findings...
  8. doi request reprint Early stages in the development of bipolar disorder
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 121:127-35. 2010
    ..We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology...
  9. pmc Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Psychiatry 9:4. 2009
    ..The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder...
  10. ncbi request reprint The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Bipolar Disord 9:828-38. 2007
    ..A major aim of this longitudinal high-risk study is to identify reliable early indicators of emerging bipolar disorder (BD) among offspring from well-characterized parents...
  11. ncbi request reprint MMPI as a measure of subthreshold and residual psychopathology among the offspring of lithium responsive and non-responsive bipolar parents
    Natasha Demidenko
    Bipolar Disorders Research Unit, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    Bipolar Disord 6:323-8. 2004
    ..The present study compares MMPI profiles completed by the well or remitted offspring of two groups of bipolar parents divided on the basis of parental response to long-term lithium...
  12. ncbi request reprint Temperament, life events, and psychopathology among the offspring of bipolar parents
    Anne Duffy
    Department of Psychiatry, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, Quebec, Canada
    Eur Child Adolesc Psychiatry 16:222-8. 2007
    ..The present study examines the relationship between temperament, recent and remote life events, and psychopathology among the offspring of parents with bipolar disorder and well comparisons...
  13. ncbi request reprint Salivary cortisol secretion in remitted bipolar patients and offspring of bipolar parents
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
    Bipolar Disord 8:345-9. 2006
    ..The purpose of this study is to replicate findings of increased cortisol secretion during clinical remission in bipolar patients and in the offspring of bipolar parents, rigorously controlling for known confounders...
  14. pmc Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses
    Catalina Lopez de Lara
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 13:1397-410. 2010
    ..Further studies are warranted to demonstrate the functional role of these genes in BD...
  15. ncbi request reprint The cortisol awakening response in bipolar illness: a pilot study
    Dorian Deshauer
    Department of Psychiatry, University of Ottawa, Ottawa, Ontario
    Can J Psychiatry 48:462-6. 2003
    ..We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value...
  16. pmc Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 108:263-9. 2008
    ..This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders...
  17. doi request reprint Biological indicators of suicide risk in youth with mood disorders: what do we know so far?
    Ute Lewitzka
    Department of Psychiatry, IWK Health Centre, Dalhousie University, 5850 University Ave, Halifax, B3K 6R8, Canada
    Curr Psychiatry Rep 14:705-12. 2012
    ..In the meantime, there are clear clinical indicators of risk to help identify youth who would benefit from close surveillance and early intervention...
  18. ncbi request reprint Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder
    Xiujun Sun
    Department of Psychiatry, University of Toronto, Toronto, Canada
    Neuropsychopharmacology 29:799-804. 2004
    ..Our findings indicate that alpha1B-AR may play an important role in the mechanism of action of lithium treatment...
  19. ncbi request reprint Selecting effective long-term treatment for bipolar patients: monotherapy and combinations
    Paul Grof
    Department of Psychiatry, University of Ottawa Royal Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Psychiatry 64:53-61. 2003
    ..Combinations appear indicated particularly in bipolar patients who are treatment-resistant to monotherapy, do not tolerate it well, or have not yet exhibited the clinical characteristics needed to choose an effective monotherapy...
  20. ncbi request reprint A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment
    Anne Duffy
    Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada
    J Clin Psychiatry 63:1171-8. 2002
    ..The aim of this study was to prospectively characterize the clinical course, including antecedent and comorbid conditions, among the offspring of 2 groups of bipolar parents divided on the basis of response to lithium...
  21. ncbi request reprint Approximate entropy of self-reported mood prior to episodes in bipolar disorder
    Tasha Glenn
    ChronoRecord Association, Inc, Fullerton, CA 92834, USA
    Bipolar Disord 8:424-9. 2006
    ....
  22. pmc No association between the PREP gene and lithium responsive bipolar disorder
    Firoza Mamdani
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    BMC Psychiatry 7:9. 2007
    ....
  23. doi request reprint Changes in self-reported sleep duration predict mood changes in bipolar disorder
    Michael Bauer
    Psychol Med 38:1069-71. 2008
  24. doi request reprint Self-reporting software for bipolar disorder: validation of ChronoRecord by patients with mania
    Michael Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Psychiatry Res 159:359-66. 2008
    ..Post-hoc analysis of the level of agreement between ChronoRecord and YMRS ratings was excellent or good in all cases using the kappa statistic. These data demonstrate concurrent validity between ChronoRecord and YMRS...
  25. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  26. ncbi request reprint Is response to prophylactic lithium a familial trait?
    Paul Grof
    Department of Psychiatry, University of Ottawa, Ontario, Canada
    J Clin Psychiatry 63:942-7. 2002
    ..However, this recommendation has not been adequately substantiated in the literature. We tested the hypothesis that response to long-term lithium treatment is a familial trait...
  27. doi request reprint Pure and mixed manic subtypes: a review of diagnostic classification and validation
    Frederick Cassidy
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Bipolar Disord 10:131-43. 2008
    ..To review issues surrounding the diagnosis and validity of bipolar manic states...
  28. doi request reprint Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....
  29. pmc Lithium response and genetic variation in the CREB family of genes
    Firoza Mamdani
    McGill Group for Suicide Studies Depressive Disorders Group, Douglas Hospital, Research Centre, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:500-4. 2008
    ..Following correction for multiple testing, our results suggest that the CREB1-1H SNP (G/A change, P < 0.002) and the CREB1-7H SNP (T/C change, P < 0.002) may be associated with BD and/or lithium response...
  30. ncbi request reprint Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder
    Martin Alda
    Department of Psychiatry, Dalhousie University, 5909 Jubilee Road, Halifax, Nova Scotia, Canada B3H 2E2
    Prog Neuropsychopharmacol Biol Psychiatry 29:1038-45. 2005
    ..A combination of research strategies employing multiple methods such as linkage, association, and gene-expression studies will be needed to clarify which of these represent true susceptibility loci...
  31. pmc Does the use of an automated tool for self-reporting mood by patients with bipolar disorder bias the collected data?
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Germany
    MedGenMed 7:21. 2005
    ..Automating data collection from patients can improve data quality, enhance compliance, and decrease costs in longitudinal studies. About half of all households in industrialized countries now have a home computer...
  32. ncbi request reprint Temporal relation between sleep and mood in patients with bipolar disorder
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Bipolar Disord 8:160-7. 2006
    ..Sleep disturbances are frequent warning signs of both mania and depression. This study used cross correlation analysis to characterize the relationship between mood, sleep and bedrest in longitudinal data...
  33. ncbi request reprint Self-reported data from patients with bipolar disorder: impact on minimum episode length for hypomania
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charité Mitte CCM, Schumannstr 20 21, 10117 Berlin, Germany
    J Affect Disord 96:101-5. 2006
    ..Using daily self-reported mood ratings, we studied the impact of changing the length requirement on the number of hypomanic episodes in patients with bipolar disorder...
  34. ncbi request reprint Sex-specific self-reported mood changes by patients with bipolar disorder
    Natalie Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Room 2360, Palo Alto, CA 94305 5723, USA
    J Psychiatr Res 39:77-83. 2005
    ..While the prevalence of bipolar disorder I is similar between men and women, the clinical course may differ. This study investigated if there are differences in the clinical presentation of bipolar disorder between the sexes...
  35. ncbi request reprint Self-reported data from patients with bipolar disorder: frequency of brief depression
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Germany
    J Affect Disord 101:227-33. 2007
    ..Using daily self-reported mood ratings, we studied how changing the length requirement to that typical of recurrent brief depression (2-4 days) would impact the number of depressed episodes...
  36. ncbi request reprint Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders
    Patrizia Cavazzoni
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Bipolar Disord 9:377-85. 2007
    ..These observations raise questions about the nature of the relationship between the neurobiological mechanisms of BD and suicide, namely whether they are shared or independent...
  37. ncbi request reprint A consecutive series of treated affected offspring of parents with bipolar disorder: is response associated with the clinical profile?
    Anne Duffy
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 52:369-76. 2007
    ..Long-term treatment studies of youth with BD are lacking. This paper provides longitudinal observations of response to mood stabilizers early in the course of illness in youth with BD...
  38. ncbi request reprint Using technology to improve longitudinal studies: self-reporting with ChronoRecord in bipolar disorder
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Berlin, Germany
    Bipolar Disord 6:67-74. 2004
    ....
  39. ncbi request reprint Mood changes related to antidepressants: a longitudinal study of patients with bipolar disorder in a naturalistic setting
    Michael Bauer
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr 20 21, 10117 Berlin, Germany
    Psychiatry Res 133:73-80. 2005
    ..The primary difference in pattern between the groups was the time spent in depressed or normal mood, with minor daily mood variations...