Research Topics
| Boris GorzalkaSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Conditioned taste aversion: modulation by 5-HT receptor activity and corticosteroneBoris Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada, V6T 1Z4
Eur J Pharmacol 471:129-34. 2003..These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion...- Endocannabinoid modulation of male rat sexual behaviorBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada, V6T1Z4
Psychopharmacology (Berl) 198:479-86. 2008..The aim of this experiment was to determine the effect of pharmacological facilitation or antagonism of endocannabinoid signaling on male rat sexual behavior... - Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effectRyan J McLaughlin
Department of Psychology, University of British Columbia, Vancouver, Canada
Behav Pharmacol 18:431-8. 2007..Collectively, these data highlight the potential importance of changes in the hippocampal endocannabinoid system following stress or antidepressant treatment with respect to the manifestation and/or treatment of depression... 
Serum contents of endocannabinoids are correlated with blood pressure in depressed womenW S Vanessa Ho
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Lipids Health Dis 11:32. 2012....
Minireview: Endocannabinoids and gonadal hormones: bidirectional interactions in physiology and behaviorBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, Canada
Endocrinology 153:1016-24. 2012....- Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressantsBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Prog Neuropsychopharmacol Biol Psychiatry 35:1575-85. 2011..Ultimately, these data present a compelling picture of the putative role of the endocannabinoid system in the processes subserving both the development and treatment of depression... - Functional role of the endocannabinoid system and AMPA/kainate receptors in 5-HT2A receptor-mediated wet dog shakesBoris B Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B C, Canada V6T 1Z4
Eur J Pharmacol 516:28-33. 2005.... - Integration of endocannabinoid signaling into the neural network regulating stress-induced activation of the hypothalamic-pituitary-adrenal axisBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Curr Top Behav Neurosci 1:289-306. 2009..The relevance of this relationship has not been fully explored with respect to both normal homeostasis and pathological states characterized by alterations in HPA axis function, but will be a focus of future research... - Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone functionBoris B Gorzalka
Department of Psychology, University of British Columbia, Vancouver, Canada, BC V6T 1Z4
Horm Behav 58:91-9. 2010..Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review... - Regulation of endocannabinoid signaling by stress: implications for stress-related affective disordersBoris B Gorzalka
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Neurosci Biobehav Rev 32:1152-60. 2008.... - Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 34:2733-45. 2009..Taken together, these findings suggest that the degree to which stressful stimuli reduce amygdalar AEA/CB(1) receptor signaling contributes to the magnitude of the HPA response... - Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behavioursMatthew N Hill
Department of Psychology and the Brain Research Centre, University of British Columbia, Vancouver, BC, Canada V6T1Z4
Eur J Neurosci 24:1845-9. 2006..They also suggest that endocannabinoids may play a complex role in the regulation of neurogenesis via cell proliferation in the hippocampus... - Endogenous cannabinoid signaling is essential for stress adaptationMatthew N Hill
Departments of Psychology and Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T1Z3
Proc Natl Acad Sci U S A 107:9406-11. 2010.... - Rape myth acceptance in men who completed the prostitution offender program of British ColumbiaCarolin Klein
Department of Psychology, The University of British Columbia, Vancouver, Canada
Int J Offender Ther Comp Criminol 53:305-15. 2009..Results are discussed in terms of the association between rape myth acceptance and the violence frequently perpetrated against those working in the sex trade... - Sexual functioning in transsexuals following hormone therapy and genital surgery: a reviewCarolin Klein
University of British Columbia Department of Psychology, 2136 West Mall, Vancouver V6T 1Z4, Canada
J Sex Med 6:2922-39; quiz 2940-1. 2009..However, compared to other outcome measures, little clinical and research attention has been given to sexual functioning following SRS... - Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmissionAnna C Morrish
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Physiol Behav 98:118-24. 2009..These results show that protracted administration of a CB(1) receptor agonist produces an antidepressant-like response in the FST in both sexes, which appears to involve the noradrenergic system... - Estrogen recruits the endocannabinoid system to modulate emotionalityMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4
Psychoneuroendocrinology 32:350-7. 2007..Collectively, these data demonstrate that estrogen may elicit changes in emotional behavior through an endocannabinoid mechanism, and suggest that inhibition of FAAH represents a therapeutic target for anxiety and depression in women... - Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatmentMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 106:2322-36. 2008.... - Long-term kindling of the basolateral amygdala impairs copulatory behavior in male ratsOrsolya Magyar
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Neurosci Lett 390:162-5. 2005..These results suggest that kindled rats may exhibit elevated levels of endogenous serotonin during exposure to a female rat, which would attenuate copulatory behavior, while concurrently increasing WDS expression... - Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axisMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Neuropsychopharmacology 31:2591-9. 2006.... - Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Neuropsychopharmacology 30:508-15. 2005.... - Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim testMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, 2136 West Mall, Canada V6T 1Z4
Eur Neuropsychopharmacol 15:593-9. 2005..These data suggest that enhancement of CB1 receptor signaling results in antidepressant effects in the forced swim test similar to that seen following conventional antidepressant administration... - Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdalaMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B.C. Canada V6T1Z4
Eur J Pharmacol 528:99-102. 2005..Given the role of amygdalar endocannabinoids in the regulation of emotionality, this suggests that the ability of glucocorticoids to influence affective behavior may involve interactions with regulation of endocannabinoid content... - Increased sensitivity to restraint stress and novelty-induced emotionality following long-term, high dose cannabinoid exposureMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Psychoneuroendocrinology 31:526-36. 2006..This interaction was not seen in the basolateral amygdala. Together, these findings suggest that chronic high dose, but not low dose, cannabinoid administration may result in increased emotionality and sensitization of the stress axis... - Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female ratsMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, B.C, Canada V6T 1Z4
Prog Neuropsychopharmacol Biol Psychiatry 27:905-11. 2003..01), as well as attenuate the anti-immobility effects of melatonin (P=.03). These findings suggest that while melatonin may possess antidepressant-like qualities, high levels of corticosterone seem capable of attenuating these effects... - Augmentation of the development of behavioral tolerance to cannabinoid administration through pavlovian conditioningMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B.C, Canada
Neuropsychobiology 49:94-100. 2004.... - Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivoMatthew N Hill
Department of Psychology and the Brain Research Centre, 2136 West Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Eur J Neurosci 20:859-63. 2004..These results indicate that long-term cannabinoid exposure can produce marked deficits in reference and working memory performance, and also impair hippocampal synaptic plasticity in vivo... - Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stressMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Psychoneuroendocrinology 34:1257-62. 2009..The magnitude of these responses did not differ between depressed and control subjects. These are the first data to demonstrate that the peripheral endocannabinoid/NAE system is responsive to exposure to stress... - Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activityMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
J Neurochem 103:47-56. 2007.... - Psychophysiological and subjective sexual arousal to visual sexual stimuli in new womenLori A Brotto
Department of Obstetrics Gynaecology, University of British Columbia, Vancouver, Canada
J Psychosom Obstet Gynaecol 26:237-44. 2005..These data are discussed in the context of differences in pelvic musculature between natal and new women and have implications for future studies that aim to measure sexual arousal objectively in MTF women... - Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contentsMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
J Neural Transm 115:1673-9. 2008..These data suggest that monoaminergic neurotransmission can regulate the endocannabinoid system and further indicates a role of the endocannabinoid system in affective illness and its treatment... - Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampusMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
Hippocampus 18:221-6. 2008.... - Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatmentMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Int J Neuropsychopharmacol 9:277-86. 2006..This may partially explain the association between excessive cannabis consumption and the induction of affective disease... - Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behaviorCaitlin J Riebe
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada V6T1Z4
Neurosci Lett 472:171-4. 2010.... - A questionnaire study of cervical cancer screening beliefs and practices of Chinese and Caucasian mother-daughter pairs living in CanadaSabrina C H Chang
Department of Psychology, University of British Columbia, Vancouver BC
J Obstet Gynaecol Can 32:254-62. 2010..We examined three potential predictors of Pap testing behaviour in Chinese women: acculturation, cervical cancer screening belief accuracy, and intergenerational transmission... - Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stressMatthew N Hill
Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
Eur J Pharmacol 499:291-5. 2004..These findings suggest that chronic stress enhances either cannabinoid receptor responsivity or one of the interacting systems implicated in emotional states... - Monoaminergic neurotransmission contributes to cannabinoid-induced activation of the hypothalamic-pituitary-adrenal axisRyan J McLaughlin
Department of Psychology, University of British Columbia, Vancouver, B C V6T1Z4, Canada
Eur J Pharmacol 624:71-6. 2009..These data suggest that acute administration of exogenous cannabinoid ligands activates the HPA axis indirectly through an increase in serotonergic and noradrenergic neurotransmission... - The role of sexuality in cervical cancer screening among Chinese womenJane S T Woo
Department of Psychology, University of British Columbia, Canada
Health Psychol 28:598-604. 2009..The purpose of this study was to explore the role of sexuality in the interaction between acculturation and Pap testing... - Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampusMatthew N Hill
Department of Psychology, University of British Columbia, Vancouver, B C, Canada
Hippocampus 20:513-23. 2010..These data demonstrate that the endocannabinoid system in the hippocampus is sensitive to environmental change and suggest that it is a mediator of experience-induced plasticity... - Conscious regulation of sexual arousal in menJason Winters
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
J Sex Res 46:330-43. 2009..Increased sexual excitation and desire were associated with poorer regulatory performance, whereas a propensity for sexual inhibition due to fear of performance consequences was related to regulatory success... - 5-HT(2A) receptor mediated neuronal activation within the paraventricular nucleus of the hypothalamus is desensitized following prolonged glucocorticoid treatmentTiffany T Y Lee
Department of Psychology, University of British Columbia, Vancouver, BC Canada V6T1Z4
Eur J Pharmacol 602:54-7. 2009.... - Laboratory-induced hyperventilation differentiates female sexual arousal disorder subtypesLori A Brotto
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
Arch Sex Behav 38:463-75. 2009..There was no significant effect of LIH on any self-report measure of sexual arousal following erotic stimuli. Implications of the results for the conceptualization, diagnosis, and treatment of SAD are discussed... - Acculturation and sexual function in Asian womenLori A Brotto
Department of Obstetrics and Gyneacology, University of British Columbia, Vancouver, Canada
Arch Sex Behav 34:613-26. 2005.... - Genital and subjective sexual arousal in postmenopausal women: influence of laboratory-induced hyperventilationLori A Brotto
University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada
J Sex Marital Ther 28:39-53. 2002..These data are the first to directly compare genital-subjective correlations between pre- and postmenopausal women...