T Gordon

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Transforming growth factor-beta and forskolin attenuate the adverse effects of long-term Schwann cell denervation on peripheral nerve regeneration in vivo
    Olawale A R Sulaiman
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Glia 37:206-18. 2002
  2. ncbi request reprint Method for counting motor units in mice and validation using a mathematical model
    Lora A Major
    Centre for Neuroscience, and Department of Biomedical Engineering, University of Alberta, 8308 114 Street, Edmonton, Alberta T6G 2V2, Canada
    J Neurophysiol 97:1846-56. 2007
  3. ncbi request reprint Prolonged target deprivation reduces the capacity of injured motoneurons to regenerate
    Matthew J Furey
    Center for Neuroscience, University of Alberta, Edmonton, Canada
    Neurosurgery 60:723-32; discussion 732-3. 2007
  4. ncbi request reprint Neuromuscular activity impairs axonal sprouting in partially denervated muscles by inhibiting bridge formation of perisynaptic Schwann cells
    S L Tam
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada T6G 2S2
    J Neurobiol 57:221-34. 2003
  5. ncbi request reprint Adaptive and maladaptive motor axonal sprouting in aging and motoneuron disease
    Tessa Gordon
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Neurol Res 26:174-85. 2004
  6. ncbi request reprint The potential of electrical stimulation to promote functional recovery after peripheral nerve injury--comparisons between rats and humans
    T Gordon
    Division of Physical Medicine and Rehabilitation, Centre for Neuroscience, Faculty of Medicine, University of Alberta, Alberta, Canada
    Acta Neurochir Suppl 100:3-11. 2007
  7. ncbi request reprint Experimental strategies to promote functional recovery after peripheral nerve injuries
    Tessa Gordon
    Center for Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Peripher Nerv Syst 8:236-50. 2003
  8. doi request reprint Early detection of denervated muscle fibers in hindlimb muscles after sciatic nerve transection in wild type mice and in the G93A mouse model of amyotrophic lateral sclerosis
    T Gordon
    Division of Physical Medicine and Rehabilitation Centre for Neuroscience, Faculty of Medicine, University of Alberta, Edmonton, Alta T6G 2S2, Canada
    Neurol Res 31:28-42. 2009
  9. doi request reprint Functional over-load saves motor units in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis
    T Gordon
    Division of Physical Medicine and Rehabilitation Center for Neuroscience, University of Alberta, Edmonton, AB, Canada
    Neurobiol Dis 37:412-22. 2010
  10. doi request reprint The role of neurotrophic factors in nerve regeneration
    Tessa Gordon
    Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Neurosurg Focus 26:E3. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Transforming growth factor-beta and forskolin attenuate the adverse effects of long-term Schwann cell denervation on peripheral nerve regeneration in vivo
    Olawale A R Sulaiman
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Glia 37:206-18. 2002
    ..Hence, acute treatment of atrophic SC with TGF-beta can reactivate the growth-permissive SC phenotype to support axonal regeneration...
  2. ncbi request reprint Method for counting motor units in mice and validation using a mathematical model
    Lora A Major
    Centre for Neuroscience, and Department of Biomedical Engineering, University of Alberta, 8308 114 Street, Edmonton, Alberta T6G 2V2, Canada
    J Neurophysiol 97:1846-56. 2007
    ..The ITS-MUNE analysis method has the potential to quantitatively measure the progression of motor neuron diseases and therefore the efficacy of treatments designed to alleviate pathologic processes of muscle denervation...
  3. ncbi request reprint Prolonged target deprivation reduces the capacity of injured motoneurons to regenerate
    Matthew J Furey
    Center for Neuroscience, University of Alberta, Edmonton, Canada
    Neurosurgery 60:723-32; discussion 732-3. 2007
    ....
  4. ncbi request reprint Neuromuscular activity impairs axonal sprouting in partially denervated muscles by inhibiting bridge formation of perisynaptic Schwann cells
    S L Tam
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada T6G 2S2
    J Neurobiol 57:221-34. 2003
    ..Our findings suggest that failure of Schwann cell processes to bridge between endplates accounts, at least in part, for the inhibitory effect of increased neuromuscular activity on sprouting...
  5. ncbi request reprint Adaptive and maladaptive motor axonal sprouting in aging and motoneuron disease
    Tessa Gordon
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Neurol Res 26:174-85. 2004
    ..The progression is accelerated in motoneuron disease, progressing more rapidly in the post-polio syndrome after prolonged denervation and extremely rapidly in ALS...
  6. ncbi request reprint The potential of electrical stimulation to promote functional recovery after peripheral nerve injury--comparisons between rats and humans
    T Gordon
    Division of Physical Medicine and Rehabilitation, Centre for Neuroscience, Faculty of Medicine, University of Alberta, Alberta, Canada
    Acta Neurochir Suppl 100:3-11. 2007
    ....
  7. ncbi request reprint Experimental strategies to promote functional recovery after peripheral nerve injuries
    Tessa Gordon
    Center for Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Peripher Nerv Syst 8:236-50. 2003
    ..Finally, we consider the effectiveness of a brief period of 20 Hz electrical stimulation in promoting the regeneration of axons across the surgical gap after nerve repair...
  8. doi request reprint Early detection of denervated muscle fibers in hindlimb muscles after sciatic nerve transection in wild type mice and in the G93A mouse model of amyotrophic lateral sclerosis
    T Gordon
    Division of Physical Medicine and Rehabilitation Centre for Neuroscience, Faculty of Medicine, University of Alberta, Edmonton, Alta T6G 2S2, Canada
    Neurol Res 31:28-42. 2009
    ..We conclude that the N-CAM immunoreactivity on muscle fiber membranes in muscle cross-sections provides a sensitive means of detecting early muscle fiber denervation...
  9. doi request reprint Functional over-load saves motor units in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis
    T Gordon
    Division of Physical Medicine and Rehabilitation Center for Neuroscience, University of Alberta, Edmonton, AB, Canada
    Neurobiol Dis 37:412-22. 2010
    ..We conclude that the vulnerable motor units are saved by increasing their neuromuscular activity and consequently, converting them to slower, less forceful, fatigue resistant motor units...
  10. doi request reprint The role of neurotrophic factors in nerve regeneration
    Tessa Gordon
    Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Neurosurg Focus 26:E3. 2009
    ..The findings provide strong support for endogenous neurotrophic factors of axotomized neurons and of denervated Schwann cells playing a critical role in supporting axon regeneration in the PNS...
  11. doi request reprint Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury
    Tessa Gordon
    Center for Neuroscience, Division of Neuroscience, Faculty of Medicine, University of Alberta, Edmonton, Canada
    Neurosurgery 65:A132-44. 2009
    ..Recently, low-frequency electrical stimulation (as brief as an hour) has shown promise, as it significantly accelerated regeneration in animal models through speeding of axon growth across the injury site...
  12. ncbi request reprint The resilience of the size principle in the organization of motor unit properties in normal and reinnervated adult skeletal muscles
    Tessa Gordon
    Division of Physical Therapy and Rehabilitation, Centre for Neuroscience, 525 Heritage Medical Research Center, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Can J Physiol Pharmacol 82:645-61. 2004
    ....
  13. doi request reprint The physiology of neural injury and regeneration: The role of neurotrophic factors
    Tessa Gordon
    Division of Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
    J Commun Disord 43:265-73. 2010
    ..In addition, findings that BDNF is essential for the effectiveness of brief low frequency electrical stimulation in promoting nerve growth, provides further support for a central role of BNDF in motor nerve regeneration...
  14. pmc Sprouting capacity of lumbar motoneurons in normal and hemisected spinal cords of the rat
    T Gordon
    Department of Surgery, Division of Plastic Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    J Physiol 588:2745-68. 2010
    ..We conclude that the upper limit of MU enlargement may be explained by the reinnervation of denervated muscle fibres by axon sprouts within the spatial territory of the muscle unit, formerly distributed in a mosaic pattern...
  15. doi request reprint Nerve regeneration in the peripheral nervous system versus the central nervous system and the relevance to speech and hearing after nerve injuries
    Tessa Gordon
    Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Alberta, Edmonton, Alberta, T6H 2S2, Canada
    J Commun Disord 43:274-85. 2010
    ..The misdirection of laryngeal nerve reinnervation can be alleviated surgically by strategies favoring inspiratory abduction...
  16. pmc Size of myelinated nerve fibres is not increased by expansion of the peripheral field in cats
    T Gordon
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Physiol 532:835-49. 2001
    ..Retrograde control of size in non-myelinated but not in myelinated nerve fibres demonstrates differences in plasticity of neurons in the somatic and autonomic nervous systems...
  17. ncbi request reprint Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
    J Hegedus
    Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Neurobiol Dis 28:154-64. 2007
    ..We conclude that size of motoneurons, their axons, and their motor unit size are important determinants of motoneuron susceptibility in ALS...
  18. ncbi request reprint The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration
    J G Boyd
    University Centre for Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, 523 Heritage Medical Research Centre, Edmonton, AB T6G 2S2, Canada
    J Neurobiol 49:314-25. 2001
    ..In addition, full expression of trkB is critical for complete axonal regeneration to proceed...
  19. pmc Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis
    J Hegedus
    Centre for Neuroscience, 525 Heritage Medical Research Centre, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada
    J Physiol 586:3337-51. 2008
    ....
  20. doi request reprint Progressive motor unit loss in the G93A mouse model of amyotrophic lateral sclerosis is unaffected by gender
    J Hegedus
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Muscle Nerve 39:318-27. 2009
    ..We conclude that gender does not alter progressive, muscle-specific motor unit loss in ALS, even though gender does influence disease onset...
  21. ncbi request reprint Increased neuromuscular activity reduces sprouting in partially denervated muscles
    S L Tam
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Canada T6G 2S2
    J Neurosci 21:654-67. 2001
    ..Thus, increased neuromuscular activity is detrimental primarily in muscles that are extensively denervated, and the MUs are smaller than under conditions in which the muscles experience normal physiological levels of activation...
  22. ncbi request reprint A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor
    J G Boyd
    University Centre for Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Eur J Neurosci 15:613-26. 2002
    ..The inhibitory actions of high dose BDNF could be reversed by functional blockade of p75 receptors, thus implicating these receptors as mediators of the inhibitory effects of high dose exogenous BDNF...
  23. doi request reprint Augmenting nerve regeneration with electrical stimulation
    T Gordon
    Division of Physical Medicine and Rehabilitation Centre for Neuroscience, Faculty of Medicine, University of Alberta, Edmonton, Alta T6G 2S2, Canada
    Neurol Res 30:1012-22. 2008
    ..In carpal tunnel syndrome (CTS) patients with severe axon degeneration and release surgery, we asked whether ES accelerates muscle reinnervation...
  24. ncbi request reprint Effect of exercise on stability of chronically enlarged motor units
    Siu Lin Tam
    Department of Pharmacology, Division of Neuroscience, Faculty of Medicine, University of Alberta, 525 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2 Canada
    Muscle Nerve 25:359-69. 2002
    ....
  25. ncbi request reprint FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic schwann cell denervation
    Olawale A R Sulaiman
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Exp Neurol 175:127-37. 2002
    ....
  26. pmc Rolipram-induced elevation of cAMP or chondroitinase ABC breakdown of inhibitory proteoglycans in the extracellular matrix promotes peripheral nerve regeneration
    E Udina
    Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, Center for Neurosciences, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Exp Neurol 223:143-52. 2010
    ....
  27. ncbi request reprint Electrical stimulation accelerates and enhances expression of regeneration-associated genes in regenerating rat femoral motoneurons
    Abdulhakeem A Al-Majed
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada
    Cell Mol Neurobiol 24:379-402. 2004
    ....
  28. ncbi request reprint Brief electrical stimulation accelerates axon regeneration in the peripheral nervous system and promotes sensory axon regeneration in the central nervous system
    Tessa Gordon
    Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, Alberta
    Motor Control 13:412-41. 2009
    ....
  29. pmc Tetrodotoxin prevents motor unit enlargement after partial denervation in rat hindlimb muscles
    S L Tam
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Canada T6G 2S2
    J Physiol 543:655-63. 2002
    ..These data demonstrate that a reduction in neuromuscular activity mediated by presynaptic blockade of neural action potentials reduces MU enlargement in partially denervated muscles by reducing axonal sprouting...
  30. ncbi request reprint Effects of long-term creatine feeding and running on isometric functional measures and myosin heavy chain content of rat skeletal muscles
    Maria Gallo
    Exercise Biochemistry Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton T6G 2H9, Alberta, Canada
    Pflugers Arch 452:744-55. 2006
    ..Cr feeding combined with running exercise resulted in a faster MHC-based phenotype in the rat plantaris but the impact on associated isometric contractile properties was minimal...
  31. ncbi request reprint An investigation into the potential for activity-dependent regeneration of the rubrospinal tract after spinal cord injury
    Philip J Harvey
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Eur J Neurosci 22:3025-35. 2005
    ..In summary, direct stimulation of the injured RST axons for the periods tested does not increase expression of GAP-43 and BDNF, and ultimately does not promote regeneration of these central nervous system axons...
  32. doi request reprint cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons
    C Aglah
    Division of Physical Medicine and Rehabilitation, Centre for Neuroscience, University of Alberta, 525 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2
    Neuropharmacology 55:8-17. 2008
    ..These findings provide evidence for a key role of cAMP in promoting peripheral nerve regeneration after nerve injuries and indicate that this effect is unusual in not being mediated via Erk phosphorylation...
  33. doi request reprint Motoneuron survival after chronic and sequential peripheral nerve injuries in the rat
    Qing Gui Xu
    Division of Neurosurgery, Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    J Neurosurg 112:890-9. 2010
    ..An underlying possibility is that chronic injuries may increase motoneuron cell death. The hypothesis that substantial motoneuron death follows chronic and sequential nerve injuries was tested in adult rats in this study...
  34. ncbi request reprint Peripheral target contact regulates Ca2+ channels in the cell bodies of bullfrog sympathetic ganglion B-neurons
    T Petrov
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Auton Neurosci 89:74-85. 2001
    ..IC and IAHP, IC, which is responsible for the peak amplitude of the a.h.p has a low affinity for Ca2+, whereas IAHP, which determines a.h.p. duration, has higher Ca2+ affinity...
  35. doi request reprint Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model
    A Ladak
    Division of Plastic Surgery, University of Alberta, Edmonton, AB, Canada
    Exp Neurol 228:242-52. 2011
    ..The nerve autograft remains the most effective conduit for supporting regeneration across nerve gaps...
  36. doi request reprint Chapter 24: Electrical stimulation for improving nerve regeneration: where do we stand?
    Tessa Gordon
    Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Int Rev Neurobiol 87:433-44. 2009
    ..These findings are very promising such that the ES method could become a clinically viable tool for accelerating axon regeneration and muscle reinnervation...
  37. doi request reprint Brief post-surgical electrical stimulation accelerates axon regeneration and muscle reinnervation without affecting the functional measures in carpal tunnel syndrome patients
    Tessa Gordon
    Division of Physical Medicine and Rehabilitation Center for Neuroscience, University of Alberta, 525 Heritage Medical Research Centre, Edmonton, Alberta, Canada T6G 2S2
    Exp Neurol 223:192-202. 2010
    ..Other outcome measures showed a significant improvement in both patient groups. We conclude that brief low frequency ES accelerates axonal regeneration and target reinnervation in humans...
  38. doi request reprint Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation
    Sarah K Walsh
    Department of Clinical Neuroscience and Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, HMRB 109 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N4N1
    Exp Neurol 223:221-8. 2010
    ..We therefore conclude that SKPs represent an easily accessible, autologous source of stem cell-derived Schwann cells that show promise in improving regeneration through chronically injured nerves...
  39. ncbi request reprint Chronic Schwann cell denervation and the presence of a sensory nerve reduce motor axonal regeneration
    Olawale A R Sulaiman
    Department of Pharmacology, Division of Neuroscience, University of Alberta, Edmonton, Canada
    Exp Neurol 176:342-54. 2002
    ..They also imply that repairing pure motor nerves (without their cutaneous sensory components) to distal nerve stumps should be considered clinically when motor recovery is the main desired outcome...
  40. doi request reprint Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle
    Maria Gallo
    E 417 Van Vliet Centre, Univ of Alberta, Edmonton, AB, Canada T6G 2H9
    Am J Physiol Regul Integr Comp Physiol 294:R1319-28. 2008
    ..This indicates that creatine loading during run training supports a faster muscle phenotype that is adequately supported by the existing glycolytic potential, without changes in the capacity for terminal substrate oxidation...
  41. ncbi request reprint Canadian Association of Neuroscience review: axonal regeneration in the peripheral and central nervous systems--current issues and advances
    Keith Fenrich
    Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, AB, Canada
    Can J Neurol Sci 31:142-56. 2004
    ..Strategies to overcome these limitations in the PNS are considered in detail and contrasted with strategies in the CNS...
  42. ncbi request reprint Regeneration into protected and chronically denervated peripheral nerve stumps
    Rajiv Midha
    Division of Neurosurgery, Department of Clinical Neurosciences, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Neurosurgery 57:1289-99; discussion 1289-99. 2005
    ..This may be a result of the deterioration or loss of endoneurial pathways in the distal nerve stump before motor axons can regenerate into the stump...
  43. pmc Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle
    Karen J B Martins
    E 417 Van Vliet Centre, University of Alberta, Edmonton, Alberta, Canada
    J Physiol 572:281-94. 2006
    ..Comparable changes were observed at the protein level by SDS-PAGE. It is concluded that although considerable adaptive potential exists within myonuclei, satellite cells play a role in facilitating fast-to-slow fibre-type transitions...
  44. doi request reprint Satellite cell ablation attenuates short-term fast-to-slow fibre type transformations in rat fast-twitch skeletal muscle
    Karen J B Martins
    Exercise Biochemistry Laboratory, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada T6G 2H9
    Pflugers Arch 458:325-35. 2009
    ..These findings indicate satellite cells play active and obligatory roles early on in the time course during skeletal muscle fibre type adaptations to CLFS...
  45. ncbi request reprint Force and stiffness of old dystrophic (mdx) mouse skeletal muscles
    J Bobet
    Department of Physical Therapy, University of Alberta, Edmonton, Canada
    Muscle Nerve 21:536-9. 1998
    ..They were also equally stiff. The results show that the mechanics of aged mdx limb muscles differ greatly from Duchenne muscular dystrophy in humans, and disagree with the hypothesis...
  46. doi request reprint Electrical stimulation of intact peripheral sensory axons in rats promotes outgrowth of their central projections
    Esther Udina
    Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Exp Neurol 210:238-47. 2008
    ..Thus elevation of cAMP may account for the central axonal outgrowth after ES and a CL...
  47. ncbi request reprint Development and use of the incremental twitch subtraction MUNE method in mice
    Janka Hegedus
    Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, 525, Heritage Medical Research Center, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Suppl Clin Neurophysiol 60:209-17. 2009
    ..Motor unit loss was found to occur well in advance of behavioral changes and the degree of reinnervation is dependent upon motor unit fiber types...
  48. ncbi request reprint Normative values and the effects of age, gender, and handedness on the Moberg Pick-Up Test
    Nasim Amirjani
    Centre for Neuroscience, University of Alberta, 513 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    Muscle Nerve 35:788-92. 2007
    ..Use of normative values established based on age and gender is a valuable objective tool to gauge hand function in patients with different neurologic disorders...
  49. ncbi request reprint Mechanisms controlling axonal sprouting at the neuromuscular junction
    Siu Lin Tam
    Centre of Neuroscience, Division of Physical Medicine and Rehabilitation, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada T6G 2S2
    J Neurocytol 32:961-74. 2003
    ..The role of neuromuscular activity in axonal sprouting will be considered critically in the context of the roles of sprouting stimuli and perisynaptic Schwann cells in the process of axonal sprouting...
  50. ncbi request reprint Postnatal development of adrenergic responsiveness in the rabbit heart
    Z P Feng
    Department of Pharmacology, University of Alberta, Edmonton, Canada
    Can J Physiol Pharmacol 67:883-9. 1989
    ....
  51. ncbi request reprint Reliability of isolated isometric function measures in rat muscles composed of different fibre types
    Maria Gallo
    E 417 Van Vliet Centre, University of Alberta, Edmonton, Alberta, Canada
    Exp Physiol 89:583-92. 2004
    ....
  52. ncbi request reprint Electrical stimulation restores the specificity of sensory axon regeneration
    Thomas M Brushart
    Department of Orthopaedic Surgery, Johns Hopkins Medical Institutions, 601 N Caroline Street, Baltimore, MD 21287, USA
    Exp Neurol 194:221-9. 2005
    ..If the enhanced regeneration specificity resulting from electrical stimulation is found to improve function in a large animal model, this convenient and safe technique may be a useful adjunct to clinical nerve repair...
  53. ncbi request reprint Changes in spinal cord architecture after brachial plexus injury in the newborn
    Klaus J Korak
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University Clinics of Vienna School of Medicine, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Brain 127:1488-95. 2004
    ..While present treatment is directed towards the restoration of neural continuity, future treatment strategies must recognize and take advantage of CNS participation in the injury and recovery process...
  54. ncbi request reprint Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression
    Nicole M Geremia
    Department of Anatomy and Cell Biology, Cameco MS Neuroscience Research Center University of Saskatchewan, Saskatoon City Hospital, Saskatchewan, Canada
    Exp Neurol 205:347-59. 2007
    ..The effect of brief stimulation on enhancing sensory and motoneuron regeneration holds promise for inducing improved peripheral nerve repair in the clinical setting...
  55. ncbi request reprint BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair
    Kirsten A Eberhardt
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Exp Neurol 198:500-10. 2006
    ..These findings indicate that BDNF/TrkB signaling is important for functional recovery after nerve repair and suggest that up-regulation of the HNK-1 glycan is linked to this phenomenon...
  56. ncbi request reprint Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron
    Thomas M Brushart
    Department of Orthopaedics, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore Maryland 21287, USA
    J Neurosci 22:6631-8. 2002
    ..This finding suggests a combined approach to improving the outcome of nerve repair, beginning with stimulation to recruit all motoneurons across the repair, followed by other treatments to speed and prolong axonal elongation...
  57. ncbi request reprint Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury
    J Gordon Boyd
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada
    Mol Neurobiol 27:277-324. 2003
    ....