Boris Gorzalka

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone
    Boris Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada, V6T 1Z4
    Eur J Pharmacol 471:129-34. 2003
  2. ncbi request reprint Endocannabinoid modulation of male rat sexual behavior
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada, V6T1Z4
    Psychopharmacology (Berl) 198:479-86. 2008
  3. ncbi request reprint Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Pharmacol 18:431-8. 2007
  4. pmc Serum contents of endocannabinoids are correlated with blood pressure in depressed women
    W S Vanessa Ho
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lipids Health Dis 11:32. 2012
  5. doi request reprint Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Endocrinology 153:1016-24. 2012
  6. doi request reprint Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:1575-85. 2011
  7. ncbi request reprint Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakes
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
    Eur J Pharmacol 516:28-33. 2005
  8. doi request reprint Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Curr Top Behav Neurosci 1:289-306. 2009
  9. doi request reprint Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, Canada, BC V6T 1Z4
    Horm Behav 58:91-9. 2010
  10. doi request reprint Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Neurosci Biobehav Rev 32:1152-60. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone
    Boris Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada, V6T 1Z4
    Eur J Pharmacol 471:129-34. 2003
    ..These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion...
  2. ncbi request reprint Endocannabinoid modulation of male rat sexual behavior
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada, V6T1Z4
    Psychopharmacology (Berl) 198:479-86. 2008
    ..The aim of this experiment was to determine the effect of pharmacological facilitation or antagonism of endocannabinoid signaling on male rat sexual behavior...
  3. ncbi request reprint Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Pharmacol 18:431-8. 2007
    ..Collectively, these data highlight the potential importance of changes in the hippocampal endocannabinoid system following stress or antidepressant treatment with respect to the manifestation and/or treatment of depression...
  4. pmc Serum contents of endocannabinoids are correlated with blood pressure in depressed women
    W S Vanessa Ho
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lipids Health Dis 11:32. 2012
    ....
  5. doi request reprint Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behavior
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Endocrinology 153:1016-24. 2012
    ....
  6. doi request reprint Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 35:1575-85. 2011
    ..Ultimately, these data present a compelling picture of the putative role of the endocannabinoid system in the processes subserving both the development and treatment of depression...
  7. ncbi request reprint Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakes
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
    Eur J Pharmacol 516:28-33. 2005
    ....
  8. doi request reprint Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Curr Top Behav Neurosci 1:289-306. 2009
    ..The relevance of this relationship has not been fully explored with respect to both normal homeostasis and pathological states characterized by alterations in HPA axis function, but will be a focus of future research...
  9. doi request reprint Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, Vancouver, Canada, BC V6T 1Z4
    Horm Behav 58:91-9. 2010
    ..Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review...
  10. doi request reprint Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders
    Boris B Gorzalka
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Neurosci Biobehav Rev 32:1152-60. 2008
    ....
  11. pmc Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 34:2733-45. 2009
    ..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response...
  12. ncbi request reprint Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z4
    Eur J Neurosci 24:1845-9. 2006
    ..They also suggest that endocannabinoids may play a complex role in the regulation of neurogenesis via cell proliferation in the hippocampus...
  13. pmc Endogenous cannabinoid signaling is essential for stress adaptation
    Matthew N Hill
    Departments of Psychology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T1Z3
    Proc Natl Acad Sci U S A 107:9406-11. 2010
    ....
  14. doi request reprint Rape myth acceptance in men who completed the prostitution offender program of British Columbia
    Carolin Klein
    Department of Psychology, The University of British Columbia, Vancouver, Canada
    Int J Offender Ther Comp Criminol 53:305-15. 2009
    ..Results are discussed in terms of the association between rape myth acceptance and the violence frequently perpetrated against those working in the sex trade...
  15. doi request reprint Sexual functioning in transsexuals following hormone therapy and genital surgery: a review
    Carolin Klein
    University of British Columbia Department of Psychology, 2136 West Mall, Vancouver V6T 1Z4, Canada
    J Sex Med 6:2922-39; quiz 2940-1. 2009
    ..However, compared to other outcome measures, little clinical and research attention has been given to sexual functioning following SRS...
  16. doi request reprint Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission
    Anna C Morrish
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Physiol Behav 98:118-24. 2009
    ..These results show that protracted administration of a CB(1) receptor agonist produces an antidepressant-like response in the FST in both sexes, which appears to involve the noradrenergic system...
  17. ncbi request reprint Estrogen recruits the endocannabinoid system to modulate emotionality
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
    Psychoneuroendocrinology 32:350-7. 2007
    ..Collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of FAAH represents a therapeutic target for anxiety and depression in women...
  18. pmc Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 106:2322-36. 2008
    ....
  19. ncbi request reprint Long-term kindling of the basolateral amygdala impairs copulatory behavior in male rats
    Orsolya Magyar
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Neurosci Lett 390:162-5. 2005
    ..These results suggest that kindled rats may exhibit elevated levels of endogenous serotonin during exposure to a female rat, which would attenuate copulatory behavior, while concurrently increasing WDS expression...
  20. ncbi request reprint Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropsychopharmacology 31:2591-9. 2006
    ....
  21. ncbi request reprint Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuropsychopharmacology 30:508-15. 2005
    ....
  22. ncbi request reprint Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, 2136 West Mall, Canada V6T 1Z4
    Eur Neuropsychopharmacol 15:593-9. 2005
    ..These data suggest that enhancement of CB1 receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration...
  23. ncbi request reprint Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C Canada V6T1Z4
    Eur J Pharmacol 528:99-102. 2005
    ..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content...
  24. ncbi request reprint Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposure
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Psychoneuroendocrinology 31:526-36. 2006
    ..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis...
  25. ncbi request reprint Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
    Prog Neuropsychopharmacol Biol Psychiatry 27:905-11. 2003
    ..01), as well as attenuate the anti-immobility effects of melatonin (P=.03). These findings suggest that while melatonin may possess antidepressant-like qualities, high levels of corticosterone seem capable of attenuating these effects...
  26. ncbi request reprint Augmentation of the development of behavioral tolerance to cannabinoid administration through pavlovian conditioning
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Neuropsychobiology 49:94-100. 2004
    ....
  27. ncbi request reprint Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo
    Matthew N Hill
    Department of Psychology and the Brain Research Centre, 2136 West Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Eur J Neurosci 20:859-63. 2004
    ..These results indicate that long-term cannabinoid exposure can produce marked deficits in reference and working memory performance, and also impair hippocampal synaptic plasticity in vivo...
  28. pmc Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Psychoneuroendocrinology 34:1257-62. 2009
    ..The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress...
  29. ncbi request reprint Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurochem 103:47-56. 2007
    ....
  30. ncbi request reprint Psychophysiological and subjective sexual arousal to visual sexual stimuli in new women
    Lori A Brotto
    Department of Obstetrics Gynaecology, University of British Columbia, Vancouver, Canada
    J Psychosom Obstet Gynaecol 26:237-44. 2005
    ..These data are discussed in the context of differences in pelvic musculature between natal and new women and have implications for future studies that aim to measure sexual arousal objectively in MTF women...
  31. pmc Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Neural Transm 115:1673-9. 2008
    ..These data suggest that monoaminergic neurotransmission can regulate the endocannabinoid system and further indicates a role of the endocannabinoid system in affective illness and its treatment...
  32. ncbi request reprint Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Hippocampus 18:221-6. 2008
    ....
  33. ncbi request reprint Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Int J Neuropsychopharmacol 9:277-86. 2006
    ..This may partially explain the association between excessive cannabis consumption and the induction of affective disease...
  34. doi request reprint Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behavior
    Caitlin J Riebe
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada V6T1Z4
    Neurosci Lett 472:171-4. 2010
    ....
  35. ncbi request reprint A questionnaire study of cervical cancer screening beliefs and practices of Chinese and Caucasian mother-daughter pairs living in Canada
    Sabrina C H Chang
    Department of Psychology, University of British Columbia, Vancouver BC
    J Obstet Gynaecol Can 32:254-62. 2010
    ..We examined three potential predictors of Pap testing behaviour in Chinese women: acculturation, cervical cancer screening belief accuracy, and intergenerational transmission...
  36. ncbi request reprint Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
    Eur J Pharmacol 499:291-5. 2004
    ..These findings suggest that chronic stress enhances either cannabinoid receptor responsivity or one of the interacting systems implicated in emotional states...
  37. doi request reprint Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic-pituitary-adrenal axis
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, B C V6T1Z4, Canada
    Eur J Pharmacol 624:71-6. 2009
    ..These data suggest that acute administration of exogenous cannabinoid ligands activates the HPA axis indirectly through an increase in serotonergic and noradrenergic neurotransmission...
  38. doi request reprint The role of sexuality in cervical cancer screening among Chinese women
    Jane S T Woo
    Department of Psychology, University of British Columbia, Canada
    Health Psychol 28:598-604. 2009
    ..The purpose of this study was to explore the role of sexuality in the interaction between acculturation and Pap testing...
  39. pmc Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, B C, Canada
    Hippocampus 20:513-23. 2010
    ..These data demonstrate that the endocannabinoid system in the hippocampus is sensitive to environmental change and suggest that it is a mediator of experience-induced plasticity...
  40. doi request reprint Conscious regulation of sexual arousal in men
    Jason Winters
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    J Sex Res 46:330-43. 2009
    ..Increased sexual excitation and desire were associated with poorer regulatory performance, whereas a propensity for sexual inhibition due to fear of performance consequences was related to regulatory success...
  41. doi request reprint 5-HT(2A) receptor mediated neuronal activation within the paraventricular nucleus of the hypothalamus is desensitized following prolonged glucocorticoid treatment
    Tiffany T Y Lee
    Department of Psychology, University of British Columbia, Vancouver, BC Canada V6T1Z4
    Eur J Pharmacol 602:54-7. 2009
    ....
  42. doi request reprint Laboratory-induced hyperventilation differentiates female sexual arousal disorder subtypes
    Lori A Brotto
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Arch Sex Behav 38:463-75. 2009
    ..There was no significant effect of LIH on any self-report measure of sexual arousal following erotic stimuli. Implications of the results for the conceptualization, diagnosis, and treatment of SAD are discussed...
  43. ncbi request reprint Acculturation and sexual function in Asian women
    Lori A Brotto
    Department of Obstetrics and Gyneacology, University of British Columbia, Vancouver, Canada
    Arch Sex Behav 34:613-26. 2005
    ....
  44. ncbi request reprint Genital and subjective sexual arousal in postmenopausal women: influence of laboratory-induced hyperventilation
    Lori A Brotto
    University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
    J Sex Marital Ther 28:39-53. 2002
    ..These data are the first to directly compare genital-subjective correlations between pre- and postmenopausal women...