Savraj S Grewal

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Controlling animal growth and body size - does fruit fly physiology point the way?
    Savraj S Grewal
    Clark Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary Alberta, T2N 1N4 Canada
    F1000 Biol Rep 4:12. 2012
  2. pmc Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 179:1105-13. 2007
  3. doi Insulin/TOR signaling in growth and homeostasis: a view from the fly world
    Savraj S Grewal
    Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive, Calgary, AB T2N4N1, Canada
    Int J Biochem Cell Biol 41:1006-10. 2009
  4. pmc Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila
    Lynne Marshall
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, HRIC, Calgary, Alberta, Canada
    EMBO J 31:1916-30. 2012
  5. pmc Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element
    Ling Li
    Clark H, Smith Brain Tumour Center, Southern Alberta Cancer Research Institute, Calgary, Alberta T2N 4N1, Canada
    BMC Cell Biol 11:7. 2010
  6. pmc Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    Dayna J Hall
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    BMC Biol 5:10. 2007
  7. ncbi Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Cell Biol 7:295-302. 2005
  8. pmc Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling
    Elizabeth J Rideout
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 109:1139-44. 2012
  9. ncbi Chewing the fat; regulating autophagy in Drosophila
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA
    Dev Cell 7:148-50. 2004

Detail Information

Publications9

  1. pmc Controlling animal growth and body size - does fruit fly physiology point the way?
    Savraj S Grewal
    Clark Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary Alberta, T2N 1N4 Canada
    F1000 Biol Rep 4:12. 2012
    ..While this concept is obviously not new, these fly studies now open up the possibility of using a genetically tractable system to dissect in detail how organ-to-organ communication dictates body size...
  2. pmc Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Cell Biol 179:1105-13. 2007
    ..Stimulation of rRNA synthesis by TIF-IA may therefore provide a feed-forward mechanism to coregulate the levels of other ribosome components...
  3. doi Insulin/TOR signaling in growth and homeostasis: a view from the fly world
    Savraj S Grewal
    Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive, Calgary, AB T2N4N1, Canada
    Int J Biochem Cell Biol 41:1006-10. 2009
    ..The mechanisms identified in Drosophila likely operate in most metazoans, and are relevent to our understanding of diseases caused by aberrent insulin/TOR signaling such as cancer, diabetes and obesity...
  4. pmc Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila
    Lynne Marshall
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, HRIC, Calgary, Alberta, Canada
    EMBO J 31:1916-30. 2012
    ..Thus, stimulation of Pol III is a key downstream effector of TOR in the control of cellular and systemic growth...
  5. pmc Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element
    Ling Li
    Clark H, Smith Brain Tumour Center, Southern Alberta Cancer Research Institute, Calgary, Alberta T2N 4N1, Canada
    BMC Cell Biol 11:7. 2010
    ..However, less is known about the corresponding mechanisms that operate in metazoans. We used gene expression profiling to explore this issue in developing Drosophila larvae...
  6. pmc Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    Dayna J Hall
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    BMC Biol 5:10. 2007
    ..TOR activity is regulated by nutritional cues, suggesting that Rheb might either control, or respond to, nutrient availability...
  7. ncbi Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nat Cell Biol 7:295-302. 2005
    ..In addition, the growth effects of dMyc in larval wing imaginal discs require de novo rRNA synthesis. We suggest that during animal development, the control of rRNA synthesis and ribosome biogenesis is an essential Myc function...
  8. pmc Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling
    Elizabeth J Rideout
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 109:1139-44. 2012
    ..These findings suggest the stimulation of tRNA(i)(Met) synthesis via inhibition of dMaf1 is limiting for nutrition-dependent growth during development...
  9. ncbi Chewing the fat; regulating autophagy in Drosophila
    Savraj S Grewal
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 USA
    Dev Cell 7:148-50. 2004
    ..Two reports in this issue of Developmental Cell describe how both PI3 kinase and TOR signaling in Drosophila are critical for controlling autophagy in response to developmental and environmental cues...