T E Graham

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. pmc The acute impact of ingestion of sourdough and whole-grain breads on blood glucose, insulin, and incretins in overweight and obese men
    Anita Mofidi
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Nutr Metab 2012:184710. 2012
  2. pmc The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial
    Amy J Tucker
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Nutr Metab (Lond) 7:37. 2010
  3. ncbi Caffeine and exercise: metabolism, endurance and performance
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Sports Med 31:785-807. 2001
  4. ncbi Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, ON, Canada
    Can J Physiol Pharmacol 79:559-65. 2001
  5. ncbi Pro- and macroglycogenolysis: relationship with exercise intensity and duration
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 90:873-9. 2001
  6. pmc Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Physiol 529:837-47. 2000
  7. doi Does caffeine alter muscle carbohydrate and fat metabolism during exercise?
    Terry E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G2W1, Canada
    Appl Physiol Nutr Metab 33:1311-8. 2008
  8. doi Glycogen: an overview of possible regulatory roles of the proteins associated with the granule
    Terry E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:488-92. 2009
  9. doi The regulation of muscle glycogen: the granule and its proteins
    T E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Acta Physiol (Oxf) 199:489-98. 2010
  10. ncbi Metabolic and exercise endurance effects of coffee and caffeine ingestion
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 85:883-9. 1998

Collaborators

Detail Information

Publications32

  1. pmc The acute impact of ingestion of sourdough and whole-grain breads on blood glucose, insulin, and incretins in overweight and obese men
    Anita Mofidi
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Nutr Metab 2012:184710. 2012
    ..In overweight and obese men, the glycemic response to sprouted grain bread was reduced in both parts 1 and 2 while the other whole-grain test breads did not improve metabolic responses in the acute postprandial state...
  2. pmc The effect of whole grain wheat sourdough bread consumption on serum lipids in healthy normoglycemic/normoinsulinemic and hyperglycemic/hyperinsulinemic adults depends on presence of the APOE E3/E3 genotype: a randomized controlled trial
    Amy J Tucker
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Nutr Metab (Lond) 7:37. 2010
    ..Epidemiological studies associate consumption of whole grain foods, including breads, with reduced cardiovascular disease (CVD) risk; however, few studies have compared wheat whole grains with wheat refined grains...
  3. ncbi Caffeine and exercise: metabolism, endurance and performance
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Sports Med 31:785-807. 2001
    ..Caffeine may work, in part, by creating a more favourable intracellular ionic environment in active muscle. This could facilitate force production by each motor unit...
  4. ncbi Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, ON, Canada
    Can J Physiol Pharmacol 79:559-65. 2001
    ..This, together with a trend towards a greater rather than a more modest response in blood glucose, suggests that caffeine ingestion may have resulted in insulin resistance...
  5. ncbi Pro- and macroglycogenolysis: relationship with exercise intensity and duration
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 90:873-9. 2001
    ..0 and 10.8 +/- 5.6. The MG pool appeared to be more resistant to mobilization, and, when activated, its catabolism was inhibited more rapidly than that of PG. This suggests that the metabolic regulation of the two pools must be different...
  6. pmc Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Physiol 529:837-47. 2000
    ..Other tissues must have been involved in the changes in circulating potassium, fatty acids, glucose and lactate...
  7. doi Does caffeine alter muscle carbohydrate and fat metabolism during exercise?
    Terry E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G2W1, Canada
    Appl Physiol Nutr Metab 33:1311-8. 2008
    ..Individuals may, however, respond differently to the effects of caffeine, and there is growing evidence that this could be explained by common genetic variations...
  8. doi Glycogen: an overview of possible regulatory roles of the proteins associated with the granule
    Terry E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 34:488-92. 2009
    ..These various processes appear to be the mechanisms that give the glycogen granule precise yet dynamic regulation. This may also allow the stores to serve as an important metabolic regulator of other metabolic events...
  9. doi The regulation of muscle glycogen: the granule and its proteins
    T E Graham
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Acta Physiol (Oxf) 199:489-98. 2010
    ..These various processes appear to be the mechanisms that give the glycogen granule precise, yet dynamic regulation...
  10. ncbi Metabolic and exercise endurance effects of coffee and caffeine ingestion
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 85:883-9. 1998
    ..05) in the Caf capsule trial; there were no differences among the other four tests. One cannot extrapolate the effects of Caf to Cof; there must be a component(s) of Cof that moderates the actions of Caf...
  11. pmc Anaplerotic processes in human skeletal muscle during brief dynamic exercise
    M J Gibala
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    J Physiol 502:703-13. 1997
    ....
  12. pmc Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans
    D S Battram
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Physiol 583:1069-77. 2007
    ..08). Furthermore, CAF decreased IMGD to a similar magnitude as ADR despite a 50% lower [ADR]. In summary, while ADR contributes to the CAF-induced impairment in IMGD, it is not solely responsible for caffeine's effects...
  13. ncbi Plasma leptin in female athletes: relationship with body fat, reproductive, nutritional, and endocrine factors
    F S Thong
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    J Appl Physiol (1985) 88:2037-44. 2000
    ..These data suggest that in female athletes 1) leptin may be a metabolic signal that provides a link between adipose tissue, energy availability, and the reproductive axis and 2) sex hormones do not directly regulate leptin secretion...
  14. doi Glutamate availability is important in intramuscular amino acid metabolism and TCA cycle intermediates but does not affect peak oxidative metabolism
    M Mourtzakis
    Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 105:547-54. 2008
    ..Although glutamate may have a role in the expansion of the TCA cycle, glutamate and TCA cycle intermediates do not directly affect VO2peak in either trained or untrained muscle...
  15. ncbi Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen
    J E Gusba
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Scand J Med Sci Sports 18:77-85. 2008
    ..05) and 40% in the carbohydrate and water trials, respectively. Therefore, the declining IL-6 mRNA and IL-6 plasma concentrations during recovery were not related to carbohydrate availability or changes in glycogen...
  16. ncbi Hemodynamics and O2 uptake during maximal knee extensor exercise in untrained and trained human quadriceps muscle: effects of hyperoxia
    M Mourtzakis
    Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 97:1796-802. 2004
    ....
  17. pmc Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans
    M A Tarnopolsky
    Department of Medicine and Kinesiology, McMaster University, Hamilton, Ontario, Canada
    J Physiol 533:881-9. 2001
    ..4. In summary, complete and partial muscle AMPD deficiency did not affect TCA cycle anaplerosis, phosphocreatine hydrolysis, energy charge or exercise performance...
  18. doi Whole grain wheat sourdough bread does not affect plasminogen activator inhibitor-1 in adults with normal or impaired carbohydrate metabolism
    K A MacKay
    Department of Human Health and Nutritional Sciences, University of Guelph, Animal Science Nutrition Bldg 70, Guelph, ON, Canada N1G 2W1
    Nutr Metab Cardiovasc Dis 22:704-11. 2012
    ..Our aim was to investigate the effect of 6 wk of whole grain wheat sourdough bread consumption versus refined white bread on PAI-1...
  19. ncbi Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia
    D S Battram
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 102:374-81. 2007
    ..8 mM at the end of the OGTT (time = 180 min), classifying them as glucose intolerant. In summary, acute Caf ingestion does not increase epinephrine concentration or impair glucose tolerance in TP...
  20. ncbi Caffeine ingestion does not impede the resynthesis of proglycogen and macroglycogen after prolonged exercise and carbohydrate supplementation in humans
    D S Battram
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    J Appl Physiol (1985) 96:943-50. 2004
    ..In conclusion, Caf ingestion does not impede the resynthesis of PG or MG after an extensive depletion of muscle glycogen and with the provision of exogenous dietary carbohydrate...
  21. ncbi Thermal, metabolic, and cardiovascular changes in men and women during cold stress
    T E Graham
    School of Human Biology, University of Guelph, Ontario, Canada
    Med Sci Sports Exerc 20:S185-92. 1988
    ..Many of these gender-specific responses cannot be explained fully by differences in body morphology and support the concept that men and women respond differently to the cold...
  22. ncbi Ammonia and amino acid metabolism in skeletal muscle: human, rodent and canine models
    T E Graham
    Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Med Sci Sports Exerc 30:34-46. 1998
    ..The leg extensor model and the canine gastrocnemius offer the greatest opportunities to quantify these responses during prolonged exercise...
  23. ncbi Cardiovascular and norepinephrine responses of men and women to two cold pressor tests
    J K McLean
    School of Human Biology, University of Guelph, Ont, Canada
    Can J Physiol Pharmacol 70:36-42. 1992
    ..The study demonstrated that gender differences exist in the blood pressure responses to local cold, but that the mechanisms involved do not include a parallel difference in heart rate or venous plasma norepinephrine concentration...
  24. ncbi Quantification of subcellular glycogen in resting human muscle: granule size, number, and location
    I Marchand
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, N1G 2W1, Ontario, Canada
    J Appl Physiol 93:1598-607. 2002
    ..These results demonstrate a compartmentalized pattern of subcellular G deposition in human skeletal muscle for both the size and density of granules...
  25. ncbi Glycogenin activity in human skeletal muscle is proportional to muscle glycogen concentration
    J Shearer
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1, Canada L8N 3Z5
    Am J Physiol Endocrinol Metab 278:E177-80. 2000
    ..84). It can be concluded that glycogenin does display activity in human skeletal muscle and is proportional to glycogen concentration. Thus it must be considered as a potential regulator of glycogen synthesis in human skeletal muscle...
  26. ncbi Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans
    T E Graham
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph N1G 2W1, Canada L85 4L8
    Am J Physiol Endocrinol Metab 278:E83-9. 2000
    ..This increase in muscle glutamate concentration could account for approximately 40% of the MSG ingested; we propose that resting skeletal muscle is a major sink for the glutamate and metabolizes it to aspartate...
  27. ncbi Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women
    C McLean
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 93:1471-8. 2002
    ..There was a trend for higher plasma caffeine and lower plasma paraxanthine concentrations in the women. These results confirm that gender, exercise, and thermal stress have no effect on caffeine pharmacokinetics in men and women...
  28. ncbi Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise
    F S Thong
    Department of Human Biology and Nutritional Sciences, University of Guelph, N1G 2W1, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Endocrinol Metab 279:E307-13. 2000
    ..We conclude that reduction in adipose tissue after weight loss results in a collateral decrease in circulating leptin, and exercise, independent of its effects on weight loss, has no profound influence on leptin secretion...
  29. ncbi Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects
    T E Graham
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 99 Brookline Avenue Research North, Rm 380C, Boston, MA 02215, USA
    Diabetologia 50:814-23. 2007
    ..Therefore serum RBP4 may be useful for early diagnosis of insulin resistance and for monitoring improvements in insulin sensitivity. We sought to determine the performance of assays for this application...
  30. pmc Quantitative assessment of human muscle glycogen granules size and number in subcellular locations during recovery from prolonged exercise
    I Marchand
    CLSC Faubourg, Montreal, Quebec, Canada
    J Physiol 580:617-28. 2007
    ..Glycogen granules varied in size and number depending on location, and in all compartments resynthesis of glycogen was characterized initially by an increase in granule number and later by an increase in size...
  31. ncbi Caffeine, coffee and ephedrine: impact on exercise performance and metabolism
    T E Graham
    Department of Human Biology and Nutritional Sciences, University of Guelph Guelph, ON
    Can J Appl Physiol 26:S103-19. 2001
    ..It appears unlikely that increased fat oxidation and glycogen sparing is the prime ergogenic mechanism...
  32. ncbi Effects of chronic coffee consumption on glucose kinetics in the conscious rat
    J Shearer
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Light Hall 702, Nashville, TN 37215, USA
    Can J Physiol Pharmacol 85:823-30. 2007
    ..Given these findings, decaffeinated coffee may represent a nutritional means of combating insulin resistance...