Scott D Gray-Owen

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa
    Kay O Johswich
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 9:e1003509. 2013
  2. pmc Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication
    Wendy N Dobson-Belaire
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e18133. 2011
  3. pmc Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
    Raymond Wong
    Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Retrovirology 8:47. 2011
  4. ncbi request reprint Neisserial Opa proteins: impact on colonization, dissemination and immunity
    Scott D Gray-Owen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Scand J Infect Dis 35:614-8. 2003
  5. ncbi request reprint CEACAM1: contact-dependent control of immunity
    Scott D Gray-Owen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Nat Rev Immunol 6:433-46. 2006
  6. ncbi request reprint Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae
    James W Booth
    Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:14037-45. 2003
  7. ncbi request reprint Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor
    Shannon E McCaw
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
    Mol Microbiol 49:623-37. 2003
  8. pmc Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function
    Hannah S W Lee
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 75:4449-55. 2007
  9. pmc Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression
    Rebecca J Malott
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 110:10234-9. 2013
  10. ncbi request reprint CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation
    Hannah S W Lee
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Immunol 180:6827-35. 2008

Collaborators

Detail Information

Publications31

  1. pmc In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa
    Kay O Johswich
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Pathog 9:e1003509. 2013
    ....
  2. pmc Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication
    Wendy N Dobson-Belaire
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e18133. 2011
    ..Combined, these results indicate that N. gonorrhoeae elicits immune-modulating cytokines that both activate and inhibit HIV-production; the outcome of co-infection depending upon the balance between these opposing signals...
  3. pmc Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
    Raymond Wong
    Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Retrovirology 8:47. 2011
    ....
  4. ncbi request reprint Neisserial Opa proteins: impact on colonization, dissemination and immunity
    Scott D Gray-Owen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Scand J Infect Dis 35:614-8. 2003
    ..Recent advances in our understanding of how these Opa protein-mediated interactions influence the host cellular response are discussed in the context of their impact on various stages of neisserial infection...
  5. ncbi request reprint CEACAM1: contact-dependent control of immunity
    Scott D Gray-Owen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Nat Rev Immunol 6:433-46. 2006
    ..In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types...
  6. ncbi request reprint Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae
    James W Booth
    Division of Cell Biology, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:14037-45. 2003
    ....
  7. ncbi request reprint Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor
    Shannon E McCaw
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
    Mol Microbiol 49:623-37. 2003
    ..gonorrhoeae via either an efficient, ITAM phosphorylation-dependent process that resembles phagocytosis or a less efficient, tyrosine phosphorylation-independent mechanism...
  8. pmc Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function
    Hannah S W Lee
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 75:4449-55. 2007
    ..Moreover, it demonstrates that OMV-based vaccines must be developed from strains that lack CEACAM1-binding Opa variants...
  9. pmc Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression
    Rebecca J Malott
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 110:10234-9. 2013
    ..Our study thereby shows that heptose is a microbial-specific product that is sensed as an innate immune agonist and unveils the molecular link between N. gonorrhoeae and HIV-1...
  10. ncbi request reprint CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation
    Hannah S W Lee
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Immunol 180:6827-35. 2008
    ..Combined, this dynamic response allows the bacteria to effectively harness the coinhibitory function of CEACAM1 to suppress the adaptive immune response at its earliest step...
  11. pmc Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae
    Helen Sarantis
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 80:345-58. 2012
    ..These observations illustrate a divergence in function of CEACAMs in neutrophils and implicate the human-restricted CEACAM3 in the neutrophil innate response to neisserial infection...
  12. ncbi request reprint Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes
    Ian C Boulton
    Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building Rm 4381, 1 Kings College Circle, Toronto, Ontario M5S1A8, Canada
    Nat Immunol 3:229-36. 2002
    ..CEACAM1 bound by gonococcal Opa52 associated with the tyrosine phosphatases SHP-1 and SHP-2, which implicates the receptor's ITIM (immunoreceptor tyrosine-based inhibitory motif) in this effect...
  13. pmc Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function
    Michael J Brooks
    Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 76:5330-40. 2008
    ..The exchange of certain variant cassettes correlates with strain-specific differences in UspA protein function and confers differing phenotypes upon these mucosal surface pathogens...
  14. ncbi request reprint The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway
    Helen Sarantis
    Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Cell Microbiol 9:2167-80. 2007
    ....
  15. ncbi request reprint CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway
    Qigui Yu
    Clinical Sciences Division and Department of Medical Genetics and Microbiology, University of Toronto, Toronto, M5S 1A8 Ontario, Canada
    J Biol Chem 281:39179-93. 2006
    ..By controlling both ERK/MEK and PI3K/Akt pathways, CEACAM1 functions as a key regulator of contact-dependent control of cell survival, differentiation, and growth...
  16. pmc Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors
    Shannon E McCaw
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 72:2742-52. 2004
    ....
  17. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013
    ..We conclude that the suppression of epithelial cell STAT1 signal transduction by AIEC strains isolated from patients with Crohn disease represents a novel mechanism by which the pathogen evades host immune responses to the infection...
  18. doi request reprint Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells
    Wendy N Dobson-Belaire
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Cell Microbiol 12:1703-17. 2010
    ..In the context of HIV, this overcomes the virus's otherwise effective avoidance of the interferon response and represents a previously unrecognized intersection between these two sexually transmitted pathogens...
  19. pmc Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis
    Kay O Johswich
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 80:2346-53. 2012
    ..Our results suggest the acquisition of a new virulence phenotype by these nonencapsulated strains...
  20. pmc Impact of the Listeria monocytogenes protein InlC on infection in mice
    Nelly Leung
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 81:1334-40. 2013
    ..These smaller foci are consistent with a role for InlC in cell-to-cell spread in vivo. Taken together, these results provide evidence that interaction of InlC with host Tuba is important for full virulence...
  21. doi request reprint Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae
    Nancy S Y So
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Immunol 188:4008-22. 2012
    ..This unfocused T-independent response explains the localized Ig response that occurs, despite an absence of immunologic memory elicited during gonorrhea...
  22. pmc Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteins
    Michael J Brooks
    Department of Medical Genetics and Microbiology, Room 4381, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Bacteriol 189:76-82. 2007
    ..Genome-based analyses indicate that OlpA and Opa derive from a conserved family of proteins shared by a broad array of gram-negative bacteria...
  23. ncbi request reprint Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2
    Marcelo G Binker
    Cell Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Cell Microbiol 9:2153-66. 2007
    ....
  24. pmc Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants
    Michael J Brooks
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Infect Immun 76:5322-9. 2008
    ..Instead, UspA1 proteins must be considered as variants with the potential to confer both different cell tropisms and host cell responses...
  25. ncbi request reprint Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis
    Marco A O Magalhaes
    CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of Dentistry, University of Toronto, 241 Fitzgerald Building, 150 College Street, Toronto, Canada M5S 3E2
    J Leukoc Biol 82:559-66. 2007
    ..The visualization and analysis of transfected fluorescent markers in primary neutrophils are a powerful technique to monitor chemotaxis signaling pathways in real time...
  26. ncbi request reprint Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae
    Adrienne Chen
    Department of Medical Genetics and Microbiology, University of Toronto, Ontario, Canada
    AIDS 17:625-8. 2003
    ..These data suggest that gonococcal infection directly impacts HIV-1 transmission through the localized stimulation of viral expression...
  27. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
    ..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD...
  28. pmc Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
    Aisha Nazli
    Center for Gene Therapeutics, Michael G DeGroote Center for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada
    PLoS Pathog 6:e1000852. 2010
    ..This mechanism could be particularly relevant to mucosal transmission of HIV-1 as well as immune activation seen in HIV-1 infected individuals...
  29. pmc The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria
    Tina Rajabian
    Department of Molecular Genetics, University of Toronto Toronto, Ontario, M5S 1A8, Canada
    Nat Cell Biol 11:1212-8. 2009
    ..Collectively, our results suggest that InlC promotes bacterial dissemination by relieving cortical tension, thereby enhancing the ability of motile bacteria to deform the plasma membrane into protrusions...
  30. ncbi request reprint Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1
    Noam Stern
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 174:6692-701. 2005
    ..Finally, we suggest that the involvement of additional domains beside the N domain in the heterophilic and homophilic interactions is important for regulating the balance between cis and trans interactions...
  31. pmc A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin
    James E Bookwalter
    The Research Institute at Nationwide Children s Hospital, Center for Microbial Pathogenesis, The Ohio State University College of Medicine, Department of Pediatrics, 700 Children s Drive, Rm W591, Columbus, OH 43205 2696, USA
    Infect Immun 76:48-55. 2008
    ....