John T Granton

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Pulmonary arterial hypertension in congenital heart disease
    John T Granton
    Department of Medicine, University of Toronto, Division of Respirology and Critical Care Medicine Programme, University Health Network, 10 EN 220, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Cardiol Clin 20:441-57, vii. 2002
  2. pmc 8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada
    Jeff Granton
    Programme Director, Critical Care Medicine Programme, University of Toronto, Canada
    Crit Care 8:58-66. 2004
  3. ncbi request reprint Inhaled nitric oxide for acute lung injury: no place for NO?
    Neill Adhikari
    JAMA 291:1629-31. 2004
  4. ncbi request reprint Update of early respiratory failure in the lung transplant recipient
    John Granton
    Faculty of Medicine, University of Toronto, Pulmonary Hypertension Programme, Toronto General Hospital, Toronto, Ontario, Canada
    Curr Opin Crit Care 12:19-24. 2006
  5. pmc Science review: Vasopressin and the cardiovascular system part 1--receptor physiology
    Cheryl L Holmes
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care 7:427-34. 2003
  6. pmc Critical care procedure logging using handheld computers
    J Carlos Martinez-Motta
    Technology Application Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Crit Care 8:R336-42. 2004
  7. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
  8. ncbi request reprint Pulmonary vasodilators--treating the right ventricle
    John Granton
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario M5G 2N2, Canada
    Anesthesiol Clin 26:337-53, vii. 2008
  9. doi request reprint Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: the Toronto experience
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:692-7. 2011
  10. doi request reprint Warfarin in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. A Bayesian approach to evaluating treatment for uncommon disease
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 39:276-85. 2012

Detail Information

Publications64

  1. ncbi request reprint Pulmonary arterial hypertension in congenital heart disease
    John T Granton
    Department of Medicine, University of Toronto, Division of Respirology and Critical Care Medicine Programme, University Health Network, 10 EN 220, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Cardiol Clin 20:441-57, vii. 2002
    ..Despite differences in etiology and pathobiology, therapies that have proven successful for primary PAH may benefit this group of patients...
  2. pmc 8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada
    Jeff Granton
    Programme Director, Critical Care Medicine Programme, University of Toronto, Canada
    Crit Care 8:58-66. 2004
  3. ncbi request reprint Inhaled nitric oxide for acute lung injury: no place for NO?
    Neill Adhikari
    JAMA 291:1629-31. 2004
  4. ncbi request reprint Update of early respiratory failure in the lung transplant recipient
    John Granton
    Faculty of Medicine, University of Toronto, Pulmonary Hypertension Programme, Toronto General Hospital, Toronto, Ontario, Canada
    Curr Opin Crit Care 12:19-24. 2006
    ..Owing to its relative importance, advances in the understanding and treatment of ischaemia-reperfusion injury are highlighted...
  5. pmc Science review: Vasopressin and the cardiovascular system part 1--receptor physiology
    Cheryl L Holmes
    Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Crit Care 7:427-34. 2003
    ..In part 2 of the review we discuss the effects of vasopressin on vascular smooth muscle and the heart, and we summarize clinical studies of vasopressin in shock states...
  6. pmc Critical care procedure logging using handheld computers
    J Carlos Martinez-Motta
    Technology Application Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Crit Care 8:R336-42. 2004
    ..We conducted this study to evaluate the feasibility of implementing an internet-linked handheld computer procedure logging system in a critical care training program...
  7. pmc Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors
    Deborah Cook
    Department of Medicine, 1200 Main Street, McMaster University, Hamilton, Canada
    Crit Care 12:R32. 2008
    ..The objective of the present study was to evaluate the prevalence, incidence and predictors of DVT and the incidence of bleeding in intensive care unit (ICU) patients with estimated creatinine clearance <30 ml/min...
  8. ncbi request reprint Pulmonary vasodilators--treating the right ventricle
    John Granton
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario M5G 2N2, Canada
    Anesthesiol Clin 26:337-53, vii. 2008
    ..An additional merit of selective pulmonary vasodilation consists of augmenting oxygenation by improving ventilation perfusion matching...
  9. doi request reprint Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: the Toronto experience
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Can J Cardiol 27:692-7. 2011
    ..However, this surgery remains performed in few experienced centres only. The goal of the study is to review our overall experience since the implementation of our program in August 2005...
  10. doi request reprint Warfarin in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. A Bayesian approach to evaluating treatment for uncommon disease
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 39:276-85. 2012
    ..There is no evidence to support this in SSc-PAH and the evidence in IPAH is conflicting. We evaluated the ability of warfarin to improve survival using 2 large SSc-PAH and IPAH cohorts...
  11. doi request reprint Early postoperative pulmonary vascular compliance predicts outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Marc de Perrot
    Toronto Pulmonary Endarterectomy Program, Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada
    Chest 140:34-41. 2011
    ..We hypothesized that residual abnormal compliance (Cp) after PEA is associated with incomplete functional recovery despite major improvement in PVR...
  12. doi request reprint N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 37:1929-34. 2009
    ..We, therefore, performed a post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine whether N-acetylcysteine was associated with increased blood loss and blood product transfusion...
  13. doi request reprint A valid and reliable belief elicitation method for Bayesian priors
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Clin Epidemiol 63:370-83. 2010
    ..The objectives of this study were to evaluate the feasibility, validity, and reliability of a belief elicitation method for Bayesian priors...
  14. doi request reprint Effect of warfarin on survival in scleroderma-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH. Belief elicitation for Bayesian priors
    Sindhu R Johnson
    Division of Rheumatology, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol 38:462-9. 2011
    ..A prerequisite for a trial is the demonstration of community uncertainty. We evaluated experts' beliefs about the effect of warfarin on 3-year survival in SSc-PAH and IPAH, and factors that influence warfarin use...
  15. ncbi request reprint High-frequency oscillation in early acute respiratory distress syndrome
    Niall D Ferguson
    Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada
    N Engl J Med 368:795-805. 2013
    ....
  16. doi request reprint Outcome of patients with pulmonary arterial hypertension referred for lung transplantation: a 14-year single-center experience
    Marc de Perrot
    Toronto Lung Transplant Program and Pulmonary Hypertension Program, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 143:910-8. 2012
    ..To analyze the outcomes of patients with pulmonary arterial hypertension referred for lung transplantation and determine the changes over time...
  17. ncbi request reprint Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation
    Jonathan A Cardella
    Thoracic Surgery Research Laboratory, University Health Network, Toronto General Hospital, and Department of Surgery and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Transplantation 77:886-90. 2004
    ..The effects of NO inhalation on endogenous NOS expression and activity are controversial. The authors hypothesized that NO inhalation may affect ischemia-reperfusion-induced alterations of the endogenous NOS system...
  18. doi request reprint Feasibility of blood conservation strategies in pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
    Karen McRae
    Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, Toronto, Ont, Canada
    Interact Cardiovasc Thorac Surg 13:35-8. 2011
    ..In conclusion, a conservative blood transfusion strategy allows PEA to be safely performed with no or minimal blood product transfusions in a majority of patients despite deep hypothermic circulatory arrest...
  19. pmc Science Review: Vasopressin and the cardiovascular system part 2 - clinical physiology
    Cheryl L Holmes
    Department of Medicine, Division of Critical Care, Kelowna General Hospital, Kelowna BC, Canada
    Crit Care 8:15-23. 2004
    ..Because of potential adverse effects of vasopressin, clinical use of vasopressin in vasodilatory shock should await a randomized controlled trial of the effect of vasopressin's effect on outcomes such as organ failure and mortality...
  20. doi request reprint Gene expression profiling in the lungs of patients with pulmonary hypertension associated with pulmonary fibrosis
    Marco Mura
    Toronto General Hospital, Toronto, ON, Canada
    Chest 141:661-73. 2012
    ..We sought to determine if different gene expression signatures in PF could be determined based on pulmonary arterial pressures (PAPs) and to provide new insights into the pathobiology of APH...
  21. ncbi request reprint Impact of extracorporeal life support on outcome in patients with idiopathic pulmonary arterial hypertension awaiting lung transplantation
    Marc de Perrot
    Toronto Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 30:997-1002. 2011
    ....
  22. doi request reprint The effect of endogenous estrogen on Doppler-estimated right ventricular systolic pressure during exercise
    Vicki N Wang
    Department of Medicine, Division of Cardiology and the John H Daniels Cardiac Research Centre, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Can J Physiol Pharmacol 90:1364-71. 2012
    ..Our findings did not demonstrate any effect of endogenous estrogen levels on the modulation of the pulmonary vascular response to exercise in healthy women...
  23. doi request reprint Generalised muscle weakness in young adults with congenital heart disease
    Matthias Greutmann
    Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Division of Cardiology, University of Toronto, Toronto, Canada
    Heart 97:1164-8. 2011
    ..Despite a different underlying pathology, many young adults with congenital heart disease (CHD) develop a syndrome comparable to heart failure from acquired cardiomyopathy and may be at risk for a similar skeletal muscle weakness...
  24. doi request reprint High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  25. doi request reprint Prophylaxis against venous thromboembolism in neurointensive care patients: survey of Canadian practice
    Damon C Scales
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    J Crit Care 24:176-84. 2009
    ..For this population, anticoagulant thromboprophylaxis remains controversial and randomized controlled studies are sparse. Our goal was to establish sufficient clinical equipoise to facilitate future research in this area...
  26. pmc Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
    ....
  27. ncbi request reprint A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation
    Maureen O Meade
    FRCPC, Toronto General Hospital, 200 Elizabeth Street, EN 10 220, Toronto, ON, M5G 2C4 Canada
    Am J Respir Crit Care Med 167:1483-9. 2003
    ..In conclusion, we did not detect a significant effect of inhaled NO administered 10 minutes after reperfusion on physiologic variables or outcomes in lung transplant patients...
  28. ncbi request reprint N-acetylcysteine for preventing acute kidney injury in cardiac surgery patients with pre-existing moderate renal insufficiency
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, EN 3 450, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Can J Anaesth 54:872-81. 2007
    ..To determine if N-acetylcysteine warrants definitive evaluation in a large multicentre trial, we evaluated its effects on a surrogate outcome, estimated glomerular filtration rate (eGFR), in a randomized trial...
  29. doi request reprint Survival after lung transplantation in systemic sclerosis. A systematic review
    Irfan Y Khan
    Pulmonary Hypertension Programme, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Respir Med 107:2081-7. 2013
    ..We secondarily evaluated SSc lung transplant recipient characteristics (age, sex, and type of SSc lung disease), and discussed post-lung transplantation survival of SSc patients and non-SSc patients (idiopathic PAH, and ILD)...
  30. doi request reprint Complications from recruitment maneuvers in patients with acute lung injury: secondary analysis from the lung open ventilation study
    Eddy Fan
    Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Respir Care 57:1842-9. 2012
    ..There are limited data on the safety and efficacy of recruitment maneuvers (RMs) in acute lung injury (ALI) patients...
  31. pmc Prophylactic anticoagulation to prevent venous thromboembolism in traumatic intracranial hemorrhage: a decision analysis
    Damon C Scales
    Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Room D108, Toronto, ON, Canada
    Crit Care 14:R72. 2010
    ..Using decision analysis modeling techniques, we developed a model for examining this trade-off for trauma patients with documented ICH...
  32. ncbi request reprint A pilot study of exercise training in adult patients with repaired tetralogy of Fallot
    Judith Therrien
    University of Toronto Congenital Cardiac Centre for Adults, Ontario, Canada
    Can J Cardiol 19:685-9. 2003
    ..Positive effects of physical training in adults with acquired heart disease have been reported. The role of exercise training in adults with congenital heart disease, however, is less well defined...
  33. doi request reprint Right heart characteristics and exercise parameters in adults with Ebstein anomaly: new perspectives from cardiac magnetic resonance imaging studies
    Daniel Tobler
    Division of Cardiology, Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Int J Cardiol 165:146-50. 2013
    ..The utility of cardiac magnetic resonance imaging (CMR) for assessment of adults with Ebstein anomaly is not well-defined. We sought to evaluate CMR characteristics in this population and to relate these to exercise parameters...
  34. doi request reprint Using standardized family members to teach communication skills and ethical principles to critical care trainees
    James Downar
    Faculty of Medicine, University of Toronto, Ontario, Canada
    Crit Care Med 40:1814-9. 2012
    ..We sought to determine the effectiveness of standardized family members for improving communication skills and ethical and legal knowledge of senior intensive care unit trainees...
  35. ncbi request reprint Evaluation of persistent pulmonary hypertension after acute pulmonary embolism
    Marc de Perrot
    Division of Thoracic Surgery, Toronto General Hospital, 9N 961, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada
    Chest 132:780-5. 2007
    ..Better knowledge of the evolution of persistent pulmonary hypertension after acute pulmonary embolism (PE) is required to optimize the indication and timing of pulmonary endarterectomy (PEA)...
  36. ncbi request reprint Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study
    Niall D Ferguson
    Department of Medicine, Division of Respirology, and the Interdepartmental Division of Critical Care Medicine, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Crit Care Med 33:479-86. 2005
    ..To determine the safety, feasibility, and lung-recruitment efficacy of an explicit ventilation protocol combining high-frequency oscillatory ventilation and recruitment maneuvers...
  37. ncbi request reprint Prognostic factors for survival in scleroderma associated pulmonary arterial hypertension
    Sindhu R Johnson
    University Health Network, University of Toronto, Toronto, ON, Canada
    J Rheumatol 35:1584-90. 2008
    ..Our objectives were (1) to identify factors associated with survival in SSc-PAH and (2) to evaluate the methodologic quality of prognostic studies against current standards...
  38. doi request reprint A randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial
    Sangeeta Mehta
    Inter Departmental Division of Critical Care Medicine, Mount Sinai Hospital, University Health Network, and University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 36:2092-9. 2008
    ..Our objective was to determine the safety and feasibility of a randomized trial to determine whether adults managed with both PS + DI have a shorter duration of MV than patients managed with PS alone...
  39. doi request reprint Dual therapy in IPAH and SSc-PAH. A qualitative systematic review
    Sindhu R Johnson
    University Health Network, Pulmonary Hypertension Programme, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Respir Med 106:730-9. 2012
    ..However, patients often deteriorate on monotherapy. The objective of this study is to evaluate the effect of dual therapy on outcomes in IPAH and SSc-PAH...
  40. ncbi request reprint Thrombotic arteriopathy and anticoagulation in pulmonary hypertension
    Sindhu R Johnson
    Division of Rheumatology, University Health Network, University of Toronto, Canada
    Chest 130:545-52. 2006
    ..To date, the data from observational studies suggest that anticoagulation with warfarin is an effective intervention in patients with IPAH. Its efficacy in other causes of PAH remains speculative...
  41. ncbi request reprint Critical care lessons from severe acute respiratory syndrome
    Stephen E Lapinsky
    Mount Sinai Hospital, University Health Network, and the Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Crit Care 10:53-8. 2004
    ..This paper reviews the current status of this knowledge base, with particular reference to the critically ill patient...
  42. doi request reprint Methods to elicit beliefs for Bayesian priors: a systematic review
    Sindhu R Johnson
    Division of Rheumatology, Department of Medicine, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Clin Epidemiol 63:355-69. 2010
    ..We review belief-elicitation methods for Bayesian analysis and determine if any of them had an incremental value over the others based on its validity, reliability, and responsiveness...
  43. ncbi request reprint Pulmonary thrombosis in adults with Eisenmenger syndrome
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, Toronto, Canada
    J Am Coll Cardiol 42:1982-7. 2003
    ..We sought to determine the prevalence of pulmonary artery thrombosis in patients with Eisenmenger syndrome and to identify individuals at highest risk...
  44. ncbi request reprint Pulmonary veno-occlusive disease and scleroderma associated pulmonary hypertension
    Sindhu R Johnson
    Division of Rheumatology, Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 33:2347-50. 2006
    ..In our case series, treatment with an endothelin receptor antagonist did not confer a beneficial treatment effect...
  45. doi request reprint Examining nursing vital signs documentation workflow: barriers and opportunities in general internal medicine units
    Melanie S Yeung
    Centre for Global eHealth Innovation, University Health Network, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada
    J Clin Nurs 21:975-82. 2012
    ..To characterise the nursing practices of vital signs collection and documentation in a general internal medicine environment to inform strategies for improving workflow design...
  46. ncbi request reprint Cost-effectiveness of treprostinil versus epoprostenol in patients with pulmonary arterial hypertension: a Canadian analysis
    T R Einarson
    Faculty of Pharmacy, University of Toronto, Toronto, Canada
    Can Respir J 12:419-25. 2005
    ..In the present study, an economic evaluation of patients with PAH treated with either treprostinil or epoprostenol was performed...
  47. ncbi request reprint Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery
    Duminda N Wijeysundera
    Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    JAMA 297:1801-9. 2007
    ..A predictive index for renal replacement therapy (RRT; hemodialysis or continuous venovenous hemodiafiltration) after cardiac surgery may improve clinical decision making and research design...
  48. ncbi request reprint Noninvasive nocturnal ventilatory support in advanced lung disease from cystic fibrosis
    John T Granton
    The Toronto Hospital, Toronto, Canada
    Respir Care 47:675-81. 2002
    ..We therefore sought to determine the tolerability and efficacy of NPPV in people with advanced lung disease from CF...
  49. ncbi request reprint The ICU outreach team
    Damon C Scales
    Adult Critical Care Program, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    J Crit Care 18:95-106. 2003
  50. doi request reprint Exercise capacity and biventricular function in adult patients with repaired tetralogy of Fallot
    Ahmed Samman
    Toronto Congenital Cardiac Centre for Adults, University of Toronto, University Health Network, Toronto, Ontario, Canada
    Am Heart J 156:100-5. 2008
    ..The primary objective of this study was to examine whether abnormalities of biventricular function play a role in exercise limitation in patients with rTOF...
  51. pmc Feasibility of internet-based health-related quality of life data collection in a large patient cohort
    Sacha Bhinder
    Faculty of Medicine, University of Toronto, Toronto, Canada
    J Med Internet Res 12:e35. 2010
    ..Internet-based HRQOL questionnaires are a potential solution, allowing home data collection with immediate storage in a central database...
  52. ncbi request reprint Risk quantification of early outcome after lung transplantation: donor, recipient, operative, and post-transplant parameters
    Yasuo Sekine
    Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 23:96-104. 2004
    ..The purpose of our study was to identify risk factors for 30-day mortality and prolonged intensive care unit stay and to develop a scoring system to evaluate the severity of impairment and to predict surgical outcomes...
  53. ncbi request reprint High-frequency oscillatory ventilation in adults: the Toronto experience
    Sangeeta Mehta
    Mount Sinai Hospital, 600 University Ave, No 1818, Toronto, ON, Canada, M5G 1X5
    Chest 126:518-27. 2004
    ..To review the clinical experience with high-frequency oscillatory ventilation (HFOV) in three medical-surgical ICUs in Toronto, ON, Canada, and to describe patient characteristics, HFOV strategies, and outcomes...
  54. pmc Clinically important deep vein thrombosis in the intensive care unit: a survey of intensivists
    Deborah Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Crit Care 8:R145-52. 2004
    ..The objective of the present survey is to identify the patient factors and radiologic features of lower limb DVT that intensivists consider more or less likely to make a DVT clinically important in ICU patients...
  55. ncbi request reprint Prophylaxis of Thromboembolism in Critical Care (PROTECT) Trial: a pilot study
    Deborah J Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    J Crit Care 20:364-72. 2005
    ..Its additional goals were to evaluate the suitability of the exclusion criteria and to document the range of research activities that precede accrual of patients into a trial to plan multisite management...
  56. pmc Eisenmenger syndrome and atrial septal defect: nature or nurture?
    Judith Therrien
    Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, Canada
    Can J Cardiol 22:1133-6. 2006
    ....
  57. ncbi request reprint Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial
    Lauralyn A McIntyre
    University of Ottawa Centre for Transfusion and Critical Care Research, Ottawa Hospital, Ottawa, Ontario, Canada
    Can J Anaesth 55:819-26. 2008
    ..This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarch vs normal saline in early septic shock, powered for a difference in mortality...
  58. doi request reprint Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis
    D Cook
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 24:168-75. 2009
    ....
  59. ncbi request reprint The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients
    Mark Andrew Crowther
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Crit Care 25:287-93. 2010
    ..The 4Ts score (Thrombocytopenia, Timing of thrombocytopenia, Thrombosis, and oTher reason) might identify individual patients at risk of having this disorder...
  60. ncbi request reprint In-house, overnight physician staffing: a cross-sectional survey of Canadian adult and pediatric intensive care units
    Christopher S Parshuram
    Department of Critical Care Medicine and Division of Clinical Pharmacology, Population Health Sciences, The Research Institute, The Hospital for Sick Children, Toronto, and McMaster University, Hamilton, Ontario, Canada
    Crit Care Med 34:1674-8. 2006
    ..Physician staffing is an important determinant of patient outcomes following intensive care unit (ICU) admission. We conducted a national survey of in-house after-hours physician staffing in Canadian ICUs...
  61. ncbi request reprint Empiric antimicrobial therapy in critical illness: results of a surgical infection society survey
    Mary Anne W Aarts
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Surg Infect (Larchmt) 8:329-36. 2007
    ..Often, therapy is initiated empirically; practice patterns are not well characterized. We documented approaches to empiric antibiotic therapy among members of the Surgical Infection Society (SIS)...
  62. pmc An open-label, multicentre pilot study of bosentan in pulmonary arterial hypertension related to congenital heart disease
    Reda Ibrahim
    Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada
    Can Respir J 13:415-20. 2006
    ..However, there are limited studies examining the benefits of bosentan in PAH associated with congenital heart disease (CHD)...
  63. ncbi request reprint Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial
    Gerald Simonneau
    Service de Pneumologie, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    Ann Intern Med 149:521-30. 2008
    ..Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension...
  64. ncbi request reprint Vasopressin versus norepinephrine infusion in patients with septic shock
    James A Russell
    iCAPTURE Centre, Vancouver, BC, Canada
    N Engl J Med 358:877-87. 2008
    ..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors...