D A Grimes

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. pmc Phenocopies in a large GCH1 mutation positive family with dopa responsive dystonia: confusing the picture?
    D A Grimes
    Parkinson s Disease and Movement disorders Clinic, The Ottawa Hospital, Ottawa, Canada
    J Neurol Neurosurg Psychiatry 72:801-4. 2002
  2. ncbi request reprint Neurofilament M gene in a French-Canadian population with Parkinson's disease
    F Han
    Ottawa Health Research Institute, University of Ottawa, Centre for Neuromuscular Disease, Ottawa, Canada
    Can J Neurol Sci 32:68-70. 2005
  3. ncbi request reprint Translated mutation in the Nurr1 gene as a cause for Parkinson's disease
    David A Grimes
    Department of Medicine, Division of Neurology, Ottawa Hospital, Ottawa, Ontario, Canada
    Mov Disord 21:906-9. 2006
  4. ncbi request reprint Hereditary chin trembling: a new family with exclusion of the chromosome 9q13-q21 Locus
    David A Grimes
    Ottawa Health Research Institute, Ottawa, Canada
    Mov Disord 17:1390-2. 2002
  5. ncbi request reprint Large French-Canadian family with Lewy body parkinsonism: exclusion of known loci
    David A Grimes
    Ottawa Health Research Institute, Ottawa, Canada
    Mov Disord 17:1205-12. 2002
  6. ncbi request reprint A novel locus for inherited myoclonus-dystonia on 18p11
    D A Grimes
    Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada
    Neurology 59:1183-6. 2002
  7. ncbi request reprint Parkinson's genetics--creating exciting new insights
    D A Grimes
    Parkinson s Disease and Movement disorders Clinic, The Ottawa Hospital, Civic Campus, 1053 Carling Ave, K1Y 4E9, Ottawa, Ont, Canada
    Parkinsonism Relat Disord 8:459-64. 2002
  8. ncbi request reprint LRRK2 screening in a Canadian Parkinson's disease cohort
    D A Grimes
    Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa Health Research Institute, University of Ottawa, ON, Canada
    Can J Neurol Sci 34:336-8. 2007
  9. ncbi request reprint Mutations in the epsilon-sarcoglycan gene found to be uncommon in seven myoclonus-dystonia families
    F Han
    Ottawa Health Research Institute, Centre for Neuromuscular Disease, University of Ottawa, Ontario, Canada
    Neurology 61:244-6. 2003
  10. ncbi request reprint A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
    Kirsten X Jacobsen
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Neurobiol Dis 29:117-22. 2008

Collaborators

Detail Information

Publications16

  1. pmc Phenocopies in a large GCH1 mutation positive family with dopa responsive dystonia: confusing the picture?
    D A Grimes
    Parkinson s Disease and Movement disorders Clinic, The Ottawa Hospital, Ottawa, Canada
    J Neurol Neurosurg Psychiatry 72:801-4. 2002
    ..Dopa responsive dystonia (DRD) is a disorder characterised by childhood onset dystonia but a wide range of clinical presentations has now been described...
  2. ncbi request reprint Neurofilament M gene in a French-Canadian population with Parkinson's disease
    F Han
    Ottawa Health Research Institute, University of Ottawa, Centre for Neuromuscular Disease, Ottawa, Canada
    Can J Neurol Sci 32:68-70. 2005
    ..No other individuals with Parkinson's disease and of similar ethnic background have been screened for this mutation...
  3. ncbi request reprint Translated mutation in the Nurr1 gene as a cause for Parkinson's disease
    David A Grimes
    Department of Medicine, Division of Neurology, Ottawa Hospital, Ottawa, Ontario, Canada
    Mov Disord 21:906-9. 2006
    ..The novel mutation in exon 3 is predicted to affect phosphorylation and functional studies to assess this are underway. This is the first coding mutation identified in the Nurr1 gene for Parkinson's disease...
  4. ncbi request reprint Hereditary chin trembling: a new family with exclusion of the chromosome 9q13-q21 Locus
    David A Grimes
    Ottawa Health Research Institute, Ottawa, Canada
    Mov Disord 17:1390-2. 2002
    ..We describe a four-generation family with this condition and, using linkage analysis, have excluded the 9q13-21 region as causing the chin trembling in this family...
  5. ncbi request reprint Large French-Canadian family with Lewy body parkinsonism: exclusion of known loci
    David A Grimes
    Ottawa Health Research Institute, Ottawa, Canada
    Mov Disord 17:1205-12. 2002
    ..This family further demonstrates the known genetic heterogeneity in PD and is large enough that a genome-wide screen has been undertaken in an effort to identify a novel PD gene...
  6. ncbi request reprint A novel locus for inherited myoclonus-dystonia on 18p11
    D A Grimes
    Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa, Canada
    Neurology 59:1183-6. 2002
    ....
  7. ncbi request reprint Parkinson's genetics--creating exciting new insights
    D A Grimes
    Parkinson s Disease and Movement disorders Clinic, The Ottawa Hospital, Civic Campus, 1053 Carling Ave, K1Y 4E9, Ottawa, Ont, Canada
    Parkinsonism Relat Disord 8:459-64. 2002
    ..As additional Parkinson's disease loci are mapped and their genes identified we will continue to add to our understating of the critical biochemical pathways involved and be able to develop effective disease altering treatments...
  8. ncbi request reprint LRRK2 screening in a Canadian Parkinson's disease cohort
    D A Grimes
    Department of Medicine, Division of Neurology, The Ottawa Hospital, Ottawa Health Research Institute, University of Ottawa, ON, Canada
    Can J Neurol Sci 34:336-8. 2007
    ..The frequency of mutations described in the literature varies widely depending on the population studied with most reports focusing only on screening for the most common G2019S mutation in exon 41...
  9. ncbi request reprint Mutations in the epsilon-sarcoglycan gene found to be uncommon in seven myoclonus-dystonia families
    F Han
    Ottawa Health Research Institute, Centre for Neuromuscular Disease, University of Ottawa, Ontario, Canada
    Neurology 61:244-6. 2003
    ..Mutations in the SGCE gene were found in the minority of families screened in this series...
  10. ncbi request reprint A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription
    Kirsten X Jacobsen
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Neurobiol Dis 29:117-22. 2008
    ..These results indicate that Ser125 is critical for basal and ERK1/2-induced NURR1 activity and suggest a role for this and other NURR1 mutations in the regulation of dopamine synthesis and predisposition to Parkinson's disease...
  11. ncbi request reprint Tremor--easily seen but difficult to describe and treat
    D A Grimes
    Parkinson s Disease and Movement disorders Clinic, The Ottawa Hospital, Ottawa, Canada
    Can J Neurol Sci 30:S59-63. 2003
    ..The diagnosis and management of essential tremor is presented in more detail, as it is the most commonly encountered tremor...
  12. ncbi request reprint Refinement of the DYT15 locus in myoclonus dystonia
    Fabin Han
    Ottawa Health Research Institute, University of Ottawa, Centre for Neuromuscular Disease, Ottawa, Canada
    Mov Disord 22:888-92. 2007
    ..Our previous linked region has now been reduced to 3.18 Mb but direct sequencing of all seven known and four predicted genes with EST support did not identify any mutations....
  13. ncbi request reprint Large deletions account for an increasing number of mutations in SGCE
    Fabin Han
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Mov Disord 23:456-60. 2008
    ..This is only the second report of intragenic deletions with SGCE and it highlights the need to include exonic copy number variation when performing mutational analysis of SGCE...
  14. ncbi request reprint Is there seasonal variation in risk of Parkinson's disease?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 22:1097-101. 2007
    ..We found no evidence of systematic seasonal variation in PD incidence by birth date, or of clustering of birth dates during influenza pandemic years in PD patients...
  15. ncbi request reprint Uncertainty
    David A Grimes
    Family Health International, Research Triangle Park, NC 27709, USA
    Lancet 360:1242. 2002
  16. ncbi request reprint The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
    Hsien Yang Lee
    Department of Neurology, UCSF, San Francisco, CA, USA
    Hum Mol Genet 13:3161-70. 2004
    ..Stress response pathways will be important areas for elucidation of episodic disease genetics where stress is a common precipitant of many common disorders like epilepsy, migraine and cardiac arrhythmias...