Research Topics
Genomes and Genes | Scott D Gray-OwenSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapyRaymond Wong
Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Retrovirology 8:47. 2011....
Neisserial Opa proteins: impact on colonization, dissemination and immunityScott D Gray-Owen
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
Scand J Infect Dis 35:614-8. 2003..Recent advances in our understanding of how these Opa protein-mediated interactions influence the host cellular response are discussed in the context of their impact on various stages of neisserial infection...- CEACAM1: contact-dependent control of immunityScott D Gray-Owen
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Nat Rev Immunol 6:433-46. 2006..In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types... - Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeaeJames W Booth
Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada
J Biol Chem 278:14037-45. 2003.... - Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptorShannon E McCaw
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
Mol Microbiol 49:623-37. 2003..gonorrhoeae via either an efficient, ITAM phosphorylation-dependent process that resembles phagocytosis or a less efficient, tyrosine phosphorylation-independent mechanism... - Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeaeHelen Sarantis
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Infect Immun 80:345-58. 2012..These observations illustrate a divergence in function of CEACAMs in neutrophils and implicate the human-restricted CEACAM3 in the neutrophil innate response to neisserial infection... - Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytesIan C Boulton
Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
Nat Immunol 3:229-36. 2002..CEACAM1 bound by gonococcal Opa52 associated with the tyrosine phosphatases SHP-1 and SHP-2, which implicates the receptor's ITIM (immunoreceptor tyrosine-based inhibitory motif) in this effect... - Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein functionMichael J Brooks
Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada
Infect Immun 76:5330-40. 2008..The exchange of certain variant cassettes correlates with strain-specific differences in UspA protein function and confers differing phenotypes upon these mucosal surface pathogens... - Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte functionHannah S W Lee
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Infect Immun 75:4449-55. 2007..Moreover, it demonstrates that OMV-based vaccines must be developed from strains that lack CEACAM1-binding Opa variants... - The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathwayHelen Sarantis
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Cell Microbiol 9:2167-80. 2007.... - CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathwayQigui Yu
Clinical Sciences Division and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, M5S 1A8 Ontario, Canada
J Biol Chem 281:39179-93. 2006..By controlling both ERK/MEK and PI3K/Akt pathways, CEACAM1 functions as a key regulator of contact-dependent control of cell survival, differentiation, and growth... - CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activationHannah S W Lee
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
J Immunol 180:6827-35. 2008..Combined, this dynamic response allows the bacteria to effectively harness the coinhibitory function of CEACAM1 to suppress the adaptive immune response at its earliest step... - Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variantsMichael J Brooks
Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Infect Immun 76:5322-9. 2008..Instead, UspA1 proteins must be considered as variants with the potential to confer both different cell tropisms and host cell responses... 
Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeaeNancy S Y So
Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Immunol 188:4008-22. 2012..This unfocused T-independent response explains the localized Ig response that occurs, despite an absence of immunologic memory elicited during gonorrhea...- Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replicationWendy N Dobson-Belaire
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 6:e18133. 2011..Combined, these results indicate that N. gonorrhoeae elicits immune-modulating cytokines that both activate and inhibit HIV-production; the outcome of co-infection depending upon the balance between these opposing signals... - Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2Marcelo G Binker
Cell Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Cell Microbiol 9:2153-66. 2007.... - Invasive potential of nonencapsulated disease isolates of Neisseria meningitidisKay O Johswich
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Infect Immun 80:2346-53. 2012..Our results suggest the acquisition of a new virulence phenotype by these nonencapsulated strains... - Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cellsWendy N Dobson-Belaire
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Cell Microbiol 12:1703-17. 2010..In the context of HIV, this overcomes the virus's otherwise effective avoidance of the interferon response and represents a previously unrecognized intersection between these two sexually transmitted pathogens... - Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptorsShannon E McCaw
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Infect Immun 72:2742-52. 2004.... - Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxisMarco A O Magalhaes
CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of Dentistry, University of Toronto, 241 Fitzgerald Building, 150 College Street, Toronto, Canada M5S 3E2
J Leukoc Biol 82:559-66. 2007..The visualization and analysis of transfected fluorescent markers in primary neutrophils are a powerful technique to monitor chemotaxis signaling pathways in real time... - Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epitheliaEytan Wine
Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
BMC Microbiol 9:180. 2009..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD... - Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteinsMichael J Brooks
Department of Medical Genetics and Microbiology, Room 4381, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
J Bacteriol 189:76-82. 2007..Genome-based analyses indicate that OlpA and Opa derive from a conserved family of proteins shared by a broad array of gram-negative bacteria... - The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of ListeriaTina Rajabian
Department of Molecular Genetics, University of Toronto Toronto, Ontario, M5S 1A8, Canada
Nat Cell Biol 11:1212-8. 2009..Collectively, our results suggest that InlC promotes bacterial dissemination by relieving cortical tension, thereby enhancing the ability of motile bacteria to deform the plasma membrane into protrusions... - A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesinJames E Bookwalter
The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Department of Pediatrics, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
Infect Immun 76:48-55. 2008.... - Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1Noam Stern
Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
J Immunol 174:6692-701. 2005..Finally, we suggest that the involvement of additional domains beside the N domain in the heterophilic and homophilic interactions is important for regulating the balance between cis and trans interactions...